知搜-全球专利检索

  1. 登录
  2. 注册

搜索结果

6 条记录 (耗时 0.015 秒)

    Non-M, non-O HIV-1 strains, fragments and uses
    1.
    发明授权
    Non-M, non-O HIV-1 strains, fragments and uses 有权
    非M，非O型HIV-1株，片段和用途

    公开(公告)号：US07534877B2

    公开(公告)日：2009-05-19

    申请号：US11226240

    申请日：2005-09-15

    申请人： Phillippe Mauclere ,  Ibtissam Loussert-Ajaka ,  Francois Simon ,  Sentob Saragosti ,  Francoise Barre-Sinoussi

    发明人： Phillippe Mauclere ,  Ibtissam Loussert-Ajaka ,  Francois Simon ,  Sentob Saragosti ,  Francoise Barre-Sinoussi

    IPC分类号： C07H21/04 ,  C12Q1/68 ,  C12P19/34

    CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K2039/525 ,  C12N7/00 ,  C12N2740/15022 ,  C12N2740/16021 ,  C12N2740/16122 ,  C12N2740/16222 ,  C12N2740/16322 ,  G01N33/56988 ,  Y10S435/975

    摘要： Retroviral strains of the non-M, non-O HIV-1 group, in particular a strain designated YBE30, its fragments and also its uses as a diagnostic reagent and as an immunogenic agent.The HIV-1 viruses which differ both from the M group and the O group exhibit the following characteristics: little or no serological reactivity with regard to the proteins of the M and O groups and strong serological reactivity with regard to the proteins which are derived from the strain YBF30 according to the invention or the strain CPZGAB SIV; absence of genomic amplification when using primers from the env and gag regions of the M and O HIV-1 groups; genomic amplification in the presence of primers which are derived from the YBF30 strain according to the invention; and homology of the products of the envelope gene which is greater than 70% with regard to the YBF30 strain.

    摘要翻译： 非M，非O HIV-1组的逆转录病毒株，特别是称为YBE30的菌株，其片段以及其用作诊断试剂和作为免疫原性试剂。 不同于M组和O组的HIV-1病毒表现出以下特征：对于M和O组的蛋白质而言，血清学反应性很小或没有，对于衍生自M组和O组的蛋白质具有强烈的血清学反应性 根据本发明的菌株YBF30或菌株CPZGAB SIV; 当使用来自M和O HIV-1组的env和gag区域的引物时，不存在基因组扩增; 在根据本发明的YBF30菌株衍生的引物的存在下进行基因组扩增; 以及相对于YBF30菌株大于70％的包膜基因的产物的同源性。

    Non-M, non-O HIV-1 strains, fragments and uses
    4.
    发明授权
    Non-M, non-O HIV-1 strains, fragments and uses 有权
    非M，非O型HIV-1株，片段和用途

    公开(公告)号：US08227185B2

    公开(公告)日：2012-07-24

    申请号：US12385973

    申请日：2009-04-24

    申请人： Phillippe Mauclere ,  Ibtissam Loussert-Ajaka ,  Francois Simon ,  Sentob Saragosti ,  Francoise Barre-Sinoussi

    发明人： Phillippe Mauclere ,  Ibtissam Loussert-Ajaka ,  Francois Simon ,  Sentob Saragosti ,  Francoise Barre-Sinoussi

    IPC分类号： C12Q1/70 ,  C19H19/00

    CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K2039/525 ,  C12N7/00 ,  C12N2740/15022 ,  C12N2740/16021 ,  C12N2740/16122 ,  C12N2740/16222 ,  C12N2740/16322 ,  G01N33/56988 ,  Y10S435/975

    摘要： Retroviral strains of the non-M, non-O HIV-1 group, in particular a strain designated YBF30, its fragments and also its uses as a diagnostic reagent and as an immunogenic agent.The HIV-1 viruses which differ both from the M group and the O group exhibit the following characteristics: little or no serological reactivity with regard to the proteins of the M and O groups and strong serological reactivity with regard to the proteins which are derived from the strain YBF30 according to the invention or the strain CPZGAB SIV; absence of genomic amplification when using primers from the env and gag regions of the M and O HIV-1 groups; genomic amplification in the presence of primers which are derived from the YBF30 strain according to the invention; and homology of the products of the envelope gene which is greater than 70% with regard to the YBF30 strain.

    摘要翻译： 非M，非O HIV-1组的逆转录病毒株，特别是称为YBF30的菌株，其片段以及其作为诊断试剂的用途和作为免疫原性试剂。 不同于M组和O组的HIV-1病毒表现出以下特征：对于M和O组的蛋白质而言，血清学反应性很小或没有，对于衍生自M组和O组的蛋白质具有强烈的血清学反应性 根据本发明的菌株YBF30或菌株CPZGAB SIV; 当使用来自M和O HIV-1组的env和gag区域的引物时，不存在基因组扩增; 在根据本发明的YBF30菌株衍生的引物的存在下进行基因组扩增; 以及相对于YBF30菌株大于70％的包膜基因的产物的同源性。