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    Methods and Devices for Transdermal Electrotransport Delivery of Lofentanil and Carfentanil
    2.
    发明申请
    Methods and Devices for Transdermal Electrotransport Delivery of Lofentanil and Carfentanil 审中-公开
    Lofentanil和Carfentanil的透皮电传递方法和装置

    公开(公告)号：US20080009782A1

    公开(公告)日：2008-01-10

    申请号：US11768569

    申请日：2007-06-26

    申请人： Robert Gale ,  Rama Padmanabhan ,  Joseph Phipps

    发明人： Robert Gale ,  Rama Padmanabhan ,  Joseph Phipps

    IPC分类号： A61N1/30

    CPC分类号： A61N1/30 ,  A61N1/0424 ,  A61N1/044 ,  A61N1/0444 ,  A61N1/327

    摘要： Electrotransport drug delivery devices, systems and methods for delivery of lofentanil or carfentanil are disclosed. The lofentanil or carfentanil may be provided as a water soluble salt (e.g., lofentanil or carfentanil hydrochloride), such as in a hydrogel formulation. A transdermal, electrotransport delivered dose of lofentanil or carfentanil is provided which is sufficient to induce analgesia in (e.g., adult) human patients suffering from chronic, acute and/or breakthrough pain.

    摘要翻译： 公开了递送药物递送装置，递送洛芬太尼或卡芬太尼的系统和方法。 洛芬太尼或卡芬太尼可以作为水溶性盐（例如，洛芬太尼或盐酸卡芬太尼）提供，例如在水凝胶制剂中。 提供透皮，电转运量的洛芬太尼或卡芬太尼，其足以在患有慢性，急性和/或突破性疼痛的（例如成人）人类患者中诱发镇痛。

    PYLORIC VALVE DEVICES AND METHODS
    5.
    发明申请
    PYLORIC VALVE DEVICES AND METHODS 有权

    公开(公告)号：US20130006381A1

    公开(公告)日：2013-01-03

    申请号：US13336196

    申请日：2011-12-23

    申请人： Buket Grau ,  David Robert Gale ,  Sam Anne Musgrave ,  George McGee Perkins ,  Mark Jeffrey Edhouse ,  Marc Graham ,  Christopher Kadamus

    发明人： Buket Grau ,  David Robert Gale ,  Sam Anne Musgrave ,  George McGee Perkins ,  Mark Jeffrey Edhouse ,  Marc Graham ,  Christopher Kadamus

    IPC分类号： A61F2/04

    CPC分类号： A61F5/0079 ,  A61F5/0089

    摘要： A pyloric valve is provided for inhibiting the flow of chyme through the pyloric region of the gastrointestinal tract. The pyloric valve includes a blocking portion having at least one axially-aligned annular flange defining a central opening and a support having a rim and a support surface. The support may be disposed in a nested position wherein the support surface is disposed within the central opening and an inverted position wherein the support surface is disposed away from the central opening. The pyloric valve may further include a sleeve that may have a beveled distal end. The pyloric valve may be constructed of silicon. Also provided are methods of inserting and removing the pyloric valve, which each include a step of manipulating the support between its inverted and nested positions. Insertion and removal systems are also provided for use with the pyloric valve.

    摘要翻译： 提供幽门阀用于抑制食道通过胃肠道幽门区域的流动。 幽门阀包括阻挡部分，其具有限定中心开口的至少一个轴向对准的环形凸缘和具有边缘和支撑表面的支撑件。 支撑件可以设置在嵌套位置，其中支撑表面设置在中心开口内，并且倒置位置，其中支撑表面远离中心开口设置。 幽门阀还可以包括可具有斜切远端的套筒。 幽门阀可以由硅构成。 还提供了插入和移除幽门阀的方法，每个都包括在其倒置位置和嵌套位置之间操纵支撑件的步骤。 还提供插入和移除系统以用于幽门阀。

    PYLORIC VALVE DEVICES AND METHODS
    6.
    发明申请
    PYLORIC VALVE DEVICES AND METHODS 失效

    公开(公告)号：US20120136457A1

    公开(公告)日：2012-05-31

    申请号：US13363509

    申请日：2012-02-01

    申请人： Buket Grau ,  David Robert Gale ,  Sam Anne Musgrave ,  George McGee Perkins ,  Mark Jeffrey Edhouse ,  Marc Graham ,  Christopher Kadamus

    发明人： Buket Grau ,  David Robert Gale ,  Sam Anne Musgrave ,  George McGee Perkins ,  Mark Jeffrey Edhouse ,  Marc Graham ,  Christopher Kadamus

    IPC分类号： A61F2/04

    CPC分类号： A61F5/0079 ,  A61F5/0089

    摘要： A pyloric valve is provided for inhibiting the flow of chyme through the pyloric region of the gastrointestinal tract. The pyloric valve includes a blocking portion having a disc-shaped inlet and a helical flange. The helical flange may be disposed in a contracted position defining a contracted length and a contracted diameter and an extended position defining an extended length and an extended diameter, wherein the extended length is longer than the contracted length and the extended diameter is smaller than the contracted diameter. The pyloric valve may further include a sleeve that may have a beveled distal end. The pyloric valve may be constructed of silicon. Also provided are methods of inserting and removing the pyloric valve, which each include a step of manipulating the support between its contracted and extended positions. Insertion and removal systems are also provided for use with the pyloric valve.

    摘要翻译： 提供幽门阀用于抑制食道通过胃肠道幽门区域的流动。 幽门阀包括具有盘形入口和螺旋凸缘的阻挡部分。 螺旋形凸缘可以设置在限定收缩长度和收缩直径的收缩位置以及限定延伸长度和延伸直径的延伸位置，其中延伸长度长于收缩长度，并且延伸直径小于收缩长度 直径。 幽门阀还可以包括可具有斜切远端的套筒。 幽门阀可由硅构成。 还提供了插入和移除幽门阀的方法，每个都包括在收缩位置和伸展位置之间操纵支撑件的步骤。 还提供插入和移除系统以用于幽门阀。

    Pyloric valve devices and methods
    7.
    发明申请
    Pyloric valve devices and methods 有权
    幽门阀装置及方法

    公开(公告)号：US20090259239A1

    公开(公告)日：2009-10-15

    申请号：US12384898

    申请日：2009-04-09

    申请人： Buket Grau ,  David Robert Gale ,  Sam Anne Musgrave ,  George McGee Perkins ,  Mark Jeffrey Edhouse ,  Marc Graham ,  Christopher Kadamus

    发明人： Buket Grau ,  David Robert Gale ,  Sam Anne Musgrave ,  George McGee Perkins ,  Mark Jeffrey Edhouse ,  Marc Graham ,  Christopher Kadamus

    IPC分类号： A61B17/08

    CPC分类号： A61F5/0079 ,  A61F5/0089

    摘要： A pyloric valve is provided for inhibiting the flow of chyme through the pyloric region of the gastrointestinal tract. The pyloric valve includes a blocking portion having at least one axially-aligned annular flange defining a central opening and a support having a rim and a support surface. The support may be disposed in a nested position wherein the support surface is disposed within the central opening and an inverted position wherein the support surface is disposed away from the central opening. The pyloric valve may further include a sleeve that may have a beveled distal end. The pyloric valve may be constructed of silicon. Also provided are methods of inserting and removing the pyloric valve, which each include a step of manipulating the support between its inverted and nested positions. Insertion and removal systems are also provided for use with the pyloric valve.

    摘要翻译： 提供幽门阀用于抑制食道通过胃肠道幽门区域的流动。 幽门阀包括阻挡部分，其具有限定中心开口的至少一个轴向对齐的环形凸缘和具有边缘和支撑表面的支撑件。 支撑件可以设置在嵌套位置，其中支撑表面设置在中心开口内，并且倒置位置，其中支撑表面远离中心开口设置。 幽门阀还可以包括可具有斜切远端的套筒。 幽门阀可以由硅构成。 还提供了插入和移除幽门阀的方法，每个都包括在其倒置位置和嵌套位置之间操纵支撑件的步骤。 还提供插入和移除系统用于幽门阀。

    Pyloric valve devices and methods
    8.
    发明申请
    Pyloric valve devices and methods 有权
    幽门阀装置及方法

    公开(公告)号：US20090259238A1

    公开(公告)日：2009-10-15

    申请号：US12384890

    申请日：2009-04-09

    申请人： Buket Grau ,  David Robert Gale ,  Sam Anne Musgrave ,  George McGee Perkins ,  Mark Jeffrey Edhouse ,  Marc Graham ,  Christopher Kadamus

    发明人： Buket Grau ,  David Robert Gale ,  Sam Anne Musgrave ,  George McGee Perkins ,  Mark Jeffrey Edhouse ,  Marc Graham ,  Christopher Kadamus

    IPC分类号： A61B17/08

    CPC分类号： A61F5/0079 ,  A61F5/0089

    摘要： A pyloric valve is provided for inhibiting the flow of chyme through the pyloric region of the gastrointestinal tract. The pyloric valve includes a blocking portion having a disc-shaped inlet and a helical flange. The helical flange may be disposed in a contracted position defining a contracted length and a contracted diameter and an extended position defining an extended length and an extended diameter, wherein the extended length is longer than the contracted length and the extended diameter is smaller than the contracted diameter. The pyloric valve may further include a sleeve that may have a beveled distal end. The pyloric valve may be constructed of silicon. Also provided are methods of inserting and removing the pyloric valve, which each include a step of manipulating the support between its contracted and extended positions. Insertion and removal systems are also provided for use with the pyloric valve.

    摘要翻译： 提供幽门阀用于抑制食道通过胃肠道幽门区域的流动。 幽门阀包括具有盘形入口和螺旋凸缘的阻挡部分。 螺旋形凸缘可以设置在限定收缩长度和收缩直径的收缩位置以及限定延伸长度和延伸直径的延伸位置，其中延伸长度长于收缩长度，并且延伸直径小于收缩长度 直径。 幽门阀还可以包括可具有斜切远端的套筒。 幽门阀可以由硅构成。 还提供了插入和移除幽门阀的方法，每个都包括在收缩位置和伸展位置之间操纵支撑件的步骤。 还提供插入和移除系统以用于幽门阀。