公开(公告)号：US08283336B2

公开(公告)日：2012-10-09

申请号：US12740435

申请日：2008-10-27

Applicant: Martine Groenendijk ,  Robert Johan Joseph Hageman ,  Patrick Joseph Gerardus Hendrikus Kamphuis ,  Erwin Peke Meijer

Inventor： Martine Groenendijk ,  Robert Johan Joseph Hageman ,  Patrick Joseph Gerardus Hendrikus Kamphuis ,  Erwin Peke Meijer

IPC: A01N43/04 ,  A61K31/70

CPC classification number: A61K31/202 ,  A61K31/355 ,  A61K31/7072 ,  A61K45/06 ,  A61K2300/00

Abstract: The invention pertains to a composition comprising (i) uridine in nucleobase, nucleoside and/or nucleotide form; (ii) docosahexaenoic acid (DHA) and/or eicosapentaenoic acid (EPA); and (iii) a tocopherol and/or an equivalent thereof, wherein said composition has: a) a weight of 200-3000 mg per unit dose; b) an energy content of less than 50 kcal per unit dose; and/or c) a volume between 0.1 and 10 ml per unit dose. The invention also pertains to the use of such composition in reducing abeta plaque burden and neurodegeneration, in the treatment of diseases related with imparted nerve functioning, in particular dementia, Alzheimer's disease and memory disorders.

Abstract translation: 本发明涉及包含（i）核碱基中的尿苷，核苷和/或核苷酸形式的组合物; （ii）二十二碳六烯酸（DHA）和/或二十碳五烯酸（EPA）; 和（iii）生育酚和/或其等同物，其中所述组合物具有：a）每单位剂量200-3000mg的重量; b）每单位剂量的能量含量小于50kcal; 和/或c）每单位剂量为0.1至10ml的体积。 本发明还涉及这种组合物在减少白斑斑块负荷和神经变性中用于治疗与所施加的神经功能，特别是痴呆，阿尔茨海默病和记忆障碍相关的疾病的用途。

公开(公告)号：US08282965B2

公开(公告)日：2012-10-09

申请号：US12809418

申请日：2008-03-04

Applicant: Esther Jacqueline de Kort ,  Robert Johan Joseph Hageman ,  Martine Groenendijk ,  Patrick Joseph Gerardus Hendrikus Kamphuis

Inventor： Esther Jacqueline de Kort ,  Robert Johan Joseph Hageman ,  Martine Groenendijk ,  Patrick Joseph Gerardus Hendrikus Kamphuis

IPC: A01N59/06 ,  A61K33/06

CPC classification number: A61K47/38 ,  A23L29/262 ,  A23L29/269 ,  A23L29/272 ,  A23L33/115 ,  A23L33/13 ,  A23L33/17 ,  A23L33/40 ,  A23V2002/00 ,  A61K9/0095 ,  A61K31/7052 ,  A61K31/7072 ,  A61K33/06 ,  A61K35/60 ,  A61K38/02 ,  A61K47/36 ,  A61K47/42 ,  A61K47/44 ,  A61K2300/00 ,  A23V2200/322 ,  A23V2200/302 ,  A23V2250/712 ,  A23V2250/708 ,  A23V2250/7052 ,  A23V2250/706 ,  A23V2250/714 ,  A23V2250/702 ,  A23V2250/72 ,  A23V2250/1588 ,  A23V2250/1614 ,  A23V2250/1608 ,  A23V2250/1612 ,  A23V2250/1642 ,  A23V2250/1868 ,  A23V2250/187 ,  A23V2250/51082 ,  A23V2250/54246 ,  A23V2250/54252 ,  A23V2250/628 ,  A23V2250/5114

Abstract: The invention pertains to a liquid composition for preventing and/or treating memory decline and/or cognitive dysfunction, Alzheimer's, Parkinson's and/or dementia, said composition comprising: (i) at least 50 mg nucleoside and/or nucleotide per 100 ml; (ii) between 0.2 and 10 grams protein per 100 ml; (iii) between 0.05 and 3 wt. % of 5 thickener, based on total weight of the composition. The thickener is preferably selected from the group consisting of cellulose, xanthan gum, gellan gum, alginate, guar gum, locust bean gum, gum karaya, gum tragacanth, carrageenan, and mixtures thereof. The composition preferably has a loss factor tan δ between 0.1 and 100, as measured at any strain in the range of 1 100% at 0.1 Hz and 20° C. It is particularly found that a thickener selected from the group consisting of gellan gum, xanthan gum and cellulose greatly reduces sedimentation.

Abstract translation: 本发明涉及用于预防和/或治疗记忆衰退和/或认知功能障碍，阿尔茨海默病，帕金森病和/或痴呆症的液体组合物，所述组合物包含：（i）每100ml至少50mg核苷和/或核苷酸; （ii）每100毫升0.2至10克蛋白质; （iii）0.05〜3重量％ 5份增稠剂，基于组合物的总重量。 增稠剂优选选自纤维素，黄原胶，结冷胶，藻酸盐，瓜尔胶，刺槐豆胶，刺梧桐胶，黄蓍胶，角叉菜胶，及其混合物。 该组合物优选具有0.1至100之间的损失因子tanδ，如在0.1Hz和20℃下在1 100％范围内的任何应变下测量的。特别地，发现选自吉兰胶， 黄原胶和纤维素大大降低沉降。

公开(公告)号：US20100331258A1

公开(公告)日：2010-12-30

申请号：US12666611

申请日：2008-06-20

Applicant: Patrick Joseph Gerardus Hendrikus Kamphuis ,  Martine Groenendijk ,  Anke Bongers

Inventor： Patrick Joseph Gerardus Hendrikus Kamphuis ,  Martine Groenendijk ,  Anke Bongers

IPC: A61K38/02 ,  A61K31/7072 ,  A61P25/28

CPC classification number: A61K31/202 ,  A23L33/10 ,  A23L33/12 ,  A23L33/15 ,  A23L33/16 ,  A23L33/40 ,  A23V2002/00 ,  A61K31/14 ,  A61K31/557 ,  A61K31/7072 ,  A61K45/06 ,  A61K2300/00 ,  A23V2200/322 ,  A23V2250/1868

Abstract: The invention thus pertains to the use of a composition comprising: (a) uridine or uridine phosphate; and (b) docosahexaenoic acid and/or eicosapentaenoic acid, for improving memory and/or the treatment or prevention of impaired memory function, in a subject with a mini-mental state examination of 24-26, wherein said composition is enterally administered to the subject. In the MMSE test, any score of 27 or higher (out of 30) is effectively normal. In the patients with dementia, 20-26 indicates mild dementia, 10-19 moderate dementia, and below 10 severe dementia. It was the present inventors' belief that within the group of 20-26, the memory impairment in the sub-group of 24-26 may even be reversible, as the pathological pathways have just started to develop. In this group of subjects the pathological pathways have just started to develop. Clinical studies show excellent results for this subgroup.

Abstract translation: 因此，本发明涉及组合物的用途，所述组合物包含：（a）尿苷或磷酸尿苷; 和（b）二十二碳六烯酸和/或二十碳五烯酸，用于改善记忆和/或治疗或预防受损的记忆功能，在具有24-26的微小精神状态检查的受试者中，其中所述组合物肠内施用于 学科。 在MMSE测试中，任何得分为27或更高（30分之一）是有效的。 在痴呆症患者中，20-26岁轻度痴呆，10-19例中度痴呆，10例严重痴呆。 本发明人认为，在20-26年的组内，24-26分组的记忆障碍甚至可以逆转，因为病理学途径刚刚开始发展。 在这组受试者中，病理学途径刚刚开始发展。 这个亚组的临床研究显示出很好的结果。

公开(公告)号：US08759319B2

公开(公告)日：2014-06-24

申请号：US13620382

申请日：2012-09-14

Applicant: Robert Johan Joseph Hageman ,  Eline Marleen Van Der Beek ,  Martine Groenendijk ,  Patrick Joseph Gerardus Hendrikus Kamphuis

Inventor： Robert Johan Joseph Hageman ,  Eline Marleen Van Der Beek ,  Martine Groenendijk ,  Patrick Joseph Gerardus Hendrikus Kamphuis

IPC: A01N43/04 ,  A61K31/70

CPC classification number: A23L2/52 ,  A23L33/115 ,  A23L33/12 ,  A23L33/40 ,  A23V2002/00 ,  A61K31/19 ,  A61K31/201 ,  A61K31/202 ,  A61K2300/00 ,  A23V2250/187 ,  A23V2250/1868 ,  A23V2250/1874 ,  A23V2250/1882 ,  A23V2250/28 ,  A23V2250/54246 ,  A23V2250/704 ,  A23V2250/7056 ,  A23V2250/70 ,  A23V2250/156

Abstract: The invention pertains to the use of a lipid fraction for the support of brain function. The lipid fraction comprises the medium-chain fatty acids at least 4 g hexanoic acid and/or at least 5 g octanoic acid, at least 1 g eicosapentaenoic acid, and in addition more than 0.4 g α-linolenic acid per 100 g fatty acids of the lipid fraction.

Abstract translation: 本发明涉及用于支持脑功能的脂质部分。 脂质部分包含中链脂肪酸至少4g己酸和/或至少5g辛酸，至少1g二十碳五烯酸，并且还包含多于0.4gα-亚麻酸/ 100g脂肪酸 脂质分数。

公开(公告)号：US20130331352A1

公开(公告)日：2013-12-12

申请号：US13977168

申请日：2011-12-28

Applicant: Robert Johan Joseph Hageman ,  Mattheus Cornelis De Wilde ,  Martine Groenendijk ,  Patrick Joseph Gerardus Hendrikus Kamphuis

Inventor： Robert Johan Joseph Hageman ,  Mattheus Cornelis De Wilde ,  Martine Groenendijk ,  Patrick Joseph Gerardus Hendrikus Kamphuis

IPC: A61K31/7072 ,  A61K31/20 ,  A61K31/14 ,  A61K31/7056 ,  A61K31/661

CPC classification number: A61K31/675 ,  A23L33/12 ,  A23L33/13 ,  A23L33/15 ,  A23L33/40 ,  A23V2002/00 ,  A61K31/14 ,  A61K31/20 ,  A61K31/202 ,  A61K31/355 ,  A61K31/375 ,  A61K31/4415 ,  A61K31/519 ,  A61K31/661 ,  A61K31/683 ,  A61K31/685 ,  A61K31/70 ,  A61K31/7056 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/714 ,  A61K33/04 ,  A61K45/06 ,  A61P25/28 ,  C07H19/052 ,  C07H19/06 ,  A61K2300/00 ,  A23V2200/316 ,  A23V2200/322 ,  A23V2250/1882 ,  A23V2250/304 ,  A23V2250/704 ,  A23V2250/156 ,  A23V2250/1626 ,  A23V2250/1844 ,  A23V2250/1846 ,  A23V2250/1848 ,  A23V2250/185 ,  A23V2250/1852 ,  A23V2250/1868 ,  A23V2250/187 ,  A23V2250/5424 ,  A23V2250/7052 ,  A23V2250/7058 ,  A23V2250/706 ,  A23V2250/308

Abstract: Composition comprising at least two components, more preferably at least three components, more preferably at least four components, selected from the group of (i) a nucleoside equivalent, (ii) an ω-3 polyunsaturated fatty acid selected from the group of DHA, DPA and EPA, (iii) a vitamin B, (iv) a phospholipid, (v) an antioxidant and (vi) a choline, with the proviso that at least component (i) or (iii) is present, for use in the prevention or treatment of frailty in a mammal, wherein frailty is determined by compliance with at least 2 criterions, preferably 3 criterions, selected from the group of muscle weakness, excessive feelings of exhaustion or fatigue, abnormally low physical activity, slow or unsteady gait, weight loss, and neurological dysfunction.

Abstract translation: 组合物，其包含至少两种组分，更优选至少三种组分，更优选至少四种组分，其选自（i）核苷当量，（ii）选自DHA的ω-3多不饱和脂肪酸， DPA和EPA，（iii）维生素B，（iv）磷脂，（v）抗氧化剂和（vi）胆碱，条件是存在至少组分（i）或（iii），用于 预防或治疗哺乳动物的虚弱，其中通过符合从肌肉无力，疲劳或疲劳过度感觉，异常低体力活动，慢或不稳定步态组中选择的至少2个标准，优选3个标准来确定虚弱， 体重减轻和神经功能障碍。

公开(公告)号：US08361989B2

公开(公告)日：2013-01-29

申请号：US12666621

申请日：2008-06-20

Applicant: Martine Groenendijk ,  Mattheus Cornelis de Wilde ,  Robert Johan Joseph Hageman ,  Patrick Joseph Gerardus Hendrikus Kamphuis

Inventor： Martine Groenendijk ,  Mattheus Cornelis de Wilde ,  Robert Johan Joseph Hageman ,  Patrick Joseph Gerardus Hendrikus Kamphuis

IPC: A01N43/04 ,  A61K31/70

CPC classification number: A61K31/7072 ,  A23L33/10 ,  A23L33/12 ,  A23L33/15 ,  A23L33/40 ,  A61K31/14 ,  A61K31/202 ,  A61K31/4415 ,  A61K31/519 ,  A61K31/70 ,  A61K31/7056 ,  A61K38/00 ,  A61K45/06 ,  A61K2300/00

Abstract: The invention provides a method for supporting operational activities in daily living by providing a combination of (a) long-chain polyunsaturated fatty acids, particularly DHA and/or EPA, and (b) nucleosides or nucleotides, particularly uridine or its equivalent. The operational activities comprise eating; walking; toileting; bathing; grooming; dressing; use of communication equipment; making conversations; keeping appointments; use of household appliances; cleaning dishes; preparation of meal or drink; writing; reading; independent housekeeping; transportation and shopping.

Abstract translation: 本发明提供了一种通过提供（a）长链多不饱和脂肪酸，特别是DHA和/或EPA的组合和（b）核苷或核苷酸，特别是尿苷或其等同物的组合来支持日常生活中的操作活动的方法。 营业活动包括吃饭; 步行; 厕所 洗澡 修饰 敷料; 使用通讯设备; 进行对话 保留约会; 使用家用电器; 清洗菜肴; 准备饮食或饮料; 写作; 读; 独立家政 交通和购物。

公开(公告)号：US20130012469A1

公开(公告)日：2013-01-10

申请号：US13620442

申请日：2012-09-14

Applicant: Esther Jacqueline DE KORT ,  Robert Johan Joseph Hageman ,  Martine Groenendijk ,  Patrick Joseph Gerardus Hendrikus Kamphuis

Inventor： Esther Jacqueline DE KORT ,  Robert Johan Joseph Hageman ,  Martine Groenendijk ,  Patrick Joseph Gerardus Hendrikus Kamphuis

IPC: A61K31/7052 ,  A61K31/7072 ,  A61P25/16 ,  A61P25/00 ,  A61P25/28

CPC classification number: A61K47/38 ,  A23L29/262 ,  A23L29/269 ,  A23L29/272 ,  A23L33/115 ,  A23L33/13 ,  A23L33/17 ,  A23L33/40 ,  A23V2002/00 ,  A61K9/0095 ,  A61K31/7052 ,  A61K31/7072 ,  A61K33/06 ,  A61K35/60 ,  A61K38/02 ,  A61K47/36 ,  A61K47/42 ,  A61K47/44 ,  A61K2300/00 ,  A23V2200/322 ,  A23V2200/302 ,  A23V2250/712 ,  A23V2250/708 ,  A23V2250/7052 ,  A23V2250/706 ,  A23V2250/714 ,  A23V2250/702 ,  A23V2250/72 ,  A23V2250/1588 ,  A23V2250/1614 ,  A23V2250/1608 ,  A23V2250/1612 ,  A23V2250/1642 ,  A23V2250/1868 ,  A23V2250/187 ,  A23V2250/51082 ,  A23V2250/54246 ,  A23V2250/54252 ,  A23V2250/628 ,  A23V2250/5114

Abstract: The invention pertains to a liquid composition for preventing and/or treating memory decline and/or cognitive dysfunction, Alzheimer's, Parkinson's and/or dementia, said composition comprising: (i) at least 50 mg nucleoside and/or nucleotide per 100 ml; (ii) between 0.2 and 10 grams protein per 100 ml; (iii) between 0.05 and 3 wt. % of thickener, based on total weight of the composition. The thickener is preferably selected from the group consisting of cellulose, xanthan gum, gellan gum, alginate, guar gum, locust bean gum, gum karaya, gum tragacanth, carrageenan, and mixtures thereof. The composition preferably has a loss factor tan δ between 0.1 and 100, as measured at any strain in the range of 1-100% at 0.1 Hz and 20° C. It is particularly found that a thickener selected from the group consisting of gellan gum, xanthan gum and cellulose greatly reduces sedimentation.

Abstract translation: 本发明涉及用于预防和/或治疗记忆衰退和/或认知功能障碍，阿尔茨海默病，帕金森病和/或痴呆症的液体组合物，所述组合物包含：（i）每100ml至少50mg核苷和/或核苷酸; （ii）每100毫升0.2至10克蛋白质; （iii）0.05〜3重量％ ％的增稠剂，基于组合物的总重量。 增稠剂优选选自纤维素，黄原胶，结冷胶，藻酸盐，瓜尔胶，刺槐豆胶，刺梧桐胶，黄蓍胶，角叉菜胶，及其混合物。 该组合物优选具有0.1至100之间的损失因子tanδ，如在0.1Hz和20℃下在1-100％范围内的任何应变所测量的。特别地，发现选自吉兰胶 ，黄原胶和纤维素大大降低了沉降。

公开(公告)号：US20130330424A1

公开(公告)日：2013-12-12

申请号：US13977162

申请日：2011-08-11

Applicant: Martine Groenendijk ,  Patrick Joseph Gerardus Hendrikus Kamphuis ,  Mattheus Cornelis De Wilde ,  Robert Johan Joseph Hageman

Inventor： Martine Groenendijk ,  Patrick Joseph Gerardus Hendrikus Kamphuis ,  Mattheus Cornelis De Wilde ,  Robert Johan Joseph Hageman

IPC: A61K33/04 ,  A61K31/202 ,  A61K31/675 ,  A61K31/14 ,  A61K31/519 ,  A61K31/685 ,  A61K31/375 ,  A61K31/355 ,  A61K31/7072 ,  A61K31/714

CPC classification number: A61K31/675 ,  A23L33/12 ,  A23L33/13 ,  A23L33/15 ,  A23L33/40 ,  A23V2002/00 ,  A61K31/14 ,  A61K31/20 ,  A61K31/202 ,  A61K31/355 ,  A61K31/375 ,  A61K31/4415 ,  A61K31/519 ,  A61K31/661 ,  A61K31/683 ,  A61K31/685 ,  A61K31/70 ,  A61K31/7056 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/714 ,  A61K33/04 ,  A61K45/06 ,  C07H19/052 ,  C07H19/06 ,  A61K2300/00 ,  A23V2200/316 ,  A23V2200/322 ,  A23V2250/1882 ,  A23V2250/304 ,  A23V2250/704 ,  A23V2250/156 ,  A23V2250/1626 ,  A23V2250/1844 ,  A23V2250/1846 ,  A23V2250/1848 ,  A23V2250/185 ,  A23V2250/1852 ,  A23V2250/1868 ,  A23V2250/187 ,  A23V2250/5424 ,  A23V2250/7052 ,  A23V2250/7058 ,  A23V2250/706 ,  A23V2250/308

Abstract: Non-medical use of at least two components selected from the group of: (i) nucleoside equivalents, (ii) n-3 polyunsaturated fatty acids selected from the group of DHA, DPA and EPA, (iii) vitamins B, (iv) phospholipids, (v) antioxidants and (vi) cholines—with the proviso that at least one (i) nucleoside or at least one (iii) vitamin B is present—for increasing or maintaining the body weight, for improving the ability to perform an activity of daily living of a mammal, for maintaining the ability to perform an activity of daily living of a mammal, or for reducing a deterioration in the ability to perform an activity of daily living of a mammal.

Abstract translation: 至少两种选自下组的组分的非医疗用途：（i）核苷当量，（ii）选自DHA，DPA和EPA的n-3多不饱和脂肪酸，（iii）维生素B，（iv） 磷脂，（v）抗氧化剂和（vi）胆碱 - 条件是存在至少一种（i）核苷或至少一种（iii）维生素B），用于增加或维持体重，以提高执行 哺乳动物的日常生活活动，维持哺乳动物日常生活活动的能力，或降低进行哺乳动物日常生活活动能力的劣化。

公开(公告)号：US08604000B2

公开(公告)日：2013-12-10

申请号：US12809431

申请日：2008-12-22

Applicant: Esther Jacqueline de Kort ,  Martine Groenendijk ,  Patrick Joseph Gerardus Hendrikus Kamphuis

Inventor： Esther Jacqueline de Kort ,  Martine Groenendijk ,  Patrick Joseph Gerardus Hendrikus Kamphuis

IPC: A01N43/04 ,  A61K31/70

CPC classification number: A61K47/38 ,  A23L29/262 ,  A23L29/269 ,  A23L29/272 ,  A23L33/115 ,  A23L33/13 ,  A23L33/17 ,  A23L33/40 ,  A23V2002/00 ,  A61K9/0095 ,  A61K31/7052 ,  A61K31/7072 ,  A61K33/06 ,  A61K35/60 ,  A61K38/02 ,  A61K47/36 ,  A61K47/42 ,  A61K47/44 ,  A61K2300/00 ,  A23V2200/322 ,  A23V2200/302 ,  A23V2250/712 ,  A23V2250/708 ,  A23V2250/7052 ,  A23V2250/706 ,  A23V2250/714 ,  A23V2250/702 ,  A23V2250/72 ,  A23V2250/1588 ,  A23V2250/1614 ,  A23V2250/1608 ,  A23V2250/1612 ,  A23V2250/1642 ,  A23V2250/1868 ,  A23V2250/187 ,  A23V2250/51082 ,  A23V2250/54246 ,  A23V2250/54252 ,  A23V2250/628 ,  A23V2250/5114

Abstract: The present invention relates to the use of a taste masking agent selected from the group of cellulose; starch; xanthan gum; gellan gum; alginate; galactomannans such as fenugreek, guar gum, tara gum, locust bean gum, and cassia gum; gum karaya; gum tragacanth; carrageenan; and mixture thereof, for improving one or more of mouth feel, taste, aftertaste and smell of a liquid aqueous nutritional composition comprising a nucleotide and/or a nucleoside. It also relates to a nutritional composition comprising an unsavory nucleotide and/or a nucleoside component, having improved sensory characteristics such as improved mouth feel, taste, aftertaste and smell. In particular, it relates to a composition comprising said un-savory nucleotide and/or a nucleoside component, in particular comprising an uridine-containing nucleotide and/or a nucleoside in combination with an unsavory edible oil, such as a fish oil.

Abstract translation: 本发明涉及使用选自纤维素的掩味剂; 淀粉; 黄原胶; 结冷胶 藻酸盐 半乳甘露聚糖如葫芦巴，瓜尔胶，塔拉胶，刺槐豆胶和肉桂胶; 口香糖 黄蓍胶 角叉菜胶 及其混合物，用于改善包含核苷酸和/或核苷的液体含水营养组合物的口感，味觉，余味和气味中的一种或多种。 它还涉及包含龋齿性核苷酸和/或核苷成分的营养组合物，具有改善的感官特征，例如改善的口感，味道，余味和气味。 特别地，本发明涉及包含所述不利食物核苷酸和/或核苷组分的组合物，特别是包含含有尿苷的核苷酸和/或核苷，以及与食用油（例如鱼油）不利的食用油组合。

公开(公告)号：US20100331275A1

公开(公告)日：2010-12-30

申请号：US12666621

申请日：2008-06-20

Applicant: Martine Groenendijk ,  Mattheus Cornelis De Wilde ,  Robert Johan Joseph Hageman ,  Patrick Joseph Gerardus Hendrikus Kamphuis

Inventor： Martine Groenendijk ,  Mattheus Cornelis De Wilde ,  Robert Johan Joseph Hageman ,  Patrick Joseph Gerardus Hendrikus Kamphuis

IPC: A61K31/7072 ,  A61P25/28

CPC classification number: A61K31/7072 ,  A23L33/10 ,  A23L33/12 ,  A23L33/15 ,  A23L33/40 ,  A61K31/14 ,  A61K31/202 ,  A61K31/4415 ,  A61K31/519 ,  A61K31/70 ,  A61K31/7056 ,  A61K38/00 ,  A61K45/06 ,  A61K2300/00

Abstract: The invention provides a method for supporting operational activities in daily living by providing a combination of (a) long-chain polyunsaturated fatty acids, particularly DHA and/or EPA, and (b) nucleosides or nucleotides, particularly uridine or its equivalent. The operational activities comprise eating; walking; toileting; bathing; grooming; dressing; u se of communication equipment; making conversations; keeping appointments; use of household appliances; cleaning dishes; preparation of meal or drink; writing; reading; independent housekeeping; transportation and shopping.

Abstract translation: 本发明提供了一种通过提供（a）长链多不饱和脂肪酸，特别是DHA和/或EPA的组合和（b）核苷或核苷酸，特别是尿苷或其等同物的组合来支持日常生活中的操作活动的方法。 营业活动包括吃饭; 步行; 厕所 洗澡 梳理 敷料; 我的通讯设备; 进行对话 保留约会; 使用家用电器; 清洗菜肴; 准备饮食或饮料; 写作; 读; 独立家政 交通和购物。