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公开(公告)号：US20070041983A1
公开(公告)日：2007-02-22
申请号：US11536489
申请日：2006-09-28
申请人： Avi Ashkenazi , Robert Pitti , Thomas Wu , Zemin Zhang
发明人： Avi Ashkenazi , Robert Pitti , Thomas Wu , Zemin Zhang
IPC分类号： A61K39/395 , C12P21/04
CPC分类号： C07K16/24 , A61K2039/505 , C07K2317/76
摘要： The present invention is directed to compositions of matter useful for the treatment of tumor in mammals and to methods of using those compositions of matter for the same.
摘要翻译： 本发明涉及可用于治疗哺乳动物肿瘤的物质组合物，以及使用这些物质组合物的方法。
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公开(公告)号：US20060141573A1
公开(公告)日：2006-06-29
申请号：US11315825
申请日：2005-12-22
申请人： Avi Ashkenazi , Audrey Goddard , Austin Gurney , Scot Marsters , Robert Pitti , William Wood
发明人： Avi Ashkenazi , Audrey Goddard , Austin Gurney , Scot Marsters , Robert Pitti , William Wood
IPC分类号： C07H21/04 , C12P21/06 , C07K14/715
CPC分类号： C07K14/70578 , A61K38/00 , C07K14/4747 , C07K14/70575 , C07K2319/00 , C12N2799/026
摘要： The present invention is directed to novel polypeptides having homology to members of the tumor necrosis factor receptor family and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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3.发明申请Uses of agonists and antagonists to modulate activity of TNF-related molecules 审中-公开激动剂和拮抗剂用于调节TNF相关分子的活性公开(公告)号：US20060073146A1
公开(公告)日：2006-04-06
申请号：US11069473
申请日：2005-02-28
申请人： Avi Ashkenazi , Kelly Dodge , Iqbal Grewal , Kyung Kim , Scot Marsters , Robert Pitti , Minhong Yan
发明人： Avi Ashkenazi , Kelly Dodge , Iqbal Grewal , Kyung Kim , Scot Marsters , Robert Pitti , Minhong Yan
IPC分类号： A61K39/395 , A61K38/17
CPC分类号： C07K14/525 , A61K38/00 , A61K2039/505 , C07K14/52 , C07K16/2875 , C07K2317/76 , C07K2319/00 , C07K2319/30 , C07K2319/43
摘要： Methods of using one or more agonists or antagonists to modulate activity of the members of the TNF and TNFR families referred to as TALL-1, APRIL, TACI, and BCMA are provided. The methods include in vitro, in situ, and/or in vivo diagnosis and/or treatment of mammalian cells or pathological conditions associated with TALL-1, APRIL, TACI, or BCMA, using one or more agonist or antagonist molecules. The methods of treatment disclosed by the invention include methods of treating immune related diseases and cancer.
摘要翻译： 提供了使用一种或多种激动剂或拮抗剂调节称为TALL-1，APRIL，TACI和BCMA的TNF和TNFR家族成员的活性的方法。 所述方法包括使用一种或多种激动剂或拮抗剂分子的体外，原位和/或体内诊断和/或治疗哺乳动物细胞或与TALL-1，APRIL，TACI或BCMA相关的病理状况。 本发明公开的治疗方法包括治疗免疫相关疾病和癌症的方法。
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公开(公告)号：US20100080793A1
公开(公告)日：2010-04-01
申请号：US12287735
申请日：2008-10-14
申请人： Avi J. Ashkenazi , David Botstein , Kelly H. Dodge , Audrey Goddard , Austin L. Gurney , Kyung Jim Kim , David A. Lawrence , Robert Pitti , Margaret A. Roy , Daniel B. Tumas , William I. Wood
发明人： Avi J. Ashkenazi , David Botstein , Kelly H. Dodge , Audrey Goddard , Austin L. Gurney , Kyung Jim Kim , David A. Lawrence , Robert Pitti , Margaret A. Roy , Daniel B. Tumas , William I. Wood
IPC分类号： A61K39/395 , A61K38/00 , A61K39/00
CPC分类号： A01K67/0275 , A01K2217/05 , A61K38/00 , C07K14/70575 , C07K14/70578 , C07K16/2875 , C07K16/2878 , C07K2317/73 , C07K2319/00 , C12N2799/026
摘要： A TNFR homolog, identified as DcR3, is provided. Nucleic acid molecules encoding DcR3, chimeric molecules and antibodies to DcR3 are also provided.
摘要翻译： 提供了标识为DcR3的TNFR同源物。 还提供了编码DcR3的核酸分子，嵌合分子和DcR3的抗体。
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公开(公告)号：US20080213837A1
公开(公告)日：2008-09-04
申请号：US11980174
申请日：2007-10-30
申请人： Avi J. Ashkenazi , Scot A. Marsters , Robert Pitti
发明人： Avi J. Ashkenazi , Scot A. Marsters , Robert Pitti
CPC分类号： C07K14/70575 , A61K38/00 , C07K2317/24 , C07K2319/02 , G01N2333/4718
摘要： A tumor necrosis factor and lymphotoxin homolog having apoptotic activity, identified as Apo-3 Ligand, is provided. Nucleic acid molecules encoding Apo-3 Ligand, chimeric molecules and antibodies to Apo-3 Ligand are also provided.
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6.发明申请Novel cycloalkyl derivatives as inhibitors of bone resorption and vitronectin receptor antagonists 审中-公开新型环烷基衍生物作为骨吸收抑制剂和玻连蛋白受体拮抗剂公开(公告)号：US20080021055A1
公开(公告)日：2008-01-24
申请号：US11892235
申请日：2007-08-21
申请人： Volkmar Wehner , Jochen Knolle , Hans Stilz , Jean-Francois Gourvest , Denis Carniato , Thomas Gadek , Robert McDowell , Robert Pitti , Sarah Bodary
发明人： Volkmar Wehner , Jochen Knolle , Hans Stilz , Jean-Francois Gourvest , Denis Carniato , Thomas Gadek , Robert McDowell , Robert Pitti , Sarah Bodary
IPC分类号： A61K31/505 , A61K31/27 , A61P9/10 , C07D233/00 , C07D239/02 , C07C269/00 , A61K31/4164
CPC分类号： C07C277/08 , C07C279/20 , C07C2603/74 , C07D233/48 , C07D239/16 , C07C279/22
摘要： There are described cycloalkyl derivatives of the formula (I) R1—Y-A-B-D-E-F-G (I) in which R1, Y, A, B, D, E, F and G have the meaning indicated herein, their preparation and their use as medicaments. The compounds according to the invention can be used as vitronectin receptor antagonists and as inhibitors of bone resorption.
摘要翻译： 描述式（I）的环烷基衍生物<？in-line-formula description =“In-line Formulas”end =“lead”？> R 1 -YABDEFG（I）<αin 其中R 1，Y，A，B，D，E，F和G具有本文所示的含义，-line-formula description =“In-line Formulas”end =“tail”？> 他们的准备和用作药物。 根据本发明的化合物可用作玻连蛋白受体拮抗剂和骨吸收抑制剂。
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公开(公告)号：US20060216270A1
公开(公告)日：2006-09-28
申请号：US11353441
申请日：2006-02-14
申请人： Avi Ashkenazi , Kevin Baker , Paul Godowski , Austin Gurney , Melanie Mark , Scot Marsters , Robert Pitti
发明人： Avi Ashkenazi , Kevin Baker , Paul Godowski , Austin Gurney , Melanie Mark , Scot Marsters , Robert Pitti
CPC分类号： C07K14/525 , A61K38/00 , C07K2319/02
摘要： A tumor necrosis factor homolog, identified as DNA19355, is provided. DNA19355 polypeptide has apoptotic activity in mammalian cancer cells and may be involved in proinflammatory responses. Nucleic acid molecules encoding DNA19355, chimeric molecules and antibodies to DNA19355 are also provided.
摘要翻译： 提供了鉴定为DNA19355的肿瘤坏死因子同源物。 DNA19355多肽在哺乳动物癌细胞中具有凋亡活性，可能参与促炎反应。 还提供了编码DNA19355的核酸分子，嵌合分子和DNA19355的抗体。
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公开(公告)号：US20050226868A1
公开(公告)日：2005-10-13
申请号：US10964462
申请日：2004-10-13
申请人： Avi Ashkenazi , Robert Pitti , Thomas Wu , Zemin Zhang
发明人： Avi Ashkenazi , Robert Pitti , Thomas Wu , Zemin Zhang
IPC分类号： A61K39/395 , C07K16/24
CPC分类号： C07K16/24 , A61K2039/505 , C07K2317/76
摘要： The present invention is directed to compositions of matter useful for the treatment of tumor in mammals and to methods of using those compositions of matter for the same.
摘要翻译： 本发明涉及可用于治疗哺乳动物肿瘤的物质组合物，以及使用这些物质组合物的方法。
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公开(公告)号：US06764679B2
公开(公告)日：2004-07-20
申请号：US09896096
申请日：2001-06-28
申请人： Avi J. Ashkenazi , David Botstein , Kelly H. Dodge , Audrey Goddard , Austin L. Gurney , Kyung Jin Kim , David A. Lawrence , Robert Pitti , Margaret A. Roy , Daniel B. Tumas , William I. Wood
发明人： Avi J. Ashkenazi , David Botstein , Kelly H. Dodge , Audrey Goddard , Austin L. Gurney , Kyung Jin Kim , David A. Lawrence , Robert Pitti , Margaret A. Roy , Daniel B. Tumas , William I. Wood
IPC分类号： C07K1628
CPC分类号： A01K67/0275 , A01K2217/05 , A61K38/00 , C07K14/70575 , C07K14/70578 , C07K16/2875 , C07K16/2878 , C07K2317/73 , C07K2319/00 , C12N2799/026
摘要： A TNFR homolog, identified as DcR3, is provided. Nucleic acid molecules encoding DcR3, chimeric molecules and antibodies to DcR3 are also provided.
摘要翻译： 提供了标识为DcR3的TNFR同源物。 还提供了编码DcR3的核酸分子，嵌合分子和DcR3的抗体。
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公开(公告)号：US20090191184A1
公开(公告)日：2009-07-30
申请号：US12287810
申请日：2008-10-14
申请人： Avi J. Ashkenazi , David Botstein , Kelly H. Dodge , Audrey Goddard , Austin L. Gurney , Kyung Jin Kim , David A. Lawrence , Robert Pitti , Margaret A. Roy , Daniel B. Tumas , William I. Wood
发明人： Avi J. Ashkenazi , David Botstein , Kelly H. Dodge , Audrey Goddard , Austin L. Gurney , Kyung Jin Kim , David A. Lawrence , Robert Pitti , Margaret A. Roy , Daniel B. Tumas , William I. Wood
IPC分类号： A61K38/17 , A61K39/395
CPC分类号： C07K14/70578 , A01K2217/05 , C07H21/04
摘要： A TNFR homolog, identified as DcR3, is provided. Nucleic acid molecules encoding DcR3, chimeric molecules and antibodies to DcR3 are also provided.
摘要翻译： 提供了标识为DcR3的TNFR同源物。 还提供了编码DcR3的核酸分子，嵌合分子和DcR3的抗体。
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