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公开(公告)号:US06294311B1
公开(公告)日:2001-09-25
申请号:US09469493
申请日:1999-12-22
IPC分类号: G03F7004
CPC分类号: B41C1/1016 , B41C2210/02 , B41C2210/06 , B41C2210/14 , B41C2210/22 , B41C2210/24 , B41C2210/262 , B41N3/00
摘要: Imageable elements useful as lithographic printing members are disclosed. The elements contain a substrate, an underlayer, and a top layer. The underlayer contains a combination of polymeric materials that provides resistance both to fountain solution and to aggressive washes, such as a UV wash. The underlayer can be used in either thermally imageable or photochemically imageable elements.
摘要翻译: 公开了可用作平版印刷构件的可成像元件。 元件包含基底,底层和顶层。 底层包含聚合材料的组合,其提供对润版液和侵蚀性洗涤(例如UV洗涤)的电阻。 底层可用于可热成像或光电化学成像的元件。
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公开(公告)号:US20120213804A1
公开(公告)日:2012-08-23
申请号:US13372172
申请日:2012-02-13
申请人: ARTHUR KUNZ , Justin Keith Moran , Joseph Thomas Rubino , Neera Jain , Eugene Joseph Vidunas , John McLean Simpson , Paul David Robbins , Nishith Merchant , John Francis Dijoseph , Mark Edward Ruppen , Nitin Krishnaji Damle , Andrew George Popplewell
发明人: ARTHUR KUNZ , Justin Keith Moran , Joseph Thomas Rubino , Neera Jain , Eugene Joseph Vidunas , John McLean Simpson , Paul David Robbins , Nishith Merchant , John Francis Dijoseph , Mark Edward Ruppen , Nitin Krishnaji Damle , Andrew George Popplewell
CPC分类号: A61K31/704 , A61K47/48384 , A61K47/48407 , A61K47/48507 , A61K47/48561 , A61K47/6803 , A61K47/6809 , A61K47/6849 , C07K16/2803 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/76
摘要: Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
摘要翻译: 描述了具有显着高于先前报道的程序并且具有降低的聚集和低共轭分数(LCF)的药物负载的单体细胞毒性药物/载体缀合物的方法。 还描述了细胞毒性药物衍生物/抗体缀合物,包含缀合物的组合物和缀合物的用途。 还描述了单体加利车霉素衍生物/抗-CD22抗体缀合物,包含缀合物的组合物和缀合物的用途。
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公开(公告)号:US06352811B1
公开(公告)日:2002-03-05
申请号:US09469490
申请日:1999-12-22
申请人: Jayanti Patel , Shahhikant Saraiya , Celin Savariar-Hauck , Jianbing Huang , Frederic Mikell , Ken-ichi Shimazu , Nishith Merchant
发明人: Jayanti Patel , Shahhikant Saraiya , Celin Savariar-Hauck , Jianbing Huang , Frederic Mikell , Ken-ichi Shimazu , Nishith Merchant
IPC分类号: G03F709
CPC分类号: B41C1/1016 , B41C2210/02 , B41C2210/06 , B41C2210/14 , B41C2210/22 , B41C2210/24 , B41C2210/26 , B41C2210/262 , B41C2210/264 , B41C2210/266 , B41M5/368 , B41M5/42 , B41M5/44 , B41M5/465
摘要: A thermal lithographic printing plate, which can be imaged by thermal energy typically by imagewise exposure with an infrared emitting laser, a thermal printing head, etc., is made up of a hydrophilic substrate, and a composite layer structure composed of two layer coatings. Preferably, the first layer of the composite is composed of an aqueous developable polymer mixture containing a solubility inhibiting material and a photothermal conversion material which is contiguous to the hydrophilic substrate. The second layer of the composite is insoluble in the aqueous solution, is ink receptive, and is composed of one or more non-aqueous soluble polymers which are soluble or dispersible in a solvent which does not dissolve the first layer. The plate is exposed with an infrared laser or a thermal print head, and upon aqueous development of the imaged plate, the exposed portions are removed exposing hydrophilic substrate surfaces receptive to conventional aqueous fountain solutions. The unexposed portions contain the ink-receptive image areas. The second layer may also contain a photothermal conversion material. Alternatively, the composite layer may be free of photothermal conversion material when thermal imaging is carried out using a thermal printing head.
摘要翻译: 可以通过热能成像通过用红外发射激光成像曝光,热打印头等来成像的热平版印刷版由亲水基材和由两层涂层组成的复合层结构构成。 优选地,复合材料的第一层由含有可溶解性抑制材料和与亲水基底邻接的光热转换材料的水性可显影聚合物混合物组成。 复合材料的第二层不溶于水溶液,是油墨接受的,并且由一种或多种可溶于或不溶于不溶于第一层的溶剂中的非水溶性聚合物组成。 该板用红外激光或热打印头曝光,并且在成像板的水性显影时,去除曝光部分,暴露接受常规水性喷泉溶液的亲水底物表面。 未曝光部分包含吸墨图像区域。 第二层也可以含有光热转换材料。 或者,当使用热敏打印头进行热成像时,复合层可以不含光热转换材料。
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公开(公告)号:US08835611B2
公开(公告)日:2014-09-16
申请号:US13372172
申请日:2012-02-13
申请人: Arthur Kunz , Justin Keith Moran , Joseph Thomas Rubino , Neera Jain , Eugene Joseph Vidunas , John McLean Simpson , Paul David Robbins , Nishith Merchant , John Francis Dijoseph , Mark Edward Ruppen , Nitin Krishnaji Damle , Andrew George Popplewell
发明人: Arthur Kunz , Justin Keith Moran , Joseph Thomas Rubino , Neera Jain , Eugene Joseph Vidunas , John McLean Simpson , Paul David Robbins , Nishith Merchant , John Francis Dijoseph , Mark Edward Ruppen , Nitin Krishnaji Damle , Andrew George Popplewell
CPC分类号: A61K31/704 , A61K47/48384 , A61K47/48407 , A61K47/48507 , A61K47/48561 , A61K47/6803 , A61K47/6809 , A61K47/6849 , C07K16/2803 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/76
摘要: Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
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公开(公告)号:US06352812B1
公开(公告)日:2002-03-05
申请号:US09301866
申请日:1999-04-29
申请人: Ken-Ichi Shimazu , Jayanti Patel , Shashikant Saraiya , Nishith Merchant , Celin Savariar-Hauck , Hans-Joachim Timpe , Christopher D. McCullough
发明人: Ken-Ichi Shimazu , Jayanti Patel , Shashikant Saraiya , Nishith Merchant , Celin Savariar-Hauck , Hans-Joachim Timpe , Christopher D. McCullough
IPC分类号: G03F709
CPC分类号: B41M5/42 , B41C1/1016 , B41C2201/04 , B41C2210/02 , B41C2210/06 , B41C2210/14 , B41C2210/24 , B41C2210/26 , B41C2210/262 , B41C2210/264 , B41C2210/266 , B41M5/368 , B41M5/44 , B41M5/465
摘要: A thermal lithographic printing plate, which can be imaged by thermal energy typically by imagewise exposure with an infrared emitting laser, a thermal printing head, etc., is made up of a hydrophilic substrate, and a composite layer structure composed of two layer coatings. Preferably, the first layer of the composite is composed of an aqueous developable polymer mixture containing a photothermal conversion material which is contiguous to the hydrophilic substrate. The second layer of the composite is composed of one or more non-aqueous soluble polymers which are soluble or dispersible in a solvent which does not dissolve the first layer. The plate is exposed with an infrared laser or a thermal print head, and upon aqueous development of the imaged plate, the exposed portions are removed exposing hydrophilic substrate surfaces receptive to conventional aqueous fountain solutions. The unexposed portions contain the ink-receptive image areas. The second layer may also contain a photothermal conversion material. Alternatively, the composite layer may be free of photothermal conversion material when thermal imaging is carried out using a thermal printing head.
摘要翻译: 可以通过热能成像通过用红外发射激光成像曝光,热打印头等来成像的热平版印刷版由亲水基材和由两层涂层组成的复合层结构构成。 优选地,复合材料的第一层由包含与亲水基底邻接的光热转换材料的水性可显影聚合物混合物组成。 复合材料的第二层由一种或多种可溶于或不溶于不溶于第一层的溶剂中的非水溶性聚合物组成。 该板用红外激光或热打印头曝光,并且在成像板的水性显影时,去除曝光部分,暴露接受常规水性喷泉溶液的亲水底物表面。 未曝光部分包含吸墨图像区域。 第二层也可以含有光热转换材料。 或者,当使用热敏打印头进行热成像时,复合层可以不含光热转换材料。
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公开(公告)号:US6060217A
公开(公告)日:2000-05-09
申请号:US922190
申请日:1997-09-02
申请人: My T. Nguyen , Nishith Merchant , Ken-Ichi Shimazu , S. Peter Pappas , Robert Hallman , Jerome Philip Kesselman , Celin Savariar-Hauck , Gerhard Hauck , Hans-Joachim Timpe , Omkar J. Natu , Ajay Shah
发明人: My T. Nguyen , Nishith Merchant , Ken-Ichi Shimazu , S. Peter Pappas , Robert Hallman , Jerome Philip Kesselman , Celin Savariar-Hauck , Gerhard Hauck , Hans-Joachim Timpe , Omkar J. Natu , Ajay Shah
CPC分类号: B41C1/1008 , B41M5/368 , B41C2210/02 , B41C2210/06 , B41C2210/24 , B41C2210/262 , B41M5/36 , Y10S430/107 , Y10S430/145
摘要: A method for directly imaging a lithographic printing surface using infrared radiation without the requirement of pre- or post-UV-light exposure, or heat treatment employs a printing plate which contains a support with a hydrophilic surface overcoated with an imaging layer. The imaging layer contains at least one polymer having bonded pendent groups which are hydroxy, carboxylic acid, tert-butyl-oxycarbonyl, sulfonamide, amide, nitrile, urea, or combinations thereof; as well as an infrared absorbing compound. The imaging layer may contain a second polymer which has bonded pendent groups which are 1,2-napthoquinone diazide, hydroxy, carboxylic acid, sulfonamide, hydroxymethyl amide, alkoxymethyl amide, nitrile, maleimide, urea, or combinations thereof. The imaging layer may also contain a visible absorption dye, a solubility inhibiting agent, or both. In practice, the imaging layer is imagewise exposed to infrared radiation to produce exposed image areas in the imaged layer which have transient solubility in aqueous alkaline developing solution, so that solubility is gradually lost over a period of time until the imaged areas become as insoluble as non-imaged areas. Within a short time period of the imaging exposure, the imaged layer is developed with an aqueous alkaline developing solution to form the lithographic printing surface. In this method, the infrared radiation preferably is laser radiation which is digitally controlled.
摘要翻译: 使用红外线辐射直接对平版印刷表面进行成像的方法,而不需要进行紫外线照射之前或之后的曝光或热处理,使用包含具有用成像层涂覆的亲水表面的载体的印刷版。 成像层含有至少一种具有键合的侧基的聚合物,其为羟基,羧酸,叔丁基 - 氧羰基,磺酰胺,酰胺,腈,脲或其组合; 以及红外线吸收剂。 成像层可以含有具有键合的侧基的第二聚合物,其为1,2-萘醌二叠氮,羟基,羧酸,磺酰胺,羟甲基酰胺,烷氧基甲基酰胺,腈,马来酰亚胺,脲或其组合。 成像层还可以含有可见吸收染料,溶解性抑制剂,或两者。 在实践中,成像层被成像地暴露于红外辐射,以在成像层中产生在含水碱性显影液中具有瞬时溶解度的曝光图像区域,使得溶解度在一段时间内逐渐丧失,直到成像区域变得不溶于 非成像区域。 在成像曝光的短时间内,用含水碱性显影液显影成像层以形成平版印刷表面。 在该方法中,红外辐射优选为数字控制的激光辐射。
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公开(公告)号:US08747857B2
公开(公告)日:2014-06-10
申请号:US10699874
申请日:2003-11-03
申请人: Arthur Kunz , Justin Keith Moran , Joseph Thomas Rubino , Neera Jain , Eugene Joseph Vidunas , John McLean Simpson , Nishith Merchant , John Francis Dijoseph , Mark Edward Ruppen , Nitin Krishnaji Damle , Paul David Robbins , Andrew George Popplewell
发明人: Arthur Kunz , Justin Keith Moran , Joseph Thomas Rubino , Neera Jain , Eugene Joseph Vidunas , John McLean Simpson , Nishith Merchant , John Francis Dijoseph , Mark Edward Ruppen , Nitin Krishnaji Damle , Paul David Robbins , Andrew George Popplewell
CPC分类号: A61K31/704 , A61K47/48384 , A61K47/48407 , A61K47/48507 , A61K47/48561 , A61K47/6803 , A61K47/6809 , A61K47/6849 , C07K16/2803 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/76
摘要: Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
摘要翻译: 描述了具有显着高于先前报道的程序并且具有降低的聚集和低共轭分数(LCF)的药物负载的单体细胞毒性药物/载体缀合物的方法。 还描述了细胞毒性药物衍生物/抗体缀合物,包含缀合物的组合物和缀合物的用途。 还描述了单体加利车霉素衍生物/抗-CD22抗体缀合物,包含缀合物的组合物和缀合物的用途。
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公开(公告)号:US08153768B2
公开(公告)日:2012-04-10
申请号:US10428894
申请日:2003-05-02
申请人: Arthur Kunz , Justin Keith Moran , Joseph Thomas Rubino , Neera Jain , Eugene Joseph Vidunas , John McLean Simpson , Paul David Robbins , Nishith Merchant , John Francis DiJoseph , Mark Edward Ruppen , Nitin Krishnaji Damle , Andrew George Popplewell
发明人: Arthur Kunz , Justin Keith Moran , Joseph Thomas Rubino , Neera Jain , Eugene Joseph Vidunas , John McLean Simpson , Paul David Robbins , Nishith Merchant , John Francis DiJoseph , Mark Edward Ruppen , Nitin Krishnaji Damle , Andrew George Popplewell
CPC分类号: A61K31/704 , A61K47/48384 , A61K47/48407 , A61K47/48507 , A61K47/48561 , A61K47/6803 , A61K47/6809 , A61K47/6849 , C07K16/2803 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/76
摘要: Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
摘要翻译: 描述了具有显着高于先前报道的程序并且具有降低的聚集和低共轭分数(LCF)的药物负载的单体细胞毒性药物/载体缀合物的方法。 还描述了细胞毒性药物衍生物/抗体缀合物,包含缀合物的组合物和缀合物的用途。 还描述了单体加利车霉素衍生物/抗-CD22抗体缀合物,包含缀合物的组合物和缀合物的用途。
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公开(公告)号:US06451505B1
公开(公告)日:2002-09-17
申请号:US09633029
申请日:2000-08-04
IPC分类号: G03G7004
CPC分类号: G03F7/202 , B41C1/1033 , B41M5/368 , Y10S430/145
摘要: An imageable element comprises: (A) a substrate; and (B) an imageable composition applied to the substrate comprising: (1) a first layer, comprising: (a) a photosensitive composition capable of absorbing actinic radiation; and (b) a photothermal converter; and (2) an ablatable second layer contiguous to the first layer, wherein the second layer is opaque to the actinic radiation. This imageable element advantageously is useful in both positive and negative working printing plate applications, increases the efficiency of use of mask-generating radiation such as IR radiation and eliminates the need for chemicals and additional time to create a mask.
摘要翻译: 可成像元件包括:(A)基材; 和(B)施加到基材上的可成像组合物,包括:(1)第一层,其包含:(a)能够吸收光化辐射的光敏组合物; 和(b)光热转换器; 和(2)与第一层邻接的可烧蚀的第二层,其中第二层对于光化辐射是不透明的。该可成像元件有利地用于正和负作业印刷板应用中,提高了掩模产生的使用效率 辐射如红外辐射,消除了化学品的需要和额外的时间来创建一个面具。
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