公开(公告)号：US5977378A

公开(公告)日：1999-11-02

申请号：US4247

申请日：1998-01-08

申请人： Nikolaus Muller ,  Lutz Heuer ,  Johannes Kanellakopoulos ,  Andreas Sattler ,  Klaus-Peter Heise

发明人： Nikolaus Muller ,  Lutz Heuer ,  Johannes Kanellakopoulos ,  Andreas Sattler ,  Klaus-Peter Heise

IPC分类号： C07D231/14

CPC分类号： C07D231/14

摘要： 1-alkyl-pyrazole-5-carboxylic acid esters are prepared by reacting the enolate of a 2,4-diketocarboxylic acid ester with an N-alkylhydrazinium salt in the presence of a solvent. This process allows a particularly economic preparation of 1-alkyl-pyrazole-5-carboxylic acid esters in a simple manner and with only little formation of undesirable isomers.

摘要翻译： 1-烷基 - 吡唑-5-羧酸酯通过在溶剂存在下使2,4-二酮羧酸酯的烯醇化物与N-烷基肼鎓盐反应来制备。 该方法允许以简单的方式特别经济地制备1-烷基 - 吡唑-5-羧酸酯，并且几乎不形成不期望的异构体。

公开(公告)号：US5969152A

公开(公告)日：1999-10-19

申请号：US888889

申请日：1997-07-07

申请人： Lutz Heuer ,  Nikolaus Muller ,  Guido Steffan

发明人： Lutz Heuer ,  Nikolaus Muller ,  Guido Steffan

IPC分类号： C07D231/10 ,  C07D231/16 ,  C07D231/14

CPC分类号： C07D231/16

摘要： Nitropyrazole esters of the formula ##STR1## in which R.sup.1 represents C.sub.1 -C.sub.6 -alkyl, are prepared by nitration of the corresponding pyrazole esters. The nitropyrazole esters permit the preparation of a known nitropyrazole amide in a particularly simple and economical manner and thereby improve the preparation of active compounds which are accessible from the nitropyrazole amide.

摘要翻译： 通过硝化相应的吡唑酯制备其中R 1表示C 1 -C 6 - 烷基的式的硝基吡唑酯。 硝基吡唑酯可以以特别简单和经济的方式制备已知的硝基吡唑酰胺，从而改进可从硝基吡唑酰胺获得的活性化合物的制备。

公开(公告)号：US5885474A

公开(公告)日：1999-03-23

申请号：US11241

申请日：1998-01-28

申请人： Jurgen Reiners ,  Manfred Schnee ,  Torsten Groth ,  Winfried Joentgen ,  Gerd Schmitz ,  Harro Traubel ,  Nikolaus Muller

发明人： Jurgen Reiners ,  Manfred Schnee ,  Torsten Groth ,  Winfried Joentgen ,  Gerd Schmitz ,  Harro Traubel ,  Nikolaus Muller

IPC分类号： C08G73/10 ,  C14C9/00

CPC分类号： C08G73/1092 ,  C14C9/00 ,  Y10T428/4935

摘要： Leather can be pretreated to obtain good body, soft feel, and excellent grain smoothness and solidity with products having a molecular weight of 700 to 30,000 and which are obtainable by reaction ofA. polysuccinimide having a molecular weight, determined as the number-average, of 500 to 10,000, withB. 5 to 90 mol % based on the succinimide units of polysuccinimide A, and/or secondary amine, the nitrogen substituents of which contain 1 to 60 carbon atoms and which can be unsubstituted or substituted, at least 2.5 mol % of the nitrogen substituents of the amine containing at least 12 carbon atoms,C. optionally, (i) derivatives of C.sub.1 -C.sub.18 -monocarboxylic acids, C.sub.2 -C.sub.10 -dicarboxylic acids, and/or (ii) monoisocyanates, diisocyanates epichlorohydrin (for reaction of amino and/or hydroxyl groups on the nitrogen substituents of the reaction product of A and B), andD. 95 to 10 mol % of ring-opening base in the presence of water.

摘要翻译： PCT No.PCT / EP96 / 03241 Sec。 371日期1998年1月28日 102（e）1998年1月28日PCT PCT 1996年7月23日PCT公布。 公开号WO97 / 06279 日期1997年2月20日可以预处理具有分子量为700〜30,000的产品的良好的身体，柔软的手感和良好的颗粒光滑度和稳定性，并且可以通过将分子量为A的聚琥珀酰亚胺 数均分子量为500〜10000，B为5〜90摩尔％，基于琥珀酰亚胺单元的聚琥珀酰亚胺A，和/或仲胺，其氮取代基含有1〜60个碳原子，可以是未取代的或 至少2.5mol％含有至少12个碳原子的胺的氮取代基，C.任选地，（i）C 1 -C 18 - 一元羧酸的衍生物，C 2 -C 10 - 二羧酸和/或（ii） 单异氰酸酯，二异氰酸酯表氯醇（用于在A和B的反应产物的氮取代基上的氨基和/或羟基的反应）和D.95至10摩尔％的开环碱在水的存在下反应。

公开(公告)号：US5236939A

公开(公告)日：1993-08-17

申请号：US778023

申请日：1991-10-17

申请人： Gerhard Bonse ,  Nikolaus Muller ,  Achim Harder

发明人： Gerhard Bonse ,  Nikolaus Muller ,  Achim Harder

IPC分类号： A01N43/824 ,  C07D271/10 ,  C07D271/113 ,  C07D285/12 ,  C07D285/125 ,  C07D285/13

CPC分类号： C07D271/113 ,  C07D285/125 ,  C07D285/13

摘要： Substituted 1,3,4 -oxa- diazolinones of the formula (I) ##STR1## in which X represents O andY represents O or S,are disclosed as useful to combat endoparasites.

摘要翻译： 公开了其中X代表O且Y代表O或S的式（I）的取代的1,3,4-恶二唑啉酮用于对抗内寄生虫。

公开(公告)号：US5093343A

公开(公告)日：1992-03-03

申请号：US577970

申请日：1990-09-05

申请人： Gerhard Bonse ,  Nikolaus Muller ,  Achim Harder

发明人： Gerhard Bonse ,  Nikolaus Muller ,  Achim Harder

IPC分类号： A01N43/824 ,  A61K31/41 ,  A61K31/4245 ,  A61K31/433 ,  A61P33/10 ,  C07D271/10 ,  C07D271/113 ,  C07D285/12 ,  C07D285/125 ,  C07D285/13

CPC分类号： C07D271/113 ,  C07D285/125 ,  C07D285/13

摘要： Substituted 1,3,4-oxa- and thiadiazolinones of the formula (I) ##STR1## in which R.sup.1 represents hydrogen, alkyl, alkoxy, alkylthio, halogen, halogenoalkyl, halogenoalkoxy or halogenoalkylthio,R.sup.2 represents one or more identical or different radicals from among hydrogen, alkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy, halogenoalkylthio, alkylenedioxy, halogenoalkylenedioxy, halogen, CN, NO.sub.2, NH.sub.2, alkylamino, dialkylamino, alkylcarbonyl, carbalkoxy, alkylsulphonyl, arylsulphonyl, sulphamoyl, alkylsulphamoyl, dialkylsulphamoyl, aryl, aryloxy or arylthio, which, in turn, can be sutstituted,R.sup.3 represents one or more identical or different radicals from among hydrogen, alkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy, halogenoalkylthio, alkylenedioxy, halogenoalkylenedioxy, halogen, CN, NO.sub.2, alkylcarbonyl, carbalkoxy, alkylsulphonyl, arylsulphonyl, sulphamoyl, alkylsulphamoyl, dialkylsulphamoyl, aryl, aryloxy or arylthio, which, in turn, can be substituted,X represents O or S, andY represents O or S,with the exception of the compounds 5-phenoxy-3-(3,4-dichlorophenyl)-1,3,4-oxadiazol-2(3H)-one, and 5-phenoxy-3-(3-chloro-4-fluorophenyl)-1,3,4-oxadiazol-2-(3H)-one are disclosed as useful to combat endoparasites. Compositions containing these compounds and process for preparing them are also disclosed.The present invention relates to new substituted 1,3,4-oxa(thia)diazolinones, process for their preparation, and their use for combating endoparasites.Substituted 2-alkoxy-1,3,4-oxathiazolinones and their use against endoparasites are already known, but their actions are not always satisfactory (DE-OS (German Published Specification) 2,604,110). Previously described compounds are furthermore 2-aryloxy-1,3,4-oxadiazolinones (Pilgram, J. Heterocyclic Chem. 39, 823 (1982)); however, nothing is known about their use for combating endoparasites.The present invention relates to substituted 1,3,4-oxa-and thiadiazolinones of the formula (I) ##STR2## in which R.sup.1 represents hydrogen, alkyl, alkoxy, alkylthio, halogen, halogenoalkyl, halogenoalkoxy or halogeno-alkylthio,R.sup.2 represents one or more identical or different radicals from amongst hydrogen, alkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy, halogeno-alkylthio, alkylenedioxy, halogenoalkylenedioxy, halogen, CN, NO.sub.2, NH.sub.2, alkylamino, dialkylamino, alkylcarbonyl, carbalkoxy, alkylsulphonyl, arylsulphonyl, sulphamoyl, alkylsulphamoyl, dialkyl-sulphamoyl, aryl, aryloxy or arylthio, which, in turn, can be substituted,R.sup.3 represents one or more identical or different radicals from amongst hydrogen, alkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy, halogeno-alkylthio, alkylenedioxy, halogenoalkylenedioxy, halogen, CN, NO.sub.2, alkylcarbonyl, carbalkoxy, alkyl-sulphonyl, arylsulphonyl, sulphamoyl, alkyl-sulphamoyl, dialkylsulphamoyl, aryl, aryloxy or arylthio, which, in turn, can be substituted,X represents 0 or S, andY represents 0 or S,with the exception of the compounds 5-phenoxy-3-(3,4-dichlorophenyl)-1,3,4-oxadiazol-2(3H)-one and 5-phenoxy-(3-chloro-4-fluorophenyl)-1,3,4-oxadiazol-2-(3H)-one.The invention also relates to a process for the preparation of the new substituted 1,3,4-oxa- and thiadiazolinones of the formula ##STR3## in which R.sup.1 represents hydrogen, alkyl, alkoxy, alkylthio, halogen, halogenoalkyl, halogenoalkoxy or halogeno-alkylthio,R.sup.2 represents one or more identical or different radicals from amongst hydrogen, alkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy, halogeno-alkylthio, alkylenedioxy, halogenoalkylenedioxy, halogen, CN, NO.sub.2, NH.sub.2, alkylamino, dialkylamino, alkylcarbonyl, carbalkoxy, alkylsulphonyl, aryl-sulphonyl, sulphamoyl, alkylsulphamoyl, dialkyl-sulphamoyl, aryl, aryloxy or arylthio, which, in turn, can be substituted,R.sup.3 represents one or more identical or different radicals from amongst hydrogen, alkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy, halogeno-alkylthio, alkylenedioxy, halogenoalkylenedioxy, halogen, CN, NO.sub.2, alkylcarbonyl, carbalkoxy, alkyl-sulphonyl, arylsulphonyl, sulphamoyl, alkyl-sulphamoyl, dialkylsulphamoyl, aryl, aryloxy or arylthio, which, in turn, can be substituted,X represents O or S, andY represents O or S,with the exception of the compounds 5-phenoxy-3-(3,4-dichlorophenyl)-1,3,4-oxadiazol-2(3H)-one and 5-phenoxy-3-(3-chloro-4-fluorophenyl)-1,3,4-oxadiazol-2-(3H)-one, characterized in that compounds of the formula (II) ##STR4## in which X, Y, R.sup.1, R.sup.2 and R.sup.3 have the abovementioned meaning, are reacted with carbonylation reagents such as phosgene, phosgene or triphosgene, and the compounds obtained in this process, of the formula III ##STR5## in which X, Y, R.sup.1, R.sup.2 and R.sup.3 have the abovementioned meaning, are cyclized in the presence of bases.

公开(公告)号：US4771048A

公开(公告)日：1988-09-13

申请号：US66787

申请日：1987-06-25

申请人： Nikolaus Muller ,  Peter Andrews

发明人： Nikolaus Muller ,  Peter Andrews

IPC分类号： A01N43/88 ,  C07D285/16 ,  C07D417/12 ,  A61K31/54

CPC分类号： C07D285/16

摘要： The present invention relates to the use of thiadiazinones of the formula I ##STR1## in which R represents the radical of the formula ##STR2## wherein X.sup.1 represents O or S,R.sup.4 represents hydrogen or alkyl,R.sup.5 represents optionally substituted phenyl,R.sup.2 represents hydrogen, alkyl, cycloalkyl, aryl or aralkylfor combating endoparasites in veterinary medicine and to new thiadiazinones of the formula I and the preparation thereof.

摘要翻译： 本发明涉及式Ⅰa的噻二嗪酮的用途，其中R表示式的基团，其中X 1表示O或S，R 4表示氢或烷基，R 5表示任意取代的苯基，R 2表示 氢，烷基，环烷基，芳基或芳烷基，用于对抗兽医学中的内寄生虫和新的式I的噻二嗪酮及其制备。

公开(公告)号：US20090143594A1

公开(公告)日：2009-06-04

申请号：US12275316

申请日：2008-11-21

申请人： Alain Cotte ,  Nikolaus Muller ,  Matthias Gotta ,  Matthias Beller ,  Thomas Schareina ,  Alexander Zapf

发明人： Alain Cotte ,  Nikolaus Muller ,  Matthias Gotta ,  Matthias Beller ,  Thomas Schareina ,  Alexander Zapf

IPC分类号： C07C41/01 ,  C07C209/00 ,  C07D213/63 ,  B01J31/18

CPC分类号： C07C41/16 ,  C07C201/12 ,  C07C213/00 ,  C07C231/12 ,  C07D213/643 ,  C07C217/90 ,  C07C233/25 ,  C07C205/38 ,  C07C43/275 ,  C07C43/263 ,  C07C43/257

摘要： Described is a process for preparing diaryl ethers of the formula (I) Ar—O—Ar′  (I) In which Ar is an aryl or substituted aryl group and Ar′ is an aryl, substituted aryl, heteroaryl or substituted heteroaryl group, by reacting an aryl of formula (II) or a aryloxy salt of formula (III) Ar—OH   (II) Ar—OR   (III) In which Ar has the same meaning as in formula (I) and R is an alkali metal, with an aryl or heteroaryl bromide of formula (IV) Ar′—Br   (IV) In which Ar′ has the same meaning as in formula (I), characterized in that the reaction is carried out in the presence of a copper(I)salt and a 1-substituted imidazole as catalyst system.

摘要翻译： 描述了制备式（I）的二芳基醚的方法<？in-line-formula description =“In-line Formulas”end =“lead”→Ar-O-Ar'（I） -formulae description =“In-line Formulas”end =“tail”？>其中Ar是芳基或取代的芳基，Ar'是芳基，取代的芳基，杂芳基或取代的杂芳基，通过使式 II）或式（III）的芳氧基盐<？in-line-formula description =“In-line Formulas”end =“lead”？> Ar-OH（II）<？in-line-formula description =“In “公式”end =“tail”？> <？in-line-formula description =“In-line Formulas”end =“lead”？> Ar-OR（III）<？in-line-formula description =“In 其中Ar具有与式（I）中相同的含义并且R是碱金属，其中式（IV）的芳基或杂芳基溴<？在线配方说明书 =“在线公式”end =“lead”？> Ar'-Br（IV）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中Ar' 意义如式（I）所示 其特征在于反应在铜（I）盐和1-取代的咪唑作为催化剂体系的存在下进行。

公开(公告)号：US20080093139A1

公开(公告)日：2008-04-24

申请号：US11821737

申请日：2007-06-25

申请人： Rolf Dobereiner ,  Nikolaus Muller

发明人： Rolf Dobereiner ,  Nikolaus Muller

IPC分类号： B60R16/02 ,  B60K1/00

CPC分类号： H01L23/44 ,  H01L23/467 ,  H01L2924/0002 ,  H01L2924/00

摘要： A drive for a vehicle, especially a tracked vehicle or a vehicle with wheel-based steering, with at least one component which consumes electric energy and at least one power electronic component (power electronics) for providing the necessary electric energy, where the power electronics can be cooled with a fluid by the evaporative cooling process.

摘要翻译： 用于车辆的驱动器，特别是跟踪车辆或具有轮子转向的车辆，其具有消耗电能的至少一个部件和用于提供所需电能的至少一个电力电子部件（电力电子部件），其中电力电子 可以通过蒸发冷却过程用流体冷却。

公开(公告)号：US5977362A

公开(公告)日：1999-11-02

申请号：US84695

申请日：1998-05-26

申请人： Nikolaus Muller ,  Klaus-Christian Paetz ,  Wolfgang Kiel

发明人： Nikolaus Muller ,  Klaus-Christian Paetz ,  Wolfgang Kiel

IPC分类号： C07D239/96 ,  C07D239/72

CPC分类号： C07D239/96

摘要： Quinazoline-2,4-diones are obtained in high yields and purities by reacting anthranilic acids with isocyanates and then, without isolation of the urea formed as intermediate, treating the reaction mixture with acid.

摘要翻译： 通过使邻氨基苯甲酸与异氰酸酯反应然后在不分离形成中间体的脲的情况下，用酸处理反应混合物，以高产率和纯度获得喹唑啉-2,4-二酮。

公开(公告)号：US4766144A

公开(公告)日：1988-08-23

申请号：US35543

申请日：1987-04-03

申请人： Nikolaus Muller ,  Eckart Kranz ,  Peter Andrews

发明人： Nikolaus Muller ,  Eckart Kranz ,  Peter Andrews

IPC分类号： A61K31/37 ,  A61K31/443 ,  A61K31/445 ,  A61P33/00 ,  C07D311/56 ,  C07D405/12 ,  C07D311/12

CPC分类号： C07D405/12 ,  C07D311/56

摘要： 3-carbamoyl-4-hydroxy-couramins for combating parasitic helminths of the formula ##STR1## in which R.sup.1 represents hydrogen, halogen, alkyl, NO.sub.2, CN or alkoxy,X represents O, S, SO or SO.sub.2R.sup.2 represents alkyl, halogenoalkyl, phenyl, naphthyl or pyridyl, which can optionally be substituted; or the radical -X-R.sup.2, together with the radical R.sup.3 can also form an alkylenedioxy (-O-alk-O), halogenoalkylenedioxy, oxyalkyleneoxyalkylene (-O-Alk-O-Alk-) or oxyhalogenoalkylene-oxyhalogenoalkylene bridge; andR.sup.3 and R.sup.4 independently of one another represent hydrogen, halogen, CN, OH, NO.sub.2, amino, mono- or dialklylamino, alkyl, halogenoalkyl, aralkyl or aryl, which can optionally be substituted,can be used for combating parasitic helminths.

摘要翻译： 3-氨基甲酰基-4-羟基维生素，用于对抗式为“IMAGE”的寄生蠕虫，其中R 1表示氢，卤素，烷基，NO 2，CN或烷氧基，X表示O，S，SO或SO 2 R 2表示烷基，卤代烷基， 苯基，萘基或吡啶基，其可任选被取代; 或基团-X-R2与基团R3一起也可以形成亚烷基二氧基（-O-烷基-O），卤代亚烷基二氧基，氧亚烷基氧化烯（-O-Alk-O-Alk-）或氧卤代亚烷基 - 氧卤代亚烷基桥; 并且R 3和R 4彼此独立地表示氢，卤素，CN，OH，NO 2，氨基，单或二烷基氨基，烷基，卤代烷基，芳烷基或芳基，其可任选被取代，可用于对抗寄生蠕虫。