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1.发明申请Compositions comprising viruses and methods for concentrating virus preparations 审中-公开包含病毒的组合物和用于浓缩病毒制剂的方法公开(公告)号：US20090098632A1
公开(公告)日：2009-04-16
申请号：US12080653
申请日：2008-04-04
Applicant: Andreas Frei , Henry K.H. Kwan , Varda E. Sandweiss , Gary J. Vellekamp , Pui-Ho Yuen , Laureano L. Bondoc, JR. , Frederick William Porter, IV , John Chu-Tay Tang , Peter Ihnat
Inventor： Andreas Frei , Henry K.H. Kwan , Varda E. Sandweiss , Gary J. Vellekamp , Pui-Ho Yuen , Laureano L. Bondoc, JR. , Frederick William Porter, IV , John Chu-Tay Tang , Peter Ihnat
IPC: C12N7/00
CPC classification number: C12N7/00 , A61K39/12 , A61K39/235 , A61K48/0091 , C12N15/86 , C12N2710/10334 , C12N2710/10343 , C12N2710/10351 , Y10S514/937
Abstract: A composition is disclosed comprising virus in a formulation comprising a polyhydroxy hydrocarbon buffered to maintain a pH in a range from about 7 to about 8.5 at a temperature in the range from about 2° C. to 27° C. Methods for concentrating and purifying virus preparations are also disclosed.
Abstract translation: 公开了一种组合物，其包含缓冲的多羟基烃的制剂中的病毒，以在约2℃至27℃的温度范围内将pH保持在约7至约8.5的范围内。浓缩和纯化病毒的方法 准备工作也被披露。
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2.发明申请Compositions comprising viruses and methods for concentrating virus preparations 审中-公开包含病毒的组合物和用于浓缩病毒制剂的方法公开(公告)号：US20080194002A1
公开(公告)日：2008-08-14
申请号：US12082853
申请日：2008-04-14
Applicant: Andreas Frei , Henry K.H. Kwan , Varda E. Sandweiss , Gary J. Vellekamp , Pui-Ho Yuen , Laureano L. Bondoc , Frederick William Porter , John Chu-Tay Tang , Peter Ihnat
Inventor： Andreas Frei , Henry K.H. Kwan , Varda E. Sandweiss , Gary J. Vellekamp , Pui-Ho Yuen , Laureano L. Bondoc , Frederick William Porter , John Chu-Tay Tang , Peter Ihnat
IPC: C12N7/02
CPC classification number: C12N7/00 , A61K39/12 , A61K39/235 , A61K48/0091 , C12N15/86 , C12N2710/10334 , C12N2710/10343 , C12N2710/10351 , Y10S514/937
Abstract: A composition is disclosed comprising virus in a formulation comprising a polyhydroxy hydrocarbon buffered to maintain a pH in a range from about 7 to about 8.5 at a temperature in the range from about 2° C. to 27° C. Methods for concentrating and purifying virus preparations are also disclosed.
Abstract translation: 公开了一种组合物，其包含缓冲的多羟基烃的制剂中的病毒，以在约2℃至27℃的温度范围内将pH保持在约7至约8.5的范围内。浓缩和纯化病毒的方法 准备工作也被披露。
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3.发明申请公开(公告)号：US20060122163A1
公开(公告)日：2006-06-08
申请号：US11332721
申请日：2006-01-13
Applicant: Sydney Ugwu , Vinay Radhakrishnan , Peter Ihnat , Leonore Witchey-Lakshmanan
Inventor： Sydney Ugwu , Vinay Radhakrishnan , Peter Ihnat , Leonore Witchey-Lakshmanan
IPC: A61K31/4188 , A61K31/4172 , A61K31/198
CPC classification number: A61K31/495 , A61K9/0019 , A61K9/19 , A61K31/395 , A61K31/522 , A61K31/66 , A61K31/704 , A61K47/02 , A61K47/12 , A61K47/18 , A61K47/183 , A61K47/22 , A61K47/26
Abstract: In its several embodiments, this invention discloses a pharmaceutical formulation comprising at least one antineoplastic agent or a pharmaceutically acceptable salt thereof, and at least one dissolution enhancing agent sufficient to substantially dissolve said at least one antineoplastic agent in at least one aqueous diluent, wherein said dissolution enhancing agent is urea, L-histidine, L-threonine, L-asparagine, L-serine, L-glutamine or mixtures thereof; a lyophilized powder comprising said pharmaceutical formulation, and articles of manufacture thereof.
Abstract translation: 在其几个实施方案中，本发明公开了一种药物制剂，其包含至少一种抗肿瘤剂或其药学上可接受的盐，以及至少一种溶解增强剂，其足以在至少一种含水稀释剂中基本上溶解所述至少一种抗肿瘤剂，其中所述 溶解促进剂是尿素，L-组氨酸，L-苏氨酸，L-天冬酰胺，L-丝氨酸，L-谷氨酰胺或其混合物; 包含所述药物制剂的冻干粉末及其制品。
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公开(公告)号：US20060018930A1
公开(公告)日：2006-01-26
申请号：US11053181
申请日：2005-02-07
Applicant: Andreas Frei , Henry Kwan , Varda Sandweiss , Gary Vellekamp , Pui-Ho Yuen , Laureano Bondoc , Frederick Porter , John Tang , Peter Ihnat
Inventor： Andreas Frei , Henry Kwan , Varda Sandweiss , Gary Vellekamp , Pui-Ho Yuen , Laureano Bondoc , Frederick Porter , John Tang , Peter Ihnat
IPC: A61K39/23 , C12N7/00 , A61K31/7012
CPC classification number: C12N7/00 , A61K39/12 , A61K39/235 , A61K48/0091 , C12N15/86 , C12N2710/10334 , C12N2710/10343 , C12N2710/10351 , Y10S514/937
Abstract: A composition is disclosed comprising virus in a formulation comprising a polyhydroxy hydrocarbon buffered to maintain a pH in a range from about 7 to about 8.5 at a temperature in the range from about 2° C. to 27° C. Methods for concentrating and purifying virus preparations are also disclosed.
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5.发明申请COMPOSITIONS COMPRISING VIRUSES AND METHODS FOR CONCENTRATING VIRUS PREPARATIONS 审中-公开包含病毒的组合物和用于浓缩病毒制备的方法公开(公告)号：US20080293123A1
公开(公告)日：2008-11-27
申请号：US12188067
申请日：2008-08-07
Applicant: Andreas Frei , Henry K.H. Kwan , Varda E. Sandweiss , Gary J. Vellekamp , Pui-Ho Yuen , Laureano L. Bondoc, JR. , Frederick William Porter, IV , John Chu-Tay Tang , Peter Ihnat
Inventor： Andreas Frei , Henry K.H. Kwan , Varda E. Sandweiss , Gary J. Vellekamp , Pui-Ho Yuen , Laureano L. Bondoc, JR. , Frederick William Porter, IV , John Chu-Tay Tang , Peter Ihnat
IPC: C12N7/02
CPC classification number: C12N7/00 , A61K39/12 , A61K39/235 , A61K48/0091 , C12N15/86 , C12N2710/10334 , C12N2710/10343 , C12N2710/10351 , Y10S514/937
Abstract: A composition is disclosed comprising virus in a formulation comprising a polyhydroxy hydrocarbon buffered to maintain a pH in a range from about 7 to about 8.5 at a temperature in the range from about 2° C. to 27° C. Methods for concentrating and purifying virus preparations are also disclosed.
Abstract translation: 公开了一种组合物，其包含缓冲的多羟基烃的制剂中的病毒，以在约2℃至27℃的温度范围内将pH保持在约7至约8.5的范围内。浓缩和纯化病毒的方法 准备工作也被披露。
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Patent Agency Ranking
6.发明授权Compostions comprising viruses and methods for concentrating virus preparations 有权包含病毒的组合物和用于浓缩病毒制剂的方法公开(公告)号：US06544769B1
公开(公告)日：2003-04-08
申请号：US09249646
申请日：1999-02-12
Applicant: Andreas Frei , Henry K. H. Kwan , Varda E. Sandweiss , Gary J. Vellekamp , Pui-Ho Yuen , Peter Ihnat
Inventor： Andreas Frei , Henry K. H. Kwan , Varda E. Sandweiss , Gary J. Vellekamp , Pui-Ho Yuen , Peter Ihnat
IPC: C12N700
CPC classification number: C12N7/00 , A61K39/12 , A61K39/235 , A61K48/0091 , C12N15/86 , C12N2710/10334 , C12N2710/10343 , C12N2710/10351 , Y10S514/937
Abstract: A composition is disclosed comprising virus in a formulation comprising a polyhydroxy hydrocarbon buffered to maintain a pH in a range from about 7 to about 8.5 at a temperature in the range from about 2° C. to 27° C. Methods for concentrating and purifying virus preparations are also disclosed.
Abstract translation: 公开了一种组合物，其包含缓冲的多羟基烃的制剂中的病毒，以在约2℃至27℃的温度范围内将pH保持在约7至约8.5的范围内。浓缩和纯化病毒的方法 准备工作也被披露。
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公开(公告)号：US20080085545A1
公开(公告)日：2008-04-10
申请号：US11977732
申请日：2007-10-24
Applicant: Andreas Frei , Henry Kwan , Varda Sandweiss , Gary Vellekamp , Pui-Ho Yuen , Laureano Bondoc , Fredrick Porter , John Tang , Peter Ihnat
Inventor： Andreas Frei , Henry Kwan , Varda Sandweiss , Gary Vellekamp , Pui-Ho Yuen , Laureano Bondoc , Fredrick Porter , John Tang , Peter Ihnat
IPC: C12N7/02
CPC classification number: C12N7/00 , A61K39/12 , A61K39/235 , A61K48/0091 , C12N15/86 , C12N2710/10334 , C12N2710/10343 , C12N2710/10351 , Y10S514/937
Abstract: A composition is disclosed comprising virus in a formulation comprising a polyhydroxy hydrocarbon buffered to maintain a pH in a range from about 7 to about 8.5 at a temperature in the range from about 2° C. to 27° C. Methods for concentrating and purifying virus preparations are also disclosed.
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8.发明申请Compositions comprising viruses and methods for concentrating virus preparations 审中-公开包含病毒的组合物和用于浓缩病毒制剂的方法公开(公告)号：US20050260168A1
公开(公告)日：2005-11-24
申请号：US11116944
申请日：2005-04-27
Applicant: Andreas Frei , Henry Kwan , Varda Sandweiss , Gary Vellekamp , Pui-Ho Yuen , Laureano Bondoc , Frederick Porter , John Tang , Peter Ihnat
Inventor： Andreas Frei , Henry Kwan , Varda Sandweiss , Gary Vellekamp , Pui-Ho Yuen , Laureano Bondoc , Frederick Porter , John Tang , Peter Ihnat
IPC: A61K39/235 , A61K48/00 , C12N7/02 , C12N15/861 , C12Q1/68
CPC classification number: C12N7/00 , A61K39/12 , A61K39/235 , A61K48/0091 , C12N15/86 , C12N2710/10334 , C12N2710/10343 , C12N2710/10351 , Y10S514/937
Abstract: A composition is disclosed comprising virus in a formulation comprising a polyhydroxy hydrocarbon buffered to maintain a pH in a range from about 7 to about 8.5 at a temperature in the range from about 2° C. to 27° C. Methods for concentrating and purifying virus preparations are also disclosed.
Abstract translation: 公开了一种组合物，其包含缓冲的多羟基烃的制剂中的病毒，以在约2℃至27℃的温度范围内将pH保持在约7至约8.5的范围内。浓缩和纯化病毒的方法 准备工作也被披露。
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9.发明申请COMPOSITIONS COMPRISING VIRUSES AND METHODS FOR CONCENTRATING VIRUS PREPARATIONS 审中-公开包含病毒的组合物和用于浓缩病毒制备的方法公开(公告)号：US20120093777A1
公开(公告)日：2012-04-19
申请号：US13334403
申请日：2011-12-22
Applicant: Andreas Frei , Henry K.H. Kwan , Varda E. Sandweiss , Gary J. Vellekamp , Pui-Ho Yuen , Laureano L. Bondoc, JR. , Frederick William Porter, IV , John Chu-Tay Tang , Peter Ihnat
Inventor： Andreas Frei , Henry K.H. Kwan , Varda E. Sandweiss , Gary J. Vellekamp , Pui-Ho Yuen , Laureano L. Bondoc, JR. , Frederick William Porter, IV , John Chu-Tay Tang , Peter Ihnat
IPC: A61K35/76
CPC classification number: C12N7/00 , A61K39/12 , A61K39/235 , A61K48/0091 , C12N15/86 , C12N2710/10334 , C12N2710/10343 , C12N2710/10351 , Y10S514/937
Abstract: A composition is disclosed comprising virus in a formulation comprising a polyhydroxy hydrocarbon buffered to maintain a pH in a range from about 7 to about 8.5 at a temperature in the range from about 2° C. to 27° C. Methods for concentrating and purifying virus preparations are also disclosed.
Abstract translation: 公开了一种组合物，其包含缓冲的多羟基烃的制剂中的病毒，以在约2℃至27℃的温度范围内将pH保持在约7至约8.5的范围内。浓缩和纯化病毒的方法 准备工作也被披露。
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公开(公告)号：US20080261289A1
公开(公告)日：2008-10-23
申请号：US12147391
申请日：2008-06-26
Applicant: Andreas Frei , Henry K.H. Kwan , Varda E. Sandweiss , Gary J. Vellkamp , Pui-Ho Yuen , Laureano L. Bondoc , Frederick William Porter , John Chu-Tay Tang , Peter Ihnat
Inventor： Andreas Frei , Henry K.H. Kwan , Varda E. Sandweiss , Gary J. Vellkamp , Pui-Ho Yuen , Laureano L. Bondoc , Frederick William Porter , John Chu-Tay Tang , Peter Ihnat
IPC: C12N7/00
CPC classification number: C12N15/86 , C12N7/00 , C12N2710/10343 , C12N2710/10351
Abstract: A composition is disclosed comprising virus in a formulation comprising a polyhydroxy hydrocarbon buffered to maintain a pH in a range from about 7 to about 8.5 at a temperature in the range from about 2° C. to 27° C. Methods for concentrating and purifying virus preparations are also disclosed.
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