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    Method, system and device for treating disorders of the pelvic floor by electrical stimulation of the sacral and/or pudendal nerves
    2.
    发明授权
    Method, system and device for treating disorders of the pelvic floor by electrical stimulation of the sacral and/or pudendal nerves 有权
    用于通过电刺激骶神经和/或阴部神经来治疗盆底疾病的方法，系统和装置

    公开(公告)号：US09272140B2

    公开(公告)日：2016-03-01

    申请号：US12059243

    申请日：2008-03-31

    申请人： Martin T. Gerber

    发明人： Martin T. Gerber

    IPC分类号： A61N1/36 ,  A61N1/05

    CPC分类号： A61N1/36007 ,  A61N1/0507 ,  A61N1/0521 ,  A61N1/0551 ,  A61N1/36071 ,  A61N1/36107

    摘要： Described are implantable devices and methods for treating various disorders of the pelvic floor by means of electrical stimulation of tissue volumes at two or more locations adjacent sacral nerves or portions thereof, and/or pudendal nerves or portions thereof. Two or more electrical stimulation regimes are applied on a continuous, alternating, intermittent or other basis to the respective tissue volumes in an amount and manner effective to treat a number of disorders, including, but not limited to, urinary and/or fecal voiding dysfunctions such as constipation, incontinence disorders such as urge frequency and urinary retention disorders, sexual dysfunctions such as orgasmic and erectile dysfunction, pelvic pain, prostatitis, prostatalgia and prostatodynia.

    摘要翻译： 描述了通过在邻近骶神经或其部分的两个或更多个位置和/或阴部神经或其部分上的组织体积的电刺激来治疗盆底的各种疾病的可植入装置和方法。 两种或更多种电刺激方案以连续，交替，间歇或其他方式以相应的组织体积施用，其数量和方式有效地治疗许多障碍，包括但不限于尿和/或粪便排泄功能障碍 例如便秘，失禁症例如呼吸频率和尿潴留障碍，性功能障碍如高血压和勃起功能障碍，盆腔疼痛，前列腺炎，前列腺痛和前列腺痛。

    Sorbent cartridge configurations for improved dialysate regeneration
    3.
    发明授权
    Sorbent cartridge configurations for improved dialysate regeneration 有权
    吸附剂盒配置，用于改善透析液再生

    公开(公告)号：US09144640B2

    公开(公告)日：2015-09-29

    申请号：US13836973

    申请日：2013-03-15

    申请人： Bryant J. Pudil ,  Thomas E. Meyer ,  David B. Lura ,  Martin T. Gerber

    发明人： Bryant J. Pudil ,  Thomas E. Meyer ,  David B. Lura ,  Martin T. Gerber

    IPC分类号： A61M1/16

    CPC分类号： A61M1/1656 ,  A61M1/1654 ,  A61M1/1668 ,  A61M1/167 ,  A61M1/1696 ,  A61M1/287 ,  A61M1/3486 ,  A61M2205/02 ,  B01D15/08

    摘要： A regeneration system that has a first regeneration module containing a first chosen regenerative substance; a second regeneration module containing the first chosen regenerative substance; and a first mixing chamber. A first outlet stream of a fluid sequentially exits the first mixing chamber, flows through the first regeneration module in fluid communication with the first chosen regenerative substance and returns to the first mixing chamber, and a second outlet stream of the fluid sequentially exits the first mixing chamber and flows through the second regeneration module in fluid communication with the first chosen regenerative substance.

    摘要翻译： 一种再生系统，其具有包含第一选择再生物质的第一再生模块; 包含第一选择再生物质的第二再生模块; 和第一混合室。 流体的第一出口流顺序地离开第一混合室，流过第一再生模块与第一选择的再生物质流体连通并返回到第一混合室，并且流体的第二出口流依次离开第一混合 并且与第一选择的再生物质流体连通地流过第二再生模块。

    SORBENT CARTRIDGE CONFIGURATIONS FOR IMPROVED DIALYSATE REGENERATION
    4.
    发明申请
    SORBENT CARTRIDGE CONFIGURATIONS FOR IMPROVED DIALYSATE REGENERATION 有权
    用于改进的透析再生的SORBENT CARTRIDGE配置

    公开(公告)号：US20140217028A1

    公开(公告)日：2014-08-07

    申请号：US13836973

    申请日：2013-03-15

    申请人： Bryant J. Pudil ,  Thomas E. Meyer ,  David B. Lura ,  Martin T. Gerber

    发明人： Bryant J. Pudil ,  Thomas E. Meyer ,  David B. Lura ,  Martin T. Gerber

    IPC分类号： A61M1/16

    CPC分类号： A61M1/1656 ,  A61M1/1654 ,  A61M1/1668 ,  A61M1/167 ,  A61M1/1696 ,  A61M1/287 ,  A61M1/3486 ,  A61M2205/02 ,  B01D15/08

    摘要： A regeneration system that has a first regeneration module containing a first chosen regenerative substance; a second regeneration module containing the first chosen regenerative substance; and a first mixing chamber. A first outlet stream of a fluid sequentially exits the first mixing chamber, flows through the first regeneration module in fluid communication with the first chosen regenerative substance and returns to the first mixing chamber, and a second outlet stream of the fluid sequentially exits the first mixing chamber and flows through the second regeneration module in fluid communication with the first chosen regenerative substance.

    摘要翻译： 一种再生系统，其具有包含第一选择再生物质的第一再生模块; 包含第一选择再生物质的第二再生模块; 和第一混合室。 流体的第一出口流顺序地离开第一混合室，流过第一再生模块与第一选择的再生物质流体连通并返回到第一混合室，并且流体的第二出口流依次离开第一混合 并且与第一选择的再生物质流体连通地流过第二再生模块。

    Multi-location posture sensing
    6.
    发明授权
    Multi-location posture sensing 有权
    多位置姿态检测

    公开(公告)号：US08788055B2

    公开(公告)日：2014-07-22

    申请号：US11800653

    申请日：2007-05-07

    申请人： Martin T. Gerber ,  John C. Rondoni

    发明人： Martin T. Gerber ,  John C. Rondoni

    IPC分类号： A61N1/36 ,  A61N1/05

    CPC分类号： A61N1/36135 ,  A61N1/0551 ,  A61N1/36514 ,  A61N1/36535 ,  A61N1/36542

    摘要： Techniques for controlling therapy delivery based on the relative orientation and/or motion of a device accelerometer and a lead accelerometer are described. In one embodiment, a therapy system includes an electrical stimulator and a lead. The electrical stimulator comprises a processor that controls delivery of a therapy to a target stimulation site in a patient and a device accelerometer coupled to the electrical stimulator. The lead is coupled to the electrical stimulator to deliver the therapy from the electrical stimulator to the target stimulation site in the patient, and includes a lead accelerometer. The processor compares signals from the accelerometers, and controls delivery of the therapy to the patient based on the comparison. In this manner, the processor may adjust stimulation to, for example, address movement of electrodes relative to target tissue when a patient changes postures.

    摘要翻译： 描述了基于设备加速度计和线加速度计的相对取向和/或运动来控制治疗递送的技术。 在一个实施例中，治疗系统包括电刺激器和引线。 电刺激器包括处理器，其控制对患者的目标刺激部位的治疗传递和耦合到电刺激器的装置加速度计。 引线耦合到电刺激器以将治疗从电刺激器传递到患者中的目标刺激部位，并且包括引线加速度计。 处理器比较来自加速度计的信号，并且基于比较来控制对患者的治疗传递。 以这种方式，当患者改变姿势时，处理器可以将刺激调整为例如电极相对于靶组织的地址移动。

    Therapy program modification
    8.
    发明授权
    Therapy program modification 有权
    治疗方案修改

    公开(公告)号：US08554331B2

    公开(公告)日：2013-10-08

    申请号：US12989763

    申请日：2009-01-23

    申请人： Martin T. Gerber ,  John C. Rondoni

    发明人： Martin T. Gerber ,  John C. Rondoni

    IPC分类号： A61N1/00

    CPC分类号： A61N1/36071 ,  A61N1/08 ,  A61N1/36007

    摘要： A therapy program may be generated based on an algorithmic model of a baseline therapy field, which may represent a therapy field resulting from therapy delivery via the first therapy system based on a first therapy program. A second therapy program that controls therapy delivery by a second therapy system may be generated based on the baseline therapy field model. For example, therapy parameter values of the second therapy program may be selected to maintain at least one field characteristic of the baseline therapy field model. In some examples, the second therapy system may result from a hardware modification to the first therapy system. In other examples, the first and second therapy systems may be associated with different patients. For example, the baseline therapy field model may be an efficacious therapy field for a patient class, and a second therapy program may be generated for a patient in the class.

    摘要翻译： 可以基于基线治疗领域的算法模型来产生治疗程序，其可以代表由基于第一治疗程序的经由第一治疗系统的治疗递送产生的治疗领域。 可以基于基线治疗场模型来产生控制第二疗法系统治疗传递的第二疗法程序。 例如，可以选择第二治疗程序的治疗参数值以保持基线治疗场模型的至少一个场特征。 在一些示例中，第二治疗系统可能由对第一治疗系统的硬件修改而产生。 在其他实施例中，第一和第二治疗系统可以与不同的患者相关联。 例如，基线治疗场模型可以是患者类别的有效治疗领域，并且可以为该类别中的患者生成第二治疗程序。

    Flexible tube sensor for sensing urinary sphincter pressure
    9.
    发明授权
    Flexible tube sensor for sensing urinary sphincter pressure 有权
    柔性管传感器用于感测尿路括约肌压力

    公开(公告)号：US08478411B2

    公开(公告)日：2013-07-02

    申请号：US13279826

    申请日：2011-10-24

    申请人： Martin T. Gerber ,  Keith A. Miesel

    发明人： Martin T. Gerber ,  Keith A. Miesel

    IPC分类号： A61N1/00

    CPC分类号： A61N1/36007 ,  A61B5/0031 ,  A61B5/076 ,  A61B5/202 ,  A61B5/205 ,  A61B5/6882

    摘要： The disclosure describes a therapeutic sphincter control system with a fluid tube pressure sensor. The system senses sphincter pressure and sends the information to a stimulator that is capable of stimulation therapy to control sphincter contractility, thus reducing unwanted urinary incontinence. Measuring sphincter pressure is accomplished through the use of a fluid-filled tube placed through the sphincter and attached to a module implanted within the bladder. Pressure within the tube is transduced to generate an electrical signal that is sent wirelessly to an implanted stimulator connected to a lead positioned near pelvic floor nerves. An external device may be used to wirelessly send information to the implanted stimulator and inhibit stimulation in order for the patient to empty the bladder. Pressure information and stimulation information may be recorded and reviewed for continued patient monitoring. In addition, the system may only include the pressure sensor to monitor patient pressure information.

    摘要翻译： 本公开描述了具有流体管压力传感器的治疗括约肌控制系统。 该系统感测括约肌压力，并将信息发送到能够刺激治疗的刺激器以控制括约肌收缩力，从而减少不必要的尿失禁。 测量括约肌压力是通过使用通过括约肌放置的流体填充管并附接到植入膀胱内的模块来实现的。 所述管内的压力被传导以产生电信号，所述电信号被无线地发送到连接到靠近盆底神经的引线的植入刺激器。 外部设备可以用于向植入的刺激器无线地发送信息并抑制刺激以使患者清空膀胱。 可以记录和审查压力信息和刺激信息以进行持续的患者监测。 另外，该系统可能只包括用于监测患者压力信息的压力传感器。

    Electrical stimulation to alleviate chronic pelvic pain
    10.
    发明授权
    Electrical stimulation to alleviate chronic pelvic pain 有权
    电刺激缓解慢性盆腔疼痛

    公开(公告)号：US08423146B2

    公开(公告)日：2013-04-16

    申请号：US12861165

    申请日：2010-08-23

    申请人： Jonathon E. Giftakis ,  Martin T. Gerber

    发明人： Jonathon E. Giftakis ,  Martin T. Gerber

    IPC分类号： A61N1/34

    CPC分类号： A61N1/36071 ,  A61N1/0551 ,  A61N1/0556 ,  A61N1/36007

    摘要： The disclosure describes a method and system for applying electrical stimulation to a genitofemoral nerve or a genital branch of a genitofemoral nerve of a patient. The system includes electrical stimulators that apply electrical stimulation for alleviation of pelvic pain. The system may apply electrical stimulation for pelvic pain in men or women. The electrical stimulators may comprise various types of electrodes such as cuff electrodes, electrode leads, and microstimulators implanted at various locations proximate to a single or both genitofemoral nerves and the genital branch of a single or both genitofemoral nerves of a patient. When implanted proximate to a genital nerve branch, the electrode may be implanted proximate to the genital nerve branch. In a male patient stimulation may be delivered proximate to the spermatic cord, which contains a portion of the genital nerve branch.

    摘要翻译： 本公开描述了一种将电刺激施加到患者的基因原经神经的生殖器神经或生殖器分支的方法和系统。 该系统包括电刺激器，其应用电刺激以缓解盆腔疼痛。 该系统可以对男性或女性进行电刺激用于骨盆疼痛。 电刺激器可以包括各种类型的电极，诸如袖带电极，电极引线和微刺激器，其植入在靠近单个或两个基因视网膜神经和患者的单个或两个基因颅神经的生殖分支的不同位置处。 当植入到生殖器神经分支附近时，电极可以在生殖神经分支附近植入。 在男性患者中，刺激可以靠近精子束递送，精索包含生殖器神经分支的一部分。