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公开(公告)号:US12098185B2
公开(公告)日:2024-09-24
申请号:US17272050
申请日:2018-08-28
IPC分类号: C07K16/08 , G01N33/569
CPC分类号: C07K16/087 , G01N33/56994 , C07K2317/24 , C07K2317/565 , G01N2333/035
摘要: The present invention refers to a new monoclonal antibody or fragment thereof, called 11B2C7, which specifically recognizes herpes simplex virus (HSV), in its two types, herpes simplex virus type 1 and herpes simplex virus type 2 (HSV-1 and HSV-2). Preferably, the antibody of the invention is useful for the development of methods for the diagnosis of herpes simplex virus infection, as well as for the production of pharmaceutical compositions intended for the treatment, protection and/or prophylaxis of infection specifically caused by HSV-1 and HSV-2.
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公开(公告)号:US20240042012A1
公开(公告)日:2024-02-08
申请号:US18258943
申请日:2021-12-23
发明人: Alexis KALERGIS PARRA , Susan BUENO RAMÍREZ , Pablo GONZALEZ MUÑOZ , Angello RETAMAL DIAZ , Jorge SOTO RAMIREZ
IPC分类号: A61K39/215 , C07K14/165 , A61P31/14
CPC分类号: A61K39/215 , C07K14/165 , A61P31/14 , A61K2039/522
摘要: The invention relates to an immunogenic formulation containing one or more modified recombinant strains of Bacillus Calmette-Guerin (BCG), in a concentration between 104−109 bacteria, where each BCG strain expresses at least one protein or immunogenic fragment of SARS-CoV-2, in a pharmaceutically acceptable saline buffer, where this formulation serves to prepare vaccines to prevent, treat or attenuate SARS-CoV-2 infections.
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公开(公告)号:US11786376B2
公开(公告)日:2023-10-17
申请号:US16621207
申请日:2018-08-16
CPC分类号: A61F2/28 , A61L27/12 , A61L27/365 , A61L27/56 , A61L27/58 , A61F2240/002 , A61L27/00
摘要: Particulate biomaterial containing particles having geodesic shapes for filling or replacement of bone tissue, and a method of making the particulate biomaterial containing particles having geodesic shapes for filling or replacement of bone tissue, made by rapid prototyping technique (RP), wherein said particles have non-prismatic, semi-spherical geodesic forms.
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公开(公告)号:US20230210977A1
公开(公告)日:2023-07-06
申请号:US17995004
申请日:2021-03-31
发明人: Alexis KALERGIS , Susan BUENO , Pablo GONZÁLEZ
CPC分类号: A61K39/12 , A61P31/14 , A61K2039/523
摘要: The invention relates to the novel use of an immunogenic formulation containing Bacillus Calmette-Guerin (BCG) in a concentration between 104-109 bacteria, which recombinantly expresses at least one protein or immunogenic fragment of the human Respiratory Syncytial Virus (hRSV, human orthopneumovirus), stabilized in a pharmaceutically acceptable saline buffer solution to prevent, treat, or attenuate bRSV infections in cattle.
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公开(公告)号:US11583201B2
公开(公告)日:2023-02-21
申请号:US16958433
申请日:2018-12-27
发明人: Felipe Ignacio Valenzuela Beck , Sergio Andres Uribe Arancibia , Antonio Alejandro Eblen Zajjur , Ranganatha Sitaram , Mohit Rana
摘要: The invention consists of a device to evaluate hemodynamic response generated by the spinal cord in response to a suprasensorial stimulus applied to a peripheral nerve (medium or posterior tibial) by the use of functional near-infrared spectroscopy (fNIRS). The device consists of 3 main components, an electrical stimulator, an optical recording unit and a signal processing and control module. The device allows non-invasive, comfortable, harmless, portable, home-based, and low-cost evaluation of changes in local hemodynamic parameters in response to neuronal activation of the spinal cord by electrical stimulation of a peripheral nerve. The invention also includes a corresponding method of using the device and monitoring the spinal function.
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公开(公告)号:US20230035389A1
公开(公告)日:2023-02-02
申请号:US17758045
申请日:2019-12-27
发明人: Pablo GONZÁLEZ , Cristian AGURTO
摘要: Composition with antiviral activity comprising water-soluble extracts of Durvillaea antarctica substantially free of alginates and a carrier or vehicle, and the method of obtaining it. Where this composition serves to prepare an antiviral drug of topical application, to prevent or treat skin or oral lesions caused by herpes viruses of the subfamily Alphahehrpesvirinae, such as herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2) and varicella zoster virus (VZV), resistant or not to acyclovir (ACV).
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公开(公告)号:US11512354B2
公开(公告)日:2022-11-29
申请号:US16645250
申请日:2018-09-07
IPC分类号: C12Q1/6886 , C12Q1/6869
摘要: The invention is directed to a method for the early detection of gastric cancer, by detecting the increase in DNA methylation of the promoter region of the microRNA-335-5p in samples obtained non-invasively, preferably in plasma. Thus, it is a contribution for the early detection of gastric cancer, without invasive procedures, with rapid collection of the sample and of the delivery of the results, and of lower cost than the technologies that employ invasive diagnostic techniques to the human and animal body in general.
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公开(公告)号:US20220089697A1
公开(公告)日:2022-03-24
申请号:US17418617
申请日:2019-12-27
IPC分类号: C07K16/10 , G01N33/569
摘要: Generation of monoclonal antibodies, or fragments thereof, that recognize the human parainfluenza virus (PIV) chimeric protein L, where the monoclonal antibodies or fragments thereof have a heavy chain variable region and a light chain variable region. In addition, a method of diagnosing PIV infection in a biological sample of nasopharyngeal secretion is provided, using the monoclonal antibodies in diagnostic kit format.
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公开(公告)号:US20210170145A1
公开(公告)日:2021-06-10
申请号:US17263064
申请日:2019-07-03
发明人: Mariela Isabel CAMPOS STEMPFLE , Valentina Constanza MARQUEZ VILLABLANCA , Fernanda Sofía ROMAGNOLI TORRES , Iván Alberto CARO PINTO , Juan Carlos PATILLO SILVA , José Fernando Enrique VULETIN SOLIS , Alejandro Luis ZAVALA BUSQUETS
IPC分类号: A61M25/02
摘要: The invention relates to a mounting device for adapting a Foley urinary catheter as a percutaneous endoscopic gastrotomy (PEG) catheter for enteral feeding, which comprises a clamp-type radial retention means that holds the catheter to prevent it from migrating into the patient's stomach cavity, said clamp being secured in its position by a locking button for coupling laterally to the catheter and by a perimeter closure ring that is pressed onto the outside of the locking button.
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公开(公告)号:US20150247754A1
公开(公告)日:2015-09-03
申请号:US14429955
申请日:2013-09-11
发明人: René Zemp , Juan Carlos De La Llera
IPC分类号: G01H1/00
摘要: The present invention shows a solution to measure the relative displacements related to a structure in order to use the signal measured as feedback signal in real time for the structural monitor of the active and semi-active vibration. Said monitors reduce the structural movement caused by any source of natural or artificial vibration. The conventional measurement methods of the relative displacement are often not able to accurately measure the displacement in real time. The delay in the signal measured often has a negative effect on the feedback monitor device.The invention consists in a pre-stressed axial element (1), installed between two different points of the structure (2) using a fixed connector (5) and a flexible one (6). As the structure (2) vibrates in response to an external “source”, a relative displacement is caused between two connecting points of the axial element, which can be measured based on the rotation φ of the flexible connector (5) of the axial element. In addition, at intermediate points of the axial element (1), the relative displacement between the structure (2) and the axial element (1) can be measured through sensors (3). With these measurements, the form of discrete displacement can be obtained in real time of the whole structure where the axial element (1) is installed.In the event an axial element (4) is installed, where an upper mode passes through point zero, the modal displacement of this upper mode will not be measured. Assuming that the full displacement of the structure is associated with the first two modes, which is often a god approach in practice to earthquake-induced displacements, the modal displacement of these two modes can be measured independently in real time. A modal monitor through active or semi-active devices can improve the structural behavior in some cases.In order to keep the disturbance level of the signal measured introduced by natural vibrations of the axial element (1) as low as possible, it is important that the fundamental frequencies of the axial elements (1) are significantly higher than the natural frequencies of the structure (2). For this goal to be achieved, using materials of the axial element is necessary, which have little density and can be highly pre-stressed, such as carbon fiber.
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