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1.发明授权Biochemical assay device using frustrated total internal reflection modulator with an imaging optical waveguide 有权使用具有成像光波导的沮丧的全内反射调制器的生化测定装置公开(公告)号：US06707958B2
公开(公告)日：2004-03-16
申请号：US09988468
申请日：2001-11-20
申请人： Richard D. Pering , David A. King , Richard J. Pittaro , Shahida Rana , Frederick A. Stawitcke , Edward D. Verdonk
发明人： Richard D. Pering , David A. King , Richard J. Pittaro , Shahida Rana , Frederick A. Stawitcke , Edward D. Verdonk
IPC分类号： G02B600
CPC分类号： G01N21/552 , B01L3/5085 , G01N35/028
摘要： A biochemical assay device optically scans individual biological sample containing wells in an assay plate. The device includes an imaging system overlaying the assay plate wherein a scanning light propagates by total internal reflection within an optical waveguide. The waveguide includes a plurality of pixel locations, each aligned with a well in the assay plate, at which total internal reflection is selectively frustrated to output an incident beam of light. That light illuminates the well and causes generation of an emission beam of light that is detected by a photoreceptor. The device further includes a driver circuit that controls the selective frustration of total internal reflection at each pixel location in order to scan each well in the assay plate. A processor is also included in the device to process the detected emission beams of light generated by the scanned wells for purposes of assaying the biological sample contained in each scanned well.
摘要翻译： 生物化学测定装置在测定板中光学扫描含有孔的各种生物样品。 该装置包括覆盖测定板的成像系统，其中扫描光通过光波导内的全内反射传播。 波导包括多个像素位置，每个像素位置与测定板中的阱对准，在该位置处，全内反射被选择性地挫败以输出入射光束。 该光照射井，并产生由感光体检测到的发射光束。 该装置还包括驱动器电路，其控制每个像素位置处的全内反射的选择性挫败，以扫描测定板中的每个孔。 为了分析每个扫描井中包含的生物样品的目的，处理器还包括在该装置中以处理由扫描井产生的检测到的发射光束。
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2.发明授权公开(公告)号：US06657235B1
公开(公告)日：2003-12-02
申请号：US10153760
申请日：2002-05-22
申请人： Edward Verdonk , Richard J. Pittaro , Shahida Rana , David Andrew King , Frederick A. Stawitcke , Richard D. Pering
发明人： Edward Verdonk , Richard J. Pittaro , Shahida Rana , David Andrew King , Frederick A. Stawitcke , Richard D. Pering
IPC分类号： H01L2926
CPC分类号： H01L27/14643 , H01L25/0753 , H01L25/167 , H01L2924/0002 , H01L2924/00
摘要： The disclosure is directed toward an optical excitation/detection device that includes an arrayed plurality of photodetectors and discrete photoemitters, as well as a method for making such a device. A CMOS fabricated photodetector array includes an arrayed plurality of photoreceptor areas and photoemitter areas, wherein each photoreceptor area includes a CMOS integrated photoreceptor and each photoemitter area includes at least two buried electric contact pads. The CMOS array is selectively etched back at the locations of the photoemitter areas for regions to reveal the buried contact pads. A plurality of discrete semiconductor photoemitter devices (such as, for example, light emitting diodes) are inserted into, and mechanically retained within, the regions of the CMOS fabricated photodetector array. The inserted discrete semiconductor photoemitter devices make electrical contact with the buried electric contact pads that are revealed within each of the regions to form the optical excitation/detection device from an arrayed plurality of photodetectors and discrete semiconductor photoemitters.
摘要翻译： 本公开涉及包括阵列的多个光电探测器和分立光电发生器的光学激发/检测装置，以及用于制造这种装置的方法。 CMOS制造的光电检测器阵列包括阵列的多个感光体区域和光电发射器区域，其中每个感光体区域包括CMOS集成感光体，并且每个光电发射器区域包括至少两个埋入的电接触焊盘。 CMOS阵列在光电探测器区域的位置处被选择性地回蚀，用于区域以露出埋入的接触焊盘。 多个分立的半导体光电探测器装置（例如，发光二极管）被插入并机械地保持在CMOS制造的光电检测器阵列的区域内。 插入的分立半导体光电发生器装置与在每个区域内露出的掩埋电接触焊盘电接触，以从阵列的多个光电探测器和分立的半导体光电发生器形成光激发/检测装置。
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公开(公告)号：US06640197B2
公开(公告)日：2003-10-28
申请号：US10072240
申请日：2002-02-08
申请人： Richard J. Pittaro , David Andrew King , Richard D. Pering , Shahida Rana , Frederick A. Stawitcke , Edward Verdonk
发明人： Richard J. Pittaro , David Andrew King , Richard D. Pering , Shahida Rana , Frederick A. Stawitcke , Edward Verdonk
IPC分类号： G01C2500
CPC分类号： G01N21/253
摘要： A sensor array is bonded to or molded together with a micro-lens array to form a sensor cartridge. The micro-lenses of the micro-lens array are configured to focus light incident on the sensors, into the sensors. An alignment structure has a mating profile that receives and engages one or more micro-lenses from the micro-lens array to laterally align the cartridge to enable repeatable precise positioning of the cartridge.
摘要翻译： 传感器阵列与微透镜阵列结合或模制在一起以形成传感器盒。 微透镜阵列的微透镜被配置为将入射到传感器上的光聚焦到传感器中。 对准结构具有匹配轮廓，该配合轮廓接收并接合来自微透镜阵列的一个或多个微透镜以横向对准盒，以使得盒的可重复的精确定位。
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公开(公告)号：US5642375A
公开(公告)日：1997-06-24
申请号：US548787
申请日：1995-10-26
申请人： David A. King , Richard J. Pittaro
发明人： David A. King , Richard J. Pittaro
摘要： A laser system capable of providing light of high intensity is disclosed. This system includes a laser gain medium and three reflectors. A first reflector and a second reflector spaced from the first reflector define a laser cavity that contains the laser gain medium. The second reflector has a reflectivity (R.sub.2) larger than the reflectivity (R.sub.1) of the first reflector such that light emitted from the laser gain medium resonates in the laser cavity. A third reflector having a reflectivity (R.sub.3) larger than the reflectivity of the first reflector (R.sub.1) is spaced from the second reflector to define a resonant cavity external to the laser cavity. Light passes from the laser cavity to resonate in the external resonant cavity. Part of the light passes from the external resonant cavity to the laser cavity to optically lock the laser gain medium.
摘要翻译： 公开了一种能够提供高强度光的激光系统。 该系统包括激光增益介质和三个反射器。 与第一反射器间隔开的第一反射器和第二反射器限定包含激光增益介质的激光腔。 第二反射器具有大于第一反射器的反射率（R1）的反射率（R2），使得从激光增益介质发射的光在激光腔中共振。 具有比第一反射器（R1）的反射率大的反射率（R3）的第三反射器与第二反射器间隔开以限定激光腔外部的谐振腔。 光通过激光腔，在外部谐振腔谐振。 部分光从外部谐振腔传递到激光腔，以光学锁定激光增益介质。
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公开(公告)号：US06298735B1
公开(公告)日：2001-10-09
申请号：US09298335
申请日：1999-04-23
IPC分类号： G01F166
CPC分类号： G01F1/667 , Y10T29/42 , Y10T29/49002 , Y10T29/49011
摘要： An accurate and reliable pneumotachometer with annular ring transducers for determining the velocity of a fluid flow is provided. A novel and accurate flow measurement system for measuring transit time of a fluid flow using chirp signals and a pneumotachometer with annular ring transducers is also disclosed.
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公开(公告)号：US5835522A
公开(公告)日：1998-11-10
申请号：US752704
申请日：1996-11-19
摘要： A laser system capable of providing light of high intensity is disclosed. This system includes a laser gain medium and three reflectors. A first reflector and a second reflector spaced from the first reflector define a laser cavity that contains the laser gain medium. Light reflected by the first reflector is amplified by the laser gain medium. A third reflector is spaced from the second reflector to define a resonant cavity external to the laser cavity. Light passes from the laser cavity to resonate in the external resonant cavity. Part of the light passes from the external resonant cavity to the laser cavity. A light-screening device, e.g., an aperture, is disposed between the second reflector and the gain medium to screen light reflected from the external cavity such that the light portion of constructive interference is preferentially passed over the light portion of destructive interference. This enables the gain medium to optically lock to the resonant frequency of the external cavity.
摘要翻译： 公开了一种能够提供高强度光的激光系统。 该系统包括激光增益介质和三个反射器。 与第一反射器间隔开的第一反射器和第二反射器限定包含激光增益介质的激光腔。 由第一反射器反射的光被激光增益介质放大。 第三反射器与第二反射器间隔开以限定激光腔外部的谐振腔。 光通过激光腔，在外部谐振腔谐振。 部分光从外部谐振腔传递到激光腔。 遮光装置，例如孔，设置在第二反射器和增益介质之间，以屏蔽从外部空腔反射的光，使得建构性干涉的光部分优先通过相对干涉的光部分。 这使得增益介质能够光学锁定到外部腔的谐振频率。
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公开(公告)号：US5450193A
公开(公告)日：1995-09-12
申请号：US226245
申请日：1994-04-11
申请人： William F. Carlsen , Tad D. Simons , Richard J. Pittaro , Jeffrey Perry , George W. Hopkins, II , Damien F. Gray
发明人： William F. Carlsen , Tad D. Simons , Richard J. Pittaro , Jeffrey Perry , George W. Hopkins, II , Damien F. Gray
摘要： Method and apparatus for determining the composition and concentration of gases present in a patient's airway by measurement of the spectrum of Raman scattered light from these gases. The efficiency is improved by collecting Raman scattered light generated outside the collection region. The gases present are assumed to be drawn from a predetermined set of gases with known Raman scattering spectra, and the concentrations are determined by solution of a matrix equation Ac=b, where the c vector components are the unknown concentrations and the b vector components are determined from measurements of the Raman scattering intensifies in a plurality of wavelength or wavenumber intervals. The linear system of equations represented by the matrix equation may be overdetermined and may require solution by non-conventional methods, such as singular value decomposition.
摘要翻译： 通过测量来自这些气体的拉曼散射光的光谱来确定患者气道中存在的气体的组成和浓度的方法和装置。 通过收集在收集区域外部产生的拉曼散射光来提高效率。 存在的气体被假设从具有已知拉曼散射光谱的预定气体组中抽出，并且浓度通过矩阵方程式Ac = b的溶液来确定，其中c矢量分量是未知浓度，b矢量分量是 由拉曼散射的测量确定，以多个波长或波数间隔增强。 由矩阵方程表示的线性方程式可以被过度确定，并且可能需要通过非常规方法（例如奇异值分解）的解。
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8.发明授权Dark current subtraction with abbreviated reference cycles and recursive filtering 失效暗电流减法与缩写参考循环和递归滤波
公开(公告)号：US5408314A
公开(公告)日：1995-04-18
申请号：US21927
申请日：1993-02-24
申请人： Jeffrey Perry , Richard J. Pittaro
发明人： Jeffrey Perry , Richard J. Pittaro
CPC分类号： H04N5/361 , G01J1/44 , G01J3/44 , H04N5/3651 , G01J2001/4242 , G01J2001/444 , G01N2021/8578
摘要： A method and apparatus for performing dark signal correction on a photoelectric conversion device. A flow of light to the device is alternately conducted and interrupted. The device generates an intermixed signal while the flow of light is conducted to the device, the intermixed signal including a desired signal intermixed with an unwanted dark signal. The device generates a dark signal alone while the flow of light to the device is interrupted. The dark signal alone is filtered to produce a filtered dark signal. The filtered dark signal is subtracted from the intermixed signal to produce a corrected signal, which is representative of the desired signal.
摘要翻译： 一种用于在光电转换装置上执行暗信号校正的方法和装置。 交替传导和中断到设备的光流。 该装置在将光流传导到装置时产生混合信号，混合信号包括与不需要的暗信号混合的期望信号。 该设备单独产生暗信号，同时中断到设备的光流。 单独的暗信号被滤波以产生滤波的暗信号。 从混合信号中减去滤波后的暗信号，以产生校正信号，该校正信号代表期望信号。
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公开(公告)号：US4437332A
公开(公告)日：1984-03-20
申请号：US429127
申请日：1982-09-30
申请人： Richard J. Pittaro
发明人： Richard J. Pittaro
CPC分类号： G01B17/02 , G01N29/07 , G01N2291/0258 , G01N2291/02854 , G01N2291/02881
摘要： A programmable ultrasonic thickness and acoustic velocity measuring instrument is provided which includes automatic zeroing (calibrating) means, automatic temperature compensation and high temperature warning means, automatic probe identification means, means for automatically correcting the measurement readings for probe characteristics, means for storing and displaying of the minimum wall thickness during a predetermined time interval, and means for providing a display indicative of the difference between a measured thickness and a preprogrammed value.
摘要翻译： 提供了一种可编程超声波测厚仪和声速测量仪器，包括自动归零（校准）装置，自动温度补偿和高温报警装置，自动探头识别装置，用于自动校正探头特性的测量读数的装置，用于存储和显示的装置 在预定时间间隔内具有最小壁厚的装置，以及用于提供指示测量厚度和预编程值之间的差的显示的装置。
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公开(公告)号：US4064742A
公开(公告)日：1977-12-27
申请号：US764343
申请日：1977-01-31
申请人： Richard J. Pittaro
发明人： Richard J. Pittaro
CPC分类号： H03L7/181 , G01N29/38 , G01S7/52004 , Y10S367/902
摘要： A clock circuit comprising a synchronizable voltage controlled oscillator in combination with a programmable address means, which address means is adjusted commensurate with the acoustic velocity of the workpiece, provides clock pulses from the oscillator having a stable and accurate acoustic velocity dependent frequency. An entrant surface responsive electrical signal responsive to an ultrasonic search signal entering the workpiece is also provided to the clock circuit for assuring that the clock pulses are synchronized with the receipt of the electrical signal.
摘要翻译： 一种时钟电路，包括与可编程地址装置组合的可同步压控振荡器，所述可编程地址装置与所述工件的声速匹配地调整地址装置，提供具有稳定且准确的声学速度相关频率的振荡器的时钟脉冲。 响应于进入工件的超声波搜索信号的入射面响应电信号也被提供给时钟电路，以确保时钟脉冲与电信号的接收同步。
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