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公开(公告)号：US20120282219A1
公开(公告)日：2012-11-08
申请号：US13541436
申请日：2012-07-03
申请人： ROBERT EDWARD BABINE , SHU HUI CHEN , IVAN COLLADO , CRISTINA GARCIA-PAREDES , JOHN IRVIN GLASS , DEQI GUO , LING JIN , JASON ERIC LAMAR , RAYMOND SAMUEL PARKER, III , NANCY JUNE SNYDER , XICHENG DAVID SUN , MARK JOSEPH TEBBE , FRANTZ VICTOR , Q. MAY WANG , YVONNE YEE MAI YIP , ROBERT B. PERNI , LUC FARMER
发明人： ROBERT EDWARD BABINE , SHU HUI CHEN , IVAN COLLADO , CRISTINA GARCIA-PAREDES , JOHN IRVIN GLASS , DEQI GUO , LING JIN , JASON ERIC LAMAR , RAYMOND SAMUEL PARKER, III , NANCY JUNE SNYDER , XICHENG DAVID SUN , MARK JOSEPH TEBBE , FRANTZ VICTOR , Q. MAY WANG , YVONNE YEE MAI YIP , ROBERT B. PERNI , LUC FARMER
IPC分类号： A61K38/07 , C07D209/52 , C12N5/073 , A61P31/14 , A61K38/20 , C12N9/99 , C07K5/117 , A61K38/21
CPC分类号： C07K7/02 , A61K38/07 , A61K38/08 , A61K38/21 , A61K38/212 , A61K38/215 , A61K45/06 , C07D209/02 , C07D209/52 , C07K5/0202 , C07K5/0205 , C07K5/06052 , C07K5/0808 , C07K5/101 , C07K5/1016 , C07K7/06 , C07K14/005 , C12N2770/24222 , Y02P20/55 , A61K2300/00
摘要： The present invention relates to peptidomimetic compounds useful as protease inhibitors, particularly as serine protease inhibitors and more particularly as hepatitis C NS3 protease inhibitors; intermediates thereto; their preparation including novel stereoselective processes to intermediates. The invention is also directed to pharmaceutical compositions and to methods for using the compounds for inhibiting HCV protease or treating a patient suffering from an HCV infection or physiological condition related to the infection. Also provided are pharmaceutical combinations comprising, in addition to one or more HCV serine protease inhibitors, one or more interferons exhibiting anti-HCV activity and/or one or more compounds having anti HCV activity and a pharmaceutically acceptable carrier, and methods for treating or preventing a HCV infection in a patient using the compositions. The present invention is also directed to a kit or pharmaceutical pack for treating or preventing HCV infection in a patient.
摘要翻译： 本发明涉及可用作蛋白酶抑制剂的肽模拟化合物，特别是作为丝氨酸蛋白酶抑制剂，更具体地，涉及丙型肝炎NS3蛋白酶抑制剂; 中间体; 它们的制备包括对中间体的新的立体选择性方法。 本发明还涉及药物组合物和使用该化合物抑制HCV蛋白酶或治疗患有HCV感染或与感染有关的生理病症的患者的方法。 还提供了药物组合，除一种或多种HCV丝氨酸蛋白酶抑制剂外还包含一种或多种表现出抗HCV活性的干扰素和/或一种或多种具有抗HCV活性的化合物和药学上可接受的载体，以及用于治疗或预防的方法 使用该组合物的患者中的HCV感染。 本发明还涉及用于治疗或预防患者HCV感染的试剂盒或药物包装。
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公开(公告)号：US07820671B2
公开(公告)日：2010-10-26
申请号：US10344112
申请日：2001-08-31
申请人： Robert Edward Babine , Shu Hui Chen , Ivan Collado , Cristina Garcia-Paredes , John Irvin Glass , Deqi Guo , Ling Jin , Jason Eric Lamar , Raymond Samuel Parker, III , Nancy June Snyder , Xicheng David Sun , Mark Joseph Tebbe , Frantz Victor , Q. May Wang , Yvonne Yee Mai Yip , Robert B. Perni , Luc Farmer
发明人： Robert Edward Babine , Shu Hui Chen , Ivan Collado , Cristina Garcia-Paredes , John Irvin Glass , Deqi Guo , Ling Jin , Jason Eric Lamar , Raymond Samuel Parker, III , Nancy June Snyder , Xicheng David Sun , Mark Joseph Tebbe , Frantz Victor , Q. May Wang , Yvonne Yee Mai Yip , Robert B. Perni , Luc Farmer
IPC分类号： A61K31/497 , C07D241/02
CPC分类号： C07K7/02 , A61K38/07 , A61K38/08 , A61K38/21 , A61K38/212 , A61K38/215 , A61K45/06 , C07D209/02 , C07D209/52 , C07K5/0202 , C07K5/0205 , C07K5/06052 , C07K5/0808 , C07K5/101 , C07K5/1016 , C07K7/06 , C07K14/005 , C12N2770/24222 , Y02P20/55 , A61K2300/00
摘要： The present invention relates to peptidomimetic compounds useful as protease inhibitors, particularly as serine protease inhibitors and more particularly as hepatitis C NS3 protease inhibitors; intermediates thereto; their preparation including novel steroselective processes to intermediates. The invention is also directed to pharmaceutical compositions and to methods for using the compounds for inhibiting HCV protease or treating a patient suffering from an HCV infection or physiological condition related to the infection. Also provided are pharmaceutical combinations comprising, in addition to one or more HCV serine protease inhibitors, one or more interferons exhibiting anti-HCV activity and/or one or more compounds having anti HCV activity and a pharmaceutically acceptable carrier, and methods for treating or preventing a HCV infection in a patient using the compositions. The present invention is also directed to a kit or pharmaceutical pack for treating or preventing HCV infection in a patient.
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公开(公告)号：US06350866B1
公开(公告)日：2002-02-26
申请号：US08987146
申请日：1997-12-08
申请人： Paul Luther Skatrud , Robert Brown Peery , Q May Wang , Paul Robert Rosteck, Jr. , Pamela Kay Rockey
发明人： Paul Luther Skatrud , Robert Brown Peery , Q May Wang , Paul Robert Rosteck, Jr. , Pamela Kay Rockey
IPC分类号： C07H2104
CPC分类号： G01N33/56944 , C07K14/3156 , C12N9/1247 , C12N15/1006 , C12N15/746 , C12Y302/01018 , G01N2333/315 , Y10S435/822
摘要： The invention provides isolated nucleic acid compounds encoding FtsZ of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said protein.
摘要翻译： 本发明提供编码肺炎链球菌FtsZ的分离的核酸化合物。 还提供了用于表达编码的蛋白质的载体和转化的宿主细胞，以及用于鉴定结合和/或抑制所述蛋白质的化合物的方法。
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公开(公告)号：US6136557A
公开(公告)日：2000-10-24
申请号：US987123
申请日：1997-12-08
IPC分类号： C07K14/315 , C12N1/21 , C12N9/12 , C12N9/24 , C12N15/10 , C12N15/31 , C12N15/74 , C12P21/04 , G01N33/569 , C07H21/04 , C12N1/20 , C12N15/00 , C12N15/63
CPC分类号： G01N33/56944 , C07K14/3156 , C12N15/1006 , C12N15/746 , C12N9/1247 , C12Y302/01018 , G01N2333/315 , Y10S435/822
摘要： The invention provides isolated nucleic acid compounds encoding FtsH of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said protein.
摘要翻译： 本发明提供编码肺炎链球菌FtsH的分离的核酸化合物。 还提供了用于表达编码的蛋白质的载体和转化的宿主细胞，以及用于鉴定结合和/或抑制所述蛋白质的化合物的方法。
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公开(公告)号：US08252923B2
公开(公告)日：2012-08-28
申请号：US12231982
申请日：2008-09-08
申请人： Robert Edward Babine , Shu-Hui Chen , Jason Eric Lamar , Nancy June Snyder , Xicheng Sun , Mark Joseph Tebbe , Frantz Victor , Q. May Wang , Yvonne Yee Mai Yip , Ivan Collado , Cristina Garcia-Paredes , Raymond Samuel Parker, III , Ling Jin , Deqi Guo , John Irvin Glass
发明人： Robert Edward Babine , Shu-Hui Chen , Jason Eric Lamar , Nancy June Snyder , Xicheng Sun , Mark Joseph Tebbe , Frantz Victor , Q. May Wang , Yvonne Yee Mai Yip , Ivan Collado , Cristina Garcia-Paredes , Raymond Samuel Parker, III , Ling Jin , Deqi Guo , John Irvin Glass
IPC分类号： C07D265/34 , C07D241/08 , C07D275/06 , C07D417/02 , C07D233/32 , C07D403/02 , C07D207/08 , C07D493/14 , C07C229/00
CPC分类号： C07K7/02 , A61K38/07 , A61K38/08 , A61K38/21 , A61K38/212 , A61K38/215 , A61K45/06 , C07D209/02 , C07D209/52 , C07K5/0202 , C07K5/0205 , C07K5/06052 , C07K5/0808 , C07K5/101 , C07K5/1016 , C07K7/06 , C07K14/005 , C12N2770/24222 , Y02P20/55 , A61K2300/00
摘要： The present invention relates to peptidomimetic compounds useful as protease inhibitors, particularly as serine protease inhibitors and more particularly as hepatitis C NS3 protease inhibitors; intermediates thereto; their preparation including novel steroselective processes to intermediates. The invention is also directed to pharmaceutical compositions and to methods for using the compounds for inhibiting HCV protease or treating a patient suffering from an HCV infection or physiological condition related to the infection. Also provided are pharmaceutical combinations comprising, in addition to one or more HCV serine protease inhibitors, one or more interferons exhibiting anti-HCV activity and/or one or more compounds having anti HCV activity and a pharmaceutically acceptable carrier, and methods for treating or preventing a HCV infection in a patient using the compositions. The present invention is also directed to a kit or pharmaceutical pack for treating or preventing HCV infection in a patient.
摘要翻译： 本发明涉及可用作蛋白酶抑制剂的肽模拟化合物，特别是作为丝氨酸蛋白酶抑制剂，更具体地，涉及丙型肝炎NS3蛋白酶抑制剂; 中间体; 它们的制备方法包括对中间体的新型置换步骤。 本发明还涉及药物组合物和使用该化合物抑制HCV蛋白酶或治疗患有HCV感染或与感染有关的生理病症的患者的方法。 还提供了药物组合，除一种或多种HCV丝氨酸蛋白酶抑制剂外还包含一种或多种表现出抗HCV活性的干扰素和/或一种或多种具有抗HCV活性的化合物和药学上可接受的载体，以及用于治疗或预防的方法 使用该组合物的患者中的HCV感染。 本发明还涉及用于治疗或预防患者HCV感染的试剂盒或药物包装。
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公开(公告)号：US20120064034A1
公开(公告)日：2012-03-15
申请号：US13293812
申请日：2011-11-10
申请人： ROBERT EDWARD BABINE , SHU HUI CHEN , IVAN COLLADO , CRISTINA GARCIA-PAREDES , JOHN IRVIN GLASS , DEQI GUO , LING JIN , JASON ERIC LAMAR , RAYMOND SAMUEL PARKER, III , NANCY JUNE SNYDER , XICHENG DAVID SUN , YVONNE YEE MAI YIP , Q. MAY WANG , FRANTZ VICTOR , MARK JOSEPH TEBBE , ROBERT B. PERNI , LUC FARMER
发明人： ROBERT EDWARD BABINE , SHU HUI CHEN , IVAN COLLADO , CRISTINA GARCIA-PAREDES , JOHN IRVIN GLASS , DEQI GUO , LING JIN , JASON ERIC LAMAR , RAYMOND SAMUEL PARKER, III , NANCY JUNE SNYDER , XICHENG DAVID SUN , YVONNE YEE MAI YIP , Q. MAY WANG , FRANTZ VICTOR , MARK JOSEPH TEBBE , ROBERT B. PERNI , LUC FARMER
IPC分类号： A61K38/08 , C07K5/037 , A61K38/21 , C12N5/071 , C07C229/42 , C07D209/52 , C12N9/99 , C07K7/06 , A61K38/20
CPC分类号： C07K7/02 , A61K38/07 , A61K38/08 , A61K38/21 , A61K38/212 , A61K38/215 , A61K45/06 , C07D209/02 , C07D209/52 , C07K5/0202 , C07K5/0205 , C07K5/06052 , C07K5/0808 , C07K5/101 , C07K5/1016 , C07K7/06 , C07K14/005 , C12N2770/24222 , Y02P20/55 , A61K2300/00
摘要： The present invention relates to peptidomimetic compounds useful as protease inhibitors, particularly as serine protease inhibitors and more particularly as hepatitis C NS3 protease inhibitors; intermediates thereto; their preparation including novel steroselective processes to intermediates. The invention is also directed to pharmaceutical compositions and to methods for using the compounds for inhibiting HCV protease or treating a patient suffering from an HCV infection or physiological condition related to the infection. Also provided are pharmaceutical combinations comprising, in addition to one or more HCV serine protease inhibitors, one or more interferons exhibiting anti-HCV activity and/or one or more compounds having anti HCV activity and a pharmaceutically acceptable carrier, and methods for treating or preventing a HCV infection in a patient using the compositions. The present invention is also directed to a kit or pharmaceutical pack for treating or preventing HCV infection in a patient.
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公开(公告)号：US20100137583A1
公开(公告)日：2010-06-03
申请号：US12231982
申请日：2008-09-08
申请人： Robert Edward Babine , Shu-Hui Chen , Jason Eric Lamar , Nancy June Snyder , Xicheng Sun , Mark Joseph Tebbe , Frantz Victor , Q. May Wang , Yvonne Yee Mai Yip , Ivan Collado , Cristina Garcia-Paredes , Raymond Samuel Parker, III , Ling Jin , Deqi Guo , John Irvin Glass
发明人： Robert Edward Babine , Shu-Hui Chen , Jason Eric Lamar , Nancy June Snyder , Xicheng Sun , Mark Joseph Tebbe , Frantz Victor , Q. May Wang , Yvonne Yee Mai Yip , Ivan Collado , Cristina Garcia-Paredes , Raymond Samuel Parker, III , Ling Jin , Deqi Guo , John Irvin Glass
IPC分类号： C07D265/34 , C07D265/32 , C07D241/08 , C07D275/06 , C07D417/02 , C07D233/32 , C07D403/02 , C07D207/08 , C07D493/14 , C07C229/00
CPC分类号： C07K7/02 , A61K38/07 , A61K38/08 , A61K38/21 , A61K38/212 , A61K38/215 , A61K45/06 , C07D209/02 , C07D209/52 , C07K5/0202 , C07K5/0205 , C07K5/06052 , C07K5/0808 , C07K5/101 , C07K5/1016 , C07K7/06 , C07K14/005 , C12N2770/24222 , Y02P20/55 , A61K2300/00
摘要： The present invention relates to peptidomimetic compounds useful as protease inhibitors, particularly as serine protease inhibitors and more particularly as hepatitis C NS3 protease inhibitors; intermediates thereto; their preparation including novel steroselective processes to intermediates. The invention is also directed to pharmaceutical compositions and to methods for using the compounds for inhibiting HCV protease or treating a patient suffering from an HCV infection or physiological condition related to the infection. Also provided are pharmaceutical combinations comprising, in addition to one or more HCV serine protease inhibitors, one or more interferons exhibiting anti-HCV activity and/or one or more compounds having anti HCV activity and a pharmaceutically acceptable carrier, and methods for treating or preventing a HCV infection in a patient using the compositions. The present invention is also directed to a kit or pharmaceutical pack for treating or preventing HCV infection in a patient.
摘要翻译： 本发明涉及可用作蛋白酶抑制剂的肽模拟化合物，特别是作为丝氨酸蛋白酶抑制剂，更具体地，涉及丙型肝炎NS3蛋白酶抑制剂; 中间体; 它们的制备方法包括对中间体的新型置换步骤。 本发明还涉及药物组合物和使用该化合物抑制HCV蛋白酶或治疗患有HCV感染或与感染有关的生理病症的患者的方法。 还提供了药物组合，除一种或多种HCV丝氨酸蛋白酶抑制剂外还包含一种或多种表现出抗HCV活性的干扰素和/或一种或多种具有抗HCV活性的化合物和药学上可接受的载体，以及用于治疗或预防的方法 使用该组合物的患者中的HCV感染。 本发明还涉及用于治疗或预防患者HCV感染的试剂盒或药物包装。
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![[4-(Benzo[B]thiophen-2-yl) Pyrimidin-2-yl]-amine derivatives as IKK-beta inhibitors for the treatment of cancer and inflammatory diseases](/abs-image/US/2009/06/16/US07547691B2/abs.jpg.150x150.jpg)
8.发明授权[4-(Benzo[B]thiophen-2-yl) Pyrimidin-2-yl]-amine derivatives as IKK-beta inhibitors for the treatment of cancer and inflammatory diseases 失效[4-（苯并[B]噻吩-2-基）嘧啶-2-基] - 胺衍生物作为治疗癌症和炎性疾病的IKK-β抑制剂公开(公告)号：US07547691B2
公开(公告)日：2009-06-16
申请号：US12093024
申请日：2006-11-15
申请人： Karl Robert Dahnke , Ho-Shen Lin , Michael Enrico Richett , Chuan Shih , Q May Wang , Bo Zhang
发明人： Karl Robert Dahnke , Ho-Shen Lin , Michael Enrico Richett , Chuan Shih , Q May Wang , Bo Zhang
IPC分类号： C07D409/04 , A61K31/506
CPC分类号： C07D409/04
摘要： The present invention provides compounds of Formula I: useful in the treatment of cancer and inflammatory diseases.
摘要翻译： 本发明提供式I化合物：可用于治疗癌症和炎性疾病。
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公开(公告)号：US08529882B2
公开(公告)日：2013-09-10
申请号：US13541436
申请日：2012-07-03
申请人： Robert Edward Babine , Shu Hui Chen , Ivan Collado , Cristina Garcia-Paredes , John Irvin Glass , Ling Jin , Jason Eric Lamar , Raymond Samuel Parker, III , Nancy June Snyder , Xicheng David Sun , Deqi Guo , Yvonne Yee Mai Yip , Q. May Wang , Frantz Victor , Mark Joseph Tebbe , Robert B. Perni , Luc Farmer
发明人： Robert Edward Babine , Shu Hui Chen , Ivan Collado , Cristina Garcia-Paredes , John Irvin Glass , Ling Jin , Jason Eric Lamar , Raymond Samuel Parker, III , Nancy June Snyder , Xicheng David Sun , Deqi Guo , Yvonne Yee Mai Yip , Q. May Wang , Frantz Victor , Mark Joseph Tebbe , Robert B. Perni , Luc Farmer
IPC分类号： A61K38/07 , A61K38/20 , A61K38/21 , C07D209/52 , C12N5/073 , C12N9/99 , A61P31/14 , C07K5/117
CPC分类号： C07K7/02 , A61K38/07 , A61K38/08 , A61K38/21 , A61K38/212 , A61K38/215 , A61K45/06 , C07D209/02 , C07D209/52 , C07K5/0202 , C07K5/0205 , C07K5/06052 , C07K5/0808 , C07K5/101 , C07K5/1016 , C07K7/06 , C07K14/005 , C12N2770/24222 , Y02P20/55 , A61K2300/00
摘要： The present invention relates to peptidomimetic compounds useful as protease inhibitors, particularly as serine protease inhibitors and more particularly as hepatitis C NS3 protease inhibitors; intermediates thereto; their preparation including novel stereoselective processes to intermediates. The invention is also directed to pharmaceutical compositions and to methods for using the compounds for inhibiting HCV protease or treating a patient suffering from an HCV infection or physiological condition related to the infection. Also provided are pharmaceutical combinations comprising, in addition to one or more HCV serine protease inhibitors, one or more interferons exhibiting anti-HCV activity and/or one or more compounds having anti HCV activity and a pharmaceutically acceptable carrier, and methods for treating or preventing a HCV infection in a patient using the compositions. The present invention is also directed to a kit or pharmaceutical pack for treating or preventing HCV infection in a patient.
摘要翻译： 本发明涉及可用作蛋白酶抑制剂的肽模拟化合物，特别是作为丝氨酸蛋白酶抑制剂，更具体地说，涉及丙型肝炎NS3蛋白酶抑制剂; 中间体; 它们的制备包括对中间体的新的立体选择性方法。 本发明还涉及药物组合物以及使用该化合物抑制HCV蛋白酶或治疗患有HCV感染或感染相关生理状况的患者的方法。 还提供了药物组合，除一种或多种HCV丝氨酸蛋白酶抑制剂外还包含一种或多种表现出抗HCV活性的干扰素和/或一种或多种具有抗HCV活性的化合物和药学上可接受的载体，以及用于治疗或预防的方法 使用该组合物的患者中的HCV感染。 本发明还涉及用于治疗或预防患者HCV感染的试剂盒或药物包装。
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![[4-(Benzo[B]Thiophen-2-Yl) Pyrimidin-2-Yl]-Amine Derivatives As Ikk-Beta Inhibitors For The Treatment Of Cancer And Inflammatory Diseases](/abs-image/US/2008/12/11/US20080306082A1/abs.jpg.150x150.jpg)
10.发明申请[4-(Benzo[B]Thiophen-2-Yl) Pyrimidin-2-Yl]-Amine Derivatives As Ikk-Beta Inhibitors For The Treatment Of Cancer And Inflammatory Diseases 失效[4-（苯并[B]噻吩-2-基）嘧啶-2-基] - 衍生物作为Ikk-β抑制剂治疗癌症和炎性疾病公开(公告)号：US20080306082A1
公开(公告)日：2008-12-11
申请号：US12093024
申请日：2006-11-15
申请人： Karl Robert Dahnke , Ho-Shen Lin , Michael Enrico Richett , Chuan Shih , Q May Wang , Bo Zhang
发明人： Karl Robert Dahnke , Ho-Shen Lin , Michael Enrico Richett , Chuan Shih , Q May Wang , Bo Zhang
IPC分类号： C07D409/04 , A61K31/506 , A61K31/496 , A61P11/00 , C07D409/14 , A61P19/02 , A61P35/00 , A61P29/00
CPC分类号： C07D409/04
摘要： The present invention provides compounds of Formula I: useful in the treatment of cancer and inflammatory diseases.
摘要翻译： 本发明提供式I化合物：可用于治疗癌症和炎性疾病。
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