公开(公告)号：US20240358814A1

公开(公告)日：2024-10-31

申请号：US18770056

申请日：2024-07-11

申请人： RINUAGENE BIOTECHNOLOGY CO., LTD. ,  RINUAGENE INTERNATIONAL HK LIMITED

发明人： Shan CEN ,  Jing WANG ,  Weiguo ZHANG ,  Yijie DONG

IPC分类号： A61K39/12 ,  A61K9/51 ,  A61K39/00 ,  A61K39/39 ,  A61K39/395 ,  A61P31/20 ,  A61P35/00 ,  C07K14/005

CPC分类号： A61K39/12 ,  A61K9/5123 ,  A61K39/39 ,  A61K39/3955 ,  A61P31/20 ,  A61P35/00 ,  C07K14/005 ,  A61K2039/53 ,  A61K2039/55516 ,  C07K2319/02 ,  C12N2710/20022 ,  C12N2710/20034

摘要： The present application relates to a polynucleotide molecule that can be used for preventing or treatment HPV infection-related diseases, and a pharmaceutical product, a pharmaceutical composition, or an mRNA vaccine comprising said polynucleotide.

公开(公告)号：US20240343701A1

公开(公告)日：2024-10-17

申请号：US18675317

申请日：2024-05-28

申请人： RINUAGENE BIOTECHNOLOGY CO., LTD. ,  RINUAGENE INTERNATIONAL HK LIMITED

发明人： Shan Cen ,  Kai Lv ,  Zhenlei Yu ,  Yijie Dong

IPC分类号： C07D317/12 ,  A61K9/51 ,  A61K45/06 ,  C07D319/06 ,  C07D327/04 ,  C07D339/06

CPC分类号： C07D317/12 ,  A61K9/5123 ,  A61K45/06 ,  C07D319/06 ,  C07D327/04 ,  C07D339/06

摘要： The present application disclosed a compound of formula (I) and a salt and a stereoisomer thereof, wherein each variable is as defined in the specification. The present application also disclosed a nanoparticle composition comprising the compound or a salt or a stereoisomer thereof, and the use of the nanoparticle composition for delivering active agents.

公开(公告)号：US20240018094A1

公开(公告)日：2024-01-18

申请号：US18476222

申请日：2023-09-27

申请人： RinuaGene Biotechnology Co., Ltd. ,  RinuaGene International HK Limited

发明人： Rui XING ,  Kai LV ,  Shan CEN ,  Yijie DONG

IPC分类号： C07C229/16 ,  A61K47/18

CPC分类号： C07C229/16 ,  A61K47/183 ,  C07C2601/02 ,  C07C2601/04

摘要： The present invention relates to a long chain alkyl esteramine lipid compound as shown in Formula I, preparation method therefor as well as use thereof in nucleic acid delivery, the long chain alkyl esteramine lipid compound provided by the present invention has an excellent encapsulation rate and delivery effect as a lipid molecule in delivering disease treatment or preventive agents, showing lower toxicity and certain tissue distribution characteristics, and providing a basis of more selections for delivering disease therapeutic or prophylactic agents.