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公开(公告)号：US20240425810A1
公开(公告)日：2024-12-26
申请号：US18692404
申请日：2022-09-16
Inventor： Lourdes BASABE DESMONTS , Fernando BENITO LÓPEZ , Enrique AZUAJE HUALDE , María de los Ángeles MARTÍNEZ DE PANCORBO GÓMEZ , Yara ÁLVAREZ BRAÑA
IPC: C12N5/00
Abstract: The inventors of the present invention have developed a support that couples the controlled seeding of cells into predetermined patterns with the presentation and/or detection of molecules of interest to/from said cells. Said support is characterized for containing predetermined patterns where cells adhere to and have a uniform layer of microbeads functionalized with a molecule of interest.
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公开(公告)号：US20230042308A1
公开(公告)日：2023-02-09
申请号：US17783022
申请日：2020-12-22
Inventor： Ana DEL POZO RODRÍGUEZ , Alicia RODRÍGUEZ GASCÓN , Itziar GÓMEZ AGUADO , Mónica VICENTE PASCUAL , Maria Angeles SOLINÍS ASPIAZU
Abstract: The invention provides solid lipid nanoparticles (SLNs) which comprise gold, and are useful as vectors for the transfection of different types of nucleic acids. Different methods for obtaining such SLNs are also disclosed.
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公开(公告)号：US20220186299A1
公开(公告)日：2022-06-16
申请号：US17439446
申请日：2020-03-13
Inventor： José Ramón BILBAO CATALA , Nora FERNÁNDEZ JIMÉNEZ
IPC: C12Q1/6837 , C12Q1/6883
Abstract: The present invention relates to methods for the diagnosis of celiac disease based on the quantification of the expression level of the UBE2L3 gene, as well as of the relative expression of isoform 2 of the UBE2L3 gene with respect to the total expression of the said gene. Likewise, the invention relates to kits with the means needed to perform the diagnosis according to the methods of the invention.
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公开(公告)号：US20210251222A1
公开(公告)日：2021-08-19
申请号：US17253318
申请日：2019-06-21
Abstract: A method for preparing a wood preservative composition, includes modifying lignin with Na2B4O7 or NaNO3 and then with a chromium (II) salt, copper (II), cadmium (II) or zinc (II), for example, metal nitrates (Cr(NO3)2, Cu(NO3)2, Cd(NO3)2, Zn(NO3)2); to the preservative obtainable by this method; and to a method for preserving wood; and to the preserved wood. The preservative prevents degradation by xylophagous and fungal agents, and also improves some properties of the wood, and the hygroscopicity and fire resistance.
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5.发明申请公开(公告)号：US20220064195A1
公开(公告)日：2022-03-03
申请号：US17413738
申请日：2018-12-19
Inventor： María Carmen ESCOLANO MIRÓN , Mercè PALLÀS LLIBERIA , Cristian Gaspar GRIÑÁN FERRE , Sònia ABÁS PRADES , Luis-Felipe CALLADO HERNANDO , Jesús A. GARCÍA SEVILLA
IPC: C07F9/6561 , A61P25/28
Abstract: Compounds of formula I, their respective mirror-image enantiomers, and mixtures—preferably racemic—of both enantiomers, wherein R1 is ethyl or phenyl; R2 is methyl, phenyl, monosubstituted phenyl, benzyl, or monosubstituted benzyl; R3 is selected from the group consisting of: (C1-C6)-alkyl, (C1-C6)-cycloalkyl, —[CH2]n-phenyl, —[CH2]n-1-naphtyl, —[CH2]n-2-naphtyl, and —[CH2]n-[substituted phenyl]; wherein [substituted phenyl] is a phenyl radical with one, two or three substituents independently selected from: F, Cl, Br, (C1-C3)-alkyl, (C1-C3)-alkyloxy, phenyl, phenoxy, —CF3, —OCF3, nitro, —CN, —CO—(C1-C3)-alkyl and benzoyl; and n is an integer between 0 and 4; have a high affinity for imidazoline receptors of the I2 type, i.e. they are I2-IR ligands. Consequently they are applicable in the prevention or treatment of brain disorders in animals, including humans, particularly of neurodegenerative disorders, and more particularly of Alzheimer's disease (AD).
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Patent Agency Ranking
公开(公告)号：US20210123025A1
公开(公告)日：2021-04-29
申请号：US17257457
申请日：2019-07-02
Applicant: UNIVERSIDAD DEL PAÍS VASCO - EUSKAL HERRIKO UNIBERTSITATEA , ACHUCARRO BASQUE CENTER FOR NEUROSCIENCE FUNDAZIOA
Inventor： José Ramón PINEDA MARTÍ , Jon LUZURIAGA GONZÁLEZ , Fernando UNDA RODRÍGUEZ , Oier PASTOR ALONSO , Juan Manuel ENCINAS PÉREZ , Gaskon IBARRETXE BILBAO , Igor IRASTORZA EPELDE
Abstract: The present invention provides a serum-free endothelial cell differentiation culture medium comprising (a) a basal culture medium and (b) an endothelial cell differentiation combination of EGF, FGF and VEGF protein, wherein the amount of EGF is higher than the amount of FGF protein. The present invention further provides a process for the preparation of cellular aggregate suspensions comprising differentiated endothelial cells from dental stem cells using the serum-free medium, as well as the use of the resulting suspension in therapy.
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7.发明申请INDOLE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH INDOLES AND THEIR USE AS DNA METHYLATION MODULATORS 审中-公开含有这些衍生物，含有此类化学物质的药物组合物及其作为DNA甲基化调节剂的用途公开(公告)号：US20150336889A1
公开(公告)日：2015-11-26
申请号：US14441086
申请日：2013-11-07
Applicant: IKERCHEM, S.L. , UNIVERSIDAD DEL PAÍS VASCO
Inventor： Fernando Pedro COSSÍO MORA , Yosu Ion VARA SALAZAR , María del Carmen MASDEU MARGALEF , María Remedios ALCALÁ CAFFARENA , Sergio VILLAFRUELA CÁNEVA , Dorleta OTAEGUI ANSA , Eneko ALDABA ARÉVALO , Eider SAN SEBASTIÁN LARZABAL , Aizpea ZUBIA OLASCOAGA
IPC: C07D209/12
CPC classification number: C07C225/16 , C07D209/12
Abstract: The present invention refers to compounds of formula (I): as well as to a method for their preparation, pharmaceutical compositions comprising the same, and use thereof for the treatment and/or chemoprevention of cancer hematological malignancy, proliferative diseases, genetic diseases, neurological disorders and immunological disorders.
Abstract translation: 本发明涉及式（I）化合物：以及其制备方法，包含其的药物组合物及其用于治疗和/或化学预防癌症血液恶性肿瘤，增殖性疾病，遗传疾病，神经系统疾病 疾病和免疫学障碍。
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8.发明申请公开(公告)号：US20250045632A1
公开(公告)日：2025-02-06
申请号：US18717220
申请日：2022-12-09
Applicant: FUNDACIÓN TECNALIA RESEARCH & INNOVATION , UNIVERSIDAD DEL PAÍS VASCO - EUSKAL HERRIKO UNIBERTSITATEA (UPV / EHU)
Inventor： Oscar LAGE SERRANO , Cristina REGUEIRO SENDEROS , Iñaki SECO AGUIRRE , Borja URQUIZU GOMEZ , Eneko GOMEZ RAMOS , Idoia GÁMIZ UGARTE , Marta GONZALEZ RODRÍGUEZ , Iván GUTIERREZ AGÜERO , Esther VILLAR RODRIGUEZ
Abstract: A computer implemented method for training algorithms, including providing a data owner having datasets, an algorithm provider having algorithms to be trained and a blockchain network in whereby a training management provider is deployed; sending a training request to the training management provider, including a training manifest; sending the manifest to the data owner; sending by each data owner, an acceptance having a component ensuring the identity of the participating data owner; sending, by the training management provider and once minimal requirements have been met, the acceptance manifests to the algorithm provider; generating, by the algorithm provider, a compiled multi-party computation code; sending the algorithm to be trained and the compiled multi-party computation code to the data owners participating in training the algorithm; training; executing the multi-party computation code generating a multi-party peer-to-peer network; and generating a model based on the local models and the algorithm to be trained.
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公开(公告)号：US20240374782A1
公开(公告)日：2024-11-14
申请号：US18691129
申请日：2022-09-14
Inventor： Rosa María HERNÁNDEZ MARTÍN , Edorta SANTOS VIZCAÍNO , Manuela IGARTUA OLAECHEA , Kevin LAS HERAS ZAPATA , Jon JIMÉNEZ MARTÍN , Maria Coro DE LA CABA CIRIZA , Pedro Manuel GUERRERO MANSO , Alaitz ETXABIDE ETXEBERRIA
Abstract: The present invention has discovered that a sponge-like scaffold comprising soy protein, chitin and a plasticizer has ideal physiochemical and mechanical properties for use as a haemostasis promoter. Therefore, the present invention provides the use of said scaffold for the use in promoting haemostasis in wounds, preferably haemorrhages such as nasal haemorrhage, as well as products which comprise said scaffold for use in promoting haemostasis.
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公开(公告)号：US11796579B2
公开(公告)日：2023-10-24
申请号：US16649884
申请日：2018-09-25
Applicant: UNIVERSIDAD DEL PAÍS VASCO/EUSKAL HERRIKO UNIBERTSITATEA , AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS , UNIVERSITY OF JYVÄSKYLÄ
Inventor： Fernando Sebastian Bergeret Sbarbaro , Francesco Giazotto , Tero Heikkilä , Ilari Maasilta
CPC classification number: G01R29/0878 , G01J5/20 , H10N60/10 , G01J2005/208 , H01F1/0018 , H01F1/14708
Abstract: An electromagnetic sensor for use in a variety of applications requiring extremely high sensitivity, such as measuring power and characteristics of incident electromagnetic radiation includes a superconducting layer that carries an exchange field for providing a spin splitting effect of charge carriers in the superconducting layer, a metal electrode, and an insulating layer arranged between the superconducting layer and metal electrode to form a spin filter junction therebetween. The electromagnetic sensor provides an antenna including a wave collecting element, in contact with the superconducting layer to convey thereinto external electromagnetic waves that are generated by an external source. An electric measurement device provides an output signal responsive to the amplitude and frequency of the external electromagnetic waves, and contacts the metal electrode to measure an electric current or voltage caused by the spin splitted charge carrier flow from the superconducting layer through the spin filter junction into the metal electrode.
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