Abstract:
A locally-activatable bivalent thrombin binding agent is provided having two thrombin binding moieties for non-overlapping sites on a surface of thrombin linked together by a linker. The linker is a polypeptide having 5 to 30 amino acid residues existing in a folded state under an environmental condition where the binding agent is inactive. The linker changes conformation from the folded state to an unfolded state in response to a change in bulk temperature and/or to the presence of hyper-mobile water thereby activating the binding agent. Such locally-activatable thrombin binding agents can be administered systemically while only targeting specific sites of coagulation or inflammation since the thrombin binding agent will only activate at the site where the existence of atherosclerotic plaques has changed the local bulk temperature and/or created hyper-mobile water sufficiently to unfold the linker and activate the binding agent. Such binding agents are useful as site-specific anti-coagulant, anti-thrombotic and/or antiinflammatory agents.
Abstract:
The present invention relates to the crystal structures of dolastatin 16, dolamethylleuine and dolaphenvaline. The present invention also relates to processes for preparing dolamethylleuine and dolaphenvaline. The present invention further relates to computer readable medium with crystal structural data and/or information stored thereon.
Abstract:
A deep standby method and device for and embedded system is disclosed, wherein the method mainly includes: a selecting step for selecting an available data swap block from the data swap area of a non-volatile memory as a deep standby block; a writing step for writing the current system data and state of the CPU into the deep standby block, and writing a deep standby flag into the deep standby block; and a shutting down step for making the system off to fall into a deep standby.
Abstract:
A functional TFE copolymer fine powder is described, wherein the TFE copolymer is a polymer of TFE and at least one functional comonomer, and wherein the TFE copolymer has functional groups that are pendant to the polymer chain. The functional TFE copolymer fine powder resin is paste extrudable and expandable. Methods for making the functional TFE copolymer are also described. The expanded functional TFE copolymer material may be post-reacted after expansion.
Abstract:
An exemplary electronic apparatus includes a housing, a wireless communication device disposed on the housing, and a motherboard received in the housing. The wireless communication device includes a circuit board and a wireless communication module disposed on the circuit board. The circuit board is connected the motherboard by electrical wires. The wireless communication module is located at an outside of the housing.
Abstract:
A functional TFE copolymer fine powder is described, wherein the TFE copolymer is a polymer of TFE and at least one functional comonomer, and wherein the TFE copolymer has functional groups that are pendant to the polymer chain. The functional TFE copolymer fine powder resin is paste extrudable and expandable. Methods for making the functional TFE copolymer are also described. The expanded functional TFE copolymer material may be post-reacted after expansion.
Abstract:
Crosslinkable perfluoroelastomer compositions having low metal content and low compression set when crosslinked, and processes for producing the same, are provided. Compositions comprising terpolymers of TFE, PAVE, and CNVE having a metal content of less than 3000 ppb may be formed into high purity transparent perfluoroelastomer parts.
Abstract:
An analog-to-digital converter (ADC) and a battery operated electronic device comprising the ADC. The ADC comprising an input switch; an array of binary-weighted capacitors, the array of capacitors receiving the input voltage signal via the input switch in an on state of the input switch; a plurality of switches, each switch connected in series with a respective one of the capacitors at an opposite side compared to the input switch, wherein a VDD signal is applied to each switch in one switching state and ground in another switching state; a comparator having as one input a voltage from the input switch side of the array of capacitors and as another input a voltage of VDD/2; and a switch control unit coupled to an output of the comparator for controlling the switches based on the output from the comparator.
Abstract:
A water permeable fluoropolymer article is described comprising a functional copolymer of TFE, PSVE and sulfonic acid pendant to the polymer chain, as well as methods of making the article. The method comprises providing a copolymer membrane comprising a microstructure characterized by nodes interconnected by fibrils, wherein said membrane, immersing said membrane in hot water for a period of time to render the membrane water permeable.
Abstract:
An apparatus having means for amplifying a differential voltage signal. The means for amplifying includes at least an input stage and an output stage. The output stage includes means for preventing a trade off between a reduction in noise of an output voltage signal and an increase in a dynamic range of the output voltage signal.