公开(公告)号：US20230056088A1

公开(公告)日：2023-02-23

申请号：US17789732

申请日：2020-12-31

申请人： Adrian P. CRAWLEY ,  Rohan DHARMAKUMAR ,  James DUFFIN ,  Joseph Arnold FISHER ,  David MIKULIS ,  Julien POUBLANC ,  Behzad SHARIF ,  Olivia SOBCZYK ,  Kamil ULUDAG ,  Chau VU ,  John WOOD ,  Hsin-Jung YANG

发明人： Adrian P. CRAWLEY ,  Rohan DHARMAKUMAR ,  James DUFFIN ,  Joseph Arnold FISHER ,  David MIKULIS ,  Julien POUBLANC ,  Behzad SHARIF ,  Olivia SOBCZYK ,  Kamil ULUDAG ,  Chau VU ,  John WOOD ,  Hsin-Jung YANG

IPC分类号： G01R33/28 ,  A61B5/055 ,  A61B5/00 ,  A61B5/026 ,  A61B5/145 ,  G01R33/50 ,  G01R33/58

摘要： Deoxyhemoglobin in a subject may be modulated to act as a contrast agent for use in magnetic resonance imaging. Sequential gas delivery may be applied to adjust the level of deoxyhemoglobin in the subject. A suitable magnetic resonance imaging (MRI) pulse sequence that is sensitive to magnetic field inhomogeneities, such as a blood-oxygen-level dependent (BOLD) sequence, may be used to detect deoxyhemoglobin as a contrast agent.

公开(公告)号：US20170236294A1

公开(公告)日：2017-08-17

申请号：US15332567

申请日：2016-10-24

申请人： Joseph Fisher ,  Olivia Sobczyk ,  Adrian P. Crawley ,  Julian Poublanc ,  Kevin Sam ,  Daniel M. Mandell ,  David Mikulis ,  James Duffin

发明人： Joseph Fisher ,  Olivia Sobczyk ,  Adrian P. Crawley ,  Julian Poublanc ,  Kevin Sam ,  Daniel M. Mandell ,  David Mikulis ,  James Duffin

IPC分类号： G06T7/38 ,  A61B5/00 ,  G06T7/11 ,  A61B5/145 ,  G06T7/00 ,  A61B5/055 ,  A61B5/0205

CPC分类号： G06T7/38 ,  A61B5/0042 ,  A61B5/0205 ,  A61B5/026 ,  A61B5/0263 ,  A61B5/055 ,  A61B5/14542 ,  A61B5/4064 ,  A61B5/4836 ,  A61B2576/026 ,  G06T7/0012 ,  G06T7/11 ,  G06T2207/10088 ,  G06T2207/30016 ,  G06T2207/30104

摘要： Z maps combined with a standardized stimulus in the form of a targeted arterial partial pressures of carbon dioxide provide suprisingly enhanced images for the assessment of pathological CVR. For example, the z-map assessment of patients with known steno-occlusive diseases of the cervico-cerebral vasculature showed an enhanced resolution of the presence, localization, and severity of the pathological CVR. Z-map have been found to be useful to reduce the confounding effects of test-to-test, subject-to-subject, and platform-to-platform variability for comparison of CVR images showing the importance of combining this analysis with the standardized stimulus.