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公开(公告)号：US09561241B1
公开(公告)日：2017-02-07
申请号：US13536130
申请日：2012-06-28
Applicant: Douglas A. Bakan , Waranush Jitpraphai , Steven B. Newhard , Mitchell S. Wortzman
Inventor： Douglas A. Bakan , Waranush Jitpraphai , Steven B. Newhard , Mitchell S. Wortzman
CPC classification number: A61K31/65 , A61K9/0004 , A61K9/0065 , A61K9/2054 , A61K9/4858
Abstract: The present disclosure relates to dosage forms and methods that enhance the absorption of minocycline in the gastrointestinal tract and thereby enhance bioavailability of the minocycline, and further provides methods of using these dosage forms for the treatment of conditions such as acne.
Abstract translation: 本公开涉及增加米诺环素在胃肠道中的吸收并从而增强米诺环素的生物利用度的剂型和方法，并且还提供使用这些剂型用于治疗诸如痤疮等病症的方法。
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公开(公告)号：US07771733B2
公开(公告)日：2010-08-10
申请号：US11657880
申请日：2007-01-24
Applicant: Eugene H. Gans , Mitchell S. Wortzman
Inventor： Eugene H. Gans , Mitchell S. Wortzman
CPC classification number: A61K9/0014 , A61K31/56 , A61K31/573 , A61K31/58 , A61K47/08 , A61K47/10 , A61K47/14 , A61K47/20 , A61K47/22 , A61K47/26 , A61K47/32 , G11C16/0433 , G11C2216/10 , A61K2300/00
Abstract: The present invention comprises a composition, method of enhancing potency and method of delivering corticosteroids in a vehicle comprising at least two penetration enhancers, and solvents and emulsifiers. The propylene glycol and penetration enhancers are present in ratio to the total of the propylene glycol, penetration enhancers, and solvents and emulsifiers of at least about 0.70.
Abstract translation: 本发明包括一种组合物，增强效力的方法和在载体中递送糖皮质激素的方法，其包含至少两种渗透增强剂，以及溶剂和乳化剂。 丙二醇和渗透促进剂以至少约0.70的丙二醇，渗透促进剂，溶剂和乳化剂的总量的比例存在。
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公开(公告)号：US20120289490A1
公开(公告)日：2012-11-15
申请号：US13561277
申请日：2012-07-30
Applicant: Eugene H. Gans , Mitchell S. Wortzman
Inventor： Eugene H. Gans , Mitchell S. Wortzman
CPC classification number: A61K9/0014 , A61K31/56 , A61K31/573 , A61K31/58 , A61K47/08 , A61K47/10 , A61K47/14 , A61K47/20 , A61K47/22 , A61K47/26 , A61K47/32 , G11C16/0433 , G11C2216/10 , A61K2300/00
Abstract: The present invention comprises a composition, method of enhancing potency and method of delivering corticosteroids in a vehicle comprising at least two penetration enhancers, and solvents and emulsifiers. The propylene glycol and penetration enhancers are present in ratio to the total of the propylene glycol, penetration enhancers, and solvents and emulsifiers of at least about 0.70.
Abstract translation: 本发明包括一种组合物，增强效力的方法和在载体中递送糖皮质激素的方法，其包含至少两种渗透增强剂，以及溶剂和乳化剂。 丙二醇和渗透促进剂以至少约0.70的丙二醇，渗透促进剂，溶剂和乳化剂的总量的比例存在。
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公开(公告)号：US20090131521A1
公开(公告)日：2009-05-21
申请号：US12288411
申请日：2008-10-20
Applicant: Mitchell S. Wortzman , Waranush Jitpraphai , Manzer Durrani
Inventor： Mitchell S. Wortzman , Waranush Jitpraphai , Manzer Durrani
IPC: A61K31/327 , A61K31/19 , A61P17/10
CPC classification number: A61K31/192 , A61K9/0014 , A61K31/203 , A61K2300/00
Abstract: Embodiments of this invention relate to a composition containing both benzoyl peroxide and a retinoid. Additionally, it relates to the treatment of acne vulgaris by applying an aqueous gel comprising BPO and a retinoid.
Abstract translation: 本发明的实施方案涉及含有过氧化苯甲酰和类视黄醇的组合物。 另外，它涉及通过应用包含BPO和类视黄醇的水性凝胶来治疗寻常痤疮。
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5.发明授权Retinoid composition having enhanced bioavailability and percutaneous absorption 失效类视黄醇组合物具有增强的生物利用度和经皮吸收
公开(公告)号：US4727088A
公开(公告)日：1988-02-23
申请号：US941698
申请日：1986-12-15
Applicant: Richard A. Scott , Mitchell S. Wortzman , Eric Jungermann
Inventor： Richard A. Scott , Mitchell S. Wortzman , Eric Jungermann
IPC: A01N59/12 , A61K8/00 , A61K8/34 , A61K8/35 , A61K8/38 , A61K8/58 , A61K8/63 , A61K8/67 , A61K8/89 , A61K8/891 , A61K31/047 , A61K31/05 , A61K31/07 , A61K31/12 , A61K31/185 , A61K31/19 , A61K31/35 , A61K31/575 , A61K31/74 , A61K47/10 , A61K47/24 , A61Q17/02 , A61Q19/00 , A61Q19/02 , C08L83/04 , A61K7/48 , A61K31/20
CPC classification number: A61Q19/007 , A61K47/10 , A61K47/24 , A61K8/0229 , A61K8/342 , A61K8/347 , A61K8/38 , A61K8/585 , A61K8/63 , A61K8/671 , A61K9/0014 , A61Q17/02 , A61Q19/00 , A61Q19/02 , Y10S424/05 , Y10S424/10 , Y10S514/847 , Y10S514/848 , Y10S514/859 , Y10S514/861 , Y10S514/862 , Y10S514/863 , Y10S514/865 , Y10S514/886 , Y10S514/887 , Y10S514/889 , Y10S514/919 , Y10S514/969
Abstract: A new and improved topically applied pharmaceutical preparation for the treatment of acne and an improved vehicle for delivering the active ingredients thereof to the human skin in a manner whereby the bioavailability and percutaneous absorption of the active ingredient is remarkably enhanced. The vehicle comprises a volatile silicone, a fatty alcohol having from 12-22 carbon atoms, retinoids selected from the group consisting of tretinoin (all-trans retinoic acid) and isotretinoin (13-cis retinoic acid); and such preservatives or emulsifying agents as may be warranted.
Abstract translation: 一种新的和改进的用于治疗痤疮的局部应用药物制剂和用于将活性成分递送到人体皮肤的改进载体，其显着增强了活性成分的生物利用度和经皮吸收。 载体包含挥发性硅酮，具有12-22个碳原子的脂肪醇，选自维甲酸（全反式视黄酸）和异维A酸（13-顺式视黄酸））的类维生素A。 以及可能需要的这种防腐剂或乳化剂。
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Patent Agency Ranking
公开(公告)号：US09119793B1
公开(公告)日：2015-09-01
申请号：US13536052
申请日：2012-06-28
Applicant: Douglas A. Bakan , Waranush Jitpraphai , Steven B. Newhard , Mitchell S. Wortzman
Inventor： Douglas A. Bakan , Waranush Jitpraphai , Steven B. Newhard , Mitchell S. Wortzman
CPC classification number: A61K9/209 , A61K9/0065 , A61K9/2054 , A61K9/2086 , A61K31/65
Abstract: The present disclosure relates to dosage forms, e.g., swell, float and bioadhesive, and methods that enhance the absorption of doxycycline in the gastrointestinal tract. The oral dosage forms control the spatial and temporal delivery of doxycycline in the gastrointestinal tract. This controlled spatial and temporal delivery provides a site and rate of release, respectively, of the doxycycline into the gastrointestinal tract that enhances the amount of the doxycycline absorbed into the bloodstream.
Abstract translation: 本公开涉及剂型，例如膨胀，浮游和生物粘附，以及增强多西环素在胃肠道中的吸收的方法。 口服剂型控制多西环素在胃肠道中的空间和时间分布。 这种受控的空间和时间递送分别提供了多西环素分泌到胃肠道中的位点和释放速率，其增强了吸收到血流中的多西环素的量。
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公开(公告)号：US08455459B2
公开(公告)日：2013-06-04
申请号：US12184966
申请日：2008-08-01
Applicant: Mitchell S. Wortzman , Rhoda Narins , Xiaoming Lin
Inventor： Mitchell S. Wortzman , Rhoda Narins , Xiaoming Lin
IPC: A61K31/715 , A61K9/00 , A61K9/14 , A61F13/00 , C07H3/00
CPC classification number: A61K8/735 , A61K8/02 , A61K2800/91 , A61Q19/08
Abstract: Methods for applying injectable fillers are provided. In some embodiments, the methods can extend effectiveness of the injectable filler. In some embodiments, the methods can provide for an elevated level of effectiveness of the injectable filler. In some embodiments, the methods can prolong the effectiveness of the injectable filler.
Abstract translation: 提供了可注射填料的应用方法。 在一些实施方案中，该方法可以延长可注射填料的有效性。 在一些实施方案中，所述方法可以提供可注射填充剂的提高的有效性水平。 在一些实施方案中，该方法可以延长可注射填料的有效性。
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公开(公告)号：US08232264B2
公开(公告)日：2012-07-31
申请号：US12322346
申请日：2009-01-29
Applicant: Eugene H. Gans , Mitchell S. Wortzman
Inventor： Eugene H. Gans , Mitchell S. Wortzman
CPC classification number: A61K9/0014 , A61K31/56 , A61K31/573 , A61K31/58 , A61K47/08 , A61K47/10 , A61K47/14 , A61K47/20 , A61K47/22 , A61K47/26 , A61K47/32 , G11C16/0433 , G11C2216/10 , A61K2300/00
Abstract: The present invention comprises a composition, method of enhancing potency and method of delivering corticosteroids in a vehicle comprising at least two penetration enhancers, and solvents and emulsifiers. The propylene glycol and penetration enhancers are present in ratio to the total of the propylene glycol, penetration enhancers, and solvents and emulsifiers of at least about 0.70.
Abstract translation: 本发明包括一种组合物，增强效力的方法和在载体中递送糖皮质激素的方法，其包含至少两种渗透增强剂，以及溶剂和乳化剂。 丙二醇和渗透促进剂以至少约0.70的丙二醇，渗透促进剂，溶剂和乳化剂的总量的比例存在。
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公开(公告)号：US20090204101A1
公开(公告)日：2009-08-13
申请号：US12194934
申请日：2008-08-20
Applicant: Mitchell S. Wortzman , Xiaoming Lin , Jurrian T. Strobos , Richard G. Glogau , Michael A.C. Kane
Inventor： Mitchell S. Wortzman , Xiaoming Lin , Jurrian T. Strobos , Richard G. Glogau , Michael A.C. Kane
CPC classification number: A61K8/02 , A61K8/0241 , A61K8/735 , A61K8/8152 , A61K8/981 , A61K2800/654 , A61K2800/91 , A61Q19/08
Abstract: Methods for applying injectable fillers are provided. In some embodiments, the methods can result in a reduced risk of an adverse event occurring from the administration of the injectable filler. Also disclosed are devices and kits related to this method.
Abstract translation: 提供了可注射填料的应用方法。 在一些实施方案中，所述方法可导致从注射用填充剂的施用发生不良事件的风险降低。 还公开了与该方法相关的装置和套件。
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公开(公告)号：US20090176750A1
公开(公告)日：2009-07-09
申请号：US12322346
申请日：2009-01-29
Applicant: Eugene H. Gans , Mitchell S. Wortzman
Inventor： Eugene H. Gans , Mitchell S. Wortzman
IPC: A61K31/573
CPC classification number: A61K9/0014 , A61K31/56 , A61K31/573 , A61K31/58 , A61K47/08 , A61K47/10 , A61K47/14 , A61K47/20 , A61K47/22 , A61K47/26 , A61K47/32 , G11C16/0433 , G11C2216/10 , A61K2300/00
Abstract: The present invention comprises a composition, method of enhancing potency and method of delivering corticosteroids in a vehicle comprising at least two penetration enhancers, and solvents and emulsifiers. The propylene glycol and penetration enhancers are present in ratio to the total of the propylene glycol, penetration enhancers, and solvents and emulsifiers of at least about 0.70.
Abstract translation: 本发明包括一种组合物，增强效力的方法和在载体中递送糖皮质激素的方法，其包含至少两种渗透增强剂，以及溶剂和乳化剂。 丙二醇和渗透促进剂以至少约0.70的丙二醇，渗透促进剂，溶剂和乳化剂的总量的比例存在。
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