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公开(公告)号：US08579849B2
公开(公告)日：2013-11-12
申请号：US13363509
申请日：2012-02-01
申请人： Buket Grau , David Robert Gale , Sam Anne Musgrave , George McGee Perkins , Mark Jeffrey Edhouse , Marc Graham , Christopher Kadamus
发明人： Buket Grau , David Robert Gale , Sam Anne Musgrave , George McGee Perkins , Mark Jeffrey Edhouse , Marc Graham , Christopher Kadamus
CPC分类号： A61F5/0079 , A61F5/0089
摘要： A pyloric valve is provided for inhibiting the flow of chyme through the pyloric region of the gastrointestinal tract. The pyloric valve includes a blocking portion having a disc-shaped inlet and a helical flange. The helical flange may be disposed in a contracted position defining a contracted length and a contracted diameter and an extended position defining an extended length and an extended diameter, wherein the extended length is longer than the contracted length and the extended diameter is smaller than the contracted diameter. The pyloric valve may further include a sleeve that may have a beveled distal end. The pyloric valve may be constructed of silicon. Also provided are methods of inserting and removing the pyloric valve, which each include a step of manipulating the support between its contracted and extended positions. Insertion and removal systems are also provided for use with the pyloric valve.
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公开(公告)号：US20130006381A1
公开(公告)日：2013-01-03
申请号：US13336196
申请日：2011-12-23
申请人： Buket Grau , David Robert Gale , Sam Anne Musgrave , George McGee Perkins , Mark Jeffrey Edhouse , Marc Graham , Christopher Kadamus
发明人： Buket Grau , David Robert Gale , Sam Anne Musgrave , George McGee Perkins , Mark Jeffrey Edhouse , Marc Graham , Christopher Kadamus
IPC分类号： A61F2/04
CPC分类号： A61F5/0079 , A61F5/0089
摘要： A pyloric valve is provided for inhibiting the flow of chyme through the pyloric region of the gastrointestinal tract. The pyloric valve includes a blocking portion having at least one axially-aligned annular flange defining a central opening and a support having a rim and a support surface. The support may be disposed in a nested position wherein the support surface is disposed within the central opening and an inverted position wherein the support surface is disposed away from the central opening. The pyloric valve may further include a sleeve that may have a beveled distal end. The pyloric valve may be constructed of silicon. Also provided are methods of inserting and removing the pyloric valve, which each include a step of manipulating the support between its inverted and nested positions. Insertion and removal systems are also provided for use with the pyloric valve.
摘要翻译： 提供幽门阀用于抑制食道通过胃肠道幽门区域的流动。 幽门阀包括阻挡部分，其具有限定中心开口的至少一个轴向对准的环形凸缘和具有边缘和支撑表面的支撑件。 支撑件可以设置在嵌套位置，其中支撑表面设置在中心开口内，并且倒置位置，其中支撑表面远离中心开口设置。 幽门阀还可以包括可具有斜切远端的套筒。 幽门阀可以由硅构成。 还提供了插入和移除幽门阀的方法，每个都包括在其倒置位置和嵌套位置之间操纵支撑件的步骤。 还提供插入和移除系统以用于幽门阀。
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公开(公告)号：US20120259427A1
公开(公告)日：2012-10-11
申请号：US13530253
申请日：2012-06-22
申请人： Marc Graham , Buket Grau
发明人： Marc Graham , Buket Grau
IPC分类号： A61F2/04
CPC分类号： A61F5/0079
摘要： A pyloric valve for regulating the flow of fluids in the pyloric region a patient's gastrointestinal tract is disclosed herein. In one embodiment, a pyloric valve includes a plurality of axially connected blocking members located along a longitudinal axis of the valve in a proximal to distal direction. Each blocking member of the valve preferably includes at least one blocking portion defining at least one entryway adapted to receive fluids such as chyme therethrough. The at least one entryway of each blocking member is preferably not aligned with the at least one entryway of each blocking member adjacent thereto along the longitudinal axis. The non-alignment of the at least one entryways of the blocking members preferably creates a non-linear path for fluids such as chyme to travel through the pyloric region of the patient.
摘要翻译： 本文公开了一种用于调节患者胃肠道幽门区域中流体流动的幽门阀。 在一个实施例中，幽门阀包括沿着阀的纵向轴线沿近端到远端方向定位的多个轴向连接的阻挡构件。 阀的每个阻塞构件优选地包括限定至少一个入口通道的至少一个阻挡部分，该至少一个入口适于接收通过其中的诸如手杖之类的流体。 每个阻挡构件的至少一个入口通道优选地不沿着纵向轴线对准与其相邻的每个阻挡构件的至少一个入口。 阻挡构件的至少一个入口通道的不对准优选地产生用于流体（例如食糜）流过患者幽门区域的非线性路径。
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公开(公告)号：US08226593B2
公开(公告)日：2012-07-24
申请号：US12420219
申请日：2009-04-08
申请人： Marc Graham , Buket Grau
发明人： Marc Graham , Buket Grau
CPC分类号： A61F5/0079
摘要： A pyloric valve for regulating the flow of fluids in the pyloric region a patient's gastrointestinal tract is disclosed herein. In one embodiment, a pyloric valve includes a plurality of axially connected blocking members located along a longitudinal axis of the valve in a proximal to distal direction. Each blocking member of the valve preferably includes at least one blocking portion defining at least one entryway adapted to receive fluids such as chyme therethrough. The at least one entryway of each blocking member is preferably not aligned with the at least one entryway of each blocking member adjacent thereto along the longitudinal axis. The non-alignment of the at least one entryways of the blocking members preferably creates a non-linear path for fluids such as chyme to travel through the pyloric region of the patient.
摘要翻译： 本文公开了一种用于调节患者胃肠道幽门区域中流体流动的幽门阀。 在一个实施例中，幽门阀包括沿着阀的纵向轴线沿近端到远端方向定位的多个轴向连接的阻挡构件。 阀的每个阻塞构件优选地包括限定至少一个入口通道的至少一个阻挡部分，该至少一个入口适于接收通过其中的诸如手杖之类的流体。 每个阻挡构件的至少一个入口通道优选地不沿着纵向轴线对准与其相邻的每个阻挡构件的至少一个入口。 阻挡构件的至少一个入口通道的不对准优选地产生用于流体（例如食糜）流过患者幽门区域的非线性路径。
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公开(公告)号：US20120136457A1
公开(公告)日：2012-05-31
申请号：US13363509
申请日：2012-02-01
申请人： Buket Grau , David Robert Gale , Sam Anne Musgrave , George McGee Perkins , Mark Jeffrey Edhouse , Marc Graham , Christopher Kadamus
发明人： Buket Grau , David Robert Gale , Sam Anne Musgrave , George McGee Perkins , Mark Jeffrey Edhouse , Marc Graham , Christopher Kadamus
IPC分类号： A61F2/04
CPC分类号： A61F5/0079 , A61F5/0089
摘要： A pyloric valve is provided for inhibiting the flow of chyme through the pyloric region of the gastrointestinal tract. The pyloric valve includes a blocking portion having a disc-shaped inlet and a helical flange. The helical flange may be disposed in a contracted position defining a contracted length and a contracted diameter and an extended position defining an extended length and an extended diameter, wherein the extended length is longer than the contracted length and the extended diameter is smaller than the contracted diameter. The pyloric valve may further include a sleeve that may have a beveled distal end. The pyloric valve may be constructed of silicon. Also provided are methods of inserting and removing the pyloric valve, which each include a step of manipulating the support between its contracted and extended positions. Insertion and removal systems are also provided for use with the pyloric valve.
摘要翻译： 提供幽门阀用于抑制食道通过胃肠道幽门区域的流动。 幽门阀包括具有盘形入口和螺旋凸缘的阻挡部分。 螺旋形凸缘可以设置在限定收缩长度和收缩直径的收缩位置以及限定延伸长度和延伸直径的延伸位置，其中延伸长度长于收缩长度，并且延伸直径小于收缩长度 直径。 幽门阀还可以包括可具有斜切远端的套筒。 幽门阀可由硅构成。 还提供了插入和移除幽门阀的方法，每个都包括在收缩位置和伸展位置之间操纵支撑件的步骤。 还提供插入和移除系统以用于幽门阀。
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公开(公告)号：US20090259239A1
公开(公告)日：2009-10-15
申请号：US12384898
申请日：2009-04-09
申请人： Buket Grau , David Robert Gale , Sam Anne Musgrave , George McGee Perkins , Mark Jeffrey Edhouse , Marc Graham , Christopher Kadamus
发明人： Buket Grau , David Robert Gale , Sam Anne Musgrave , George McGee Perkins , Mark Jeffrey Edhouse , Marc Graham , Christopher Kadamus
IPC分类号： A61B17/08
CPC分类号： A61F5/0079 , A61F5/0089
摘要： A pyloric valve is provided for inhibiting the flow of chyme through the pyloric region of the gastrointestinal tract. The pyloric valve includes a blocking portion having at least one axially-aligned annular flange defining a central opening and a support having a rim and a support surface. The support may be disposed in a nested position wherein the support surface is disposed within the central opening and an inverted position wherein the support surface is disposed away from the central opening. The pyloric valve may further include a sleeve that may have a beveled distal end. The pyloric valve may be constructed of silicon. Also provided are methods of inserting and removing the pyloric valve, which each include a step of manipulating the support between its inverted and nested positions. Insertion and removal systems are also provided for use with the pyloric valve.
摘要翻译： 提供幽门阀用于抑制食道通过胃肠道幽门区域的流动。 幽门阀包括阻挡部分，其具有限定中心开口的至少一个轴向对齐的环形凸缘和具有边缘和支撑表面的支撑件。 支撑件可以设置在嵌套位置，其中支撑表面设置在中心开口内，并且倒置位置，其中支撑表面远离中心开口设置。 幽门阀还可以包括可具有斜切远端的套筒。 幽门阀可以由硅构成。 还提供了插入和移除幽门阀的方法，每个都包括在其倒置位置和嵌套位置之间操纵支撑件的步骤。 还提供插入和移除系统用于幽门阀。
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公开(公告)号：US20090259238A1
公开(公告)日：2009-10-15
申请号：US12384890
申请日：2009-04-09
申请人： Buket Grau , David Robert Gale , Sam Anne Musgrave , George McGee Perkins , Mark Jeffrey Edhouse , Marc Graham , Christopher Kadamus
发明人： Buket Grau , David Robert Gale , Sam Anne Musgrave , George McGee Perkins , Mark Jeffrey Edhouse , Marc Graham , Christopher Kadamus
IPC分类号： A61B17/08
CPC分类号： A61F5/0079 , A61F5/0089
摘要： A pyloric valve is provided for inhibiting the flow of chyme through the pyloric region of the gastrointestinal tract. The pyloric valve includes a blocking portion having a disc-shaped inlet and a helical flange. The helical flange may be disposed in a contracted position defining a contracted length and a contracted diameter and an extended position defining an extended length and an extended diameter, wherein the extended length is longer than the contracted length and the extended diameter is smaller than the contracted diameter. The pyloric valve may further include a sleeve that may have a beveled distal end. The pyloric valve may be constructed of silicon. Also provided are methods of inserting and removing the pyloric valve, which each include a step of manipulating the support between its contracted and extended positions. Insertion and removal systems are also provided for use with the pyloric valve.
摘要翻译： 提供幽门阀用于抑制食道通过胃肠道幽门区域的流动。 幽门阀包括具有盘形入口和螺旋凸缘的阻挡部分。 螺旋形凸缘可以设置在限定收缩长度和收缩直径的收缩位置以及限定延伸长度和延伸直径的延伸位置，其中延伸长度长于收缩长度，并且延伸直径小于收缩长度 直径。 幽门阀还可以包括可具有斜切远端的套筒。 幽门阀可以由硅构成。 还提供了插入和移除幽门阀的方法，每个都包括在收缩位置和伸展位置之间操纵支撑件的步骤。 还提供插入和移除系统以用于幽门阀。
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公开(公告)号：US20090259240A1
公开(公告)日：2009-10-15
申请号：US12420219
申请日：2009-04-08
申请人： Marc Graham , Buket Grau
发明人： Marc Graham , Buket Grau
IPC分类号： A61B17/08
CPC分类号： A61F5/0079
摘要： A pyloric valve for regulating the flow of fluids in the pyloric region a patient's gastrointestinal tract is disclosed herein. In one embodiment, a pyloric valve includes a plurality of axially connected blocking members located along a longitudinal axis of the valve in a proximal to distal direction. Each blocking member of the valve preferably includes at least one blocking portion defining at least one entryway adapted to receive fluids such as chyme therethrough. The at least one entryway of each blocking member is preferably not aligned with the at least one entryway of each blocking member adjacent thereto along the longitudinal axis. The non-alignment of the at least one entryways of the blocking members preferably creates a non-linear path for fluids such as chyme to travel through the pyloric region of the patient.
摘要翻译： 本文公开了一种用于调节患者胃肠道幽门区域中流体流动的幽门阀。 在一个实施例中，幽门阀包括沿着阀的纵向轴线沿近端到远端方向定位的多个轴向连接的阻挡构件。 阀的每个阻塞构件优选地包括限定至少一个入口通道的至少一个阻挡部分，该至少一个入口适于接收通过其中的诸如手杖之类的流体。 每个阻挡构件的至少一个入口通道优选地不沿着纵向轴线对准与其相邻的每个阻挡构件的至少一个入口。 阻挡构件的至少一个入口通道的不对准优选地产生用于流体（例如食糜）流过患者幽门区域的非线性路径。
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公开(公告)号：US20080125796A1
公开(公告)日：2008-05-29
申请号：US11998345
申请日：2007-11-28
申请人： Marc Graham
发明人： Marc Graham
CPC分类号： A61B17/0057 , A61B17/00491 , A61B17/0218 , A61B17/083 , A61B17/1227 , A61B2017/00557 , A61B2017/00575 , A61B2017/00592 , A61B2017/00615
摘要： Apparatus and methods for sealing an aperture in body tissue that extends from an outside surface to an inside surface of the body tissue is described. One embodiment of the apparatus includes an expandable material positioned against at least a portion of an expandable member, the expandable material having a sealing surface adapted to expand against the inside surface of the body tissue surrounding the aperture as the expandable member expands. In an alternative embodiment, tissue is pulled by a retractor mechanism between two biased legs of a deformable clip that is loaded on a trigger. As a base of the trigger is moved away from a base of a housing, the clip is released from the trigger causing the two biased legs of the clip to come together and seal tissue therebetween. Generally, the apparatus of each embodiment is delivered to an aperture site through an endoscope.
摘要翻译： 描述了用于密封从身体组织的外表面延伸到内表面的身体组织中的孔的装置和方法。 该装置的一个实施例包括抵靠可扩张构件的至少一部分定位的可膨胀材料，所述可膨胀材料具有密封表面，所述密封表面适于当可膨胀构件膨胀时抵靠围绕孔的身体组织的内表面膨胀。 在替代实施例中，组织被牵引器机构牵引在可加载在触发器上的可变形夹子的两个偏压腿之间。 当触发器的基座远离壳体的基部移动时，夹子从触发器释放，导致夹子的两个偏置腿部彼此聚集并密封组织。 通常，每个实施例的装置通过内窥镜传送到孔径部位。
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公开(公告)号：US08870808B2
公开(公告)日：2014-10-28
申请号：US13336196
申请日：2011-12-23
申请人： Buket Grau , David Robert Gale , Sam Anne Musgrave , George McGee Perkins , Mark Jeffrey Edhouse , Marc Graham , Christopher Kadamus
发明人： Buket Grau , David Robert Gale , Sam Anne Musgrave , George McGee Perkins , Mark Jeffrey Edhouse , Marc Graham , Christopher Kadamus
CPC分类号： A61F5/0079 , A61F5/0089
摘要： A pyloric valve is provided for inhibiting the flow of chyme through the pyloric region of the gastrointestinal tract. The pyloric valve includes a blocking portion having at least one axially-aligned annular flange defining a central opening and a support having a rim and a support surface. The support may be disposed in a nested position wherein the support surface is disposed within the central opening and an inverted position wherein the support surface is disposed away from the central opening. The pyloric valve may further include a sleeve that may have a beveled distal end. The pyloric valve may be constructed of silicon. Also provided are methods of inserting and removing the pyloric valve, which each include a step of manipulating the support between its inverted and nested positions. Insertion and removal systems are also provided for use with the pyloric valve.
摘要翻译： 提供幽门阀用于抑制食道通过胃肠道幽门区域的流动。 幽门阀包括阻挡部分，其具有限定中心开口的至少一个轴向对准的环形凸缘和具有边缘和支撑表面的支撑件。 支撑件可以设置在嵌套位置，其中支撑表面设置在中心开口内，并且倒置位置，其中支撑表面远离中心开口设置。 幽门阀还可以包括可具有斜切远端的套筒。 幽门阀可由硅构成。 还提供了插入和移除幽门阀的方法，每个都包括在其倒置位置和嵌套位置之间操纵支撑件的步骤。 还提供插入和移除系统以用于幽门阀。
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