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公开(公告)号：US20080244923A1
公开(公告)日：2008-10-09
申请号：US12140519
申请日：2008-06-17
IPC分类号： F26B5/06
CPC分类号： A61J1/1412 , A61M5/002 , A61M5/008 , A61M5/178 , A61M5/1782 , A61M5/31 , A61M2202/06 , F26B5/06 , Y10T436/25 , Y10T436/25375
摘要： A process for lyophilizing a solution of an active agent in a container is provided. Solution of active agent is deposited into a container, the container is covered with a covering plate and placed inside a lyophilizing apparatus. Lyophilization can be conducted to dryness by radiation, convection or both. Also provided is a device made by this process, an active agent-plastic administration device (e.g., a syringe), containing an active agent in the form of lyophilized cake, and an array of such administration devices.
摘要翻译： 提供了将活性剂溶液冻结在容器中的方法。 将活性剂溶液沉积在容器中，将容器用覆盖板覆盖并置于冻干装置内。 可以通过辐射，对流或两者将冻干物质干燥。 还提供了通过该方法制造的装置，包含冻干饼形式的活性剂的活性剂 - 塑料给药装置（例如注射器）和这种给药装置的阵列。
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公开(公告)号：US6011062A
公开(公告)日：2000-01-04
申请号：US246072
申请日：1999-02-09
申请人： L. Wayne Schneider , Rajan Bawa , Alan L. Weiner
发明人： L. Wayne Schneider , Rajan Bawa , Alan L. Weiner
IPC分类号： A61K31/5575 , A61K47/44 , A61K31/557
CPC分类号： A61K31/5575 , A61K47/44
摘要： The use of polyethoxylated castor oils in prostaglandin compositions enhances the prostaglandin's chemical stability.
摘要翻译： 在前列腺素组合物中使用聚乙氧基化蓖麻油可增强前列腺素的化学稳定性。
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公开(公告)号：US07467482B2
公开(公告)日：2008-12-23
申请号：US11099919
申请日：2005-04-06
IPC分类号： F26B5/06
CPC分类号： A61J1/1412 , A61M5/002 , A61M5/008 , A61M5/178 , A61M5/1782 , A61M5/31 , A61M2202/06 , F26B5/06 , Y10T436/25 , Y10T436/25375
摘要： A process for lyophilizing a solution of an active agent in a container is provided. Solution of active agent is deposited into a container, the container is covered with a covering plate and placed inside a lyophilizing apparatus. Lyophilization can be conducted to dryness by radiation, convection or both. Also provided is a device made by this process, an active agent-plastic administration device (e.g., a syringe), containing an active agent in the form of lyophilized cake, and an array of such administration devices.
摘要翻译： 提供了将活性剂溶液冻结在容器中的方法。 将活性剂溶液沉积在容器中，将容器用覆盖板覆盖并置于冻干装置内。 可以通过辐射，对流或两者将冻干物质干燥。 还提供了通过该方法制造的装置，包含冻干饼形式的活性剂的活性剂 - 塑料给药装置（例如注射器）和这种给药装置的阵列。
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公开(公告)号：US06566144B1
公开(公告)日：2003-05-20
申请号：US09535846
申请日：2000-03-27
IPC分类号： G01N118
CPC分类号： F26B5/06 , A61M5/008 , Y10T436/25 , Y10T436/25375
摘要： The present invention provides a cover plate that covers one or more delivery containers (e.g., syringe) during lyophilization. The cover plate includes a lid region and one or more protuberances which project perpendicularly from the lid region. The one or more protuberances are adapted to fit in the one or more delivery containers. The cover plate permits the escape of vapor from the one or more delivery containers during the lyophilization process. In addition, the cover plate prevents the escape of lyophilizate from the one or more delivery containers during the lyophilization process. The present invention also provides a system for lyophilizing a solution that contains a pharmaceutical. The system includes one or more delivery containers. The one or more delivery containers contains the solution that contains the pharmaceutical. The system also includes a cover plate used to cover the one or more delivery containers during the lyophilization. The present invention also provides a method for lyophilizing a solution that contains a pharmaceutical. The method includes depositing the solution in one or more delivery containers, covering the one or more delivery containers with a cover plate, and lyophilizing the solution comprising the pharmaceutical.
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公开(公告)号：US09003676B2
公开(公告)日：2015-04-14
申请号：US12140519
申请日：2008-06-17
CPC分类号： A61J1/1412 , A61M5/002 , A61M5/008 , A61M5/178 , A61M5/1782 , A61M5/31 , A61M2202/06 , F26B5/06 , Y10T436/25 , Y10T436/25375
摘要： A process for lyophilizing a solution of an active agent in a container is provided. Solution of active agent is deposited into a container, the container is covered with a covering plate and placed inside a lyophilizing apparatus. Lyophilization can be conducted to dryness by radiation, convection or both. Also provided is a device made by this process, an active agent-plastic administration device (e.g., a syringe), containing an active agent in the form of lyophilized cake, and an array of such administration devices.
摘要翻译： 提供了将活性剂溶液冻结在容器中的方法。 将活性剂溶液沉积在容器中，将容器用覆盖板覆盖并置于冻干装置内。 可以通过辐射，对流或两者将冻干物质干燥。 还提供了通过该方法制造的装置，包含冻干饼形式的活性剂的活性剂 - 塑料给药装置（例如注射器）和这种给药装置的阵列。
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公开(公告)号：US06722054B2
公开(公告)日：2004-04-20
申请号：US09909671
申请日：2001-07-20
IPC分类号： F26B506
摘要： A process for lyophilizing a solution of an active agent in a delivery container is provided. Solution of active agent is deposited into a delivery container, the container is covered with a covering plate and placed inside a lyophilizing apparatus. Lyophilization is conducted to dryness by radiation, convection or both. Also provided is a device made by this process, an active agent-plastic administration device such as a syringe containing an active agent in the form of lyophilized cake, and an array of such administration devices.
摘要翻译： 提供了一种用于将活性剂溶液冻干在递送容器中的方法。 将活性剂的溶液沉积到输送容器中，将容器用覆盖板覆盖并置于冻干装置内。 通过辐射，对流或两者将冻干干燥。 还提供了通过该方法制造的装置，活性剂 - 塑料给药装置，例如含有冻干饼形式的活性剂的注射器，以及这种给药装置的阵列。
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7.发明授权System for use in lyophilization comprising delivery containers and a cover plate 有权用于冻干的系统，包括输送容器和盖板公开(公告)号：US06610252B2
公开(公告)日：2003-08-26
申请号：US10054624
申请日：2002-01-22
IPC分类号： B01L300
CPC分类号： F26B5/06 , A61M5/008 , Y10T436/25 , Y10T436/25375
摘要： The present invention provides a system for lyophilization comprising one or more delivery containers, e.g. syringes, and a cover plate, which covers them during lyophilization. The cover plate includes a lid region and one or more protuberances, which project perpendicularly from the lid region and fit delivery containers such that the protuberances are not in complete and continuous contact with sidewalls of the delivery containers. The cover plate permits the escape of vapor from the delivery containers during lyophilization process through an annular gap between each protuberance and a sidewall of each container when the cover plate is resting on the top of the delivery containers. At the same the cover plate prevents the escape of lyophilizate, in particular a pharmaceutical, from the containers during lyophilization.
摘要翻译： 本发明提供一种用于冻干的系统，其包括一个或多个递送容器，例如 注射器和盖板，其在冻干期间覆盖它们。 盖板包括盖区域和一个或多个突起，其从盖区域垂直地突出并配合输送容器，使得突起不完全并且与输送容器的侧壁持续接触。 当盖板搁置在输送容器的顶部时，盖板允许在冻干过程期间通过每个突起和每个容器的侧壁之间的环形间隙从输送容器逸出蒸汽。 同样，在冷冻干燥期间，盖板防止冷冻干燥物，特别是药物从容器中逸出。
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8.发明授权Sustained-release formulation containing an amino acid polymer with a lower alkyl (C.sub.1 -C.sub.4) polar solvent 失效含有氨基酸聚合物与低级烷基（C1-C4）极性溶剂的缓释制剂
公开(公告)号：US4713244A
公开(公告)日：1987-12-15
申请号：US766734
申请日：1985-08-16
申请人： Rajan Bawa , William G. Deichert
发明人： Rajan Bawa , William G. Deichert
IPC分类号： A61K47/30 , A61K9/00 , A61K9/22 , A61K47/32 , A61K31/74 , B29D11/00 , C08F226/10 , G03B21/46
CPC分类号： A61K47/32 , A61K9/0014 , A61K9/0051 , Y10S514/912 , Y10S514/913 , Y10S514/954
摘要： A sustained-release polymeric hydrogel dosage form useful for topical, systemic or transdermal administration of a medicinal agent comprising a cross-linked, polymerized hydrophilic polymer, an amino acid polymer, a cross-linking agent, and an optional hydrophobic monomer and/or a chain regulator in conjunction with a lower alkyl (C.sub.1 -C.sub.4), polar solvent and said medicinal agent in a therapeutically effective amount.
摘要翻译： 用于局部，全身或透皮给药药剂的持续释放聚合物水凝胶剂型，其包含交联的聚合的亲水性聚合物，氨基酸聚合物，交联剂和任选的疏水性单体和/或 链转移剂与低级烷基（C1-C4），极性溶剂和所述药物剂相结合治疗有效量。
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公开(公告)号：US06261547B1
公开(公告)日：2001-07-17
申请号：US09448038
申请日：1999-11-23
申请人： Rajan Bawa , Rex E. Hall , Bhagwati P. Kabra , James E. Teague , Gerald D. Cagle , Kerry L. Markwardt , Mandar V. Shah
发明人： Rajan Bawa , Rex E. Hall , Bhagwati P. Kabra , James E. Teague , Gerald D. Cagle , Kerry L. Markwardt , Mandar V. Shah
IPC分类号： A61K3174
CPC分类号： A61K47/36 , A61K9/0048 , A61K31/5377 , Y10S514/912
摘要： Ophthalmic drug delivery vehicles which are administrable as a liquid and which gel upon contact with the eye are disclosed. The vehicles contain xanthan gum and an ophthalmically acceptable anesthetic agent.
摘要翻译： 公开了可与液体接触并与眼睛接触凝胶的眼药物递送载体。 车辆含有黄原胶和眼科可接受的麻醉剂。
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公开(公告)号：US5137728A
公开(公告)日：1992-08-11
申请号：US288398
申请日：1988-12-22
申请人： Rajan Bawa
发明人： Rajan Bawa
CPC分类号： A61K9/0051 , A61F9/0017
摘要： An ocular insert for insertion into the cul de sac of the eye which is a substantially circular disc having a concave posterior surface and a convex anterior surface with a radius of curvature less than that of the sclera and a center thickness of less than about 1.5 mm.
摘要翻译： 一种用于插入到眼睛的囊中的眼部插入物，其是具有凹后表面和具有小于巩膜的曲率半径的凸起的前表面的基本上圆形的圆盘，中心厚度小于约1.5mm 。
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