公开(公告)号：US06986837B2

公开(公告)日：2006-01-17

申请号：US10215885

申请日：2002-08-09

Applicant: Calvin Y. H. Chow ,  Morten J. Jensen ,  Colin B. Kennedy ,  Michael M. Lacy ,  Robert E. Nagle

Inventor： Calvin Y. H. Chow ,  Morten J. Jensen ,  Colin B. Kennedy ,  Michael M. Lacy ,  Robert E. Nagle

IPC: G01N27/453

CPC classification number: G01N27/44721 ,  B01L3/5027 ,  B01L9/527 ,  B01L2200/027 ,  B01L2200/148 ,  B01L2400/0415 ,  G01N27/44791

Abstract: A microfluidic controller and detector system and method for performing screening assays are disclosed. The microfluidic controller and detector system comprises a fluidic chip that includes at least two intersecting channels and a detection zone, a fluid direction system comprising an electrical interface configured for electrical contact with the at least two intersecting channels, an optics block having an objective lens disposed adjacent the detection zone, and a control system coupled to the optics block and adapted to receive and analyze data from the optics block. The electrical interface generally includes electrodes configured for electrical contact with the intersecting channels and coupled to electrode channels for supplying electrical input to the electrodes. A reference channel is optionally provided to calibrate the electrode channels.

公开(公告)号：US6151111A

公开(公告)日：2000-11-21

申请号：US929552

申请日：1997-09-15

Applicant: Mark Wechsler ,  Howard H. Barney ,  Roger A. Kaye ,  David G. Ogle ,  Michael M. Lacy ,  Calvin Y. Chow ,  Kimberly L. Crawford ,  Dean G. Hafeman

Inventor： Mark Wechsler ,  Howard H. Barney ,  Roger A. Kaye ,  David G. Ogle ,  Michael M. Lacy ,  Calvin Y. Chow ,  Kimberly L. Crawford ,  Dean G. Hafeman

IPC: G01N21/33 ,  G01N21/25 ,  G01N21/31 ,  G01N21/59 ,  G01N35/02 ,  G01J3/30

CPC classification number: G01N21/33 ,  G01N21/253 ,  G01N21/31 ,  G01N2201/0231 ,  G01N2201/0446 ,  G01N2201/1222 ,  G01N2201/127 ,  G01N35/028

Abstract: The present invention relates to a photometric device for measuring optical parameters. The invention functions in the ultraviolet light range through use of a monochromator and splits the test light in multiple channels by a rotor assembly, including a mirror.

公开(公告)号：US5557398A

公开(公告)日：1996-09-17

申请号：US228436

申请日：1994-04-15

Applicant: Mark Wechsler ,  Howard H. Barney ,  Roger A. Kaye ,  David G. Ogle ,  Michael M. Lacy ,  Calvin Y. Chow ,  Kimberly L. Crawford ,  Dean G. Hafeman

Inventor： Mark Wechsler ,  Howard H. Barney ,  Roger A. Kaye ,  David G. Ogle ,  Michael M. Lacy ,  Calvin Y. Chow ,  Kimberly L. Crawford ,  Dean G. Hafeman

IPC: G01N21/33 ,  G01N21/25 ,  G01N21/31 ,  G01N21/59 ,  G01N35/02 ,  G01J3/30

CPC classification number: G01N21/33 ,  G01N21/253 ,  G01N21/31 ,  G01N2201/0231 ,  G01N2201/0446 ,  G01N2201/1222 ,  G01N2201/127 ,  G01N35/028

Abstract: The present invention relates to a photometric device for measuring optical parameters. The invention functions in the ultraviolet light range through use of a monochromator and splits the test light in multiple channels by a rotor assembly, including a mirror.

公开(公告)号：US5112134A

公开(公告)日：1992-05-12

申请号：US639313

申请日：1991-01-08

Applicant: Calvin Y. H. Chow ,  Gillian M. Humphries ,  Viola T. Kung ,  Michael M. Lacy

Inventor： Calvin Y. H. Chow ,  Gillian M. Humphries ,  Viola T. Kung ,  Michael M. Lacy

IPC: G01N27/30 ,  G01N27/416

CPC classification number: G01N27/305 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/0063 ,  B01J2219/00659 ,  B01J2219/00702

Abstract: A multibeam photometric measuring device includes a light assembly comprising a single modulated light source along with a filter assembly for passing only a desired band of wavelengths and an optical system for suitably focusing light from the light source. A plurality of light transmitting means accept light and transmit it individually to each of the plurality of sites disposed on a multi-well sample plate.Enhancement of color distribution resulting from chromogenic reactions is provided by automatic agitation of the reacting agents within the sample wells before a reading is taken at each of the sampling intervals of a kinetic measurement sequence.

Abstract translation: 一种多光束测光装置包括一个灯组件，它包括一个单调制的光源以及仅用于通过所需波段的滤光器组件和用于适当地聚焦来自光源的光的光学系统。 多个发光装置接受光并将其单独发送到设置在多孔样品板上的多个位置中的每一个。 通过在动力学测量序列的每个采样间隔进行读取之前，通过自动搅拌样品孔内的反应剂来提供由显色反应引起的颜色分布的增强。

公开(公告)号：US4968148A

公开(公告)日：1990-11-06

申请号：US199100

申请日：1988-05-26

Applicant: Calvin Y. H. Chow ,  Gillian M. Humphries ,  Viola T. Kung ,  Michael M. Lacy ,  Paul Hayter

Inventor： Calvin Y. H. Chow ,  Gillian M. Humphries ,  Viola T. Kung ,  Michael M. Lacy ,  Paul Hayter

IPC: G01N21/25 ,  G01N27/30 ,  G01N27/416

CPC classification number: G01N21/253 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00621 ,  B01J2219/00659 ,  B01J2219/00702 ,  G01N2201/0438 ,  G01N2201/08

Abstract: A multibeam photometric measuring device includes a single light source along with a filter assembly for passing only a desired band of wavelengths and an optical system for suitably focusing light from the light source. Light is transmitted individually to each of a plurality of sites disposed on a multi-well sample plate. Enhancement of color distribution is provided by automatic agitation of the reacting agents within the sample wells before a reading is taken at each of the sampling intervals of a kinetic measurement sequence.

Abstract translation: 多光束测光装置包括单个光源以及用于仅通过期望的波长波段的滤光器组件和用于适当地聚焦来自光源的光的光学系统。 光被单独地传送到设置在多孔样品板上的多个位置中的每一个。 在动力学测量序列的每个采样间隔进行读取之前，通过自动搅拌样品孔内的反应剂来提供颜色分布的增强。

公开(公告)号：US06693709B2

公开(公告)日：2004-02-17

申请号：US10266062

申请日：2002-10-07

Applicant: Mark Wechsler ,  Howard H. Barney ,  Roger A. Kaye ,  David G. Ogle ,  Michael M. Lacy ,  Calvin Y. Chow ,  Kimberly L. Crawford ,  Dean G. Hafeman

Inventor： Mark Wechsler ,  Howard H. Barney ,  Roger A. Kaye ,  David G. Ogle ,  Michael M. Lacy ,  Calvin Y. Chow ,  Kimberly L. Crawford ,  Dean G. Hafeman

IPC: G01J330

CPC classification number: G01N21/33 ,  G01N21/253 ,  G01N21/31 ,  G01N35/028 ,  G01N2201/0231 ,  G01N2201/0446 ,  G01N2201/1222 ,  G01N2201/127

Abstract: The present invention relates to a photometric device for measuring optical parameters. The invention functions in the ultraviolet light range through use of a monochromator and splits the test light in multiple channels by a rotor assembly, including a mirror.

Abstract translation: 本发明涉及一种用于测量光学参数的测光装置。 本发明通过使用单色仪在紫外光范围内起作用，并通过包括反射镜的转子组件在多个通道中分离测试光。

公开(公告)号：US06498497B1

公开(公告)日：2002-12-24

申请号：US09374878

申请日：1999-08-13

Applicant: Calvin Y. H. Chow ,  Morten J. Jensen ,  Colin B. Kennedy ,  Michael M. Lacy ,  Robert E. Nagle

Inventor： Calvin Y. H. Chow ,  Morten J. Jensen ,  Colin B. Kennedy ,  Michael M. Lacy ,  Robert E. Nagle

IPC: G01R3500

CPC classification number: G01N27/44721 ,  B01L3/5027 ,  B01L9/527 ,  B01L2200/027 ,  B01L2200/148 ,  B01L2400/0415 ,  G01N27/44791

Abstract: A microfluidic controller and detector system and method for performing screening assays are disclosed. The microfluidic controller and detector system comprises a fluidic chip that includes at least two intersecting channels and a detection zone, a fluid direction system comprising an electrical interface configured for electrical contact with the at least two intersecting channels, an optics block having an objective lens disposed adjacent the detection zone, and a control system coupled to the optics block and adapted to receive and analyze data from the optics block. The electrical interface generally includes electrodes configured for electrical contact with the intersecting channels and coupled to electrode channels for supplying electrical input to the electrodes. A reference channel is optionally provided to calibrate the electrode channels.

Abstract translation: 公开了用于进行筛选测定的微流控制器和检测器系统和方法。 微流控制器和检测器系统包括流体芯片，其包括至少两个相交通道和检测区域，流体方向系统，包括被配置为与所述至少两个相交通道电接触的电接口， 邻近所述检测区域，以及控制系统，其耦合到所述光学块并适于从所述光学块接收和分析数据。 电接口通常包括被配置为与交叉通道电接触并且耦合到用于向电极提供电输入的电极通道的电极。 可选地提供参考通道以校准电极通道。