公开(公告)号：US06908768B2

公开(公告)日：2005-06-21

申请号：US10029891

申请日：2001-12-21

Applicant: Richard C. Willson, III

Inventor： Richard C. Willson, III

IPC: G01N25/48 ,  B01J19/00 ,  B01J21/04 ,  C40B30/08 ,  C40B40/18 ,  G01N31/10 ,  G01N21/00 ,  G01N33/48

CPC classification number: G01N31/10 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00315 ,  B01J2219/00364 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00659 ,  B01J2219/00691 ,  B01J2219/00704 ,  B01J2219/00745 ,  B01J2219/00747 ,  C40B30/08 ,  C40B40/18 ,  Y10T436/214 ,  Y10T436/24

Abstract: Apparatus for testing catalyst candidates including a multi-cell holder e.g. a honeycomb or plate, or a collection of individual support particles that have been treated with solutions/suspensions of catalyst ingredients to produce cells, spots or pellets holding each of a variety of combinations of the ingredients and dried, calcined or treated as necessary to stabilize the ingredients in the cells, spots or pellets. The apparatus also includes structure for contacting the catalyst candidates with a potentially reactive feed stream or batch e.g., biochemical, gas oil, hydrogen plus oxygen, propylene plus oxygen, CCl2F2 and hydrogen, etc. The reaction occurring in each cell can be measured, e.g. by infrared thermography, spectroscopic detection of products or residual reactants, or by sampling, e.g. by multistreaming through low volume tubing, from the vicinity of each combination, followed by analysis e.g. spectral analysis, chromatography etc., or by observing temperature change in the vicinity of the catalyst e.g. by thermographic techniques, to determine the relative efficacy of the catalysts in each combination. Robotic techniques can be employed in producing the cells, spots, pellets, etc.

Abstract translation: 用于测试催化剂候选物的装置，包括多电池座，例如 蜂窝或板，或已经用催化剂成分的溶液/悬浮液处理的单独的载体颗粒的集合，以产生保持成分的各种组合的各种组分的细胞，斑点或颗粒，并根据需要进行干燥，煅烧或处理以稳定 细胞中的成分，斑点或颗粒。 该装置还包括用于使催化剂候选物与潜在的反应性进料流或批料接触的结构，例如生物化学，瓦斯油，氢气加氧气，丙烯加氧气，CCl 2/2F 2 >和氢等。可以测量每个电池中发生的反应，例如 通过红外热像仪，产物或残余反应物的光谱检测，或通过采样，例如， 通过低体积管道从每个组合的附近进行多流，然后进行分析。 光谱分析，色谱等，或通过观察催化剂附近的温度变化， 通过热成像技术确定催化剂在每种组合中的相对功效。 机器人技术可用于生产细胞，斑点，丸粒等。

公开(公告)号：US06623970B1

公开(公告)日：2003-09-23

申请号：US09613877

申请日：2000-07-10

Applicant: Richard C. Willson, III

Inventor： Richard C. Willson, III

IPC: G01N3110

CPC classification number: G01N31/10 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00315 ,  B01J2219/00364 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00659 ,  B01J2219/00691 ,  B01J2219/00704 ,  B01J2219/00745 ,  B01J2219/00747 ,  C40B30/08 ,  C40B40/18 ,  Y10T436/214 ,  Y10T436/24

Abstract: Methods for evaluating catalysts, in which a multicell holder, e.g., a honeycomb or plate, or a collection of individual support particles, is treated with solutions/suspensions of catalyst ingredients to produce cells, spots or pellets holding each of a variety of combinations of the ingredients, is dried, calcined or treated as necessary to stabilize the ingredients in the cells, spots or pellets, then is contacted with a potentially reactive feed stream or batch, e.g., biochemical, gas oil, hydrogen plus oxygen, propylene plus oxygen, CCl2F2 and hydrogen, etc. The reaction occurring in each cell can be measured, e.g., by infrared thermography, spectroscopic detection of products or residual reactants, or by sampling, e.g., multistreaming through low volume tubing, from the vicinity of each combination, followed by analysis, e.g., spectral analysis, chromatography, etc., or by observing temperature change in the vicinity of the catalyst, e.g., by thermographic techniques, to determine the relative efficacy of the catalysts in each combination. Robotic techniques can be employed in producing the cells, spots, pellets, etc.

Abstract translation: 用于评价催化剂的方法，其中多单元保持器例如蜂窝或板或各个支撑颗粒的集合用催化剂成分的溶液/悬浮液处理以产生保持各种各样的组合的细胞，斑点或颗粒 根据需要将成分干燥，煅烧或处理以稳定细胞，斑点或丸粒中的成分，然后与潜在的反应性进料流或批次接触，例如生化，瓦斯油，氢加氧，丙烯加氧， CCl 2 F 2和氢等。可以测量每个电池中发生的反应，例如通过红外热像仪，产物或残留反应物的光谱检测，或通过采样，例如通过低体积管道从每个组合的附近进行多流式化，随后 通过分析，例如光谱分析，色谱法等，或通过观察催化剂附近的温度变化，例如通过热成像技术测定 e催化剂在每种组合中的相对功效。 机器人技术可用于生产细胞，斑点，丸粒等。

公开(公告)号：US06623968B1

公开(公告)日：2003-09-23

申请号：US09612857

申请日：2000-07-10

Applicant: Richard C. Willson, III

Inventor： Richard C. Willson, III

IPC: G01N3110

CPC classification number: G01N31/10 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00315 ,  B01J2219/00364 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00659 ,  B01J2219/00691 ,  B01J2219/00704 ,  B01J2219/00745 ,  B01J2219/00747 ,  C40B30/08 ,  C40B40/18 ,  Y10T436/214 ,  Y10T436/24

Abstract: Apparatus for evaluating catalysts, including a multicell holder, e.g., a honeycomb or plate, or a collection of individual support particles, is treated with solutions/suspensions of catalyst ingredients to produce cells, spots or pellets holding each of a variety of combinations of the ingredients, is dried, calcined or treated as necessary to stabilize the ingredients in the cells, spots or pellets, then is contacted with a potentially reactive feed stream or batch, e.g., biochemical, gas oil, hydrogen plus oxygen, propylene plus oxygen, CCl2F2 and hydrogen, etc. The reaction occurring in each cell can be measured, e.g., by infrared thermography, spectroscopic detection of products or residual reactants, or by sampling, e.g., multistreaming through low volume tubing, from the vicinity of each combination, followed by analysis, e.g., spectral analysis, chromatography, etc., or by observing temperature change in the vicinity of the catalyst, e.g., by thermographic techniques, to determine the relative efficacy of the catalysts in each combination. Robotic techniques can be employed in producing the cells, spots, pellets, etc.

Abstract translation: 用于评价催化剂的装置，包括多单元保持器，例如蜂窝或板，或各个支撑颗粒的集合，用催化剂成分的溶液/悬浮液处理，以产生保持各种各样的组合的细胞，斑点或颗粒 成分，干燥，煅烧或处理以稳定细胞，斑点或丸粒中的成分，然后与潜在的反应性进料流或批次接触，例如生化，瓦斯油，氢加氧，丙烯加氧，CCl 2 F 2 和氢气等。可以测量每个电池中发生的反应，例如通过红外热成像，产物或残余反应物的光谱检测，或通过从每个组合的附近采样，例如通过低体积管进行多流，然后是 分析，例如光谱分析，色谱等，或通过观察催化剂附近的温度变化，例如通过热成像技术来阻止 在每种组合中我们的催化剂的相对功效。 机器人技术可用于生产细胞，斑点，丸粒等。

公开(公告)号：US06605470B1

公开(公告)日：2003-08-12

申请号：US09613084

申请日：2000-07-10

Applicant: Richard C. Willson, III

Inventor： Richard C. Willson, III

IPC: G01N3300

CPC classification number: G01N31/10 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00315 ,  B01J2219/00364 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00659 ,  B01J2219/00691 ,  B01J2219/00704 ,  B01J2219/00745 ,  B01J2219/00747 ,  C40B30/08 ,  C40B40/18 ,  Y10T436/214 ,  Y10T436/24

Abstract: Methods for evaluating catalysts, in which a multicell holder, e.g., a honeycomb or plate, or a collection of individual support particles, is treated with solutions/suspensions of catalyst ingredients to produce cells, spots or pellets holding each of a variety of combinations of the ingredients, is dried, calcined or treated as necessary to stabilize the ingredients in the cells, spots or pellets, then is contacted with a potentially reactive feed stream or batch, e.g., biochemical, gas oil, hydrogen plus oxygen, propylene plus oxygen, CCl2F2 and hydrogen, etc. The reaction occurring in each cell can be measured, e.g., by infrared thermography, spectroscopic detection of products or residual reactants, or by sampling, e.g., multistreaming through low volume tubing, from the vicinity of each combination, followed by analysis, e.g., spectral analysis, chromatography, etc., or by observing temperature change in the vicinity of the catalyst, e.g., by thermographic techniques, to determine the relative efficacy of the catalysts in each combination. Robotic techniques can be employed in producing the cells, spots, pellets, etc.

Abstract translation: 用于评价催化剂的方法，其中多单元保持器例如蜂窝或板或各个支撑颗粒的集合用催化剂成分的溶液/悬浮液处理以产生保持各种各样的组合的细胞，斑点或颗粒 根据需要将成分干燥，煅烧或处理以稳定细胞，斑点或丸粒中的成分，然后与潜在的反应性进料流或批次接触，例如生化，瓦斯油，氢加氧，丙烯加氧， CCl 2 F 2和氢等。可以测量每个电池中发生的反应，例如通过红外热成像，产物或残余反应物的光谱检测，或通过采样，例如通过低体积管道从每个组合的附近进行多流式化，随后 通过分析，例如光谱分析，色谱法等，或通过观察催化剂附近的温度变化，例如通过热成像技术测定 e催化剂在每种组合中的相对功效。 机器人技术可用于生产细胞，斑点，丸粒等。

公开(公告)号：US06514764B1

公开(公告)日：2003-02-04

申请号：US09727890

申请日：2000-11-28

Applicant: Richard C. Willson, III

Inventor： Richard C. Willson, III

IPC: G01N3110

CPC classification number: G01N31/10 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00315 ,  B01J2219/00364 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00659 ,  B01J2219/00691 ,  B01J2219/00704 ,  B01J2219/00745 ,  B01J2219/00747 ,  C40B30/08 ,  C40B40/18 ,  Y10T436/214 ,  Y10T436/24

Abstract: A multicell holder e.g., a honeycomb or plate, or a collection of individual support particles, is treated with solutions/suspensions of catalyst ingredients to produce cells, spots or pellets holding each of a variety of combinations of the ingredients, is dried, calcined or treated as necessary to stabilize the ingredients in the cells, spots or pellets, then is contacted with a potentially reactive feed stream or batch e.g., biochemical, gas oil, hydrogen plus oxygen, propylene plus oxygen, CCl2F2 and hydrogen, etc. The reaction occurring in each cell can be measured, e.g. by infrared thermography, spectroscopic detection of products or residual reactants, or by sampling, e.g. by multistreaming through low volume tubing, from the vicinity of each combination, followed by analysis e.g. spectral analysis, chromatography etc, or by observing temperature change in the vicinity of the catalyst e.g. by thermographic techniques, to determine the relative efficacy of the catalysts in each combination. Robotic techniques can be employed in producing the cells, spots, pellets, etc.

Abstract translation: 用催化剂成分的溶液/悬浮液处理多单元载体，例如蜂窝或板，或各个载体颗粒的集合，以产生保持成分各种组合的各种组分的细胞，斑点或颗粒，干燥，煅烧或 根据需要进行处理以稳定细胞，斑点或丸粒中的成分，然后与潜在的反应性进料流或批料例如生化，瓦斯油，氢加氧，丙烯加氧，CCl 2 F 2和氢等接触。发生反应 在每个单元格中可以测量，例如 通过红外热像仪，产物或残余反应物的光谱检测，或通过采样，例如， 通过低体积管道从每个组合的附近进行多流，然后进行分析。 光谱分析，色谱分析等，或者通过观察催化剂附近的温度变化。 通过热成像技术确定催化剂在每种组合中的相对功效。 机器人技术可用于生产细胞，斑点，丸粒等。

公开(公告)号：US6063633A

公开(公告)日：2000-05-16

申请号：US664836

申请日：1996-06-17

Applicant: Richard C. Willson, III

Inventor： Richard C. Willson, III

IPC: G01N25/48 ,  B01J19/00 ,  B01J21/04 ,  C40B30/08 ,  C40B40/18 ,  G01N31/10 ,  G01N21/75 ,  G01N21/76 ,  G01N25/20

CPC classification number: G01N31/10 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00315 ,  B01J2219/00364 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00659 ,  B01J2219/00691 ,  B01J2219/00704 ,  B01J2219/00745 ,  B01J2219/00747 ,  C40B30/08 ,  C40B40/18 ,  Y10T436/214 ,  Y10T436/24

Abstract: A multicell holder e.g. a honeycomb or plate, or a collection of individual support particles, is treated with solutions/suspensions of catalyst ingredients to produce cells, spots or pellets holding each of a variety of combinations of the ingredients, is dried, calcined or treated as necessary to stabilize the ingredients in the cells, spots or pellets, then is contacted with a potentially reactive feed stream or batch e.g., biochemical, gas oil, hydrogen plus oxygen, propylene plus oxygen, CC12F2 and hydrogen, etc. The reaction occurring in each cell can be measured, e.g. by infrared thermography, spectroscopic detection of products or residual reactants, or by sampling, e.g. by multistreaming through low volume tubing, from the vicinity of each combination, followed by analysis e.g. spectral analysis, chromatography etc, or by observing temperature change in the vicinity of the catalyst e.g. by thermographic techniques, to determine the relative efficacy of the catalysts in each combination. Robotic techniques can be employed in producing the cells, spots, pellets, etc.

Abstract translation: 多单元座 用催化剂成分的溶液/悬浮液处理蜂窝状或板状或单独的载体颗粒的集合，以产生保持成分各种组合的细胞，斑点或颗粒，根据需要进行干燥，煅烧或处理以稳定 然后将细胞，斑点或丸粒中的成分与潜在的反应性进料流或批料例如生化，瓦斯油，氢加氧，丙烯加氧，CC12F2和氢等接触。每个电池中发生的反应可以是 测量，例如 通过红外热像仪，产物或残余反应物的光谱检测，或通过采样，例如， 通过低体积管道从每个组合的附近进行多流，然后进行分析。 光谱分析，色谱分析等，或者通过观察催化剂附近的温度变化。 通过热成像技术确定催化剂在每种组合中的相对功效。 机器人技术可用于生产细胞，斑点，丸粒等。

公开(公告)号：US08214153B1

公开(公告)日：2012-07-03

申请号：US10057270

申请日：2002-01-26

Applicant: George E. Fox ,  Richard C. Willson, III ,  Zhengdong Zhang

Inventor： George E. Fox ,  Richard C. Willson, III ,  Zhengdong Zhang

IPC: G01N33/48 ,  G01N33/50

CPC classification number: G06F19/14 ,  G06F19/18 ,  G06F19/20 ,  H01J49/164

Abstract: Selecting which sub-sequences in a database of nucleic acid such as 16S rRNA are highly characteristic of particular groupings of bacteria, microorganisms, fungi, etc. on a substantially phylogenetic tree. Also applicable to viruses comprising viral genomic RNA or DNA. A catalogue of highly characteristic sequences identified by this method is assembled to establish the genetic identity of an unknown organism. The characteristic sequences are used to design nucleic acid hybridization probes that include the characteristic sequence or its complement, or are derived from one or more characteristic sequences. A plurality of these characteristic sequences is used in hybridization to determine the phylogenetic tree position of the organism(s) in a sample. Those target organisms represented in the original sequence database and sufficient characteristic sequences can identify to the species or subspecies level. Oligonucleotide arrays of many probes are especially preferred. A hybridization signal can comprise fluorescence, chemiluminescence, or isotopic labeling, etc.; or sequences in a sample can be detected by direct means, e.g. mass spectrometry. The method's characteristic sequences can also be used to design specific PCR primers. The method uniquely identifies the phylogenetic affinity of an unknown organism without requiring prior knowledge of what is present in the sample. Even if the organism has not been previously encountered, the method still provides useful information about which phylogenetic tree bifurcation nodes encompass the organism.

Abstract translation: 选择核酸数据库（如16S rRNA）中的哪些子序列在基本系统发育树上是细菌，微生物，真菌等的特定分组的高度特征。 也适用于包含病毒基因组RNA或DNA的病毒。 组合通过该方法鉴定的高度特征性序列的目录，以确定未知生物体的遗传特性。 特征序列用于设计核酸杂交探针，其包括特征序列或其补体，或衍生自一个或多个特征序列。 在杂交中使用多个这些特征序列来确定样品中生物的系统发生树位置。 在原始序列数据库中表示的目标生物体和足够的特征序列可以鉴定物种或亚种水平。 许多探针的寡核苷酸阵列是特别优选的。 杂交信号可以包括荧光，化学发光或同位素标记等; 或样品中的序列可以通过直接方式检测，例如， 质谱。 该方法的特征序列也可用于设计特异性PCR引物。 该方法唯一地识别未知生物的系统发生亲和力，而不需要事先了解样品中存在的内容。 即使生物体以前没有遇到，该方法仍然提供关于哪个系统发生树分叉节点包含有机体的有用信息。

公开(公告)号：US06623967B1

公开(公告)日：2003-09-23

申请号：US09612853

申请日：2000-07-10

Applicant: Richard C. Willson, III

Inventor： Richard C. Willson, III

IPC: G01N3110

CPC classification number: G01N31/10 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00315 ,  B01J2219/00364 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00659 ,  B01J2219/00691 ,  B01J2219/00704 ,  B01J2219/00745 ,  B01J2219/00747 ,  C40B30/08 ,  C40B40/18 ,  Y10T436/214 ,  Y10T436/24

Abstract: Methods for evaluating catalysts, in which a multicell holder, e.g., a honeycomb or plate, or a collection of individual support particles, is treated with solutions/suspensions of catalyst ingredients to produce cells, spots or pellets holding each of a variety of combinations of the ingredients, is dried, calcined or treated as necessary to stabilize the ingredients in the cells, spots or pellets, then is contacted with a potentially reactive feed stream or batch, e.g., biochemical, gas oil, hydrogen plus oxygen, propylene plus oxygen, CCl2F2 and hydrogen, etc. The reaction occurring in each cell can be measured, e.g., by infrared thermography, spectroscopic detection of products or residual reactants, or by sampling, e.g., multistreaming through low volume tubing, from the vicinity of each combination, followed by analysis, e.g., spectral analysis, chromatography, etc., or by observing temperature change in the vicinity of the catalyst, e.g., by thermographic techniques, to determine the relative efficacy of the catalysts in each combination. Robotic techniques can be employed in producing the cells, spots, pellets, etc.

Abstract translation: 用于评价催化剂的方法，其中多单元保持器例如蜂窝或板或各个支撑颗粒的集合用催化剂成分的溶液/悬浮液处理以产生保持各种各样的组合的细胞，斑点或颗粒 根据需要将成分干燥，煅烧或处理以稳定细胞，斑点或丸粒中的成分，然后与潜在的反应性进料流或批次接触，例如生化，瓦斯油，氢加氧，丙烯加氧， CCl 2 F 2和氢等。可以测量每个电池中发生的反应，例如通过红外热成像，产物或残余反应物的光谱检测，或通过采样，例如通过低体积管道从每个组合的附近进行多流式化，随后 通过分析，例如光谱分析，色谱法等，或通过观察催化剂附近的温度变化，例如通过热成像技术测定 e催化剂在每种组合中的相对功效。 机器人技术可用于生产细胞，斑点，丸粒等。

公开(公告)号：US06617108B1

公开(公告)日：2003-09-09

申请号：US09609996

申请日：2000-07-03

Applicant: Richard C. Willson, III ,  Jason Murphy

Inventor： Richard C. Willson, III ,  Jason Murphy

IPC: C12Q168

CPC classification number: C12N15/1003

Abstract: Preferred embodiments of the invention include purification of DNA, preferably plasmid DNA, by use of selective precipitation, preferably by addition of compaction agents. Also, included is a sealable method for the liquid phase separation of DNA from RNA. RNA may also be recovered by fractional precipitation according to the invention. Applicants have discovered that RNA, commonly the major contaminant in DNA preparations, can be left in solution while valuable purified plasmid DNA is directly precipitated. Additional aspects of the invention include mini-preps, preferably of plasmid and chromosomal DNA, to obtain sequenceable and restriction digestible DNA in high yields in multiple simultaneous procedures. Still further aspects disclose enhanced stripping of the compaction agent by a stripping method comprising high salt addition and pH shift, and combinations of these techniques. Also, disclosed is a method of assay in which a labeled probe is precipitated when it is hybridized to a target, (e.g. chromosomal DNA, oligonuclotides, Ribosomal RNA, tRNA), and thereafter precipitating the probe/target complex with compaction agents and leaving in solution any unhybridized probe. For example, chromosomal DNA, plasmid, ribosomal RNA, and oligonucleotides can be recovered in excellent purity; by then heating the mixture of nucleic acids (above their melting temperature if the hybridization site is buried within secondary structure) and thereafter precipitating the probe and the target.

Abstract translation: 本发明的优选实施方案包括通过使用选择性沉淀优选通过添加压实剂来纯化DNA，优选质粒DNA。 此外，包括的是用于从RNA液相分离DNA的可密封方法。 根据本发明也可以通过分级沉淀来回收RNA。 申请人已经发现，RNA（通常是DNA制剂中的主要污染物）可以留在溶液中，而有价值的纯化质粒DNA被直接沉淀。 本发明的另外的方面包括优选质粒和染色体DNA的微型制剂，以多种同时方法获得高产率的可序列和限制性可消化的DNA。 另外的方面公开了通过包括高盐添加和pH漂移的剥离方法以及这些技术的组合增强了压实剂的剥离。 此外，公开了一种测定方法，其中当标记的探针与靶标杂交时（例如染色体DNA，寡核苷酸，核糖体RNA，tRNA）沉淀，然后用压实剂沉淀探针/靶复合物并留下 解决任何未杂交的探针。 例如，染色体DNA，质粒，核糖体RNA和寡核苷酸可以以优异的纯度回收; 然后加热核酸的混合物（如果杂交位点被埋在二级结构内，高于其熔融温度），然后沉淀探针和靶标。

公开(公告)号：US4678583A

公开(公告)日：1987-07-07

申请号：US873364

申请日：1986-06-12

Applicant: Richard C. Willson, III ,  Eric Bulot ,  Charles L. Cooney

Inventor： Richard C. Willson, III ,  Eric Bulot ,  Charles L. Cooney

IPC: B01D11/04 ,  C02F1/00 ,  B01D17/00

CPC classification number: B01D11/0492 ,  C02F1/26 ,  C02F1/28 ,  C02F1/42 ,  C02F2101/30

Abstract: A process for forming a purified solute from an aqueous solution is provided whereby a mixture of an extractant, a hydrate former and the aqueous solution is first formed. The hydrate former forms a hydrate with water while the solute does not form a hydrate. The extractant takes up the solute from the aqueous solution. The mixture is subjected to a temperature and pressure sufficient to form the solid hydrate of the hydrate former, an aqueous solution of the solute and a portion comprising the extractant containing the solute. The solute is recovered from the portion comprising the extractant and the solute.

Abstract translation: 提供从水溶液形成纯化溶质的方法，其中首先形成萃取剂，水合物形成剂和水溶液的混合物。 水合物形成与水的水合物，而溶质不形成水合物。 萃取剂从水溶液中吸收溶质。 使混合物经受足够的温度和压力以形成水合物形成剂的固体水合物，溶质的水溶液和包含含有溶质的萃取剂的部分。 从包含萃取剂和溶质的部分回收溶质。