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公开(公告)号：US20170236294A1
公开(公告)日：2017-08-17
申请号：US15332567
申请日：2016-10-24
申请人： Joseph Fisher , Olivia Sobczyk , Adrian P. Crawley , Julian Poublanc , Kevin Sam , Daniel M. Mandell , David Mikulis , James Duffin
发明人： Joseph Fisher , Olivia Sobczyk , Adrian P. Crawley , Julian Poublanc , Kevin Sam , Daniel M. Mandell , David Mikulis , James Duffin
CPC分类号： G06T7/38 , A61B5/0042 , A61B5/0205 , A61B5/026 , A61B5/0263 , A61B5/055 , A61B5/14542 , A61B5/4064 , A61B5/4836 , A61B2576/026 , G06T7/0012 , G06T7/11 , G06T2207/10088 , G06T2207/30016 , G06T2207/30104
摘要： Z maps combined with a standardized stimulus in the form of a targeted arterial partial pressures of carbon dioxide provide suprisingly enhanced images for the assessment of pathological CVR. For example, the z-map assessment of patients with known steno-occlusive diseases of the cervico-cerebral vasculature showed an enhanced resolution of the presence, localization, and severity of the pathological CVR. Z-map have been found to be useful to reduce the confounding effects of test-to-test, subject-to-subject, and platform-to-platform variability for comparison of CVR images showing the importance of combining this analysis with the standardized stimulus.
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公开(公告)号：US20160220115A1
公开(公告)日：2016-08-04
申请号：US14859809
申请日：2015-09-21
申请人： Joseph A. Fisher , Olivia Sobczyk , Adrian P. Crawley , Julien Poublanc , Kevin Sam , Daniel M. Mandell , David J. Mikulis , James Duffin
发明人： Joseph A. Fisher , Olivia Sobczyk , Adrian P. Crawley , Julien Poublanc , Kevin Sam , Daniel M. Mandell , David J. Mikulis , James Duffin
IPC分类号： A61B5/00 , A61B5/145 , A61B5/026 , A61B5/0205
摘要： An algorithm including program code for analyzing a specific portion of the vasoactive response to the vasoactive stimulus corresponding to a to sub-range of increments and/or decrements of stimuli within the full range of the vasoactive stimulus, the sub-range characterized in that is more sensitive to identifying reductions in vascular reactivity in the ROI.
摘要翻译： 一种算法，其包括用于分析与血管活性刺激的全范围内的增量和/或刺激递减的范围对应的血管活性刺激的血管活性反应的特定部分的特征部分，其特征在于， 对于识别ROI中血管反应性的降低更敏感。
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公开(公告)号：US20230056088A1
公开(公告)日：2023-02-23
申请号：US17789732
申请日：2020-12-31
申请人： Adrian P. CRAWLEY , Rohan DHARMAKUMAR , James DUFFIN , Joseph Arnold FISHER , David MIKULIS , Julien POUBLANC , Behzad SHARIF , Olivia SOBCZYK , Kamil ULUDAG , Chau VU , John WOOD , Hsin-Jung YANG
发明人： Adrian P. CRAWLEY , Rohan DHARMAKUMAR , James DUFFIN , Joseph Arnold FISHER , David MIKULIS , Julien POUBLANC , Behzad SHARIF , Olivia SOBCZYK , Kamil ULUDAG , Chau VU , John WOOD , Hsin-Jung YANG
摘要： Deoxyhemoglobin in a subject may be modulated to act as a contrast agent for use in magnetic resonance imaging. Sequential gas delivery may be applied to adjust the level of deoxyhemoglobin in the subject. A suitable magnetic resonance imaging (MRI) pulse sequence that is sensitive to magnetic field inhomogeneities, such as a blood-oxygen-level dependent (BOLD) sequence, may be used to detect deoxyhemoglobin as a contrast agent.
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4.发明申请METHOD AND APPARATUS TO ATTAIN AND MAINTAIN TARGET ARTERIAL BLOOD GAS CONCENTRATIONS USING RAMP SEQUENCES 审中-公开使用RAMP序列的方法和装置来获取和维持目标病原体血气浓度公开(公告)号：US20150114394A1
公开(公告)日：2015-04-30
申请号：US14398034
申请日：2013-04-30
申请人： Michael Klein , Joseph Fisher , James Duffin , Marat Slessarev , Cathie Kessler , Shoji Ito , Olivia Sobczyk , Anne Battisti-Charbonney , Daniel Michael Mandell
发明人： Michael Klein , Joseph Fisher , James Duffin , Marat Slessarev , Cathie Kessler , Shoji Ito , Olivia Sobczyk , Anne Battisti-Charbonney , Daniel Michael Mandell
CPC分类号： A61M16/0066 , A61B5/082 , A61B5/091 , A61M16/0045 , A61M16/026 , A61M16/1005 , A61M16/12 , A61M16/122 , A61M2016/0027 , A61M2016/0036 , A61M2016/1025 , A61M2016/103 , A61M2202/0208 , A61M2202/0225 , A61M2205/3303 , A61M2205/502 , A61M2205/52 , A61M2230/04 , A61M2230/202 , A61M2230/205 , A61M2230/208 , A61M2230/432 , A61M2230/435
摘要： An apparatus and method for controlling the end tidal partial pressure of a gas X in a subject's lung, and to the use of such an apparatus and method for research, diagnostic and therapeutic purposes, wherein the method consists of: obtaining input of a series of logistically attainable PetX values for a series of respective breaths: determining an amount of gas X required to be inspired by the subject in an inspired gas to target the PetX for each of said respective breaths: and controlling a gas delivery device to deliver the amount of gas in a volume of gas delivered to the subject in each of said respective breaths to target the respective PetX for that breath.
摘要翻译： 用于控制受试者肺中气体X的末端潮气分压的装置和方法，以及用于研究，诊断和治疗目的的这种装置和方法的使用，其中该方法包括：获得一系列 用于一系列相应呼吸的逻辑上可获得的PetX值：确定在受启发气体中受试者启发的气体X的量，用于针对所述相应呼吸中的每一个的PetX;以及控制气体输送装置输送量 在每个所述各个呼吸中输送到被检者的气体体积中的气体，以对应该呼吸的各自的PetX。
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5.发明申请公开(公告)号：US20180311454A1
公开(公告)日：2018-11-01
申请号：US15904235
申请日：2018-02-23
申请人： Michael Klein , Joseph Fisher , James Duffin , Marat Slessarev , Cathie Kessler , Shoji Ito , Olivia Sobczyk , Anne Battisti-Charbonney , Daniel Michael Mandell
发明人： Michael Klein , Joseph Fisher , James Duffin , Marat Slessarev , Cathie Kessler , Shoji Ito , Olivia Sobczyk , Anne Battisti-Charbonney , Daniel Michael Mandell
CPC分类号： A61M16/0066 , A61B5/082 , A61B5/091 , A61M16/0045 , A61M16/026 , A61M16/1005 , A61M16/12 , A61M16/122 , A61M2016/0027 , A61M2016/0036 , A61M2016/1025 , A61M2016/103 , A61M2202/0208 , A61M2202/0225 , A61M2205/3303 , A61M2205/502 , A61M2205/52 , A61M2230/04 , A61M2230/202 , A61M2230/205 , A61M2230/208 , A61M2230/432 , A61M2230/435
摘要： An apparatus and method for controlling the end tidal partial pressure of a gas X in a subject's lung, and to the use of such an apparatus and method for research, diagnostic and therapeutic purposes, wherein the method consists of: obtaining input of a series of logistically attainable PetX values for a series of respective breaths: determining an amount of gas X required to be inspired by the subject in an inspired gas to target the PetX for each of said respective breaths: and controlling a gas delivery device to deliver the amount of gas in a volume of gas delivered to the subject in each of said respective breaths to target the respective PetX for that breath.
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