公开(公告)号：US07436858B2

公开(公告)日：2008-10-14

申请号：US10856788

申请日：2004-06-01

申请人： Motti Goren ,  Ron Cohen ,  Dov Wulich

发明人： Motti Goren ,  Ron Cohen ,  Dov Wulich

IPC分类号： H04L12/43

CPC分类号： H04J3/1611 ,  H04J3/0623 ,  H04J3/0632 ,  H04J3/073 ,  H04J3/1617 ,  H04L2012/5649 ,  H04L2012/5663 ,  H04L2012/5674

摘要： An adaptive rate management method and system for adapting a receiver rate to a transmission rate in a packet switch network comprises determining an error value at a sample rate, obtaining an updated accumulator value based on said error value Es at a decimated sample rate, and generating an appropriate rate command and changing said accumulator value at the decimated rate based on the updated accumulator value. The method may be adapted for either adapter point management or bit stuffing. When applied to adapter point management (APM), the method generates pointer adjustments for rate management. In a frequency locked APM preferred embodiment of the method and system, pointer adjustments in an interval are generated at a constant rate based on an average pointer adjustment value calculated in previous intervals.

摘要翻译： 一种用于使接收机速率适应分组交换网络中的传输速率的自适应速率管理方法和系统包括以采样速率确定误差值，基于所述误差值E < 以抽取采样率，并产生适当的速率命令，并且基于所更新的累加器值以所述抽取率改变所述累加器值。 该方法可适用于适配器点管理或位填充。 当应用于适配器点管理（APM）时，该方法生成用于速率管理的指针调整。 在方法和系统的频率锁定APM优选实施例中，基于在先前间隔中计算的平均指针调整值，以恒定速率生成间隔中的指针调整。

公开(公告)号：US08551523B2

公开(公告)日：2013-10-08

申请号：US13187158

申请日：2011-07-20

申请人： Andrew R. Blight ,  Ron Cohen

发明人： Andrew R. Blight ,  Ron Cohen

IPC分类号： A61K31/44 ,  A61K9/22

摘要： A pharmaceutical composition which comprises a therapeutically effective amount of a aminopyridine dispersed in a release matrix, including, for example, a composition that can be formulated into a stable, sustained-release oral dosage formulation, such as a tablet which provides, upon administration to a patient, a therapeutically effective plasma level of the aminopyridine for a period of at least 12 hours, preferably 24 hours or more and the use of the composition to treat various neurological diseases.

公开(公告)号：US08440703B2

公开(公告)日：2013-05-14

申请号：US13299969

申请日：2011-11-18

申请人： Andrew R. Blight ,  Ron Cohen

发明人： Andrew R. Blight ,  Ron Cohen

IPC分类号： A61K31/44 ,  A61K9/22

CPC分类号： A61K31/4409 ,  A61K9/20 ,  A61K31/435 ,  A61K31/44

摘要： A pharmaceutical composition which comprises a therapeutically effective amount of a aminopyridine dispersed in a release matrix, including, for example, a composition that can be formulated into a stable, sustained-release oral dosage formulation, such as a tablet which provides, upon administration to a patient, a therapeutically effective plasma level of the aminopyridine for a period of at about 12 hours and the use of the composition to treat various neurological diseases, including multiple sclerosis. A method of selecting individuals based on responsiveness to a treatment, including, for example, identifying individuals who responded to treatment with a sustained release fampridine composition.

摘要翻译： 一种药物组合物，其包含分散在释放基质中的治疗有效量的氨基吡啶，包括例如可以配制成稳定的持续释放口服剂量制剂的组合物，例如在给药至 患者，氨基吡啶的治疗有效血浆水平约12小时，以及使用该组合物治疗各种神经疾病，包括多发性硬化。 基于对治疗的反应性来选择个体的方法，包括例如鉴定用持续释放的芬太尼组合物治疗反应的个体。

公开(公告)号：US20120064007A1

公开(公告)日：2012-03-15

申请号：US13299969

申请日：2011-11-18

申请人： Andrew R. Blight ,  Lawrence Maranucci ,  Ron Cohen

发明人： Andrew R. Blight ,  Lawrence Maranucci ,  Ron Cohen

IPC分类号： A61K49/00 ,  A61P25/00 ,  A61K31/4409

CPC分类号： A61K31/4409 ,  A61K9/20 ,  A61K31/435 ,  A61K31/44

摘要： A pharmaceutical composition which comprises a therapeutically effective amount of a aminopyridine dispersed in a release matrix, including, for example, a composition that can be formulated into a stable, sustained-release oral dosage formulation, such as a tablet which provides, upon administration to a patient, a therapeutically effective plasma level of the aminopyridine for a period of at about 12 hours and the use of the composition to treat various neurological diseases, including multiple sclerosis. A method of selecting individuals based on responsiveness to a treatment, including, for example, identifying individuals who responded to treatment with a sustained release fampridine composition.

公开(公告)号：US20070104228A1

公开(公告)日：2007-05-10

申请号：US11555283

申请日：2006-11-01

申请人： Ron Cohen ,  Bar Gal-On ,  Zohar Peleg ,  David Brief

发明人： Ron Cohen ,  Bar Gal-On ,  Zohar Peleg ,  David Brief

IPC分类号： H04J3/06

CPC分类号： H04J3/0691

摘要： A system and method for reconstructing a service clock between two, first and second subsystems communicating therebetween, comprising a first subsystem operative to generate first subsystem timestamps, a second subsystem operative to generate second subsystem timestamps at a second frequency different from the first timestamps, wherein the generations of both first and second timestamps are based on sampling of the service clock by a common clock available at both subsystems, and an aligner for arithmetically aligning the different first and second subsystem timestamps to reconstruct the service clock.

摘要翻译： 一种用于重建在其间通信的两个第一和第二子系统之间的服务时钟的系统和方法，包括：第一子系统，用于产生第一子系统时间戳;第二子系统，用于以不同于所述第一时间戳的第二频率生成第二子系统时间戳，其中 第一和第二时间戳的代都基于通过在两个子系统可用的公共时钟的服务时钟的采样，以及用于对不同的第一和第二子系统时间戳进行算术对准以重构服务时钟的对准器。

公开(公告)号：US07050396B1

公开(公告)日：2006-05-23

申请号：US09729623

申请日：2000-11-30

申请人： Ron Cohen ,  Yoram Snir ,  John Schnizlein

发明人： Ron Cohen ,  Yoram Snir ,  John Schnizlein

IPC分类号： H04L1/00

CPC分类号： H04L12/2854 ,  H04L47/2408 ,  H04W72/12 ,  H04W76/10

摘要： A method of automatically establishing differentiated services quality of service treatment for a return packet flow that is associated with an originating packet flow in a network is disclosed. The originating packet flow is received, and it is determined that one or more packets in the originating packet flow are marked with a DSCP value that matches a policy rule that instruct setting of a specified DSCP value to the return packet flow. In response, information identifying the originating packet flow and a second DSCP value for marking the return packet flow is created and stored. When a corresponding return packet flow is received and determined to be associated with the originating packet flow, packets of the return packet flow are automatically marked with the second DSCP value. Once the packet flow terminates, all stored information is removed.

摘要翻译： 公开了一种与网络中的始发分组流相关联的返回分组流自动建立差分服务质量服务质量的方法。 接收始发分组流，并且确定始发分组流中的一个或多个分组被标记为与指示将指定的DSCP值的设置指定给返回分组流的策略规则相匹配的DSCP值。 作为响应，创建并存储识别发起分组流的信息和用于标记返回分组流的第二DSCP值。 当相应的返回分组流被接收并确定为与发起分组流相关联时，返回分组流的分组被自动标记为具有第二DSCP值。 一旦数据包流终止，所有存储的信息都被删除。

公开(公告)号：US5864714A

公开(公告)日：1999-01-26

申请号：US632931

申请日：1996-04-16

申请人： Nir Tal ,  Ron Cohen ,  Zeev Collin

发明人： Nir Tal ,  Ron Cohen ,  Zeev Collin

IPC分类号： G06F13/00 ,  H04L13/08 ,  H04L29/10 ,  H04M11/00 ,  H04M11/06

CPC分类号： H04M11/06 ,  H04L7/005

摘要： An apparatus for and method of implementing a novel buffer ba full duplex communication system is disclosed. The disclosed invention is particularly useful in native sign processing systems wherein heavy contention of processor resources typically exist, such as in systems running multi-tasking operating systems. The communication system of the present invention includes a receiver, transmitter, echo canceler. CODEC and telephone hybrid. The major components of the system operate on a buffer of input samples consisting of a set of input bits. The communication system operates to generate a buffer of output samples consisting of a set of output bits. The invention utilizes a novel buffer switching mechanism to optimize the tradeoff between processing response time, on one hand, and robustness to interrupt latency and processor implementation on the other hand. The internal processing of the modem works on a buffer full of samples once every time slice thus reducing the probability of a buffer underrun/overrun error occurring. The reduction in probability of data underrun/overrun is achieved by increasing the buffer size, thus giving the operating system greater leeway in choosing the exact time the signal processing functions are run. Small buffers, however, provide the communication system with short and accurate response time. These contradicting motives lead to the novel switchable size buffer scheme of the present invention. This is achieved without a loss of signal coherency.

摘要翻译： 公开了一种实现新型缓冲器全双工通信系统的方法和方法。 所公开的发明在诸如在运行多任务操作系统的系统中通常存在大量竞争的处理器资源的本征符号处理系统中特别有用。 本发明的通信系统包括接收机，发射机，回波消除器。 CODEC和电话混合。 系统的主要组件在由一组输入位组成的输入采样的缓冲器上操作。 通信系统用于产生由一组输出位组成的输出采样的缓冲器。 本发明利用新颖的缓冲器切换机制来优化处理响应时间，另一方面优化中断延迟和处理器实现的鲁棒性之间的权衡。 调制解调器的内部处理工作在每次采样一次的样本缓冲区中，从而降低缓冲区欠载/超限错误发生的可能性。 通过增加缓冲区大小来实现数据欠载/超载的概率的降低，从而使操作系统在选择信号处理功能的精确时间方面具有更大的余地。 然而，小缓冲器为通信系统提供了短且准确的响应时间。 这些矛盾的动机导致本发明的新颖的可切换尺寸的缓冲方案。 这是在不损失信号一致性的情况下实现的。

公开(公告)号：US08663685B2

公开(公告)日：2014-03-04

申请号：US13187158

申请日：2011-07-20

申请人： Andrew R. Blight ,  Ron Cohen

发明人： Andrew R. Blight ,  Ron Cohen

IPC分类号： A61K31/44 ,  A61K9/22

CPC分类号： A61K31/4409 ,  A61K9/20 ,  A61K9/2054 ,  A61K9/2077 ,  A61K31/44 ,  A61K47/12 ,  A61K47/14 ,  A61K47/38 ,  A61K47/44

摘要： A pharmaceutical composition which comprises a therapeutically effective amount of a aminopyridine dispersed in a release matrix, including, for example, a composition that can be formulated into a stable, sustained-release oral dosage formulation, such as a tablet which provides, upon administration to a patient, a therapeutically effective plasma level of the aminopyridine for a period of at least 12 hours, preferably 24 hours or more and the use of the composition to treat various neurological diseases.

摘要翻译： 一种药物组合物，其包含分散在释放基质中的治疗有效量的氨基吡啶，包括例如可以配制成稳定的持续释放口服剂量制剂的组合物，例如在给药至 患者，氨基吡啶的治疗有效血浆水平至少12小时，优选24小时或更长的时间，以及该组合物用于治疗各种神经疾病的用途。

公开(公告)号：US20100061935A1

公开(公告)日：2010-03-11

申请号：US12557015

申请日：2009-09-10

申请人： Andrew R. Blight ,  Ron Cohen

发明人： Andrew R. Blight ,  Ron Cohen

IPC分类号： A61K31/4409 ,  A61K38/21 ,  A61K39/395 ,  A61K49/00 ,  A61P25/00

CPC分类号： A61K31/4409 ,  A61K31/44 ,  A61K38/21 ,  A61K45/06

摘要： Disclosed herein are methods and compositions related to use of aminopyridines, such as fampridine, to improve impairments of patients with a demyelinating condition, such as MS.

摘要翻译： 本文公开了与使用氨基吡啶（例如菲啶啶）相关的方法和组合物，以改善患有脱髓鞘状况的患者（例如MS）的损伤。

公开(公告)号：US07082476B1

公开(公告)日：2006-07-25

申请号：US09578027

申请日：2000-05-24

申请人： Ron Cohen ,  Yoram Snir

发明人： Ron Cohen ,  Yoram Snir

IPC分类号： G06F15/16 ,  G06F15/173

CPC分类号： H04L29/12009 ,  G06F17/30899 ,  H04L29/12028 ,  H04L29/12066 ,  H04L61/103 ,  H04L61/1511 ,  H04L67/1002

摘要： A method and apparatus are provided for optimizing retrieval of network resources. In one embodiment, a method of optimizing access to a network resource is implemented in a computer program executed by a router, cache server, or proxy server. A network resource that contains one or more embedded symbolic host name references is received. A network address corresponding to each of the embedded symbolic host name references is determined. A modified copy of the network resource is created and stored; in the modified copy, a network address is substituted for each corresponding embedded symbolic host name reference. Thereafter, the modified copy of the network resource in responding to all subsequent client requests for the network resource, thereby greatly reducing the required number of network address lookup operations. In one specific embodiment, IP addresses are determined using DNS queries for the hostname portion of all URLs that are embedded in a Web page using image, applet, object, or embed tags. The IP addresses are stored in place of the hostname portions in a modified copy of the Web page, typically in a cache. As a result, when the modified page is subsequently served to clients, the clients need not carry out DNS resolution of all the embedded URLs, resulting in reduced network message traffic and more rapid page display.

摘要翻译： 提供一种用于优化网络资源检索的方法和装置。 在一个实施例中，优化对网络资源的访问的方法在由路由器，缓存服务器或代理服务器执行的计算机程序中实现。 收到包含一个或多个嵌入式符号主机名称引用的网络资源。 确定与每个嵌入的符号主机名称引用相对应的网络地址。 创建并存储网络资源的修改副本; 在修改的副本中，替换每个相应的嵌入式符号主机名称引用的网络地址。 此后，网络资源的修改副本响应于网络资源的所有后续客户端请求，从而大大减少了所需的网络地址查找操作数量。 在一个具体实施例中，使用对使用图像，小应用程序，对象或嵌入标签嵌入在网页中的所有URL的主机名部分的DNS查询来确定IP地址。 IP地址存储在Web页面的修改副本中，通常位于缓存中，代替主机名部分。 因此，当修改的页面随后被提供给客户端时，客户端不需要对所有嵌入式URL进行DNS解析，导致网络消息流量减少，页面显示更快速。