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公开(公告)号：US20080267885A1
公开(公告)日：2008-10-30
申请号：US10596836
申请日：2004-12-10
CPC分类号： A61K9/008 , A61K9/08 , A61K9/10 , A61K9/1647 , A61K47/34 , A61K47/593 , C08G63/912
摘要： Methods for the manufacture of medicinal compositions are described. A method for the manufacture of a medicinal composition according to the invention comprises: (a) Providing a biocompatible polymer of the general formula —[O—R1—C(O)]n— wherein: “R1” is a linear, branched, or cyclic organic group, “n” is at least three, (b) Acylating the biocompatible polymer to provide an acylated biocompatible polymer and a mixed anhydride; (c) Reacting the mixed anhydride with a nucleophile to provide an acylated biocompatible polymer with a terminal carboxylic acid derivative capable of being chemically converted to an acid in the absence of water, (d) Converting the terminal carboxylic acid derivative to an acylated biocompatible polymer with a terminal carboxylic acid; and (e) Combining the acylated biocompatible polymer with a drug to provide the medicinal composition.
摘要翻译： 描述了药物组合物的制造方法。 制备根据本发明的药物组合物的方法包括：（a）提供具有通式的生物相容性聚合物 - [OR 1 -C 2 -C（O）] n 其中：“R 1”是直链，支链或环状有机基团，“n”为至少三个，（b）酰化生物相容性聚合物以提供酰化生物相容性聚合物和混合 酐; （c）用亲核试剂反应混合酸酐以提供酰化的生物相容性聚合物，其具有能够在不存在水的情况下化学转化为酸的末端羧酸衍生物; （d）将末端羧酸衍生物与末端羧酸转化成酰化生物相容性聚合物; 和（e）将酰化的生物相容性聚合物与药物组合以提供药物组合物。
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公开(公告)号：US06566575B1
公开(公告)日：2003-05-20
申请号：US09505046
申请日：2000-02-15
IPC分类号： A61F1300
CPC分类号： A61F13/023 , A61F2013/00748 , A61F2013/00782
摘要： An absorbent dressing comprising a hydrophilic gel absorbent layer having a patterned surface on at least one major surface thereof is provided. The patterned surface allows greater surface area for absorption of wound exudate when oriented toward the wound surface, while reducing the absorbent surface area in direct or indirect contact with the wound.
摘要翻译： 提供一种吸收性敷料，其包含在其至少一个主表面上具有图案化表面的亲水性凝胶吸收层。 图案化表面允许更大的表面积用于吸收伤口渗出物，当朝向伤口表面时，同时减少与伤口直接或间接接触的吸收表面积。
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3.发明申请LEAD INCLUDING COMPOSITE DEVICE FOR ELUTING A STEROID AND AN ANTIMICROBIAL 审中-公开引导包括用于施用杀菌剂和抗微生物剂的复合装置公开(公告)号：US20110125241A1
公开(公告)日：2011-05-26
申请号：US12625385
申请日：2009-11-24
CPC分类号： A61N1/0568 , A61N1/0575
摘要： A lead may include a lead body including a proximal end and a distal end, an electrode proximate to the distal end of the lead body, and a monolithic controlled release device located proximate to the electrode. According to this aspect of the disclosure, the monolithic controlled release device includes a polymer, a steroid mixed in the polymer, and an antimicrobial mixed in the polymer.
摘要翻译： 引线可以包括引线主体，其包括近端和远端，靠近引线主体的远端的电极以及位于电极附近的单片控制释放装置。 根据本公开的该方面，单片控释装置包括聚合物，混合在聚合物中的类固醇和在聚合物中混合的抗微生物剂。
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公开(公告)号：US20100203100A1
公开(公告)日：2010-08-12
申请号：US12698858
申请日：2010-02-02
申请人： Kenneth E. Cobian , Genevieve L. Gallagher , Peter M. Seiler , Kiem H. Dang , Michael S. Hemenway , Zhongping Yang , James L. Schuld , Tico Blumenthal
发明人： Kenneth E. Cobian , Genevieve L. Gallagher , Peter M. Seiler , Kiem H. Dang , Michael S. Hemenway , Zhongping Yang , James L. Schuld , Tico Blumenthal
IPC分类号： A61F2/00 , A61K31/65 , A61K31/7036 , A61K38/12 , A61K38/14 , A61P31/00 , A61L2/00 , A61L2/08 , A61L2/16 , B29C45/00 , B05D5/00 , B29C43/00 , A61B17/00
CPC分类号： A61L2/0082 , A61K31/496 , A61K31/65 , A61L2/24 , A61L27/34 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/208 , A61L2300/404 , A61L2300/406 , A61L2300/604 , A61L2300/608 , Y10T428/249953 , C08L89/06
摘要： An antimicrobial accessory may include a pressure sensitive adhesive and an antimicrobial mixed in the pressure sensitive adhesive. In some examples, an antimicrobial accessory may include at least one first domain comprising a pressure sensitive adhesive and a first antimicrobial and at least one second domain including a second polymer and a second antimicrobial. The antimicrobial accessory may be configured to be attached to a housing of an implantable medical device (IMD).
摘要翻译： 抗微生物附件可以包括压敏粘合剂和在压敏粘合剂中混合的抗微生物剂。 在一些实例中，抗微生物附件可以包括至少一个包含压敏粘合剂的第一结构域和包含第二聚合物和第二抗微生物剂的第一抗微生物剂和至少一个第二结构域。 抗微生物附件可以被配置为附接到可植入医疗装置（IMD）的壳体。
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公开(公告)号：US07597897B2
公开(公告)日：2009-10-06
申请号：US10596836
申请日：2004-12-10
CPC分类号： A61K9/008 , A61K9/08 , A61K9/10 , A61K9/1647 , A61K47/34 , A61K47/593 , C08G63/912
摘要： Methods for the manufacture of medicinal compositions are described. A method for the manufacture of a medicinal composition according to the invention comprises: (a) Providing a biocompatible polymer of the general formula —[O—R1—C(O)]n— wherein: “R1” is a linear, branched, or cyclic organic group, “n” is at least three, (b) Acylating the biocompatible polymer to provide an acylated biocompatible polymer and a mixed anhydride; (c) Reacting the mixed anhydride with a nucleophile to provide an acylated biocompatible polymer with a terminal carboxylic acid derivative capable of being chemically converted to an acid in the absence of water, (d) Converting the terminal carboxylic acid derivative to an acylated biocompatible polymer with a terminal carboxylic acid; and (e) Combining the acylated biocompatible polymer with a drug to provide the medicinal composition.
摘要翻译： 描述了药物组合物的制造方法。 制备根据本发明的药用组合物的方法包括：（a）提供通式为[O-R 1 -C（O）] n - 的生物相容性聚合物，其中：“R 1”为直链，支链， 或环状有机基团，“n”为至少三个，（b）酰化生物相容性聚合物以提供酰化生物相容性聚合物和混合酸酐; （c）用亲核试剂反应混合酸酐以提供酰化的生物相容性聚合物，其具有能够在不存在水的情况下化学转化为酸的末端羧酸衍生物; （d）将末端羧酸衍生物与末端羧酸转化成酰化生物相容性聚合物; 和（e）将酰化的生物相容性聚合物与药物组合以提供药物组合物。
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6.发明申请DROSPIRENONE CONTAINING TRANSDERMAL DRUG DELIVERY DEVICES AND METHODS OF DELIVERY THEREOF 审中-公开包含透皮药物递送装置的DROSPIRENONE及其递送方法公开(公告)号：US20090181075A1
公开(公告)日：2009-07-16
申请号：US11995767
申请日：2006-07-13
IPC分类号： A61K31/585 , A61K9/70
CPC分类号： A61K9/7061 , A61K9/0014 , A61K31/57 , A61K31/585 , A61K2300/00
摘要： A transdermal drug delivery device comprising an adhesive matrix, an effective amount of drospirenone, and an oligomeric adjuvant selected from an oligolactic acid, oligolactic acid derivatives, or mixtures thereof. Also, a transdermal drug delivery device comprising a backing film and an adhesive matrix which comprises an effective amount of drospirenone, a solubilizing agent, and a permeation enhancer selected from the group consisting of alkyl lactates, carboxylic acids, alkyl esters of fatty acids, and mixtures thereof.
摘要翻译： 一种透皮药物递送装置，其包含粘合剂基质，有效量的屈螺酮和选自低聚乳酸，低聚乳酸衍生物或其混合物的寡聚佐剂。 另外，包含背衬膜和粘合剂基质的透皮药物递送装置，其包含有效量的屈螺酮，增溶剂和渗透促进剂，其选自乳酸烷基酯，羧酸，脂肪酸的烷基酯和 其混合物。
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7.发明授权Method of making a viscoelastic article by coating and curing on a reusable surface 有权通过在可重复使用的表面上涂覆和固化制备粘弹性制品的方法公开(公告)号：US06960275B2
公开(公告)日：2005-11-01
申请号：US10121489
申请日：2002-04-12
申请人： George F. Vesley , Gary W. Maier , Peter M. Seiler
发明人： George F. Vesley , Gary W. Maier , Peter M. Seiler
IPC分类号： B29C41/24 , B29C35/08 , B29C39/00 , B29C41/26 , C09J7/00 , C09J157/00 , B65C5/00 , B29C39/14 , B29C43/22
CPC分类号： B29C39/003 , B29C35/0805 , B29C41/26 , B29K2105/0061 , C09J7/10 , C09J2433/00 , Y10T156/1036 , Y10T428/21 , Y10T428/31909
摘要： The present invention provides methods of manufacturing a viscoelastic article by a process that includes coating a release surface with a curable composition and then curing the composition to form the viscoelastic article. Viscoelastic articles manufactured according to the methods of the present may be constructed to be self-supporting.
摘要翻译： 本发明提供了一种通过包括用可固化组合物涂布释放表面然后固化该组合物以形成粘弹性体的方法制造粘弹性体的方法。 根据本发明的方法制造的粘弹性制品可以被构造为自支撑的。
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公开(公告)号：US20120165795A1
公开(公告)日：2012-06-28
申请号：US12979580
申请日：2010-12-28
CPC分类号： A61K9/0024 , A61K9/7084 , A61K31/496 , A61K31/65 , A61K2300/00
摘要： A therapeutic agent reservoir comprises a reservoir body comprising a polymer and a therapeutic agent mixed within the polymer, and an outer coating enclosing the reservoir body, wherein at least a portion of the outer coating comprises a rate-controlling membrane configured to provide a predetermined release rate of the therapeutic agent through the rate-controlling membrane.
摘要翻译： 治疗剂贮存器包括储存器本体，其包含聚合物和混合在聚合物内的治疗剂，以及封闭储存器主体的外涂层，其中外涂层的至少一部分包括速率控制膜，其配置成提供预定释放 治疗剂通过速率控制膜的速率。
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9.发明申请COMPOSITE ANTIMICROBIAL ACCESSORY INCLUDING A MEMBRANE LAYER AND A POROUS LAYER 审中-公开包含膜层和多孔层的复合抗微生物附件公开(公告)号：US20100198278A1
公开(公告)日：2010-08-05
申请号：US12698866
申请日：2010-02-02
申请人： Kenneth E. Cobian , Genevieve L. Gallagher , James L. Schuld , Michael B. Shelton , Peter M. Seiler , Michael S. Hemenway
发明人： Kenneth E. Cobian , Genevieve L. Gallagher , James L. Schuld , Michael B. Shelton , Peter M. Seiler , Michael S. Hemenway
CPC分类号： A61L2/0082 , A61K31/496 , A61K31/65 , A61L2/24 , A61L27/34 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/208 , A61L2300/404 , A61L2300/406 , A61L2300/604 , A61L2300/608 , Y10T428/249953 , C08L89/06
摘要： An antimicrobial accessory may include a membrane layer defining a major surface comprising a first lateral portion, a second lateral portion, and a third lateral portion. The membrane layer may comprise a first biodegradable polymer. The antimicrobial accessory may further include a first porous layer overlying the first lateral portion and a second porous layer overlying the second lateral portion. The first porous layer comprises a second biodegradable polymer and a first antimicrobial, while the second porous layer comprises a third biodegradable polymer and a second antimicrobial.
摘要翻译： 抗微生物附件可以包括限定主表面的膜层，其包括第一侧部，第二侧部和第三侧部。 膜层可以包括第一可生物降解的聚合物。 抗微生物附件还可以包括覆盖第一侧面部分的第一多孔层和覆盖第二侧面部分的第二多孔层。 第一多孔层包括第二生物可降解聚合物和第一抗微生物剂，而第二多孔层包含第三生物可降解聚合物和第二抗微生物剂。
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公开(公告)号：US08911427B2
公开(公告)日：2014-12-16
申请号：US12979580
申请日：2010-12-28
IPC分类号： A61K9/22 , A61K9/00 , A61K31/496 , A61K31/65 , A61K9/70
CPC分类号： A61K9/0024 , A61K9/7084 , A61K31/496 , A61K31/65 , A61K2300/00
摘要： A therapeutic agent reservoir comprises a reservoir body comprising a polymer and a therapeutic agent mixed within the polymer, and an outer coating enclosing the reservoir body, wherein at least a portion of the outer coating comprises a rate-controlling membrane configured to provide a predetermined release rate of the therapeutic agent through the rate-controlling membrane.
摘要翻译： 治疗剂贮存器包括储存器本体，其包含聚合物和混合在聚合物内的治疗剂，以及封闭储存器主体的外涂层，其中外涂层的至少一部分包括速率控制膜，其配置成提供预定释放 治疗剂通过速率控制膜的速率。
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