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公开(公告)号：US20220213084A1
公开(公告)日：2022-07-07
申请号：US17604017
申请日：2020-04-16
申请人： QUIMATRYX, S.L. , FUNDACIÓN KERTOR
发明人： Yosu Ion VARA SALAZAR , Eneko ALDABA ARÉVALO , Tamara BELLO IGLESIAS , Richard Spurring ROBERTS , Laureano SIMÓN BUELA , José Manuel BREA , Ángel CARRACEDO , María Isabel LOZA GARCÍA
IPC分类号： C07D413/14 , C07D413/10 , C07D491/107 , C07D471/04
摘要： The present invention refers to oxadiazole compounds suitable as HDAC6 inhibitors. Processes for their preparation and their medical uses in treating HDAC6-related diseases or disorders are also disclosed.
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2.发明申请HISTONE DEACETYLASE INHIBITORS BASED ON DERIVATIVES OF TRICYCLIC POLYHYDROACRIDINE AND ANALOGS POSSESSING FUSED SATURATED FIVE-AND-SEVEN-MEMBERED RINGS 审中-公开基于TRICYCLIC聚羟基吡啶衍生物的组蛋白脱乙酰壳多糖抑制剂和受损的饱和饱和五元配合环的模拟物公开(公告)号：US20160122340A1
公开(公告)日：2016-05-05
申请号：US14890031
申请日：2014-05-09
发明人： Fernando Pedro COSSÍO MORA , Yosu Ion VARA SALAZAR , María del Carmen MASDEU MARGALEF , María Remedios ALCALÁ CAFFARENA , Sergio VILLAFRUELA CÁNEVA , Dorleta OTAEGUI ANSA , Eneko ALDABA ARÉVALO , Aizpea ZUBIA OLASCOAGA , Eider SAN SEBASTIÁN LARZABAL
IPC分类号： C07D471/04 , C07D401/12 , C07D219/04 , C07D219/10 , C07D221/16
CPC分类号： C07D471/04 , C07D219/04 , C07D219/10 , C07D221/06 , C07D221/16 , C07D401/12
摘要： The present invention refers to compounds of formula (I): as well as to a method for their preparation, pharmaceutical compositions comprising the same, and use thereof for the treatment and/or chemoprevention of cancer hematological malignancy, proliferative diseases, neurological disorders and immunological disorders.
摘要翻译： 本发明涉及式（I）的化合物：以及其制备方法，包含其的药物组合物及其用于治疗和/或化学预防癌症血液恶性肿瘤，增殖性疾病，神经障碍和免疫学 疾病
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公开(公告)号：US20190314334A1
公开(公告)日：2019-10-17
申请号：US16347845
申请日：2017-11-07
申请人： QUIMATRYX, S.L.
发明人： Yosu Ion VARA SALAZAR , Eneko ALDABA ARÉVALO , Ferdinando NICOLETTI , Massimo LIBRA , Katia Domenica MANGANO
IPC分类号： A61K31/4025 , A61P25/00 , A61P1/16
摘要： The present invention refers to the use of compounds derived from trisubstituted 1H-pyrrole rings and aromatic rings, which have the following formula (I): wherein R1 and R2 represent, independently of each other: an optionally substituted phenyl ring, or an optionally substituted 5-membered heteroaromatic ring; one of R3 and R4 is H and the other represents a group wherein W is OH or an ortho-aniline group; each A, independently of each other, represents a —CH2— group or is absent; ═Y—Y═ is ═HC—CH═, ═N—CH═, or ═HC—N═; or a salt or solvate thereof, in the prevention or treatment of an autoimmune disease.
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