公开(公告)号：US20190261580A1

公开(公告)日：2019-08-29

申请号：US16341181

申请日：2017-10-03

申请人： Ron COHEN ,  Yehonatan ANTEBI

发明人： Ron COHEN ,  Yehonatan ANTEBI

IPC分类号： A01G13/02 ,  C08J9/236

摘要： A composite characterized by an average density of 60 Kg/m3 to 180 Kg/m3, with at least two portions having a different density of at least 20 Kg/m3, made of a binder, and a foamed elastomer or a foamed rigid polymer, is disclosed herein. Uses of the composite and of matrices and articles incorporating same for the improvement of plant growing and/or weed control are further disclosed.

公开(公告)号：US08663685B2

公开(公告)日：2014-03-04

申请号：US13187158

申请日：2011-07-20

申请人： Andrew R. Blight ,  Ron Cohen

发明人： Andrew R. Blight ,  Ron Cohen

IPC分类号： A61K31/44 ,  A61K9/22

CPC分类号： A61K31/4409 ,  A61K9/20 ,  A61K9/2054 ,  A61K9/2077 ,  A61K31/44 ,  A61K47/12 ,  A61K47/14 ,  A61K47/38 ,  A61K47/44

摘要： A pharmaceutical composition which comprises a therapeutically effective amount of a aminopyridine dispersed in a release matrix, including, for example, a composition that can be formulated into a stable, sustained-release oral dosage formulation, such as a tablet which provides, upon administration to a patient, a therapeutically effective plasma level of the aminopyridine for a period of at least 12 hours, preferably 24 hours or more and the use of the composition to treat various neurological diseases.

摘要翻译： 一种药物组合物，其包含分散在释放基质中的治疗有效量的氨基吡啶，包括例如可以配制成稳定的持续释放口服剂量制剂的组合物，例如在给药至 患者，氨基吡啶的治疗有效血浆水平至少12小时，优选24小时或更长的时间，以及该组合物用于治疗各种神经疾病的用途。

公开(公告)号：US20110166189A1

公开(公告)日：2011-07-07

申请号：US12824136

申请日：2010-06-25

申请人： Andrew R. BLIGHT ,  Ron COHEN

发明人： Andrew R. BLIGHT ,  Ron COHEN

IPC分类号： A61K31/4409 ,  A61P25/28

CPC分类号： A61K31/4409 ,  A61K9/20 ,  A61K31/435 ,  A61K31/44

摘要： A pharmaceutical composition which comprises a therapeutically effective amount of a aminopyridine dispersed in a release matrix, including, for example, a composition that can be formulated into a stable, sustained-release oral dosage formulation, such as a tablet which provides, upon administration to a patient, a therapeutically effective plasma level of the aminopyridine for a period of at about 12 hours and the use of the composition to treat various neurological diseases, including multiple sclerosis. A method of selecting individuals based on responsiveness to a treatment, including, for example, identifying individuals who responded to treatment with a sustained release fampridine composition.

公开(公告)号：US20100061935A1

公开(公告)日：2010-03-11

申请号：US12557015

申请日：2009-09-10

申请人： Andrew R. Blight ,  Ron Cohen

发明人： Andrew R. Blight ,  Ron Cohen

IPC分类号： A61K31/4409 ,  A61K38/21 ,  A61K39/395 ,  A61K49/00 ,  A61P25/00

CPC分类号： A61K31/4409 ,  A61K31/44 ,  A61K38/21 ,  A61K45/06

摘要： Disclosed herein are methods and compositions related to use of aminopyridines, such as fampridine, to improve impairments of patients with a demyelinating condition, such as MS.

摘要翻译： 本文公开了与使用氨基吡啶（例如菲啶啶）相关的方法和组合物，以改善患有脱髓鞘状况的患者（例如MS）的损伤。

公开(公告)号：US07436858B2

公开(公告)日：2008-10-14

申请号：US10856788

申请日：2004-06-01

申请人： Motti Goren ,  Ron Cohen ,  Dov Wulich

发明人： Motti Goren ,  Ron Cohen ,  Dov Wulich

IPC分类号： H04L12/43

CPC分类号： H04J3/1611 ,  H04J3/0623 ,  H04J3/0632 ,  H04J3/073 ,  H04J3/1617 ,  H04L2012/5649 ,  H04L2012/5663 ,  H04L2012/5674

摘要： An adaptive rate management method and system for adapting a receiver rate to a transmission rate in a packet switch network comprises determining an error value at a sample rate, obtaining an updated accumulator value based on said error value Es at a decimated sample rate, and generating an appropriate rate command and changing said accumulator value at the decimated rate based on the updated accumulator value. The method may be adapted for either adapter point management or bit stuffing. When applied to adapter point management (APM), the method generates pointer adjustments for rate management. In a frequency locked APM preferred embodiment of the method and system, pointer adjustments in an interval are generated at a constant rate based on an average pointer adjustment value calculated in previous intervals.

摘要翻译： 一种用于使接收机速率适应分组交换网络中的传输速率的自适应速率管理方法和系统包括以采样速率确定误差值，基于所述误差值E < 以抽取采样率，并产生适当的速率命令，并且基于所更新的累加器值以所述抽取率改变所述累加器值。 该方法可适用于适配器点管理或位填充。 当应用于适配器点管理（APM）时，该方法生成用于速率管理的指针调整。 在方法和系统的频率锁定APM优选实施例中，基于在先前间隔中计算的平均指针调整值，以恒定速率生成间隔中的指针调整。

公开(公告)号：US07082476B1

公开(公告)日：2006-07-25

申请号：US09578027

申请日：2000-05-24

申请人： Ron Cohen ,  Yoram Snir

发明人： Ron Cohen ,  Yoram Snir

IPC分类号： G06F15/16 ,  G06F15/173

CPC分类号： H04L29/12009 ,  G06F17/30899 ,  H04L29/12028 ,  H04L29/12066 ,  H04L61/103 ,  H04L61/1511 ,  H04L67/1002

摘要： A method and apparatus are provided for optimizing retrieval of network resources. In one embodiment, a method of optimizing access to a network resource is implemented in a computer program executed by a router, cache server, or proxy server. A network resource that contains one or more embedded symbolic host name references is received. A network address corresponding to each of the embedded symbolic host name references is determined. A modified copy of the network resource is created and stored; in the modified copy, a network address is substituted for each corresponding embedded symbolic host name reference. Thereafter, the modified copy of the network resource in responding to all subsequent client requests for the network resource, thereby greatly reducing the required number of network address lookup operations. In one specific embodiment, IP addresses are determined using DNS queries for the hostname portion of all URLs that are embedded in a Web page using image, applet, object, or embed tags. The IP addresses are stored in place of the hostname portions in a modified copy of the Web page, typically in a cache. As a result, when the modified page is subsequently served to clients, the clients need not carry out DNS resolution of all the embedded URLs, resulting in reduced network message traffic and more rapid page display.

摘要翻译： 提供一种用于优化网络资源检索的方法和装置。 在一个实施例中，优化对网络资源的访问的方法在由路由器，缓存服务器或代理服务器执行的计算机程序中实现。 收到包含一个或多个嵌入式符号主机名称引用的网络资源。 确定与每个嵌入的符号主机名称引用相对应的网络地址。 创建并存储网络资源的修改副本; 在修改的副本中，替换每个相应的嵌入式符号主机名称引用的网络地址。 此后，网络资源的修改副本响应于网络资源的所有后续客户端请求，从而大大减少了所需的网络地址查找操作数量。 在一个具体实施例中，使用对使用图像，小应用程序，对象或嵌入标签嵌入在网页中的所有URL的主机名部分的DNS查询来确定IP地址。 IP地址存储在Web页面的修改副本中，通常位于缓存中，代替主机名部分。 因此，当修改的页面随后被提供给客户端时，客户端不需要对所有嵌入式URL进行DNS解析，导致网络消息流量减少，页面显示更快速。

公开(公告)号：US20050041599A1

公开(公告)日：2005-02-24

申请号：US10938242

申请日：2004-09-09

申请人： Arthur Zavalkovsky ,  Nitsan Elfassy ,  Ron Cohen

发明人： Arthur Zavalkovsky ,  Nitsan Elfassy ,  Ron Cohen

IPC分类号： G01R31/08 ,  G06F11/00 ,  G08C15/00 ,  H04J3/14 ,  H04L12/24 ,  H04L12/26 ,  H04L12/56

CPC分类号： H04L47/10 ,  H04L41/0893 ,  H04L47/17 ,  H04L47/20 ,  H04L47/2408 ,  H04L47/2458 ,  H04L47/30 ,  H04L47/36

摘要： A method, apparatus, and computer-readable medium configured for maintaining consistent per-hop packet forwarding behavior among a plurality of network devices in a network within a Differentiated Services (DS) domain are disclosed. In one aspect, a method involves creating and storing a network-wide PHB definition that associates a PHB with a DS code point (DSCP) value, and with a set of parameters that define the bandwidth and buffer resources allocated to the PHBs on all interfaces of network devices within the DS domain. A mapping of each of the PHBs in the network-wide PHB definition to one or more queues of the network devices is determined. Drain size and queue size values are determined for each of the queues to which PHBs are mapped. A mapping of each of the PHBs to a threshold value associated with the queues is determined. Parameters of fragmentation and interleave mechanisms are determined. Network device configuration parameter values based on the mappings, the drain size, and the queue size, etc. are sent to each of the network devices within the DS domain. As a result, consistent PHB is achieved throughout a network using abstract definitions of PHBs.

摘要翻译： 公开了一种配置用于在区分服务（DS）域内的网络中的多个网络设备之间维持一致的每跳包转发行为的方法，装置和计算机可读介质。 在一个方面，一种方法涉及创建和存储将PHB与DS代码点（DSCP）值相关联的全网PHB定义，以及定义在所有接口上分配给PHB的带宽和缓冲器资源的一组参数 的DS域内的网络设备。 确定网络范围PHB定义中的每个PHB与网络设备的一个或多个队列的映射。 为PHB映射到的每个队列确定排水大小和排队大小值。 确定每个PHB到与队列相关联的阈值的映射。 确定碎片和交织机制的参数。 基于映射，排水大小和队列大小等的网络设备配置参数值被发送到DS域内的每个网络设备。 因此，使用PHB的抽象定义，在整个网络中实现了一致的PHB。

公开(公告)号：US20130267566A1

公开(公告)日：2013-10-10

申请号：US13394044

申请日：2010-09-06

申请人： Andrew R. Blight ,  Ron Cohen

发明人： Andrew R. Blight ,  Ron Cohen

IPC分类号： A61K31/4409

CPC分类号： A61K31/4409

摘要： Disclosed herein are methods and compositions related to the durable use of aminopyridines, such as 4-aminopyridine, to improve impairments of patients with a demyelinating condition, such as MS.

摘要翻译： 本文公开了与持续使用氨基吡啶如4-氨基吡啶相关的方法和组合物，以改善患有脱髓鞘状况的患者如MS的损伤。

公开(公告)号：US20120041034A1

公开(公告)日：2012-02-16

申请号：US13187158

申请日：2011-07-20

申请人： Andrew R. Blight ,  Ron Cohen

发明人： Andrew R. Blight ,  Ron Cohen

IPC分类号： A61K31/4409 ,  A61P25/00

CPC分类号： A61K31/4409 ,  A61K9/20 ,  A61K9/2054 ,  A61K9/2077 ,  A61K31/44 ,  A61K47/12 ,  A61K47/14 ,  A61K47/38 ,  A61K47/44

摘要： A pharmaceutical composition which comprises a therapeutically effective amount of a aminopyridine dispersed in a release matrix, including, for example, a composition that can be formulated into a stable, sustained-release oral dosage formulation, such as a tablet which provides, upon administration to a patient, a therapeutically effective plasma level of the aminopyridine for a period of at least 12 hours, preferably 24 hours or more and the use of the composition to treat various neurological diseases.

摘要翻译： 一种药物组合物，其包含分散在释放基质中的治疗有效量的氨基吡啶，包括例如可以配制成稳定的持续释放口服剂量制剂的组合物，例如在给药至 患者，氨基吡啶的治疗有效血浆水平至少12小时，优选24小时或更长的时间，以及该组合物用于治疗各种神经疾病的用途。

公开(公告)号：US20090150180A1

公开(公告)日：2009-06-11

申请号：US11659456

申请日：2006-09-25

申请人： Ron Cohen ,  Andrew R. Blight ,  Lawrence Marinucci

发明人： Ron Cohen ,  Andrew R. Blight ,  Lawrence Marinucci

IPC分类号： G06Q50/00

CPC分类号： G16H50/70 ,  G06F19/3481 ,  G06Q50/24 ,  G16H10/20 ,  G16H10/60

摘要： A process for determining responders in clinical testing environments that involves, inter alia, detecting treatment response through the use of small numbers of measurements of randomly varying outcome variables in individual clinical trial subjects, and by analyzing the measurements in such a way as to eliminate troublesome variables, such as a spontaneous population variability.

摘要翻译： 用于在临床测试环境中确定应答者的过程，其特别涉及通过在个体临床试验受试者中使用少量随机变化的结果变量的测量来检测治疗反应，并且通过以消除麻烦的方式分析测量 变量，如自发人口变异性。