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    Method of preparing lipid nanoparticles
    1.
    发明授权
    Method of preparing lipid nanoparticles 有权
    制备脂质纳米粒子的方法

    公开(公告)号：US09302241B2

    公开(公告)日：2016-04-05

    申请号：US13139401

    申请日：2009-12-11

    申请人： Jean-Pierre Benoit ,  Olivier Thomas ,  Patrick Saulnier ,  Alyaa Adel Ramadan

    发明人： Jean-Pierre Benoit ,  Olivier Thomas ,  Patrick Saulnier ,  Alyaa Adel Ramadan

    IPC分类号： A61K9/50 ,  B01J13/04

    CPC分类号： B01J13/04

    摘要： Provided is a method for preparing nanocapsules having a liquid lipid core and a solid shell and charged in their lipid core with at least one hydrophilic active agent involving combining microemulsions where the active agent remains in the hydrophilic phase of a first microemulsion and chill-hardening the mixture to obtain the nanocapsules charged with the hydrophilic active agent. The nanocapsules comprise the lipid core which is liquid at room temperature and the nanocapsules are encapsulated in a film which is solid at room temperature.

    摘要翻译： 提供了一种制备具有液体脂质核和固体壳的纳米胶囊的方法，并且在其脂质核心中装入至少一种亲水性活性剂，其包括组合微乳液，其中活性剂保留在第一微乳液的亲水相中，并冷却硬化 混合物以获得装有亲水性活性剂的纳米胶囊。 纳米胶囊包含在室温下为液体的脂质核，纳米胶囊包封在室温下为固体的膜中。

    METHOD OF PREPARING LIPID NANOPARTICLES
    2.
    发明申请
    METHOD OF PREPARING LIPID NANOPARTICLES 有权
    制备脂质纳米颗粒的方法

    公开(公告)号：US20120027825A1

    公开(公告)日：2012-02-02

    申请号：US13139401

    申请日：2009-12-11

    申请人： Jean-Pierre Benoit ,  Olivier Thomas ,  Patrick Saulnier ,  Alyaa Adel Ramadan

    发明人： Jean-Pierre Benoit ,  Olivier Thomas ,  Patrick Saulnier ,  Alyaa Adel Ramadan

    IPC分类号： A01N25/26 ,  A01P15/00 ,  A61P43/00 ,  A61Q90/00 ,  A61K9/50 ,  A61K8/02

    CPC分类号： B01J13/04

    摘要： The present invention relates to a useful method for preparing nanocapsules having a liquid lipid core and a solid shell and charged with at least one active agent having a hydrophilic character, said method comprising at least the steps consisting in: i) providing at least a first microemulsion having a water-in-oil character, stabilized by at least one lipophilic surfactant and containing in its hydrophilic phase at least one active agent having a hydrophilic character, providing at least a second microemulsion, separate from the first microemulsion, formulated by phase inversion of an emulsion and stabilized by at least one heat-sensitive, nonionic hydrophilic surfactant; iii) adding said first microemulsion to said second microemulsion under conditions propitious for the formation of a novel microemulsion architecture in which said hydrophilic active agent remains present in the hydrophilic phase of the first microemulsion; and iv) chill-hardening the mixture formed in the previous step, so as to obtain nanocapsules comprising said hydrophilic active agent and being formed from a lipid core, which is liquid at room temperature, and encapsulated in a film which is solid at room temperature.Further, the invention relates to nanocapsules which are able to be obtained by said method.

    摘要翻译： 本发明涉及一种制备具有液体脂质核和固体壳并装有至少一种具有亲水特性的活性剂的纳米胶囊的有用方法，所述方法至少包括以下步骤：i）至少提供第一 具有油包水性的微乳液，由至少一种亲脂性表面活性剂稳定，并在其亲水相中含有至少一种具有亲水特性的活性剂，提供至少一种与通过相转化配制的第一微乳液分离的第二微乳液 的乳液并通过至少一种热敏非离子亲水性表面活性剂稳定; iii）在有利于形成新型微乳液结构的条件下将所述第一微乳液加入到所述第二微乳液中，其中所述亲水性活性剂保留在第一微乳液的亲水相中; 和iv）冷却前述步骤中形成的混合物，以获得包含所述亲水性活性剂并由在室温下为液体的脂核心形成并包封在室温下为固体的膜的纳米胶囊 。 此外，本发明涉及能够通过所述方法获得的纳米胶囊。

    Process for preparing lipid nanoparticles
    4.
    发明授权
    Process for preparing lipid nanoparticles 有权
    制备脂质纳米粒子的方法

    公开(公告)号：US09005666B2

    公开(公告)日：2015-04-14

    申请号：US12663960

    申请日：2008-06-11

    申请人： Patrick Saulnier ,  Jean-Pierre Benoit ,  Nicolas Anton

    发明人： Patrick Saulnier ,  Jean-Pierre Benoit ,  Nicolas Anton

    IPC分类号： A61K9/16 ,  A61K9/50 ,  A61K9/51 ,  A61K9/107 ,  A61K31/192 ,  A61K31/70

    CPC分类号： A61K9/5123 ,  A61K9/1075 ,  A61K31/192 ,  A61K31/70

    摘要： A process for preparing nanocapsules with a liquid lipid core and a solid lipid shell, charged with at least one active agent. The process contains at least the steps of formulating a microemulsion by phase inversion of an emulsion, totally or partially forming from at least one active agent a second composition different than the microemulsion, placing the microemulsion in contact with the second composition under conditions suitable for interaction of the active agent with the microemulsion, and chill-hardening the microemulsion that has interacted with the active agent, to obtain the nanocapsules.

    摘要翻译： 一种用液体脂核和固体脂壳制备纳米胶囊的方法，装有至少一种活性剂。 该方法至少包括通过乳液的相转化来配制微乳液的步骤，所述乳液由至少一种活性剂全部或部分形成第二组合物，所述第二组合物不同于微乳液，在适合于相互作用的条件下将微乳液与第二组合物接触 的活性剂与微乳液，并冷却与活性剂相互作用的微乳液，以获得纳米胶囊。

    PROCESS FOR PREPARING LIPID NANOPARTICLES
    6.
    发明申请
    PROCESS FOR PREPARING LIPID NANOPARTICLES 有权
    制备脂质纳米颗粒的方法

    公开(公告)号：US20100233275A1

    公开(公告)日：2010-09-16

    申请号：US12663960

    申请日：2008-06-11

    申请人： Patrick Saulnier ,  Jean-Pierre Benoit ,  Nicolas Anton

    发明人： Patrick Saulnier ,  Jean-Pierre Benoit ,  Nicolas Anton

    IPC分类号： A61K9/51 ,  A61K31/7048 ,  A61K31/192 ,  A61K31/704

    CPC分类号： A61K9/5123 ,  A61K9/1075 ,  A61K31/192 ,  A61K31/70

    摘要： The present invention relates to a method for use in the preparation of nanocapsules which have a liquid lipid core and a solid lipid shell and which are loaded with at least one active agent, wherein said method comprises at least the steps consisting in providing a microemulsion formulated by phase inversion of an emulsion, providing a second composition, distinct from said microemulsion and completely or partly formed from at least one active agent, placing said microemulsion in the presence of said second composition under conditions suitable for the interaction of said active agent with said microemulsion and annealing said microemulsion having interacted with said active agent in such a way as to obtain said nanocapsules. The invention also relates to a corresponding kit.

    摘要翻译： 本发明涉及一种用于制备纳米胶囊的方法，所述纳米胶囊具有液体脂质核和固体脂壳，并且装载有至少一种活性剂，其中所述方法至少包括提供配制的微乳液 通过乳液的相转化，提供与所述微乳液不同的第二组合物，并且由至少一种活性剂完全或部分形成，将所述微乳液在所述第二组合物存在下，在适于所述活性剂与所述 微乳液和退火所述微乳液与所述活性剂相互作用，以获得所述纳米胶囊。 本发明还涉及相应的试剂盒。