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公开(公告)号：US6054446A
公开(公告)日：2000-04-25
申请号：US998877
申请日：1997-12-24
Applicant: Masato Tanabe , Richard H. Peters , Wan-Ru Chao , Ling Jong
Inventor： Masato Tanabe , Richard H. Peters , Wan-Ru Chao , Ling Jong
IPC: A61K31/57 , A61K9/02 , A61K31/56 , A61K31/575 , A61K31/58 , A61P3/06 , A61P5/32 , A61P11/00 , A61P19/10 , A61P35/00 , A61P43/00 , C07J13/00 , C07J41/00 , C07J43/00 , C07J5/00
CPC classification number: C07J41/00 , C07J41/0072 , C07J41/0077 , C07J43/003 , A61K9/02
Abstract: Novel anti-estrogenic compounds are provided which are useful to treat a variety of disorders, particularly estrogen-dependent disorders. Preferred compounds have a 1,3,5-estratriene nucleus, and are substituted at the C-17 or C-11 position with a molecular moiety which renders the compounds effective to competitively block the binding of estrogen to its receptor. Particularly preferred compounds are 17-desoxy-1,3,5-estratrienes. Therapeutic methods and pharmaceutical compositions are provided as well.
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2.发明授权Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use 有权抗雌激素类固醇，以及相关的药物组合物和使用方法公开(公告)号：US06455517B1
公开(公告)日：2002-09-24
申请号：US09918890
申请日：2001-07-30
Applicant: Masato Tanabe , Richard H. Peters , Wan-Ru Chao , Ling Jong
Inventor： Masato Tanabe , Richard H. Peters , Wan-Ru Chao , Ling Jong
IPC: A61K3156
CPC classification number: C07J41/00 , A61K9/02 , C07J41/0072 , C07J41/0077 , C07J43/003
Abstract: Novel anti-estrogenic compounds are provided which are useful to treat a variety of disorders, particularly estrogen-dependent disorders. Preferred compounds have a 1,3,5-estratriene nucleus, and are substituted at the C-17 or C-11 position with a molecular moiety which renders the compounds effective to competitively block the binding of estrogen to its receptor. Particularly preferred compounds are 17-desoxy-1,3,5-estratrienes. Therapeutic methods and pharmaceutical compositions are provided as well.
Abstract translation: 提供了新的抗雌激素化合物，其可用于治疗多种疾病，特别是雌激素依赖性疾病。 优选的化合物具有1,3,5-三亚甲基核，并且在C-17或C-11位置被分子部分取代，这使得化合物有效地竞争性阻断雌激素与其受体的结合。 特别优选的化合物是17-脱氧-1,3,5-雌三烯。 也提供治疗方法和药物组合物。
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3.发明授权Steroid inhibitors of estrone sulfatase and associated pharmaceutical compositions and methods of use 失效甾体硫酸酯酶的类固醇抑制剂及其相关药物组合物和使用方法
公开(公告)号：US5861388A
公开(公告)日：1999-01-19
申请号：US1601
申请日：1997-12-31
Applicant: Masato Tanabe , Richard H. Peters , Wan-Ru Chao , Kazuhiko Shigeno
Inventor： Masato Tanabe , Richard H. Peters , Wan-Ru Chao , Kazuhiko Shigeno
CPC classification number: C07J71/0094
Abstract: Novel compounds useful as inhibitors of estrone sulfatase are provided. The compounds have the structural formula (I) ##STR1## wherein X and Y, or Y and Z, form an oxathiazine dioxide ring or a dihydro-oxathiazine dioxide ring, and the other various substituents are as defined herein. Pharmaceutical compositions and methods for using the compounds of formula (I) to treat estrogen-dependent disorders are provided as well.
Abstract translation: 提供了可用作雌酮硫酸酯酶抑制剂的新型化合物。 化合物具有结构式（I）其中X和Y或Y和Z形成氧噻嗪二氧化物环或二氢 - 噻吩二氧化物环，其它各种取代基如本文所定义。 还提供了使用式（I）化合物治疗雌激素依赖性疾病的药物组合物和方法。
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4.发明授权Steriod inhibitors of estrone sulfatase and associated pharmaceutical compositions and methods of use 失效雌酮硫酸酯酶的Steriod抑制剂及其相关药物组合物和使用方法
公开(公告)号：US5763432A
公开(公告)日：1998-06-09
申请号：US794229
申请日：1997-01-29
Applicant: Masato Tanabe , Richard H. Peters , Wan-Ru Chao , Kazuhiko Shigeno
Inventor： Masato Tanabe , Richard H. Peters , Wan-Ru Chao , Kazuhiko Shigeno
CPC classification number: C07J71/0094
Abstract: Novel compounds useful as inhibitors of estrone sulfatase are provided. The compounds have the structural formula (I) ##STR1## wherein X and Y, or Y and Z, form an oxathiazine dioxide ring or a dihydro-oxathiazine dioxide ring, and the other various substituents are as defined herein. Pharmaceutical compositions and methods for using the compounds of formula (I) to treat estrogen-dependent disorders are provided as well.
Abstract translation: 提供了可用作雌酮硫酸酯酶抑制剂的新型化合物。 化合物具有结构式（I）其中X和Y或Y和Z形成氧噻嗪二氧化物环或二氢 - 噻吩二氧化物环，其它各种取代基如本文所定义。 还提供了使用式（I）化合物治疗雌激素依赖性疾病的药物组合物和方法。
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公开(公告)号：US09090999B2
公开(公告)日：2015-07-28
申请号：US13247344
申请日：2011-09-28
Applicant: Sai-Pei Ting , Olivier Guise , Jung Ah Lee , Richard H. Peters , Hua Guo
Inventor： Sai-Pei Ting , Olivier Guise , Jung Ah Lee , Richard H. Peters , Hua Guo
IPC: D02G3/00 , B28B3/20 , C08F283/04 , D01F6/94 , C08L77/02 , C08L77/06 , B29C47/00 , D01F1/10 , D01F6/90 , D01F8/12 , B29C47/92 , C08L71/12
CPC classification number: D01F6/94 , B29C47/0014 , B29C47/92 , B29C2947/92514 , B29C2947/92704 , C08L71/12 , C08L77/02 , C08L77/06 , D01F1/10 , D01F6/90 , D01F8/12 , Y10T428/2929 , C08L71/123 , C08L77/00
Abstract: A fiber is prepared by melt extruding a composition including specific amounts of a polyamide and a polyphenylene ether along with a compatabilizer. Particular combinations produce fibers having a desirable combination of good tenacity and low denier per fiber. Compared to a fiber prepared from polyamide alone, the present fiber exhibits improved heat resistance and flame resistance.
Abstract translation: 通过将包含特定量的聚酰胺和聚苯醚的组合物与配混剂一起熔融挤出来制备纤维。 特殊的组合产生具有良好韧性和每纤维低旦数的所需组合的纤维。 与仅由聚酰胺制备的纤维相比，本发明的纤维表现出改善的耐热性和阻燃性。
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Patent Agency Ranking
公开(公告)号：US20130078465A1
公开(公告)日：2013-03-28
申请号：US13247344
申请日：2011-09-28
Applicant: Sai-Pei Ting , Olivier Guise , Jung Ah Lee , Richard H. Peters , Hua Guo
Inventor： Sai-Pei Ting , Olivier Guise , Jung Ah Lee , Richard H. Peters , Hua Guo
CPC classification number: D01F6/94 , B29C47/0014 , B29C47/92 , B29C2947/92514 , B29C2947/92704 , C08L71/12 , C08L77/02 , C08L77/06 , D01F1/10 , D01F6/90 , D01F8/12 , Y10T428/2929 , C08L71/123 , C08L77/00
Abstract: A fiber is prepared by melt extruding a composition including specific amounts of a polyamide and a polyphenylene ether along with a compatabilizer. Particular combinations produce fibers having a desirable combination of good tenacity and low denier per fiber. Compared to a fiber prepared from polyamide alone, the present fiber exhibits improved heat resistance and flame resistance.
Abstract translation: 通过将包含特定量的聚酰胺和聚苯醚的组合物与配混剂一起熔融挤出来制备纤维。 特殊的组合产生具有良好韧性和每纤维低旦数的所需组合的纤维。 与仅由聚酰胺制备的纤维相比，本发明的纤维表现出改善的耐热性和阻燃性。
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7.发明申请公开(公告)号：US20120252773A1
公开(公告)日：2012-10-04
申请号：US13457416
申请日：2012-04-26
Applicant: Khalid Amin , Joy M. Calaoagan , Wan-Ru Chao , Peter D. Hobbs , Keith R. Laderoute , Richard H. Peters , Masato Tanabe
Inventor： Khalid Amin , Joy M. Calaoagan , Wan-Ru Chao , Peter D. Hobbs , Keith R. Laderoute , Richard H. Peters , Masato Tanabe
CPC classification number: A61K31/56
Abstract: A method is provided for treating a patient with a medical condition that involves angiogenesis or HIF-1 overexpression with a compound having the structure of formula (I) wherein Z, x, y, and R1 through R11 are as defined herein.
Abstract translation: 提供了一种治疗患有涉及血管生成或HIF-1过表达的医学病症的患者的方法，其具有式（I）结构的化合物，其中Z，x，y和R 1至R 11如本文所定义。
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8.发明授权Synthesis of anti-estrogenic and other therapeutic steroids from 21-hydroxy-19-norpregna-4-en-3-one 有权从21-羟基-19-去甲孕烯-4-烯-3-酮合成抗雌激素和其它治疗类固醇公开(公告)号：US07772218B2
公开(公告)日：2010-08-10
申请号：US10915302
申请日：2004-08-09
Applicant: Richard H. Peters , Jyanwei Liu , John G. Johansson , Kenneth J. Ryan , Wan-Ru Chao , Masato Tanabe
Inventor： Richard H. Peters , Jyanwei Liu , John G. Johansson , Kenneth J. Ryan , Wan-Ru Chao , Masato Tanabe
Abstract: Syntheses of steroids such as 3-hydroxy-7α-methyl-21-[2′-methoxy-4′-(diethylaminomethyl)-phenoxy]-19-norpregna-1,3,5(10)triene citrate (“SR 16234”) and analogs thereof are provided, wherein 21-hydroxy-19-norpregna-4-en-3-one serves as a starting material or intermediate. The latter compound may be readily prepared from estrone-3-methyl ether. Certain intermediates in these syntheses also have value as therapeutic agents, for example in the treatment of prostate disorders such as prostatic cancer.
Abstract translation: 类固醇如3-羟基-7α-甲基-21- [2'-甲氧基-4' - （二乙基氨基甲基） - 苯氧基] -19-去甲基-1,3,5（10）柠檬酸三烯酸盐（“SR 16234” ）及其类似物，其中21-羟基-19-去甲基-4-烯-3-酮用作原料或中间体。 后一种化合物可以容易地由雌酮-3-甲基醚制备。 这些合成中的某些中间体也具有作为治疗剂的价值，例如在前列腺疾病如前列腺癌的治疗中。
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公开(公告)号：US06503896B1
公开(公告)日：2003-01-07
申请号：US09872826
申请日：2001-05-31
Applicant: Masato Tanabe , Richard H. Peters , Wan-Ru Chao , Ling Jong
Inventor： Masato Tanabe , Richard H. Peters , Wan-Ru Chao , Ling Jong
IPC: A61K3156
CPC classification number: C07J41/0072 , A61K9/02 , C07J41/0077 , C07J43/003
Abstract: Novel anti-estrogenic compounds are provided which are useful to treat a variety of disorders, particularly estrogen-dependent disorders. Preferred compounds have a 1,3,5-estratriene nucleus, and are substituted at the C-17 or C-11 position with a molecular moiety which renders the compounds effective to competitively block the binding of estrogen to its receptor. Particularly preferred compounds are 17-desoxy-1,3,5-estratrienes. Therapeutic methods and pharmaceutical compositions are provided as well.
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10.发明授权Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use 有权抗雌激素类固醇，以及相关的药物组合物和使用方法公开(公告)号：US06281205B1
公开(公告)日：2001-08-28
申请号：US09220408
申请日：1998-12-24
Applicant: Masato Tanabe , Richard H. Peters , Wan-Ru Chao , Ling Jong
Inventor： Masato Tanabe , Richard H. Peters , Wan-Ru Chao , Ling Jong
IPC: A61K3156
CPC classification number: C07J41/00 , A61K9/02 , C07J41/0072 , C07J41/0077 , C07J43/003
Abstract: Novel anti-estrogenic compounds are provided which are useful to treat a variety of disorders, particularly estrogen-dependent disorders. Preferred compounds have a 1,3,5(10)-estratriene nucleus, and are substituted at the C-17 or C-11 position with a molecular moiety which renders the compounds effective to competitively block the binding of estrogen to its receptor. Particularly preferred compounds are 17-desoxy-1,3,5(10)-estratrienes. Therapeutic methods and pharmaceutical compositions are provided as well.
Abstract translation: 提供了新的抗雌激素化合物，其可用于治疗多种疾病，特别是雌激素依赖性疾病。 优选的化合物具有1,3,5（10） - 三亚甲基核，并且在C-17或C-11位置被分子部分取代，这使得化合物有效地竞争性阻断雌激素与其受体的结合。 特别优选的化合物是17-脱氧-1,3,5（10） - 雌三烯。 也提供治疗方法和药物组合物。
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