公开(公告)号：US20090081127A1

公开(公告)日：2009-03-26

申请号：US12154939

申请日：2008-05-27

Applicant: Muriel Moser ,  Leo Oberdan ,  Laurence Lespagnard ,  Jacques Urbain ,  Catherine Bruyns ,  Catherine Gerard ,  Michel Goldman ,  Thierry Velu ,  Fabienne Willems ,  Nicole Tasiaux ,  Jason Perret ,  Anne-Marie Verheyden ,  Pascal Mettens ,  Kris Thielemans

Inventor： Muriel Moser ,  Leo Oberdan ,  Laurence Lespagnard ,  Jacques Urbain ,  Catherine Bruyns ,  Catherine Gerard ,  Michel Goldman ,  Thierry Velu ,  Fabienne Willems ,  Nicole Tasiaux ,  Jason Perret ,  Anne-Marie Verheyden ,  Pascal Mettens ,  Kris Thielemans

IPC: A61K51/00 ,  A61K35/12 ,  A61K39/00

CPC classification number: A61K39/0011 ,  A61K2039/5152 ,  A61K2039/5154 ,  A61K2039/5156 ,  C12N5/16

Abstract: The present invention relates to a method of producing a plurality of dendritic cell/tumor cell hybrids which induce an anti-tumor response when applied to a patient. The present invention further relates to a method of producing a dendritic cell/tumor cell hybridoma which induces an anti-tumor response when applied to a patient.

Abstract translation: 本发明涉及当应用于患者时产生多种树突状细胞/肿瘤细胞杂合体的方法，其诱导抗肿瘤反应。 本发明还涉及产生当应用于患者时诱导抗肿瘤反应的树突状细胞/肿瘤细胞杂交瘤的方法。

公开(公告)号：US20070048261A1

公开(公告)日：2007-03-01

申请号：US10582810

申请日：2004-12-14

Applicant: Pascal Mettens ,  Catherine Uyttenhove ,  Jacques Van Snick

Inventor： Pascal Mettens ,  Catherine Uyttenhove ,  Jacques Van Snick

IPC: A61K38/20 ,  A61K39/00 ,  A61K9/127

CPC classification number: A61K39/0008 ,  A61K2039/55555 ,  A61K2039/55566 ,  A61K2039/55577

Abstract: The present invention provides improved vaccines and immunogenic compositions comprising IL-12 or IL-23, and processes for the preparation of such vaccines and immunogenic compositions.

Abstract translation: 本发明提供改进的疫苗和包含IL-12或IL-23的免疫原性组合物，以及制备这种疫苗和免疫原性组合物的方法。

公开(公告)号：US20050287137A1

公开(公告)日：2005-12-29

申请号：US11167872

申请日：2005-06-27

Applicant: Patrick Dhaese ,  Pascal Mettens ,  Rene Meykens ,  Philippe Monteyne ,  Torbjorn Schiott ,  Leif Strandberg

Inventor： Patrick Dhaese ,  Pascal Mettens ,  Rene Meykens ,  Philippe Monteyne ,  Torbjorn Schiott ,  Leif Strandberg

IPC: A61K39/395 ,  C07K16/18 ,  C07K16/44

CPC classification number: C07K16/18 ,  C07K2317/622

Abstract: The present invention relates to novel therapies and treatments of atherosclerotic diseases. Accordingly there is provided, methods of treating or preventing atherosclerosis by passive vaccination through administration to a patient of a fully human antibody that is capable of binding to the specific fragments of ApoCIII. Specific human monoclonal antibodies and their use in therapy of atherosclerosis is provided. There is further provided the use of the antibodies of the present invention in medicine.

Abstract translation: 本发明涉及动脉粥样硬化疾病的新疗法和治疗。 因此，提供了通过向能够结合到ApoCIII的特异性片段的完全人抗体的患者施用被动接种来治疗或预防动脉粥样硬化的方法。 提供特异性人单克隆抗体及其在治疗动脉粥样硬化中的应用。 还提供了本发明的抗体在医药中的用途。

公开(公告)号：US20120294882A1

公开(公告)日：2012-11-22

申请号：US13574816

申请日：2011-01-27

Applicant: Normand Blais ,  James Brown ,  Anne-Marie Gelinas ,  Pascal Mettens ,  Dennis Murphy

Inventor： Normand Blais ,  James Brown ,  Anne-Marie Gelinas ,  Pascal Mettens ,  Dennis Murphy

IPC: A61K38/16 ,  A61P31/06 ,  C07H21/04 ,  A61K31/7088 ,  C07K14/35

CPC classification number: C07K14/35 ,  A61K39/04 ,  C07K2319/00

Abstract: Modified Rv3616c proteins and their use as medicaments, particularly for the prevention of reactivation of tuberculosis.

Abstract translation: 改良的Rv3616c蛋白及其用作药物，特别是用于预防结核病的再活化。

公开(公告)号：US20100172927A1

公开(公告)日：2010-07-08

申请号：US12442538

申请日：2007-10-03

Applicant: Mark Alderson ,  Rhea Coler ,  Yves Lobet ,  Jean-Francois L. Maisonneuve ,  Pascal Mettens ,  Peter Probst ,  Steven Reed

Inventor： Mark Alderson ,  Rhea Coler ,  Yves Lobet ,  Jean-Francois L. Maisonneuve ,  Pascal Mettens ,  Peter Probst ,  Steven Reed

IPC: A61K39/118 ,  A61P31/04 ,  A61P27/00 ,  C07K14/295

CPC classification number: A61K39/118 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/55555 ,  A61K2039/55566 ,  A61K2039/55572 ,  A61K2039/55577

Abstract: Methods and compositions for the treatment or prevention of ocular Chlamydia trachomatis infection. Compositions comprise one or more Chlamydia trachomatis proteins, immunogenic fragments thereof or polynucleotides encoding such proteins or fragments.

Abstract translation: 用于治疗或预防眼沙眼衣原体感染的方法和组合物。 组合物包含一种或多种沙眼衣原体蛋白，其免疫原性片段或编码这种蛋白质或片段的多核苷酸。

公开(公告)号：US20090022755A1

公开(公告)日：2009-01-22

申请号：US11909992

申请日：2006-03-24

Applicant: Brenda Barth ,  Ajay Bhatia ,  Mark Alderson ,  Jean-Francois L. Maisonneuve ,  Yves Lobet ,  Florence Bernadette Nozay ,  Martine Marchand ,  Pascal Mettens ,  Yasir A. Skeiky ,  Peter Probst

Inventor： Brenda Barth ,  Ajay Bhatia ,  Mark Alderson ,  Jean-Francois L. Maisonneuve ,  Yves Lobet ,  Florence Bernadette Nozay ,  Martine Marchand ,  Pascal Mettens ,  Yasir A. Skeiky ,  Peter Probst

IPC: A61K39/00 ,  A61P31/00

CPC classification number: A61K39/118 ,  A61K2039/55572 ,  A61K2039/55577 ,  C07K14/295

Abstract: The present invention relates to compositions comprising proteins or polynucleotides of Chlamydia sp., in particular combinations of proteins or polynucleotides encoding them, and methods for the use of the proteins or polynucleotides in the treatment, prevention and diagnosis of Chlamydia infection.

Abstract translation: 本发明涉及包含衣原体属的蛋白质或多核苷酸的组合物，特别是编码它们的蛋白质或多核苷酸的组合，以及用于治疗，预防和诊断衣原体感染的蛋白质或多核苷酸的方法。

公开(公告)号：US08932600B2

公开(公告)日：2015-01-13

申请号：US13574816

申请日：2011-01-27

Applicant: Normand Blais ,  James Brown ,  Anne-Marie Gelinas ,  Pascal Mettens ,  Dennis Murphy

Inventor： Normand Blais ,  James Brown ,  Anne-Marie Gelinas ,  Pascal Mettens ,  Dennis Murphy

IPC: A61K39/04 ,  C07K14/35

CPC classification number: C07K14/35 ,  A61K39/04 ,  C07K2319/00

Abstract: Modified Rv3616c proteins and their use as medicaments, particularly for the prevention of reactivation of tuberculosis.

Abstract translation: 改良的Rv3616c蛋白及其用作药物，特别是用于预防结核病的再活化。

公开(公告)号：US08541007B2

公开(公告)日：2013-09-24

申请号：US12974428

申请日：2010-12-21

Applicant: Mark Alderson ,  Ajay Bhatia ,  Yves Lobet ,  Brenda Maisonneuve ,  Jean-Francois L Maisonneuve ,  Martine Marchand ,  Pascal Mettens ,  Florence Bernadette Nozay ,  Peter Probst ,  Samira H Skeiky

Inventor： Mark Alderson ,  Ajay Bhatia ,  Yves Lobet ,  Brenda Maisonneuve ,  Jean-Francois L Maisonneuve ,  Martine Marchand ,  Pascal Mettens ,  Florence Bernadette Nozay ,  Peter Probst ,  Yasir A Skeiky

IPC: A61K39/118

CPC classification number: A61K39/118 ,  A61K2039/55555 ,  A61K2039/55572 ,  A61K2039/55577 ,  G01N33/56927

Abstract: The present invention relates to compositions comprising proteins or polynucleotides of Chlamydia sp., in particular combinations of proteins or polynucleotides encoding them, and methods for the use of the proteins or polynucleotides in the treatment, prevention and diagnosis of Chlamydia infection.

Abstract translation: 本发明涉及包含衣原体属的蛋白质或多核苷酸的组合物，特别是编码它们的蛋白质或多核苷酸的组合，以及用于治疗，预防和诊断衣原体感染的蛋白质或多核苷酸的方法。

公开(公告)号：US20110300206A1

公开(公告)日：2011-12-08

申请号：US12974428

申请日：2010-12-21

Applicant: Mark ALDERSON ,  Ajay BHATIA ,  Yves LOBET ,  Brenda MAISONNEUVE ,  Jean-Francois L. MAISONNEUVE ,  Martine MARCHAND ,  Pascal METTENS ,  Florence Bernadette NOZAY ,  Peter PROBST ,  Yasir A. SKEIKY ,  Samira H. SKEIKY

Inventor： Mark ALDERSON ,  Ajay BHATIA ,  Yves LOBET ,  Brenda MAISONNEUVE ,  Jean-Francois L. MAISONNEUVE ,  Martine MARCHAND ,  Pascal METTENS ,  Florence Bernadette NOZAY ,  Peter PROBST ,  Yasir A. SKEIKY ,  Samira H. SKEIKY

IPC: A61K39/118 ,  G01N33/53 ,  C12Q1/02 ,  A61K9/127 ,  A61P31/04

CPC classification number: A61K39/118 ,  A61K2039/55555 ,  A61K2039/55572 ,  A61K2039/55577 ,  G01N33/56927

Abstract: The present invention relates to compositions comprising proteins or polynucleotides of Chlamydia sp., in particular combinations of proteins or polynucleotides encoding them, and methods for the use of the proteins or polynucleotides in the treatment, prevention and diagnosis of Chlamydia infection.

Abstract translation: 本发明涉及包含衣原体属的蛋白质或多核苷酸的组合物，特别是编码它们的蛋白质或多核苷酸的组合，以及用于治疗，预防和诊断衣原体感染的蛋白质或多核苷酸的方法。

公开(公告)号：US09315556B2

公开(公告)日：2016-04-19

申请号：US13055775

申请日：2009-07-24

Applicant: James Brown ,  Pascal Mettens ,  Dennis Murphy

Inventor： James Brown ,  Pascal Mettens ,  Dennis Murphy

IPC: A61K39/04 ,  A61K39/02 ,  C07H21/04 ,  C07K14/35 ,  A61K39/00

CPC classification number: A61K39/04 ,  A61K2039/53 ,  A61K2039/55555 ,  A61K2039/55572 ,  A61K2039/55577 ,  C07H21/04 ,  C07K14/35 ,  G01N2333/35 ,  G01N2800/12

Abstract: The present invention is directed to a polypeptide which comprises: (i) an Rv1753c protein sequence; (ii) a variant of an Rv1753c protein sequence; or (iii) an immunogenic fragment of an Rv1753c protein sequence. In other aspects the invention is directed to associated polynucleotides, fusion proteins and methods for the treatment or prevention of tuberculosis.

Abstract translation: 本发明涉及一种多肽，其包含：（i）Rv1753c蛋白序列; （ii）Rv1753c蛋白序列的变体; 或（iii）Rv1753c蛋白序列的免疫原性片段。 在其它方面，本发明涉及用于治疗或预防结核病的相关多核苷酸，融合蛋白和方法。