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1.发明公开公开(公告)号：US20240358814A1
公开(公告)日：2024-10-31
申请号：US18770056
申请日：2024-07-11
发明人： Shan CEN , Jing WANG , Weiguo ZHANG , Yijie DONG
IPC分类号： A61K39/12 , A61K9/51 , A61K39/00 , A61K39/39 , A61K39/395 , A61P31/20 , A61P35/00 , C07K14/005
CPC分类号： A61K39/12 , A61K9/5123 , A61K39/39 , A61K39/3955 , A61P31/20 , A61P35/00 , C07K14/005 , A61K2039/53 , A61K2039/55516 , C07K2319/02 , C12N2710/20022 , C12N2710/20034
摘要： The present application relates to a polynucleotide molecule that can be used for preventing or treatment HPV infection-related diseases, and a pharmaceutical product, a pharmaceutical composition, or an mRNA vaccine comprising said polynucleotide.
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2.发明公开公开(公告)号：US20240018094A1
公开(公告)日：2024-01-18
申请号：US18476222
申请日：2023-09-27
发明人： Rui XING , Kai LV , Shan CEN , Yijie DONG
IPC分类号： C07C229/16 , A61K47/18
CPC分类号： C07C229/16 , A61K47/183 , C07C2601/02 , C07C2601/04
摘要： The present invention relates to a long chain alkyl esteramine lipid compound as shown in Formula I, preparation method therefor as well as use thereof in nucleic acid delivery, the long chain alkyl esteramine lipid compound provided by the present invention has an excellent encapsulation rate and delivery effect as a lipid molecule in delivering disease treatment or preventive agents, showing lower toxicity and certain tissue distribution characteristics, and providing a basis of more selections for delivering disease therapeutic or prophylactic agents.
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