公开(公告)号：US08618286B2

公开(公告)日：2013-12-31

申请号：US13360029

申请日：2012-01-27

Applicant: Jailall Ramnauth ,  Subhash C. Annedi ,  Sarah Silverman ,  Peter Dove ,  Shawn Maddaford ,  Suman Rakhit

Inventor： Jailall Ramnauth ,  Subhash C. Annedi ,  Sarah Silverman ,  Peter Dove ,  Shawn Maddaford ,  Suman Rakhit

IPC: C07D279/16

CPC classification number: C07D417/14 ,  A61K31/538 ,  A61K31/5415 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  Y02A50/475

Abstract: The present invention features benzoxazines, benzothiazines, and related compounds that inhibit nitric oxide synthase (NOS), particularly those that selectively inhibit neuronal nitric oxide synthase (nNOS) in preference to other NOS isoforms. Exemplary compounds are of the formula: The NOS inhibitors of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing various medical conditions.

Abstract translation: 本发明具有抑制一氧化氮合酶（NOS）的苯并恶嗪，苯并噻嗪和相关化合物，特别是选择性地抑制神经元一氧化氮合酶（nNOS）优先于其它NOS同种型的化合物。 示例性化合物具有下式：本发明的NOS抑制剂单独或与其它药物活性剂组合可用于治疗或预防各种医学病症。

公开(公告)号：US20090111857A1

公开(公告)日：2009-04-30

申请号：US12258119

申请日：2008-10-24

Applicant: Peter DOVE ,  Kenneth Granberg ,  Methvin Isaac ,  Mats Nagard ,  Abdelmalik Slassi

Inventor： Peter DOVE ,  Kenneth Granberg ,  Methvin Isaac ,  Mats Nagard ,  Abdelmalik Slassi

IPC: A61K31/4439 ,  C07D257/04 ,  A61K31/41 ,  A61K31/4196 ,  A61K31/4245 ,  A61P1/00 ,  A61P29/00 ,  A61P25/00 ,  C07D271/06 ,  C07D249/08 ,  C07D401/02

CPC classification number: C07D257/04 ,  C07D249/12 ,  C07D261/08 ,  C07D401/14 ,  C07D403/12 ,  C07D413/12

Abstract: The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.

Abstract translation: 本发明涉及新化合物，其制备方法，其在治疗中的应用和包含新化合物的药物组合物。

公开(公告)号：US20080312240A1

公开(公告)日：2008-12-18

申请号：US11997541

申请日：2006-08-04

Applicant: Louise Edwards ,  Methvin Isaac ,  Abdelmalik Slassi ,  Guang-Ri Sun ,  Tao Xin ,  Alexander Minidis ,  Peter Dove

Inventor： Louise Edwards ,  Methvin Isaac ,  Abdelmalik Slassi ,  Guang-Ri Sun ,  Tao Xin ,  Alexander Minidis ,  Peter Dove

IPC: A61K31/4985 ,  C07D401/14 ,  C07D403/14 ,  A61P25/00 ,  A61P1/00 ,  C07D413/14 ,  C07D471/04

CPC classification number: C07D487/04 ,  C07D471/04

Abstract: The invention relates to compounds of formula I or pharmaceutically acceptable salts or solvates thereof: where Ar1, A, Hy, R1, m and n are as defined in the description. The invention also includes pharmaceutical compositions and uses of, and processes of making the compounds, as well as methods of medical treatment of mGluR5-mediated disorders.

Abstract translation: 本发明涉及式I化合物或其药学上可接受的盐或溶剂化物：其中Ar1，A，Hy，R1，m和n如说明书中所定义。 本发明还包括药物组合物及其制备方法及其制备方法以及治疗mGluR5介导的病症的方法。

公开(公告)号：US20080194571A1

公开(公告)日：2008-08-14

申请号：US11997523

申请日：2006-08-04

Applicant: Louise Edwards ,  Mithvin Isaac ,  Abdelmalik Slassi ,  Guang-Ri Sun ,  Peter Dove ,  Erwan Arzel

Inventor： Louise Edwards ,  Mithvin Isaac ,  Abdelmalik Slassi ,  Guang-Ri Sun ,  Peter Dove ,  Erwan Arzel

IPC: A61K31/4985 ,  C07D487/04 ,  A61P25/00

CPC classification number: C07D471/04 ,  C07D487/04

Abstract: The invention relates to compounds of formula I or pharmaceutically acceptable salts or solvates thereof: where Ar1, A, B, R1, m and n are as defined in the description. The invention also includes pharmaceutical compositions and uses of, and processes of making the compounds, as well as methods of medical treatment of mGluR 5 mediated disorders.

Abstract translation: 本发明涉及式I化合物或其药学上可接受的盐或溶剂化物：其中Ar 1，A，B，R 1，m和n如说明书中所定义 。 本发明还包括药物组合物及其制备方法及其制备方法以及治疗mGluR5介导的病症的方法。

公开(公告)号：US20070259895A1

公开(公告)日：2007-11-08

申请号：US11790424

申请日：2007-04-25

Applicant: Methvin Isaac ,  Abdelmalik Slassi ,  Louise Edwards ,  Tao Xin ,  Tomislav Stefanac ,  Peter Dove ,  Mats Nagard

Inventor： Methvin Isaac ,  Abdelmalik Slassi ,  Louise Edwards ,  Tao Xin ,  Tomislav Stefanac ,  Peter Dove ,  Mats Nagard

IPC: A61K31/519 ,  C07D487/04

CPC classification number: C07D487/04

Abstract: The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.

Abstract translation: 本发明涉及新化合物，其制备方法，其在治疗中的应用和包含新化合物的药物组合物。

公开(公告)号：US20070259860A1

公开(公告)日：2007-11-08

申请号：US11790429

申请日：2007-04-25

Applicant: Andreas Wallberg ,  Karolina Nilsson ,  Kenneth Granberg ,  Saswati Ghosal ,  Abdelmalik Slassi ,  Louise Edwards ,  Methvin Isaac ,  Tao Xin ,  Tomislav Stefanac ,  Peter Dove

Inventor： Andreas Wallberg ,  Karolina Nilsson ,  Kenneth Granberg ,  Saswati Ghosal ,  Abdelmalik Slassi ,  Louise Edwards ,  Methvin Isaac ,  Tao Xin ,  Tomislav Stefanac ,  Peter Dove

IPC: A61K31/5513 ,  A61K31/519 ,  C07D487/04

CPC classification number: C07D487/04

Abstract: The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.

Abstract translation: 本发明涉及新化合物，其制备方法，其在治疗中的应用和包含新化合物的药物组合物。

公开(公告)号：US6122847A

公开(公告)日：2000-09-26

申请号：US190810

申请日：1998-11-12

Applicant: Johannes J. Treu ,  Gordon R. Wilde ,  Peter Dove

Inventor： Johannes J. Treu ,  Gordon R. Wilde ,  Peter Dove

IPC: B63B21/22 ,  B63B21/26 ,  E02D5/74 ,  E02D11/00 ,  E02D7/00

CPC classification number: B63B21/22 ,  B63B21/27 ,  E02D5/74 ,  B63B2021/007 ,  B63B2021/262 ,  E02D11/00 ,  E02D2250/0053

Abstract: In a method of and apparatus for anchor installation, a plate anchor is mounted at the bottom of a suction follower comprising a hollow cylinder having an open lower insertion end and a closable upper suspension end. The suction follower and the anchor secured thereto are engaged with the sea floor, whereupon water is pumped out of the suction follower causing the suction follower and the anchor to penetrate into the sea floor to a predetermined depth. The anchor is then disengaged from the suction follower, whereupon water is pumped into the suction follower to disengage the suction follower from the sea floor for recovery to the surface, leaving the anchor embedded in the sea floor. The plate anchor may comprise first and second plate members, the second plate member pivoting relative to the first plate member to prevent upward movement of the anchor.

Abstract translation: 在一种用于锚固装置的方法和装置中，板锚固件安装在抽吸从动件的底部，该抽吸随动件包括具有敞开的下部插入端和可封闭的上部悬挂端的中空圆柱体。 吸引跟随器和固定在其上的锚固件与海底接合，于是将水从抽吸从动件抽出，使得抽吸从动件和锚固件穿透到海底至预定的深度。 然后将锚从吸引从动件脱离，于是将水泵入抽吸从动件以将吸引从动件与海底脱离，以便回收到表面，使锚固体嵌入海底。 板锚可以包括第一和第二板构件，第二板构件相对于第一板构件枢转以防止锚的向上运动。

公开(公告)号：US20070049578A1

公开(公告)日：2007-03-01

申请号：US11503182

申请日：2006-08-14

Applicant: Louise Edwards ,  Methvin Isaac ,  Abdelmalik Slassi ,  Tao Xin ,  Peter Dove

Inventor： Louise Edwards ,  Methvin Isaac ,  Abdelmalik Slassi ,  Tao Xin ,  Peter Dove

IPC: A61K31/551 ,  A61K31/497 ,  A61K31/496 ,  C07D403/02

CPC classification number: C07D403/04 ,  C07D213/74 ,  C07D213/85 ,  C07D241/04 ,  C07D241/26 ,  C07D295/205 ,  C07D403/14 ,  C07D409/12 ,  C07F5/025

Abstract: The invention relates to compounds of formula I or pharmaceutically acceptable salts or solvates thereof: where R1, R2, R3, A, X, and n are defined in the description. The invention also includes pharmaceutical compositions and uses of, and processes of making the compounds, as well as methods of medical treatment of mGluR 5 mediated disorders.

Abstract translation: 本发明涉及式I化合物或其药学上可接受的盐或溶剂合物：其中R 1，R 2，R 3，A，X ，n在说明书中定义。 本发明还包括药物组合物及其制备方法及其制备方法以及治疗mGluR5介导的病症的方法。

公开(公告)号：US20070037816A1

公开(公告)日：2007-02-15

申请号：US11498770

申请日：2006-08-04

Applicant: Louise Edwards ,  Methvin Isaac ,  Abdelmalik Slassi ,  Guang-Ri Sun ,  Tao Xin ,  Alexander Minidis ,  Peter Dove

Inventor： Louise Edwards ,  Methvin Isaac ,  Abdelmalik Slassi ,  Guang-Ri Sun ,  Tao Xin ,  Alexander Minidis ,  Peter Dove

IPC: A61K31/498 ,  C07D487/04

CPC classification number: C07D487/04 ,  C07D471/04

Abstract: The invention relates to compounds of formula I or pharmaceutically acceptable salts or solvates thereof: where Ar1, A, Hy, R1, m and n are as defined in the description. The invention also includes pharmaceutical compositions and uses of, and processes of making the compounds, as well as methods of medical treatment of mGluR5-mediated disorders.

Abstract translation: 本发明涉及式I化合物或其药学上可接受的盐或溶剂合物：其中Ar 1，A，Hy，R 1，m和n如说明书中所定义 。 本发明还包括药物组合物及其制备方法及其制备方法以及治疗mGluR5介导的病症的方法。

公开(公告)号：US20060060126A1

公开(公告)日：2006-03-23

申请号：US11273416

申请日：2005-11-14

Applicant: Peter Dove ,  Johannes Treu

Inventor： Peter Dove ,  Johannes Treu

IPC: B63B21/50

CPC classification number: B63B21/20 ,  B63B21/04 ,  B63B21/50 ,  B63B2021/505

Abstract: In a method of and apparatus for offshore mooring, a clamping apparatus includes a clamping mechanism and a pulley. A mooring line connected to an anchor or a pendant line connected to a vessel to be moored extends through the clamping mechanism and around the pulley of the clamping apparatus. The distal end of the line extending through the clamping apparatus is connected to an anchor handling vessel. The anchor handling vessel is employed to apply a predetermined tension to the pendant line and the preset mooring line. A remote operated vehicle is then employed to actuate the clamping apparatus and to disengage the anchor handling vessel.