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    Aerosol-forming porous membrane with certain pore structure
    2.
    发明授权
    Aerosol-forming porous membrane with certain pore structure 有权
    具有一定孔结构的气溶胶形成多孔膜

    公开(公告)号：US06543442B2

    公开(公告)日：2003-04-08

    申请号：US09798083

    申请日：2001-03-02

    申请人： Igor Gonda ,  Jeffrey A. Schuster ,  Rajesh S. Patel

    发明人： Igor Gonda ,  Jeffrey A. Schuster ,  Rajesh S. Patel

    IPC分类号： A61M1100

    CPC分类号： A61M15/0045 ,  A61M11/002 ,  A61M15/0043 ,  A61M15/0051 ,  A61M15/0055

    摘要： A nozzle comprised of a thin, flexible membrane material having a plurality of pores is disclosed. In one embodiment, the pores have an unflexed exit aperture diameter in the range of about 0.5 to about 2 microns (preferably about 1 micron) and are positioned substantially uniformly in the material, preferably about 50 microns apart. The nozzle preferably has a conical or trumpet-shaped cross-section. In another aspect of the invention, the exit aperture of the nozzle is surrounded by an elevated area protruding above the substantially planar exit side of the membrane in order to prevent intrusion of liquid back into the nozzle. The nozzle can be used to form an aerosol containing a pharmaceutical composition from the exit side of the nozzle upon forcible application of the composition to the entrance side of the nozzle. This aerosol can be used to administer the pharmaceutical composition, for example, to the eye or to a selected portion of the respiratory tract. The nozzle is preferably a component of a container which holds a formulation of drug.

    摘要翻译： 公开了一种由具有多个孔的薄的柔性膜材料构成的喷嘴。 在一个实施方案中，孔具有在约0.5至约2微米（优选约1微米）范围内的非折射出口孔径，并且基本上均匀地定位在材料中，优选地相隔约50微米。 喷嘴优选地具有锥形或喇叭形横截面。 在本发明的另一方面，喷嘴的出口孔被突出在膜的基本上平面的出口侧上方的升高区域围绕，以防止液体侵入喷嘴中。 喷嘴可以在将组合物强制施加到喷嘴的入口侧时，从喷嘴的出口侧形成含有药物组合物的气溶胶。 该气溶胶可用于将药物组合物施用于例如眼睛或呼吸道的选定部分。 喷嘴优选地是容纳药物制剂的容器的组分。

    Inherently robust repair process for thin film circuitry using uv laser
    3.
    发明授权
    Inherently robust repair process for thin film circuitry using uv laser 失效
    使用uv激光器的薄膜电路的固有鲁棒的修复过程

    公开(公告)号：US06541709B1

    公开(公告)日：2003-04-01

    申请号：US08743405

    申请日：1996-11-01

    申请人： Peter A. Franklin ,  Arthur G. Merryman ,  Rajesh S. Patel ,  Thomas A. Wassick

    发明人： Peter A. Franklin ,  Arthur G. Merryman ,  Rajesh S. Patel ,  Thomas A. Wassick

    IPC分类号： H05K103

    CPC分类号： H01L21/485 ,  H01L23/49822 ,  H01L23/49827 ,  H01L23/5382 ,  H01L2924/0002 ,  H05K3/225 ,  Y10T29/49126 ,  Y10T29/49165 ,  H01L2924/00

    摘要： A multilayer thin film structure having defined strap repair lines thereon and a method for repairing interconnections in the multilayer thin film structure (MLTF) and/or making engineering changes (EC) are provided. The method determines interconnection defects in the MLTF at a thin film layer adjacent the top metal layer of the structure, defines the top surface metallization including a series of orthogonal X conductor lines and Y conductor lines using photoresist and lithography and additive or subtractive metallization techniques and then uses a phototool to selectively expose the photoresist to define top surface strap connections needed to repair the interconnections and/or make EC's, and forms the top surface metallization.

    摘要翻译： 提供了具有限定的带修复线的多层薄膜结构和用于修复多层薄膜结构（MLTF）中的互连和/或进行工程变化（EC）的方法。 该方法确定在与结构顶层金属层相邻的薄膜层处的MLTF中的互连缺陷，限定顶表面金属化，其包括使用光致抗蚀剂和光刻以及添加或减色金属化技术的一系列正交X导体线和Y导线， 然后使用光学工具选择性地暴露光致抗蚀剂以限定修复互连和/或制造EC所需的顶表面带连接并形成顶表面金属化。

    Inherently robust repair process for thin film circuitry using UV laser
    4.
    发明授权
    Inherently robust repair process for thin film circuitry using UV laser 失效
    使用紫外激光的薄膜电路固有的强大修复过程

    公开(公告)号：US06427324B1

    公开(公告)日：2002-08-06

    申请号：US09114790

    申请日：1998-07-13

    申请人： Peter A. Franklin ,  Arthur G. Merryman ,  Rajesh S. Patel ,  Thomas A. Wassick

    发明人： Peter A. Franklin ,  Arthur G. Merryman ,  Rajesh S. Patel ,  Thomas A. Wassick

    IPC分类号： H01K310

    CPC分类号： H01L21/485 ,  H01L23/49822 ,  H01L23/49827 ,  H01L23/5382 ,  H01L2924/0002 ,  H05K3/225 ,  Y10T29/49126 ,  Y10T29/49165 ,  H01L2924/00

    摘要： A multilayer thin film structure having defined strap repair lines thereon and a method for repairing interconnections in the multilayer thin film structure (MLTF) and/or making engineering changes (EC) are provided. The method comprises determining interconnection defects in the MLTF at a thin film layer adjacent the top metal layer of the structure, defining the top surface metallization including a series of orthogonal X conductor lines and Y conductor lines using photoresist and lithography and additive or phototool to selectively expose the photoresist to define top surface strap connections needed to repair the interconnections and/or make EC's, and forming the top surface metallization.

    摘要翻译： 提供了具有限定的带修复线的多层薄膜结构和用于修复多层薄膜结构（MLTF）中的互连和/或进行工程变化（EC）的方法。 该方法包括确定MLTF中邻近该结构顶层金属层的薄膜层上的互连缺陷，限定包括一系列正交X导体线的顶表面金属化和使用光刻胶和光刻术和添加剂或光学工具的Y导体线选择性地 暴露光致抗蚀剂以限定修复互连和/或制造EC并且形成顶表面金属化所需的顶表面带连接。

    Aerosol-forming porous membrane with certain pore structure
    5.
    发明授权
    Aerosol-forming porous membrane with certain pore structure 有权

    公开(公告)号：US6070575A

    公开(公告)日：2000-06-06

    申请号：US192833

    申请日：1998-11-16

    申请人： Igor Gonda ,  Jeffrey A. Schuster ,  Rajesh S. Patel

    发明人： Igor Gonda ,  Jeffrey A. Schuster ,  Rajesh S. Patel

    IPC分类号： A61M11/00 ,  A61M15/00 ,  B05B7/04

    CPC分类号： A61M15/0045 ,  A61M15/0043 ,  A61M15/0051 ,  A61M15/0055 ,  A61M11/002

    摘要： A nozzle comprised of a thin, flexible membrane material having a plurality of pores is disclosed. In one embodiment, the pores have an unflexed exit aperture diameter in the range of about 0.5 to about 2 microns (preferably about 1 micron) and are positioned substantially uniformly in the material, preferably about 50 microns apart. The nozzle preferably has a conical or trumpet-shaped cross-section. In another aspect of the invention, the exit aperture of the nozzle is surrounded by an elevated area protruding above the substantially planar exit side of the membrane in order to prevent intrusion of liquid back into the nozzle. The nozzle can be used to form an aerosol containing a pharmaceutical composition from the exit side of the nozzle upon forcible application of the composition to the entrance side of the nozzle. This aerosol can be used to administer the pharmaceutical composition, for example, to the eye or to a selected portion of the respiratory tract. The nozzle is preferably a component of a container which holds a formulation of drug.

    Pore structures for reduced pressure aerosolization
    9.
    发明授权
    Pore structures for reduced pressure aerosolization 有权
    用于减压雾化的孔结构

    公开(公告)号：US07316360B2

    公开(公告)日：2008-01-08

    申请号：US10808046

    申请日：2004-03-23

    申请人： Rajesh S. Patel ,  Sudarsan Srinivasan

    发明人： Rajesh S. Patel ,  Sudarsan Srinivasan

    IPC分类号： A24F25/00 ,  B05B11/02 ,  B05B1/14

    CPC分类号： A61M15/009 ,  A61M15/0031 ,  A61M15/0043 ,  A61M15/0045 ,  A61M15/0051 ,  A61M15/0055 ,  Y10T29/49826

    摘要： A nozzle comprising a thin, flexible substantially planar polymeric film having a plurality of pores with structures allowing for generation of an aerosol at reduced extrusion pressure is disclosed. The pores can comprise at least two sections, or steps, in which the thickness of the membrane is reduced in stepwise fashion, or the pores can be tapered. Nozzles formed comprising pores having such structures permit aerosol generation at lower extrusion pressures, thereby allowing for decreased weight of aerosolization devices, increased efficiency, increased portability and increased battery life. The pore structures also allow for the use of thicker, more easily processed polymeric films in manufacturing while having a thinner, more efficient aerosolization area. The use of decreased extrusion pressures also results in increased uniformity in aerosol generation and improved reliability of other components.

    摘要翻译： 公开了一种喷嘴，其包括薄的柔性基本平坦的聚合物膜，其具有多个具有允许以降低的挤压压力产生气溶胶的结构的孔。 孔可以包括至少两个部分或步骤，其中膜的厚度以逐步的方式减小，或者孔可以是锥形的。 形成的包括具有这种结构的孔的喷嘴允许在较低的挤出压力下产生气溶胶，从而允许雾化装置的重量减少，提高的效率，增加的便携性和延长的电池寿命。 孔结构还允许在制造中使用更厚，更容易加工的聚合物膜，同时具有更薄，更有效的雾化区域。 使用降低的挤出压力还导致气溶胶产生的均匀性增加和其他组分的可靠性提高。

    Pore structures for reduced pressure aerosolization
    10.
    发明授权
    Pore structures for reduced pressure aerosolization 有权
    用于减压雾化的孔结构

    公开(公告)号：US06855909B2

    公开(公告)日：2005-02-15

    申请号：US10733072

    申请日：2003-12-10

    申请人： Rajesh S. Patel ,  Sudarsan Srinivasan

    发明人： Rajesh S. Patel ,  Sudarsan Srinivasan

    IPC分类号： B65D83/00 ,  A61K9/12 ,  A61M11/00 ,  A61M15/00 ,  B05B11/02 ,  B23K26/38

    CPC分类号： A61M15/0045 ,  A61M15/0031 ,  A61M15/0043 ,  A61M15/0051 ,  A61M15/0055

    摘要： A nozzle comprising a thin, flexible substantially planar polymeric film having a plurality of pores with structures allowing for generation of an aerosol at reduced extrusion pressure is disclosed. The pores can comprise at least two sections, or steps, in which the thickness of the membrane is reduced in stepwise fashion, or the pores can be tapered. Nozzles formed comprising pores having such structures permit aerosol generation at lower extrusion pressures, thereby allowing for decreased weight of aerosolization devices, increased efficiency, increased portability and increased battery life. The pore structures also allow for the use of thicker, more easily processed polymeric films in manufacturing while having a thinner, more efficient aerosolization area. The use of decreased extrusion pressures also results in increased uniformity in aerosol generation and improved reliability of other components.

    摘要翻译： 公开了一种喷嘴，其包括薄的柔性基本平坦的聚合物膜，其具有多个具有允许以降低的挤压压力产生气溶胶的结构的孔。 孔可以包括至少两个部分或步骤，其中膜的厚度以逐步的方式减小，或者孔可以是锥形的。 形成的包括具有这种结构的孔的喷嘴允许在较低的挤出压力下产生气溶胶，从而允许雾化装置的重量减少，提高的效率，增加的便携性和延长的电池寿命。 孔结构还允许在制造中使用更厚，更容易加工的聚合物膜，同时具有更薄，更有效的雾化区域。 使用降低的挤出压力还导致气溶胶产生的均匀性增加和其他组分的可靠性提高。