专利检索 ap:"Pedro Nuno Leal Palma" 第 1 页

1.

发明申请
ADMINISTRATION REGIME FOR NITROCATECHOLS 审中-公开
标题翻译： NITROCATECHOLS行政管理制度

公开(公告)号：US20140045900A1

公开(公告)日：2014-02-13

申请号：US13583375

申请日：2011-10-12

申请人： Patricio Manuel Vieira Araujo Soares Da Silva , Teresa Lucia Silva Pereira Nunes , Lyndon Christopher Wright , Pedro Nuno Leal Palma , David Alexander Learmonth

发明人： Patricio Manuel Vieira Araujo Soares Da Silva , Teresa Lucia Silva Pereira Nunes , Lyndon Christopher Wright , Pedro Nuno Leal Palma , David Alexander Learmonth

IPC分类号： A61K31/4439 , A61K45/06 , A61K31/198

CPC分类号： C07D413/12 , A61K31/165 , A61K31/198 , A61K31/4439 , A61K45/06 , A61K2300/00

摘要： A compound of formula (I) where R1, R2, X, Y, n, m, R3, R4, R5, R6 and R7 are as defined herein, for use in the prophylaxis or treatment of a central and peripheral nervous system disorder, wherein the compound of formula (I) is administered prior to sleep, before bedtime or at bedtime.

摘要翻译： 其中R 1，R 2，X，Y，n，m，R 3，R 4，R 5，R 6和R 7如本文所定义的式（I）化合物用于预防或治疗中枢和周围神经系统疾病，其中式（I）化合物在睡前，睡前或睡前给药。

2.

发明申请
Pharmaceutical Compounds 有权
标题翻译：药物化合物

公开(公告)号：US20100168113A1

公开(公告)日：2010-07-01

申请号：US12226260

申请日：2007-04-10

申请人： David Alexander Learmonth , Laszlo Erno Kiss , Pedro Nuno Leal Palma , Humberto Dos Santos Ferreira , Patricio Manuel Vieira Soares da Silva

发明人： David Alexander Learmonth , Laszlo Erno Kiss , Pedro Nuno Leal Palma , Humberto Dos Santos Ferreira , Patricio Manuel Vieira Soares da Silva

IPC分类号： A61K31/53 , C07D413/04 , A61K31/4439 , A61P25/16 , A61P25/14 , A61P9/12 , A61P1/00 , A61K31/506 , C07D403/02

CPC分类号： A61K31/198 , A61K31/4439 , C07D213/26 , C07D213/57 , C07D213/82 , C07D401/04 , C07D407/04 , C07D413/04 , C07D417/04 , A61K2300/00

摘要： This invention relates to novel substituted nitrocatechol derivatives, their use in the treatment of some central and peripheral nervous system disorders and pharmaceutical compositions containing them.

摘要翻译： 本发明涉及新的取代的硝基儿茶酚衍生物，它们在治疗一些中枢和周围神经系统病症中的用途以及含有它们的药物组合物。

3.

发明申请
Nitrocatechol Derivatives as Comt Inhibitors 有权
标题翻译：硝酸酯衍生物作为抑制剂

公开(公告)号：US20090054437A1

公开(公告)日：2009-02-26

申请号：US11989447

申请日：2006-07-26

申请人： David Alexander Learmonth , Laszlo Erno Kiss , Pedro Nuno Leal Palma , Humberto Dos Santos Ferreira , Patricio Manuel Vieira Araujo Soares da Silva

发明人： David Alexander Learmonth , Laszlo Erno Kiss , Pedro Nuno Leal Palma , Humberto Dos Santos Ferreira , Patricio Manuel Vieira Araujo Soares da Silva

IPC分类号： A61K31/5377 , C07D413/04 , A61K31/443 , A61P25/16 , A61P25/14 , A61P1/00

CPC分类号： C07D413/14 , A61K31/4412 , C07D213/89 , C07D215/60 , C07D271/06 , C07D271/107 , C07D401/04 , C07D405/04 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04

摘要： New compounds of formula I are described. The compounds have potentially valuable pharmaceutical properties in the treatment of some central and peripheral nervous system disorders.

摘要翻译： 描述了新的式I化合物。这些化合物在治疗一些中枢和周围神经系统疾病中具有潜在的有价值的药物性质。

4.

发明授权
Nitrocatechol derivatives as COMT inhibitors 有权
标题翻译：硝基邻苯二酚衍生物作为COMT抑制剂

公开(公告)号：US08168793B2

公开(公告)日：2012-05-01

申请号：US11989447

申请日：2006-07-26

申请人： David Alexander Learmonth , Laszlo Erno Kiss , Pedro Nuno Leal Palma , Humberto Dos Santos Ferreira , Patricio Manuel Vieira Araújo Soares da Silva

发明人： David Alexander Learmonth , Laszlo Erno Kiss , Pedro Nuno Leal Palma , Humberto Dos Santos Ferreira , Patricio Manuel Vieira Araújo Soares da Silva

IPC分类号： C07D413/04 , A61K31/443

CPC分类号： C07D413/14 , A61K31/4412 , C07D213/89 , C07D215/60 , C07D271/06 , C07D271/107 , C07D401/04 , C07D405/04 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04

摘要： New compounds of formula I are described. The compounds have potentially valuable pharmaceutical properties in the treatment of some central and peripheral nervous system disorders.

摘要翻译： 描述了新的式I化合物。这些化合物在治疗一些中枢和周围神经系统疾病中具有潜在的有价值的药物性质。

5.

发明授权
Pharmaceutical compounds 有权
标题翻译：药物化合物

公开(公告)号：US08536203B2

公开(公告)日：2013-09-17

申请号：US12226260

申请日：2007-04-10

申请人： David Alexander Learmonth , Laszlo Erno Kiss , Pedro Nuno Leal Palma , Humberto Dos Santos Ferreira , Patricio Manuel Vieira Araujo Soares da Silva

发明人： David Alexander Learmonth , Laszlo Erno Kiss , Pedro Nuno Leal Palma , Humberto Dos Santos Ferreira , Patricio Manuel Vieira Araujo Soares da Silva

IPC分类号： A61K31/44 , C07D413/04

CPC分类号： A61K31/198 , A61K31/4439 , C07D213/26 , C07D213/57 , C07D213/82 , C07D401/04 , C07D407/04 , C07D413/04 , C07D417/04 , A61K2300/00

摘要： This invention relates to novel substituted nitrocatechol derivatives, their use in the treatment of some central and peripheral nervous system disorders and pharmaceutical compositions containing them.

摘要翻译： 本发明涉及新的取代的硝基儿茶酚衍生物，它们用于治疗一些中枢和周围神经系统障碍以及含有它们的药物组合物。

6.

发明申请
PHARMACEUTICAL COMPOUNDS 有权
标题翻译：药物化合物

公开(公告)号：US20120065191A1

公开(公告)日：2012-03-15

申请号：US13141205

申请日：2009-12-23

申请人： Laszlo Erno Kiss , David Alexander Learmonth , Carla Patrícia da Costa Pereira Rosa , Rita Gusmão de Noronha , Pedro Nuno Leal Palma , Patrício Manuel Vieira Araújo Soares da Silva , Alexander Beliaev

发明人： Laszlo Erno Kiss , David Alexander Learmonth , Carla Patrícia da Costa Pereira Rosa , Rita Gusmão de Noronha , Pedro Nuno Leal Palma , Patrício Manuel Vieira Araújo Soares da Silva , Alexander Beliaev

IPC分类号： A61K31/55 , A61K31/5377 , C07D233/14 , A61K31/4164 , C07D249/10 , A61K31/4196 , C07D231/14 , A61K31/415 , A61P29/00 , A61P25/14 , A61P25/16 , A61P3/00 , C07D413/14 , C07D401/04 , A61K31/4439 , A61K31/496 , C07D403/06 , A61P43/00 , A61P3/04 , A61P25/00 , C07D491/113 , A61P25/28 , A61P25/08 , A61P25/04 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/20 , A61P1/08 , A61P25/30 , A61P25/32 , A61P25/36 , A61P25/34 , A61P9/12 , A61P9/10 , A61P11/06 , A61P27/06 , A61P27/02 , A61P1/00 , A61P1/16 , A61P35/00 , A61P19/02 , C07D413/06

CPC分类号： C07D401/12 , C07D231/12 , C07D233/56 , C07D233/60 , C07D249/10 , C07D249/18 , C07D401/04 , C07D401/10 , C07D401/14 , C07D405/10 , C07D405/12 , C07D409/04 , C07D413/06 , C07D413/10 , C07D413/14 , C07D417/14

摘要： The invention relates to compounds and compositions for inhibiting the enzyme fatty acid amide hydrolase (FAAH), the use of the compounds in therapy and, in particular, for treating or preventing conditions whose development or symptoms are linked to substrates of the FAAH enzyme, and methods of treatment or prevention using the compounds and compositions.

摘要翻译： 本发明涉及用于抑制酶脂肪酸酰胺水解酶（FAAH）的化合物和组合物，该化合物在治疗中的用途，特别是用于治疗或预防其发展或症状与FAAH酶的底物相连的病症，以及使用化合物和组合物的治疗或预防方法。

7.

发明申请
DOSAGE REGIMEN FOR COMT INHIBITORS 有权
标题翻译： COMT抑制剂的剂量计

公开(公告)号：US20100113529A1

公开(公告)日：2010-05-06

申请号：US12524848

申请日：2007-10-10

申请人： David Alexander Learmonth , Laszlo Erno Kiss , Pedro Nuno Leal Palma , Humberto dos Santos Ferreira , Patricio Manuel Vieira Araujo Soares da Silva

发明人： David Alexander Learmonth , Laszlo Erno Kiss , Pedro Nuno Leal Palma , Humberto dos Santos Ferreira , Patricio Manuel Vieira Araujo Soares da Silva

IPC分类号： A61K31/4439 , C07D413/04 , A61P25/00 , A61P25/16 , A61P25/18

CPC分类号： C07D413/04 , A61K9/20 , A61K31/198 , A61K31/4439 , A61K45/06

摘要： The invention relates to the use of an oxodiazolyl compound (I) for the preparation of a medicament for the prevention or treatment of central and peripheral nervous system associated disorders, wherein said medicament is administered according to a dosing regimen having a dosing periodicity ranging from about twice a day to about once every other day.

摘要翻译： 本发明涉及氧基二唑基化合物（I）用于制备用于预防或治疗中枢和周围神经系统相关疾病的药物的用途，其中所述药物根据剂量方案给药，其给药周期范围为约每天两次，每隔一天约一次。

8.

发明授权
Dosage regimen for COMT inhibitors 有权
标题翻译： COMT抑制剂的剂量方案

公开(公告)号：US08524746B2

公开(公告)日：2013-09-03

申请号：US12524848

申请日：2007-10-10

申请人： David Alexander Learmonth , Laszlo Erno Kiss , Pedro Nuno Leal Palma , Humberto dos Santos Ferreira , Patricio Manuel Vieira Araujo Soares da Silva

发明人： David Alexander Learmonth , Laszlo Erno Kiss , Pedro Nuno Leal Palma , Humberto dos Santos Ferreira , Patricio Manuel Vieira Araujo Soares da Silva

IPC分类号： A61K31/4439 , A61P25/00 , A61P25/16 , A61P25/18 , C07D413/04

CPC分类号： C07D413/04 , A61K9/20 , A61K31/198 , A61K31/4439 , A61K45/06

摘要： The invention relates to the use of an oxodiazolyl compound (I) for the preparation of a medicament for the prevention or treatment of central and peripheral nervous system associated disorders, wherein said medicament is administered according to a dosing regimen having a dosing periodicity ranging from about twice a day to about once every other day.

摘要翻译： 本发明涉及氧基二唑基化合物（I）用于制备用于预防或治疗中枢和周围神经系统相关疾病的药物的用途，其中所述药物根据剂量方案给药，其给药周期范围为约每天两次，每隔一天约一次。