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公开(公告)号：US06303830B1
公开(公告)日：2001-10-16
申请号：US09526638
申请日：2000-03-15
申请人： John Nicholas Argyropoulos , Jeffrey Scott Kanel , Michael Leo Tulchinsky , David James Miller , Donald Lee Morrison , Paul Foley , David Robert Bryant
发明人： John Nicholas Argyropoulos , Jeffrey Scott Kanel , Michael Leo Tulchinsky , David James Miller , Donald Lee Morrison , Paul Foley , David Robert Bryant
IPC分类号： C07C4550
CPC分类号： C07B63/00 , C07C67/58 , Y02P20/582 , C07C69/716
摘要： This invention relates to a process for separating one or more organophosphorus ligand degradation products, one or more reaction byproducts and one or more formylester products from a reaction product fluid comprising one or more unreacted unsaturated ester reactants, a metal-organophosphorus ligand complex catalyst, optionally free organophosphorus ligand, said one or more organophosphorus ligand degradation products, said one or more reaction byproducts, said one or more products, a polar solvent and a nonpolar solvent by phase separation wherein(i) the selectivity of the polar phase for the organophosphorus ligand with respect to the one or more products is expressed by a partition coefficient ratio Ef1 which is a value greater than about 2.5, (ii) the selectivity of the polar phase for the organophosphorus ligand with respect to the one or more organophosphorus ligand degradation products is expressed by a partition coefficient ratio Ef2 which is a value greater than about 2.5, and (iii) the selectivity of the polar phase for the organophosphorus ligand with respect to the one or more reaction byproducts is expressed by a partition coefficient ratio Ef3 which is a value greater than about 2.5.
摘要翻译： 本发明涉及一种从包含一种或多种未反应的不饱和酯反应物，金属 - 有机磷配位体配合物催化剂，任选的一种或多种反应产物流体的反应产物流体中分离一种或多种有机磷配体降解产物，一种或多种反应副产物和一种或多种甲酰酯产物的方法 所述一种或多种有机磷配体降解产物，所述一种或多种反应副产物，所述一种或多种产物，极性溶剂和非极性溶剂通过相分离，其中（i）极性相对于有机磷配体的选择性 对于一种或多种产物，由分配系数比Ef1表示，该分配系数比Ef1大于约2.5，（ii）极性相对于一种或多种有机磷配体降解产物的有机磷配体的选择性为 由大于约2.5的值的分配系数比Ef2表示，a d（iii）极性相对于一种或多种反应副产物的有机磷配体的选择性由分配系数比Ef3表示，该分配系数比Ef3是大于约2.5的值。
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公开(公告)号：US06350819B1
公开(公告)日：2002-02-26
申请号：US09697837
申请日：2000-10-27
IPC分类号： C08F840
CPC分类号： C08G83/003 , C07C45/50 , C07F9/65744 , C07F9/65746 , C08G79/04 , Y02P20/582 , C07C47/02
摘要： This invention relates to dendritic macromolecules and their use in metal-dendritic macroligand complex catalyzed processes, e.g., hydroformylation. The use of metal-dendritic macroligand complex catalysts in such processes facilitates the separation of desired product from catalyst, for example, by membrane filtration.
摘要翻译： 本发明涉及树枝状大分子及其在金属树枝状大孔穴状配合物催化方法中的应用，例如加氢甲酰化。 在这样的方法中使用金属 - 树枝状大环内酯类复合催化剂有助于将所需产物与催化剂分离，例如通过膜过滤。
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公开(公告)号：US06310260B1
公开(公告)日：2001-10-30
申请号：US09526191
申请日：2000-03-15
申请人： John Nicholas Argyropoulos , Jeffrey Scott Kanel , Michael Leo Tulchinsky , David James Miller , Donald Lee Morrison , Paul Foley , David Robert Bryant , Ailene Gardner Phillips , Brian Michael Roesch , John Robert Briggs , Max Min Lee , John Michael Maher
发明人： John Nicholas Argyropoulos , Jeffrey Scott Kanel , Michael Leo Tulchinsky , David James Miller , Donald Lee Morrison , Paul Foley , David Robert Bryant , Ailene Gardner Phillips , Brian Michael Roesch , John Robert Briggs , Max Min Lee , John Michael Maher
IPC分类号： C07C4550
CPC分类号： C07C45/50 , C07B63/00 , Y02P20/582 , C07C47/02
摘要： This invention relates to a process for separating one or more organophosphorus ligand degradation products, one or more reaction byproducts and one or more products from a continuously generated reaction product fluid comprising one or more unreacted reactants, a metal-organophosphorus ligand complex catalyst, optionally free organophosphorus ligand, said one or more organophosphorus ligand degradation products, said one or more reaction byproducts, said one or more products, one or more polar solvents and one or more nonpolar solvents by phase separation wherein (i) the selectivity of the polar phase for the organophosphorus ligand with respect to the one or more products is expressed by a partition coefficient ratio Ef1 which is a value greater than about 2.5, (ii) the selectivity of the polar phase for the organophosphorus ligand with respect to the one or more organophosphorus ligand degradation products is expressed by a partition coefficient ratio Ef2 which is a value greater than about 2.5, and (iii) the selectivity of the polar phase for the organophosphorus ligand with respect to the one or more reaction byproducts is expressed by a partition coefficient ratio Ef3 which is a value greater than about 2.5.
摘要翻译： 本发明涉及从连续生成的反应产物流体中分离一种或多种有机磷配体降解产物，一种或多种反应副产物和一种或多种产物，所述反应产物流体包含一种或多种未反应的反应物，金属 - 有机磷配体络合物催化剂， 有机磷配体，所述一种或多种有机磷配体降解产物，所述一种或多种反应副产物，所述一种或多种产物，一种或多种极性溶剂和一种或多种非极性溶剂通过相分离，其中（i）极性相的选择性为 相对于一种或多种产物的有机磷配体由分配系数比Ef1表示，分配系数比Ef1大于约2.5，（ii）有机磷配体的极性相对于一种或多种有机磷配体的选择性 降解产物由分配系数比Ef2表示，该分配系数比Ef2是大于th的值 约为2.5，和（iii）极性相对于一种或多种反应副产物的有机磷配体的选择性由分配系数比Ef3表示，该分配系数比Ef3是大于约2.5的值。
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公开(公告)号：US06307110B1
公开(公告)日：2001-10-23
申请号：US09526337
申请日：2000-03-15
申请人： John Nicholas Argyropoulos , Jeffrey Scott Kanel , Michael Leo Tulchinsky , David James Miller , Donald Lee Morrison , Paul Foley , David Robert Bryant , Ailene Gardner Phillips , Brian Michael Roesch , John Robert Briggs , Max Min Lee , John Michael Maher
发明人： John Nicholas Argyropoulos , Jeffrey Scott Kanel , Michael Leo Tulchinsky , David James Miller , Donald Lee Morrison , Paul Foley , David Robert Bryant , Ailene Gardner Phillips , Brian Michael Roesch , John Robert Briggs , Max Min Lee , John Michael Maher
IPC分类号： C07C4550
CPC分类号： C07C45/50 , C07B63/00 , Y02P20/582 , C07C47/02
摘要： This invention relates to a process for separating one or more organophosphorus ligand degradation products, one or more reaction byproducts and one or more products from a continuously generated reaction product fluid comprising one or more unreacted reactants, a metal-organophosphorus ligand complex catalyst, optionally free organophosphorus ligand, said one or more organophosphorus ligand degradation products, said one or more reaction byproducts, said one or more products, one or more nonpolar solvents and one or more polar solvents by phase separation wherein (i) the selectivity of the nonpolar phase for the organophosphorus ligand with respect to the one or more products is expressed by a partition coefficient ratio Ef1which is a value greater than about 2.5, (ii) the selectivity of the nonpolar phase for the organophosphorus ligand with respect to the one or more organophosphorus ligand degradation products is expressed by a partition coefficient ratio Ef2 which is a value greater than about 2.5, and (iii) the selectivity of the nonpolar phase for the organophosphorus ligand with respect to the one or more reaction byproducts is expressed by a partition coefficient ratio Ef3 which is a value greater than about 2.5.
摘要翻译： 本发明涉及从连续生成的反应产物流体中分离一种或多种有机磷配体降解产物，一种或多种反应副产物和一种或多种产物，所述反应产物流体包含一种或多种未反应的反应物，金属 - 有机磷配体络合物催化剂， 有机磷配体，所述一种或多种有机磷配体降解产物，所述一种或多种反应副产物，所述一种或多种产物，一种或多种非极性溶剂和一种或多种极性溶剂通过相分离，其中（i）非极性相的选择性为 相对于一种或多种产物的有机磷配体由分配系数比Ef1表示，分配系数比Ef1大于约2.5，（ii）非极性相对于有机磷配体相对于一种或多种有机磷配体降解的选择性 产品由分配系数比Ef2表示，该分配系数比Ef2是一个很大的值 （iii）非极性相对于一种或多种反应副产物对有机磷配体的选择性由分配系数比Ef3表示，该分配系数比Ef3是大于约2.5的值。
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5.发明申请公开(公告)号：US20100222611A1
公开(公告)日：2010-09-02
申请号：US11922687
申请日：2006-06-29
IPC分类号： C07C209/46
CPC分类号： C07C209/26 , C07C2601/14 , Y02P20/582 , C07C211/36
摘要： Aldehyde or ketone compounds having more than one carbonyl group are reductively aminated to form a product amine compound having more than one primary amino group. The aldehyde or ketone compound is reacted with the product amine compound, to form a reaction mixture that contains one or more intermediates. The intermediate is then reductively aminated to form the desired product. This process produces the desired product in very high yields with low levels of secondary amine impurities.
摘要翻译： 具有多于一个羰基的醛或酮化合物被还原胺化以形成具有多于一个伯氨基的产物胺化合物。 使醛或酮化合物与产物胺化合物反应，形成含有一种或多种中间体的反应混合物。 然后将中间体还原胺化以形成所需产物。 该方法以非常高的产率产生具有低水平的仲胺杂质的所需产物。
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公开(公告)号：US06252121B1
公开(公告)日：2001-06-26
申请号：US09361907
申请日：1999-07-27
申请人： John Nicholas Argyropoulos , David Robert Bryant , Michael Leo Tulchinsky , Jeffrey Scott Kanel , Paul Foley , Barry Brent Fish
发明人： John Nicholas Argyropoulos , David Robert Bryant , Michael Leo Tulchinsky , Jeffrey Scott Kanel , Paul Foley , Barry Brent Fish
IPC分类号： C07C4550
CPC分类号： C07B63/00 , B33Y40/00 , B33Y70/00 , C07B2200/09 , C07C29/141 , C07C45/49 , C07C45/50 , C07C45/78 , C07C45/80 , C07C47/32 , C07C209/26 , C07C253/30 , C07C2601/14 , Y02P20/582 , C07C47/347 , C07C47/36 , C07C31/276
摘要： This invention relates to a process for separating one or more cyclic products from a reaction product fluid comprising one or more cyclic reactants, a metal-organophosphorus ligand complex catalyst, optionally free organophosphorus ligand, a non-polar solvent and said one or more cyclic products, wherein said process comprises: (1) reacting said one or more cyclic reactants in the presence of said metal-organophosphorus ligand complex catalyst, optionally free organophosphorus ligand and non-polar solvent to form a multiphase reaction product fluid; and (2) separating said multiphase reaction product fluid to obtain a non-polar phase comprising said one or more cyclic reactants, metal-organophosphorus ligand complex catalyst, optionally free organophosphorus ligand and non-polar solvent and a polar phase comprising said one or more cyclic products.
摘要翻译： 本发明涉及从包含一种或多种环状反应物，金属 - 有机磷配位体配合物催化剂，任选的游离有机磷配体，非极性溶剂和所述一种或多种环状产物的反应产物流体中分离一种或多种环状产物的方法 其中所述方法包括：（1）在所述金属 - 有机磷配体配合物催化剂，任选的游离有机磷配体和非极性溶剂的存在下使所述一种或多种环状反应物反应以形成多相反应产物流体; 和（2）分离所述多相反应产物流体以获得包含所述一种或多种环状反应物，金属 - 有机磷配体络合物催化剂，任选的游离有机磷配体和非极性溶剂的非极性相和包含所述一种或多种 循环产品。
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公开(公告)号：US06525143B2
公开(公告)日：2003-02-25
申请号：US09991572
申请日：2001-11-16
IPC分类号： C08F840
CPC分类号： C08G83/003 , C07C45/50 , C07F9/65744 , C07F9/65746 , C08G79/04 , Y02P20/582 , C07C47/02
摘要： This invention relates to dendritic macromolecules and their use in metal-dendritic macroligand complex catalyzed processes, e.g., hydroformylation. The use of metal-dendritic macroligand complex catalysts in such processes facilitates the separation of desired product from catalyst, for example, by membrane filtration.
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公开(公告)号：US06307108B1
公开(公告)日：2001-10-23
申请号：US09525651
申请日：2000-03-15
申请人： John Nicholas Argyropoulos , Jeffrey Scott Kanel , Michael Leo Tulchinsky , David James Miller , Donald Lee Morrison , Paul Foley , David Robert Bryant
发明人： John Nicholas Argyropoulos , Jeffrey Scott Kanel , Michael Leo Tulchinsky , David James Miller , Donald Lee Morrison , Paul Foley , David Robert Bryant
IPC分类号： C07C4550
CPC分类号： C07C227/08 , C07C67/347 , C07C67/58 , Y02P20/582 , C07C69/716 , C07C229/08
摘要： This invention relates to a process for separating one or more organophosphorus ligand degradation products, one or more reaction byproducts and one or more formylester products from a reaction product fluid comprising one or more unreacted unsaturated ester reactants, a metal-organophoshorus ligand complex catalyst, optionally free organophosphorus ligand, said one or more organophosphorus ligand degradation products, said one or more reaction byproducts, said one or more products, a nonpolar solvent and a polar solvent by phase separation wherein (i) the selectivity of the nonpolar phase for the organophosphorus ligand with respect to the one or more products is expressed by a partition coefficient ratio Ef1 which is a value greater than about 2.5 (ii) the selectivity of the nonpolar phase for the organophosphorus ligand with respect to the one or more organophosphorus ligand degradation products is expressed by a partition coefficient ratio Ef2 which is a value greater than about 2.5, and (iii) the selectivity of the nonpolar phase for the organophosphorus ligand with respect to the one or more reaction byproducts is expressed by a partition coefficient ratio Ef3 which is a value greater than about 2.5.
摘要翻译： 本发明涉及一种从包含一种或多种未反应的不饱和酯反应物，金属有机磷配体配合物催化剂的反应产物流体中分离一种或多种有机磷配体降解产物，一种或多种反应副产物和一种或多种甲酰酯产物的方法， 所述一种或多种有机磷配体降解产物，所述一种或多种反应副产物，所述一种或多种产物，非极性溶剂和极性溶剂通过相分离，其中（i）所述非极性相对于所述有机磷配体的选择性 对于一种或多种产物，通过分配系数比Ef1表示，该分配系数比Ef1是大于约2.5的值（ii）表示非极性相对于一种或多种有机磷配体降解产物的非极性相对于有机磷配体的选择性 通过大于约2的值的分配系数比Ef2。 5，和（iii）非极性相对于有机磷配体相对于一种或多种反应副产物的选择性由分配系数比Ef3表示，该分配系数比Ef3是大于约2.5的值。
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9.发明授权公开(公告)号：US08586793B2
公开(公告)日：2013-11-19
申请号：US11922687
申请日：2006-06-29
IPC分类号： C07C209/00
CPC分类号： C07C209/26 , C07C2601/14 , Y02P20/582 , C07C211/36
摘要： Aldehyde or ketone compounds having more than one carbonyl group are reductively aminated to form a product amine compound having more than one primary amino group. The aldehyde or ketone compound is reacted with the product amine compound, to form a reaction mixture that contains one or more intermediates. The intermediate is then reductively aminated to form the desired product. This process produces the desired product in very high yields with low levels of secondary amine impurities.
摘要翻译： 具有多于一个羰基的醛或酮化合物被还原胺化以形成具有多于一个伯氨基的产物胺化合物。 使醛或酮化合物与产物胺化合物反应，形成含有一种或多种中间体的反应混合物。 然后将中间体还原胺化以形成所需产物。 该方法以非常高的产率产生具有低水平的仲胺杂质的所需产物。
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