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    FLOW-TYPE LABORATORY OZONOLYSIS APPARATUS AND METHOD OF PERFORMING OZONOLYSIS REACTION
    1.
    发明申请
    FLOW-TYPE LABORATORY OZONOLYSIS APPARATUS AND METHOD OF PERFORMING OZONOLYSIS REACTION 审中-公开
    流动型实验室臭氧分析装置及其执行臭氧反应的方法

    公开(公告)号：US20090101519A1

    公开(公告)日：2009-04-23

    申请号：US12158814

    申请日：2006-12-22

    申请人： Daniel Szalay ,  Norbert Varga ,  Ferenc Boncz ,  Ferenc Darvas ,  Tamas Karancsi ,  Lajos Godorhazy ,  Laszlo Urge

    发明人： Daniel Szalay ,  Norbert Varga ,  Ferenc Boncz ,  Ferenc Darvas ,  Tamas Karancsi ,  Lajos Godorhazy ,  Laszlo Urge

    IPC分类号： C25B1/13

    CPC分类号： B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00788 ,  B01J2219/00833 ,  B01J2219/00835 ,  B01J2219/0086 ,  B01J2219/00867 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/0095 ,  B01J2219/00986 ,  C07C29/48 ,  C07C231/10 ,  C25B1/13 ,  C25B9/08 ,  C25B11/04 ,  C07C233/25 ,  C07C33/22 ,  C07C33/24

    摘要： A flow-type laboratory scale ozonolysis apparatus (100) according to the invention comprises a reservoir (104), a n feed pump (102), a mixing element (120) with two inlets and an outlet, a reactor unit (110) and a pressure-adjusting means (160), all connected into a flow path. The ozonolysis apparatus (100) further comprises an ozone source (110), as well as a dispensing valve (112) transmitting a gas stream only in a single direction and installed between the ozone source (110) and one of the inlets of the mixing element (120). The feed pump (102) of the ozonolysis apparatus (100) according to the invention is a liquid pump generating a constant volume rate, the reservoir (104) contains at least the substance, as a solute, to be subjected to the ozonolysis reaction and the reactor unit consists of first and second reactor zones differing in function from one another. In the flow path, the outlet of the first reactor zone is connected to the inlet of the second reactor zone. Furthermore, an inlet for feeding in substances is inserted into the flow path between the reactor zones, and the pressure-adjusting means (160) is installed into the flow path after the reactor unit and is provided with an electrically governed control.

    摘要翻译： 根据本发明的流式实验室规模臭氧分解装置（100）包括储存器（104），进料泵（102），具有两个入口和出口的混合元件（120），反应器单元（110）和 压力调节装置（160），全部连接到流路中。 臭氧分解装置（100）还包括臭氧源（110）以及仅在单个方向上传输气流并且安装在臭氧源（110）和混合入口之一之间的分配阀（112） 元件（120）。 根据本发明的臭氧分解装置（100）的进料泵（102）是产生恒定体积比的液体泵，储存器（104）至少含有作为溶质的待进行臭氧分解反应的物质， 反应器单元由功能彼此不同的第一和第二反应器区组成。 在流动路径中，第一反应器区的出口连接到第二反应器区的入口。 此外，用于进料物质的入口插入在反应器区域之间的流动路径中，并且压力调节装置（160）安装在反应器单元之后的流动路径中并且被设置有电控制的控制。

    METHOD OF FORMING A SEALED CHANNEL OF A MICROFLUIDIC REACTOR AND A MICROFLUIDIC REACTOR COMPRISING SUCH CHANNEL
    2.
    发明申请
    METHOD OF FORMING A SEALED CHANNEL OF A MICROFLUIDIC REACTOR AND A MICROFLUIDIC REACTOR COMPRISING SUCH CHANNEL 有权
    形成微流化反应器的密封通道的方法和包含这种通道的微流化反应器

    公开(公告)号：US20090098029A1

    公开(公告)日：2009-04-16

    申请号：US12158784

    申请日：2006-12-22

    申请人： Daniel Szalay ,  Norbert Varga ,  Ferenc Boncz ,  Ferenc Darvas ,  Tamas Karancsi ,  Lajos Godorhazy

    发明人： Daniel Szalay ,  Norbert Varga ,  Ferenc Boncz ,  Ferenc Darvas ,  Tamas Karancsi ,  Lajos Godorhazy

    IPC分类号： B01J19/00 ,  B29C59/04

    CPC分类号： B81C1/0046

    摘要： In a method according to the invention for forming a sealed channel (125) in the surface of a sheet made of a material with certain extent of plasticity, the machining surface of a tool with a rolling machining surface is brought into contact with a first point of the channel (125) to be formed in the surface of the sheet constituting a reactor block. Next, said machining surface is pressed onto the surface of the sheet with a compressive force (F) required to achieve the depth of the channel (125) to be formed, whereby the plastic material is squeezed out and becomes raised from the sheet surface on the peripheries of the depression being formed. After this, while maintaining the compressive force (F), by displacing said machining surface along the centerline of the channel (125) over the sheet surface it is rolled from the first point of the channel (125) to be formed to a second point thereof, whereby the channel (125) is machined in the material of the sheet and sealing edges (127) are created on the peripheries of the channel (125) from the material squeezed out and become raised. After creating said sealing edges (127), a closing member bearing against the sealing edges (127) is arranged at the surface of the sheet provided with the channel (125) and the sealing edges (127), and then said closing member is pressed onto the sheet by a compressive force required to deform said sealing edges (127) and is fixed in the position obtained, whereby a sealed channel (125) running between the first and second points is formed within the reactor block.

    摘要翻译： 在根据本发明的用于在由具有一定塑性的材料制成的片材的表面中形成密封通道（125）的方法中，具有滚动加工表面的工具的加工表面与第一点 的通道（125）形成在构成反应器块的片材的表面中。 接下来，所述加工表面以实现要形成的通道（125）的深度所需的压缩力（F）被压在片材的表面上，由此塑料材料被挤出并从片材表面升高 形成凹陷的周边。 此后，在保持压缩力（F）的同时，通过沿着通道（125）的中心线将所述加工表面移动在片材表面上，其从通道（125）的第一点被轧制以形成第二点 由此通道（125）在片材的材料中加工，并且密封边缘（127）由挤出的材料在通道（125）的周边上产生并升高。 在形成所述密封边缘（127）之后，在设置有通道（125）和密封边缘（127）的片材的表面处布置有抵靠密封边缘（127）的封闭构件，然后按压所述封闭构件 通过使所述密封边缘（127）变形所需的压缩力而被固定在片材上，并被固定在所获得的位置，由此在反应器块内形成在第一和第二点之间运行的密封通道（125）。

    Substituted azepine derivatives as serotonin receptor modulators
    4.
    发明授权
    Substituted azepine derivatives as serotonin receptor modulators 有权
    取代的吖庚因衍生物作为血清素受体调节剂

    公开(公告)号：US07718647B2

    公开(公告)日：2010-05-18

    申请号：US11170266

    申请日：2005-06-29

    申请人： Youssef L. Bennani ,  Michael J. Robarge ,  David C. Bom ,  Norbert Varga ,  Lawrence N. Tumey

    发明人： Youssef L. Bennani ,  Michael J. Robarge ,  David C. Bom ,  Norbert Varga ,  Lawrence N. Tumey

    IPC分类号： A61P25/00 ,  A61K31/55 ,  C07D223/16

    CPC分类号： C07D495/04

    摘要： The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are hexahydroazepinoindole and octahydroazepinoindole compounds. These compounds are serotonin receptor (5-HT) ligands and are useful for treating diseases, disorders, and conditions wherein modulation of the activity of serotonin receptors (5-HT) is desired (e.g. anxiety, depression and obesity).

    摘要翻译： 本发明一般涉及一系列化合物，含有该化合物的药物组合物，以及该化合物和组合物作为治疗剂的用途。 更具体地说，本发明的化合物是六氢吖庚因吲哚和八氢吖辛因吲哚化合物。 这些化合物是5-羟色胺受体（5-HT）配体，并且可用于治疗需要调节5-羟色胺受体（5-HT）的活性的疾病，病症和状况（例如焦虑，抑郁和肥胖）。

    Ozone Generating Electrolysis Cell
    5.
    发明申请
    Ozone Generating Electrolysis Cell 审中-公开
    臭氧发生电解池

    公开(公告)号：US20080314740A1

    公开(公告)日：2008-12-25

    申请号：US12158909

    申请日：2006-12-22

    申请人： Daniel Szalay ,  Norbert Varga ,  Ferenc Boncz ,  Ferenc Darvas ,  Tamas Karancsi ,  Lajos Godorhazy

    发明人： Daniel Szalay ,  Norbert Varga ,  Ferenc Boncz ,  Ferenc Darvas ,  Tamas Karancsi ,  Lajos Godorhazy

    IPC分类号： C25B9/00 ,  C25B1/13

    CPC分类号： C25B1/13 ,  C25B9/08 ,  C25B11/04

    摘要： The ozone generating electrolysis cell (10) according to the invention has a negative electrode (13) and an ozone generating positive electrode (16) comprising a mixture of lead dioxide and polytetrafluoroethylene (PTFE). A proton conducting solid electrolytic membrane (15) is arranged between the negative and positive electrodes (13, 16). The ozone generating electrolysis cell (10) also comprises an electrically conducting, liquid and gas permeable first electrode support (17) in contact with a side of the positive electrode (16) located opposite to the membrane (15), wherein said side of the electrode support (17) has a surface covered with a platinum-containing layer. The positive electrode (16) is made of a mixture prepared by the high-pressure compression of lead dioxide grains of colloid size and PTFE filaments having a dimension of at most 1 mm. Furthermore, the negative electrode (13) is adjoined to a side of the membrane (15) located opposite to the positive electrode (16) by a given compressing force and is formed on a surface of a porous second electrode support (12).

    摘要翻译： 根据本发明的臭氧发生电解槽（10）具有负极（13）和包含二氧化铅和聚四氟乙烯（PTFE）的混合物的产生臭氧的正极（16）。 质子传导固体电解质膜（15）设置在负极和正极（13,16）之间。 臭氧发生电解槽（10）还包括与位于与膜（15）相对的正电极（16）的一侧接触的导电，液体和气体可透过的第一电极支撑件（17），其中 电极支撑件（17）具有被含铂层覆盖的表面。 正极（16）由通过高压压缩胶体尺寸的二氧化铅颗粒和尺寸至多为1mm的PTFE细丝制成的混合物制成。 此外，负极（13）通过给定的压缩力与位于与正极（16）相对的膜（15）的一侧相邻，并形成在多孔第二电极支撑体（12）的表面上。

    Substituted azepine derivatives as serotonin receptor modulators
    7.
    发明申请
    Substituted azepine derivatives as serotonin receptor modulators 有权
    取代的吖庚因衍生物作为血清素受体调节剂

    公开(公告)号：US20060003990A1

    公开(公告)日：2006-01-05

    申请号：US11170266

    申请日：2005-06-29

    申请人： Youssef Bennani ,  Bayard Huck ,  Michael Robarge ,  David Bom ,  Norbert Varga ,  Lawrence Tumey

    发明人： Youssef Bennani ,  Bayard Huck ,  Michael Robarge ,  David Bom ,  Norbert Varga ,  Lawrence Tumey

    IPC分类号： A61K31/55 ,  C07D487/02

    CPC分类号： C07D495/04

    摘要： The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are hexahydroazepinoindole and octahydroazepinoindole compounds. These compounds are serotonin receptor (5-HT) ligands and are useful for treating diseases, disorders, and conditions wherein modulation of the activity of serotonin receptors (5-HT) is desired (e.g. anxiety, depression and obesity).

    摘要翻译： 本发明一般涉及一系列化合物，含有该化合物的药物组合物，以及该化合物和组合物作为治疗剂的用途。 更具体地说，本发明的化合物是六氢吖庚因吲哚和八氢吖辛因吲哚化合物。 这些化合物是5-羟色胺受体（5-HT）配体，并且可用于治疗需要调节5-羟色胺受体（5-HT）的活性的疾病，病症和状况（例如焦虑，抑郁和肥胖）。