公开(公告)号：US20100022767A1

公开(公告)日：2010-01-28

申请号：US12508964

申请日：2009-07-24

申请人： Markus Kaiser ,  Jérôme Clerc

发明人： Markus Kaiser ,  Jérôme Clerc

IPC分类号： C07D245/02

CPC分类号： C07D245/02 ,  C07D317/32

摘要： The synthesis of syringolin A and B and derivatives thereof as well as to pharmaceutical compositions containing the syringolin A or B or derivatives thereof and the use of syringolin A and B and derivatives thereof for prophylaxis and treatment of cancer.

摘要翻译： 丁腈灵A和B及其衍生物的合成以及含有丁腈灵A或B或其衍生物的药物组合物以及丁腈灵A和B及其衍生物用于预防和治疗癌症的用途。

公开(公告)号：US20120240347A1

公开(公告)日：2012-09-27

申请号：US13428692

申请日：2012-03-23

申请人： Thomas Rees ,  Peter Steinebrunner ,  Fabian Matt ,  Mathias Grossmann ,  Markus Kaiser ,  Markus Wunderle

发明人： Thomas Rees ,  Peter Steinebrunner ,  Fabian Matt ,  Mathias Grossmann ,  Markus Kaiser ,  Markus Wunderle

IPC分类号： A46B3/18 ,  A46D3/05

CPC分类号： A46D3/05

摘要： An apparatus for producing round brushes, which have bristles twisted in between two portions of a folded wire. The apparatus has a bristle feeding device and a rotary gripper for twisting two portions of wire with bristles located therebetween, a deflecting device with two deflecting rollers spaced apart in the longitudinal direction of the wire. The rotary gripper is linearly displaceable transversely in relation to the longitudinal direction of the wire, for gripping the folded region of the wire that is formed by force being applied by an application element that is adjustable between the deflecting rollers transversely in relation to the longitudinal direction of the wire. A bristle feeding device, for feeding bristles to the bent-around portions of wire, is provided in the region of the deflecting rollers. In the region of the unfolded portions of wire there is provided a device for slowing the advancement of the wire.

摘要翻译： 一种用于生产圆刷的装置，其具有在折叠线的两个部分之间扭曲的刷毛。 该装置具有刷毛供给装置和旋转夹持器，用于扭曲两根具有位于其间的刷毛的线，偏转装置具有沿导线的纵向间隔开的两个偏转辊。 旋转夹具相对于线的纵向横向地线性移位，用于夹持由施加元件施加的力而形成的线的折叠区域，该应用元件在偏转辊之间可相对于纵向方向横向地调节 的电线。 在偏转辊的区域中设置有用于将刷毛馈送到线的弯曲部分的刷毛供给装置。 在导线的展开部分的区域中，提供了一种用于减慢线的前进的装置。

公开(公告)号：US20120237903A1

公开(公告)日：2012-09-20

申请号：US13423321

申请日：2012-03-19

申请人： Martin KLARE ,  Markus Kaiser ,  Frank Gischer

发明人： Martin KLARE ,  Markus Kaiser ,  Frank Gischer

IPC分类号： A61C13/34

CPC分类号： A61C9/002

摘要： A dental modal for making a dental prosthesis has a base body formed with model teeth and model gingiva and with a cutout in an edentate area and with a hole in a floor of the cutout. A plate is releasably fittable complementarily in the cutout and is formed with a hole aligned with the hole of the cutout. A gingiva mask is fittable on the plate in the cutout and is in turn formed with a hole aligned with the holes of the plate and of the cutout. A model implant insert is releasably fittable in the holes of the mask, plate, and cutout and carries a model implant or an implant-screw mockup.

摘要翻译： 用于制造牙科假体的牙齿模具具有形成有模型牙齿和型号牙齿的基体，并且在缺口区域中具有切口并且在切口的地板中具有孔。 板在切口中可互补地可释放地配合，并且形成有与切口的孔对准的孔。 牙龈面罩可以安装在切口中的板上，并且还形成有与板和孔的孔对准的孔。 模型植入物插入物可释放地装配在掩模，板和切口的孔中，并且携带模型植入物或植入物螺钉模型。

公开(公告)号：US20150015582A1

公开(公告)日：2015-01-15

申请号：US13941815

申请日：2013-07-15

申请人： Markus Kaiser ,  Matthias John

发明人： Markus Kaiser ,  Matthias John

IPC分类号： G06T3/00 ,  G06T17/20

CPC分类号： G06T7/344 ,  G06T2207/10072 ,  G06T2207/10121 ,  G06T2207/10124 ,  G06T2207/30021 ,  G06T2207/30048

摘要： A method of 2D-3D image registration is presented. The method includes accessing a two dimensional image of a subject having an object therein, accessing a three dimensional image data of the subject with the object f, generating a plurality of mesh models from the three dimensional image data, wherein the plurality of mesh models comprise a first mesh model having a first attenuation coefficient and a second mesh model having a second attenuation coefficient, rendering the first mesh model and the second mesh model with a projection geometry of the two dimensional image to obtain a resultant image, iteratively comparing the resultant image with the two dimensional image using a similarity measure, and registering the two dimensional image with the resultant image.

摘要翻译： 提出了2D-3D图像配准的方法。 该方法包括访问其中具有对象的对象的二维图像，利用对象f访问对象的三维图像数据，从三维图像数据生成多个网格模型，其中多个网格模型包括 具有第一衰减系数的第一网格模型和具有第二衰减系数的第二网格模型，使用所述二维图像的投影几何形状渲染所述第一网格模型和所述第二网格模型以获得合成图像，迭代地比较所得到的图像 使用相似度测量的二维图像，并且使用所得到的图像来记录二维图像。

公开(公告)号：US08915551B2

公开(公告)日：2014-12-23

申请号：US13428692

申请日：2012-03-23

申请人： Thomas Rees ,  Peter Steinebrunner ,  Fabian Matt ,  Mathias Grossmann ,  Markus Kaiser ,  Markus Wunderle

发明人： Thomas Rees ,  Peter Steinebrunner ,  Fabian Matt ,  Mathias Grossmann ,  Markus Kaiser ,  Markus Wunderle

IPC分类号： A46D3/05

CPC分类号： A46D3/05

摘要： An apparatus for producing round brushes, which have bristles twisted in between two portions of a folded wire. The apparatus has a bristle feeding device and a rotary gripper for twisting two portions of wire with bristles located therebetween, a deflecting device with two deflecting rollers spaced apart in the longitudinal direction of the wire. The rotary gripper is linearly displaceable transversely in relation to the longitudinal direction of the wire, for gripping the folded region of the wire that is formed by force being applied by an application element that is adjustable between the deflecting rollers transversely in relation to the longitudinal direction of the wire. A bristle feeding device, for feeding bristles to the bent-around portions of wire, is provided in the region of the deflecting rollers. In the region of the unfolded portions of wire there is provided a device for slowing the advancement of the wire.

摘要翻译： 一种用于生产圆刷的装置，其具有在折叠线的两个部分之间扭曲的刷毛。 该装置具有刷毛供给装置和旋转夹持器，用于扭曲两根具有位于其间的刷毛的线，偏转装置具有沿导线的纵向间隔开的两个偏转辊。 旋转夹具相对于线的纵向横向地线性移位，用于夹持由施加元件施加的力而形成的线的折叠区域，该应用元件在偏转辊之间可相对于纵向方向横向地调节 的电线。 在偏转辊的区域中设置有用于将刷毛馈送到线的弯曲部分的刷毛供给装置。 在导线的展开部分的区域中，提供了一种用于减慢线的前进的装置。

公开(公告)号：US20120296202A1

公开(公告)日：2012-11-22

申请号：US13475048

申请日：2012-05-18

申请人： Peter Mountney ,  Markus Kaiser ,  Ingmar Voigt ,  Matthias John ,  Razvan Ioan Ionasec ,  Jan Boese ,  Dorin Comaniciu

发明人： Peter Mountney ,  Markus Kaiser ,  Ingmar Voigt ,  Matthias John ,  Razvan Ioan Ionasec ,  Jan Boese ,  Dorin Comaniciu

IPC分类号： A61B6/02 ,  A61B8/12

CPC分类号： A61B6/12 ,  A61B6/4417 ,  A61B6/4441 ,  A61B6/487 ,  A61B6/503 ,  A61B6/5247 ,  A61B8/0841 ,  A61B8/0883 ,  A61B8/12 ,  A61B8/4245 ,  A61B8/4416 ,  A61B8/5261

摘要： A method and system for registering ultrasound images and physiological models to x-ray fluoroscopy images is disclosed. A fluoroscopic image and an ultrasound image, such as a Transesophageal Echocardiography (TEE) image, are received. A 2D location of an ultrasound probe is detected in the fluoroscopic image. A 3D pose of the ultrasound probe is estimated based on the detected 2D location of the ultrasound probe in the fluoroscopic image. The ultrasound image is mapped to a 3D coordinate system of a fluoroscopic image acquisition device used to acquire the fluoroscopic image based on the estimated 3D pose of the ultrasound probe. The ultrasound image can then be projected into the fluoroscopic image using a projection matrix associated with the fluoroscopic image. A patient specific physiological model can be detected in the ultrasound image and projected into the fluoroscopic image.

摘要翻译： 公开了一种用于将超声图像和生理模型记录到X射线透视图像的方法和系统。 接收透视图像和超声图像，如经食道超声心动图（TEE）图像。 在透视图像中检测超声探头的2D位置。 基于在荧光镜图像中检测到的超声波探头的2D位置来估计超声探头的3D姿态。 超声图像被映射到用于根据超声探头的估计3D姿势获取荧光镜图像的荧光镜图像采集装置的3D坐标系。 然后可以使用与透视图像相关联的投影矩阵将超声图像投影到透视图像中。 可以在超声图像中检测患者特异性生理模型并将其投影到透视图像中。

公开(公告)号：US06603239B1

公开(公告)日：2003-08-05

申请号：US10048728

申请日：2002-02-25

申请人： Thomas Michely ,  Marcel Rost ,  Markus Kaiser

发明人： Thomas Michely ,  Marcel Rost ,  Markus Kaiser

IPC分类号： H02N200

CPC分类号： G01Q10/04 ,  B23Q1/34 ,  B25J7/00 ,  G01Q30/18 ,  H02N2/0055 ,  H02N2/0095 ,  H02N2/025 ,  H02N2/028 ,  Y10S977/872

摘要： The invention relates to a micromanipulator (1, 8, 14, 35) which is used to produce a relative movement between said micromanipulator and an object (7, 13, 25, 34). The micromanipulator (1, 8, 14, 35) has piezoelectric movement elements (3, 10, 15, 16, 17, 43, 44, 45) which are provided with end pieces (6, 12, 22, 23, 24, 46, 47, 48). The inventive micromanipulator is characterized in that the end pieces (6, 12, 22, 23, 24, 46, 47, 48) are magnetic or can be magnetized.

摘要翻译： 本发明涉及一种用于在所述显微操纵器和物体（7,13,25,34）之间产生相对运动的显微操纵器（1,8,14,35）。 微型操纵器（1,8,14,35）具有压电运动元件（3,10,15,16,17,43,44,45），它们具有端部件（6,12,22,23,24,46 ，47,48）。 本发明的微操纵器的特征在于，端片（6,12,22,23,24,46,47,48）是磁性的或可以被磁化。

公开(公告)号：US06381199B1

公开(公告)日：2002-04-30

申请号：US09655011

申请日：2000-09-05

申请人： Wolfgang Kröner ,  Markus Kaiser ,  Renato Schneider

发明人： Wolfgang Kröner ,  Markus Kaiser ,  Renato Schneider

IPC分类号： G04C2312

CPC分类号： H01R13/2442 ,  G04C3/008 ,  G04C10/00 ,  G04G17/06 ,  H01R11/289

摘要： An electronic device is described, for a timepiece of electronic or electromechanical type, comprising a source of electrical power (4), such as a battery, an electronic circuit (3) and an electrical connector tongue (5) effecting an electrical connection between the source of electrical power and the electronic circuit. The electrical connector tongue (5) has first and second openings (55, 56) cooperating with a pair of fixing pins (25, 26) fixed to a support (2) of the said device, and further comprises a section (57) formed between the said openings (55, 56) and adapted to deform in an elastic manner so as to alter the spacing between the openings (55, 56) and allow engagement and retention of the electrical connector tongue (5) on the fixing pins (25, 26).

摘要翻译： 描述了一种用于电子或机电类型的钟表的电子装置，其包括电力源（4），例如电池，电子电路（3）和电连接器舌片（5），其实现电连接器 电源和电子电路。 电连接器舌片（5）具有与固定到所述装置的支撑件（2）的一对固定销（25,26）配合的第一和第二开口（55,56），并且还包括形成的部分（57） 在所述开口（55,56）之间并且适于以弹性方式变形以便改变所述开口（55,56）之间的间隔并允许所述电连接器舌片（5）接合并保持在所述固定销（25）上 ，26）。

公开(公告)号：US09687204B2

公开(公告)日：2017-06-27

申请号：US13475048

申请日：2012-05-18

申请人： Peter Mountney ,  Markus Kaiser ,  Ingmar Voigt ,  Matthias John ,  Razvan Ioan Ionasec ,  Jan Boese ,  Dorin Comaniciu

发明人： Peter Mountney ,  Markus Kaiser ,  Ingmar Voigt ,  Matthias John ,  Razvan Ioan Ionasec ,  Jan Boese ,  Dorin Comaniciu

IPC分类号： A61B6/12 ,  A61B6/00 ,  A61B8/08 ,  A61B8/00 ,  A61B8/12

CPC分类号： A61B6/12 ,  A61B6/4417 ,  A61B6/4441 ,  A61B6/487 ,  A61B6/503 ,  A61B6/5247 ,  A61B8/0841 ,  A61B8/0883 ,  A61B8/12 ,  A61B8/4245 ,  A61B8/4416 ,  A61B8/5261

摘要： A method and system for registering ultrasound images and physiological models to x-ray fluoroscopy images is disclosed. A fluoroscopic image and an ultrasound image, such as a Transesophageal Echocardiography (TEE) image, are received. A 2D location of an ultrasound probe is detected in the fluoroscopic image. A 3D pose of the ultrasound probe is estimated based on the detected 2D location of the ultrasound probe in the fluoroscopic image. The ultrasound image is mapped to a 3D coordinate system of a fluoroscopic image acquisition device used to acquire the fluoroscopic image based on the estimated 3D pose of the ultrasound probe. The ultrasound image can then be projected into the fluoroscopic image using a projection matrix associated with the fluoroscopic image. A patient specific physiological model can be detected in the ultrasound image and projected into the fluoroscopic image.

公开(公告)号：US08506297B2

公开(公告)日：2013-08-13

申请号：US13423321

申请日：2012-03-19

申请人： Martin Klare ,  Markus Kaiser ,  Frank Gischer

发明人： Martin Klare ,  Markus Kaiser ,  Frank Gischer

IPC分类号： A61C11/00

CPC分类号： A61C9/002

摘要： A dental modal for making a dental prosthesis has a base body formed with model teeth and model gingiva and with a cutout in an edentate area and with a hole in a floor of the cutout. A plate is releasably fittable complementarily in the cutout and is formed with a hole aligned with the hole of the cutout. A gingiva mask is fittable on the plate in the cutout and is in turn formed with a hole aligned with the holes of the plate and of the cutout. A model implant insert is releasably fittable in the holes of the mask, plate, and cutout and carries a model implant or an implant-screw mockup.

摘要翻译： 用于制造牙科假体的牙齿模具具有形成有模型牙齿和型号牙齿的基体，并且在缺口区域中具有切口并且在切口的地板中具有孔。 板在切口中可互补地可释放地配合，并且形成有与切口的孔对准的孔。 牙龈面罩可以安装在切口中的板上，并且还形成有与板和孔的孔对准的孔。 模型植入物插入物可释放地装配在掩模，板和切口的孔中，并且携带模型植入物或植入物螺钉模型。