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    Protein(poly)peptide libraries
    3.
    发明授权
    Protein(poly)peptide libraries 有权
    蛋白质（多）肽文库

    公开(公告)号：US07264963B1

    公开(公告)日：2007-09-04

    申请号：US09490064

    申请日：2000-01-24

    申请人： Achim Knappik ,  Peter Pack ,  Liming Ge ,  Simon Moroney ,  Andreas Plückthun

    发明人： Achim Knappik ,  Peter Pack ,  Liming Ge ,  Simon Moroney ,  Andreas Plückthun

    IPC分类号： C12N15/00 ,  C12Q1/68 ,  C07H21/00

    CPC分类号： C40B40/02 ,  C07K1/047 ,  C07K16/00 ,  C07K2319/00 ,  C12N15/10 ,  C12N15/1037

    摘要： The present invention relates to synthetic DNA sequences which encode one or more collections of homologous proteins/(poly)peptides, and methods for generating and applying libraries of these DNA sequences. In particular, the invention relates to the preparation of a library of human-derived antibody genes by the use of synthetic consensus sequences which cover the structural repertoire of antibodies encoded in the human genome. Furthermore, the invention relates to the use of a single consensus antibody gene as a universal framework for highly diverse antibody libraries.

    摘要翻译： 本发明涉及编码一个或多个同源蛋白/（多）肽集合的合成DNA序列，以及用于产生和应用这些DNA序列的文库的方法。 特别地，本发明涉及通过使用覆盖人类基因组中编码的抗体结构谱的合成共有序列来制备人源抗体基因文库。 此外，本发明涉及单一共有抗体基因作为高度多样化抗体文库的通用框架的用途。

    Targeted hetero-association of recombinant proteins to multi-functional complexes
    6.
    发明授权
    Targeted hetero-association of recombinant proteins to multi-functional complexes 有权
    重组蛋白与多功能复合物的靶向异质结合

    公开(公告)号：US06692935B1

    公开(公告)日：2004-02-17

    申请号：US09583808

    申请日：2000-05-30

    申请人： Peter Pack ,  Andrei Lupas

    发明人： Peter Pack ,  Andrei Lupas

    IPC分类号： C12P2106

    CPC分类号： C07K14/001 ,  A61K38/00 ,  C07K16/468

    摘要： The present invention relates to a method for targeted assembly of distinct active peptide or protein domains into a single complex and to such complexes. The invention relates particularly to the fusion of peptide or protein domains to complementary association domains which are derived from a single tertiary or quaternary structure by segmentation. The association domains are designed to assemble in a complementary fashion, thereby providing multifunctional (poly)peptides.

    摘要翻译： 本发明涉及将不同的活性肽或蛋白质结构域靶向组装成单个复合物和这种复合物的方法。 本发明特别涉及肽或蛋白质结构域与互补关联结构域的融合，这些互补结构域通过分割从单一的三级或四级结构得到。 缔合结构域被设计成以互补的方式组装，从而提供多功能（多）肽。

    Protein/(poly)peptide libraries
    8.
    发明授权
    Protein/(poly)peptide libraries 有权
    蛋白质/（多）肽文库

    公开(公告)号：US06696248B1

    公开(公告)日：2004-02-24

    申请号：US09490070

    申请日：2000-01-24

    申请人： Achim Knappik ,  Peter Pack ,  Liming Ge ,  Simon Moroney ,  Andreas Plückthun

    发明人： Achim Knappik ,  Peter Pack ,  Liming Ge ,  Simon Moroney ,  Andreas Plückthun

    IPC分类号： C12Q168

    CPC分类号： C40B40/02 ,  C07K1/047 ,  C07K16/00 ,  C07K2319/00 ,  C12N15/10 ,  C12N15/1037

    摘要： The present invention relates to synthetic DNA sequences which encode one or more collections of homologous proteins/(poly)peptides, and methods for generating and applying libraries of these DNA sequences. In particular, the invention relates to the preparation of a library of human-derived antibody genes by the use of synthetic consensus sequences which cover the structural repertoire of antibodies encoded in the human genome. Furthermore, the invention relates to the use of a single consensus antibody gene as a universal framework for highly diverse antibody libraries.

    摘要翻译： 本发明涉及编码一个或多个同源蛋白/（多）肽集合的合成DNA序列，以及用于产生和应用这些DNA序列的文库的方法。 特别地，本发明涉及通过使用覆盖人类基因组中编码的抗体结构谱的合成共有序列来制备人源抗体基因文库。 此外，本发明涉及单一共有抗体基因作为高度多样化抗体文库的通用框架的用途。

    Targeted hetero-association of recombinant proteins to multi-functional complexes
    9.
    发明授权
    Targeted hetero-association of recombinant proteins to multi-functional complexes 失效
    重组蛋白与多功能复合物的靶向异质结合

    公开(公告)号：US06294353B1

    公开(公告)日：2001-09-25

    申请号：US08817787

    申请日：1997-09-23

    申请人： Peter Pack ,  Andrei Lupas

    发明人： Peter Pack ,  Andrei Lupas

    IPC分类号： C12P2106

    CPC分类号： C07K14/001 ,  A61K38/00 ,  C07K16/468

    摘要： The present invention relates to a method for targeted assembly of distinct active peptide or protein domains into a single complex and to such complexes. The invention relates particularly to the fusion of peptide or protein domains to complementary association domains which are derived from a single tertiary or quaternary structure by segmentation. The association domains are designed to assemble in a complementary fashion, thereby providing multifunctional (poly)peptides.

    摘要翻译： 本发明涉及将不同的活性肽或蛋白质结构域靶向组装成单个复合物和这种复合物的方法。 本发明特别涉及肽或蛋白质结构域与互补关联结构域的融合，这些互补结构域通过分割从单一的三级或四级结构得到。 缔合结构域被设计成以互补的方式组装，从而提供多功能（多）肽。