公开(公告)号：US20120168644A1

公开(公告)日：2012-07-05

申请号：US13417474

申请日：2012-03-12

申请人： Wenyi Feng ,  Theofilos Kotseroglou ,  Mark Wang ,  Alexander Triener ,  Diping Che ,  Robert Kain

发明人： Wenyi Feng ,  Theofilos Kotseroglou ,  Mark Wang ,  Alexander Triener ,  Diping Che ,  Robert Kain

IPC分类号： G01N21/64

CPC分类号： G01N21/6456 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6458 ,  G01N2021/6421 ,  G02B21/0032 ,  G02B21/004

摘要： The invention provides imaging apparatus and methods useful for obtaining a high resolution image of a sample at rapid scan rates. A rectangular detector array having a horizontal dimension that is longer than the vertical dimension can be used along with imaging optics positioned to direct a rectangular image of a portion of a sample to the rectangular detector array. A scanning device can be configured to scan the sample in a scan-axis dimension, wherein the vertical dimension for the rectangular detector array and the shorter of the two rectangular dimensions for the image are in the scan-axis dimension, and wherein the vertical dimension for the rectangular detector array is short enough to achieve confocality in a single axis.

摘要翻译： 本发明提供了用于以快速扫描速率获得样品的高分辨率图像的成像装置和方法。 具有比垂直尺寸长的水平尺寸的矩形检测器阵列可以与定位成将样本的一部分的矩形图像引导到矩形检测器阵列的成像光学元件一起使用。 扫描装置可以被配置成以扫描轴尺寸扫描样本，其中矩形检测器阵列的垂直尺寸和图像的两个矩形尺寸中的较短的尺寸在扫描轴尺寸上，并且其中垂直尺寸 因为矩形检测器阵列足够短以在单个轴上实现共焦。

公开(公告)号：US20110001789A1

公开(公告)日：2011-01-06

申请号：US12877220

申请日：2010-09-08

申请人： Gordon Wilson ,  Mark Wang

发明人： Gordon Wilson ,  Mark Wang

IPC分类号： H04N5/225

CPC分类号： G02B13/06 ,  A61B1/041 ,  G02B17/08 ,  H04N5/2254 ,  H04N5/23238 ,  H04N5/3415

摘要： An optical imaging system having a folded optical axis.

摘要翻译： 具有折叠光轴的光学成像系统。

公开(公告)号：US07439009B2

公开(公告)日：2008-10-21

申请号：US11337741

申请日：2006-01-23

申请人： Mark Wang ,  Sadik Esener

发明人： Mark Wang ,  Sadik Esener

IPC分类号： G03C1/72 ,  G03H1/04

CPC分类号： G11B7/246 ,  B82Y10/00 ,  G03H1/02 ,  G03H2001/026 ,  G03H2260/12 ,  G11B7/00455 ,  G11B7/24038 ,  G11B7/245 ,  G11B2007/24624 ,  G11C13/0014 ,  G11C13/0016 ,  G11C13/041

摘要： A host matrix—normally a binder such as cellulose acetate propionate in a solvent such as acetone—contains a radiation-polymerizable photopolymer—normally a monomer like dipentaerythritol pentaacrylate in combination with a crosslinker like 1-vinyl-2-pyrrolidinone, an initiator like N-phenyl glycine, and/or a photosensitizer like camphor quinine—that is initially uniformly doped with a stable dye—typically Rhodamine B and/or Bodipy Red—that photoinitiates photopolymerization. Upon selective exposure of certain regions of the matrix by radiation, most normally laser light radiation, the dye will initially migrate and redistribute itself to radiatively-exposed regions until, dye migration being substantially complete, photopolymerization will occur, locking the migrated dye in place at a relatively higher concentration at the selectively exposed regions. The dye therein stably located can be optically detected by, preferably, light-radiation-stimulated fluorescence. The medium thus serves as an optical memory, including of the volume type, that can be reliably permanently written quickly and inexpensively at high density.

摘要翻译： 主要基质 - 通常为粘合剂，如溶剂如丙酮中的乙酸丙酸纤维素，含有辐射聚合光聚合物 - 通常为单体，如二季戊四醇五丙烯酸酯与交联剂如1-乙烯基-2-吡咯烷酮，N， - 苯基甘氨酸和/或光敏剂如樟脑奎宁，其最初均匀掺杂有稳定的染料 - 通常为罗丹明B和/或Bodipy Red - 光引发光聚合。 通过辐射选择性地暴露基质的某些区域，大多数通常是激光辐射，染料将首先迁移并重新分布到辐射暴露的区域，直到染料迁移基本上完成，将发生光聚合，将迁移的染料锁定在 在选择性暴露区域的浓度相对较高。 其中稳定位置的染料可以通过优选光辐射刺激的荧光进行光学检测。 该介质因此用作包括体积型的光学存储器，其能够以高密度快速且廉价地可靠地永久地写入。

公开(公告)号：US20080117518A1

公开(公告)日：2008-05-22

申请号：US11602887

申请日：2006-11-21

申请人： Mark Wang ,  Wenyi Feng ,  Robert Kain

发明人： Mark Wang ,  Wenyi Feng ,  Robert Kain

IPC分类号： G02B27/10

CPC分类号： G01N21/6452 ,  G01N2021/6484 ,  G02B21/0032 ,  G02B21/0036

摘要： A line scanning arrangement for imaging microarrays includes a line illuminator that converts output from one or more lasers to a radiation line. The laser output passes through a single mode fiber and a module that converts the laser light to the radiation line. The line is confocally directed to sites on the microarray, and retrobeams returned from the sites are collected on an imaging detector. The microarray is moved in the imaging apparatus so as to progressively illuminate an array or matrix of sites for imaging.

摘要翻译： 用于成像微阵列的线扫描装置包括将一个或多个激光器的输出转换成辐射线的线照明器。 激光输出通过单模光纤和将激光转换成辐射线的模块。 该线与微阵列上的位点一致，并将从该位点返回的逆行器收集在成像检测器上。 微阵列在成像装置中移动，以逐渐照射用于成像的位点的阵列或矩阵。

公开(公告)号：US20080062353A1

公开(公告)日：2008-03-13

申请号：US11900169

申请日：2007-09-10

申请人： Xinghua (Mark) Wang

发明人： Xinghua (Mark) Wang

IPC分类号： G02F1/133 ,  G09G3/36

CPC分类号： G09G3/36 ,  G02F1/133382 ,  G09G2320/041

摘要： A temperature compensation mechanism and associated methodology to provide compensation for temperature-induced drifts in the peak transmission wavelength of a liquid crystal (LC)-based tunable optical filter stage. The filter-staged based methodology uses a simple, empirical mathematical relationship that represents thermal effects on a liquid crystal-based filter stage by taking into account a relationship among the LC material's actual temperature coefficient (of thermal expansion), the operating temperature variation, and wavelength drift attributable to the temperature variation. In one embodiment, a control channel based mechanism is used to provides appropriate temperature compensation to a liquid crystal-based tunable optical filter by accurately calculating LC driving voltage values needed for temperature compensation and then supplying the calculated drive voltage to drive various LC components in the filter.

摘要翻译： 一种温度补偿机制和相关方法，用于补偿基于液晶（LC）的可调谐光学滤波器级的峰值透射波长中的温度漂移。 基于过滤器的方法使用简单的经验数学关系，其代表了基于液晶的过滤器阶段的热效应，考虑到LC材料的实际温度系数（热膨胀），工作温度变化和 归因于温度变化的波长漂移。 在一个实施例中，基于控制通道的机构用于通过精确地计算温度补偿所需的LC驱动电压值，然后提供所计算的驱动电压来驱动各种LC部件，从而为基于液晶的可调谐滤光器提供适当的温度补偿 过滤。

公开(公告)号：US07329860B2

公开(公告)日：2008-02-12

申请号：US11286309

申请日：2005-11-23

申请人： Wenyi Feng ,  Theofilos Kotseroglou ,  Mark Wang ,  Alexander Triener ,  Diping Che ,  Robert Kain

发明人： Wenyi Feng ,  Theofilos Kotseroglou ,  Mark Wang ,  Alexander Triener ,  Diping Che ,  Robert Kain

IPC分类号： H01L27/00

CPC分类号： G01N21/6456 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6458 ,  G01N2021/6421 ,  G02B21/0032 ,  G02B21/004

摘要： The invention provides imaging apparatus and methods useful for obtaining a high resolution image of a sample at rapid scan rates. A rectangular detector array having a horizontal dimension that is longer than the vertical dimension can be used along with imaging optics positioned to direct a rectangular image of a portion of a sample to the rectangular detector array. A scanning device can be configured to scan the sample in a scan-axis dimension, wherein the vertical dimension for the rectangular detector array and the shorter of the two rectangular dimensions for the image are in the scan-axis dimension, and wherein the vertical dimension for the rectangular detector array is short enough to achieve confocality in a single axis.

摘要翻译： 本发明提供了用于以快速扫描速率获得样品的高分辨率图像的成像装置和方法。 具有比垂直尺寸长的水平尺寸的矩形检测器阵列可以与定位成将样本的一部分的矩形图像引导到矩形检测器阵列的成像光学元件一起使用。 扫描装置可以被配置成以扫描轴尺寸扫描样本，其中矩形检测器阵列的垂直尺寸和图像的两个矩形尺寸中的较短的尺寸在扫描轴尺寸上，并且其中垂直尺寸 因为矩形检测器阵列足够短以在单个轴上实现共焦。

公开(公告)号：US07068874B2

公开(公告)日：2006-06-27

申请号：US10848972

申请日：2004-05-18

申请人： Mark Wang ,  Erhan Polatkan Ata ,  Sadik C. Esener

发明人： Mark Wang ,  Erhan Polatkan Ata ,  Sadik C. Esener

IPC分类号： G02B6/26 ,  H01S3/00 ,  G01N27/26

CPC分类号： H05H3/04 ,  Y10T428/24744

摘要： Small particles, for example 5 μm diameter microspheres or cells, within, and moving with, a fluid, normally water, that is flowing within microfluidic channels within a radiation-transparent substrate, typically molded PDMS clear plastic, are selectively manipulated, normally by being pushed with optical pressure forces, with laser light, preferably as arises from VCSELs operating in Laguerre-Gaussian mode, at branching junctions in the microfluidic channels so as to enter into selected downstream branches, thereby realizing particle switching and sorting, including in parallel. Transport of the small particles thus transpires by microfluidics while manipulation in the manner of optical tweezers arises either from pushing due to optical scattering force, or from pulling due to an attractive optical gradient force. Whether pushed or pulled, the particles within the flowing fluid may be optically sensed, and highly-parallel, low-cost, cell- and particle-analysis devices efficiently realized, including as integrated on bio-chips.

摘要翻译： 选择性地操纵在通常模制的PDMS透明塑料的辐射透明基底内的微流体通道内流动的流体（通常为水）内的微粒，例如5微米直径的微球或细胞，通常是通过 通过激光照射，优选地是以在Laguerre-Gaussian模式下操作的VCSEL产生的激光照射在微流体通道中的分支结处，从而进入选择的下游分支，从而实现包括并行的粒子切换和分选。 因此，通过微流体传输小颗粒，而以光学镊子的方式进行操作会由于光学散射力的推动或由于有吸引力的光学梯度力而引起拉动。 无论是推动还是拉动，流动流体中的颗粒可以被光学感测，并且高度并行，低成本的细胞和颗粒分析装置被有效地实现，包括集成在生物芯片上。

公开(公告)号：US20050164158A1

公开(公告)日：2005-07-28

申请号：US10848972

申请日：2004-05-18

申请人： Mark Wang ,  Erhan Ata ,  Sadik Esener

发明人： Mark Wang ,  Erhan Ata ,  Sadik Esener

IPC分类号： G21K1/00 ,  H05H3/04 ,  B32B5/02

CPC分类号： H05H3/04 ,  Y10T428/24744

摘要： Small particles, for example 5 μm diameter microspheres or cells, within, and moving with, a fluid, normally water, that is flowing within microfluidic channels within a radiation-transparent substrate, typically molded PDMS clear plastic, are selectively manipulated, normally by being pushed with optical pressure forces, with laser light, preferably as arises from VCSELs operating in Laguerre-Gaussian mode, at branching junctions in the microfluidic channels so as to enter into selected downstream branches, thereby realizing particle switching and sorting, including in parallel. Transport of the small particles thus transpires by microfluidics while manipulation in the manner of optical tweezers arises either from pushing due to optical scattering force, or from pulling due to an attractive optical gradient force. Whether pushed or pulled, the particles within the flowing fluid may be optically sensed, and highly-parallel. low-cost, cell- and particle-analysis devices efficiently realized, including as integrated on bio-chips.

摘要翻译： 选择性地操纵在通常模制的PDMS透明塑料的辐射透明基底内的微流体通道内流动的流体（通常为水）内的微粒，例如5微米直径的微球或细胞，通常是通过 通过激光照射，优选地是以在Laguerre-Gaussian模式下操作的VCSEL产生的激光照射在微流体通道中的分支结处，从而进入选择的下游分支，从而实现包括并行的粒子切换和分选。 小颗粒的传输从而由Microfluidics蒸腾作用而在操纵光学镊子的方式出现无论是从推由于光学散射力，或由于从拉至一个有吸引力的光学梯度力。 无论是推动还是被拉动，流动流体中的颗粒可以被光学感测并且高度平行。 低成本，细胞和粒子分析装置有效实现，包括集成在生物芯片上。

公开(公告)号：US08717413B2

公开(公告)日：2014-05-06

申请号：US12463488

申请日：2009-05-11

申请人： Gordon Wilson ,  Mark Wang

发明人： Gordon Wilson ,  Mark Wang

IPC分类号： H04N7/00

CPC分类号： G02B13/06 ,  G02B17/08 ,  H04N5/2254 ,  H04N5/23238 ,  H04N5/3415

摘要： An imaging system having a folded optical axis that is accomplished through the effect of a first lens group, a prism, and a second lens group wherein a second surface of the prism is a mirror wherein the folded imaging system exhibits a horizontal field of view (HFOV) greater than 160 degrees and a vertical field of view (VFOV) greater than 80 degrees. Further aspects include a conjugate ratio of the lenses to be substantially 5.47 and a ratio of the entire lens focal length to the focal length of the first lens to be substantially −0.309.

摘要翻译： 一种具有通过第一透镜组，棱镜和第二透镜组的效果实现的折叠光轴的成像系统，其中棱镜的第二表面是反射镜，其中折叠成像系统呈现水平视野（ HFOV）大于160度，垂直视野（VFOV）大于80度。 另外的方面包括透镜的共轭比基本上为5.47，并且整个透镜焦距与第一透镜的焦距的比率基本上为-0.309。

公开(公告)号：US08486333B2

公开(公告)日：2013-07-16

申请号：US12321359

申请日：2009-01-16

申请人： Mark Wang ,  Nan Zhang

发明人： Mark Wang ,  Nan Zhang

IPC分类号： A61M1/00

CPC分类号： G01N35/00069 ,  G01N2035/00257 ,  G01N2035/00495 ,  Y10T436/2575

摘要： This invention provides rotors and methods of precisely metering a sample fluid and mixing the sample with a reagent. The rotors have a metering tube of defined volume that fills until sample flow is stopped by surface tension of a meniscus at a capillarity port, while excess sample is stripped from the metering tube inlet by centripetal force of the spinning rotor. By spinning the rotor at a higher speed, a reagent can be forced from a reagent chamber to contact the meniscus, breaking the surface tension and allowing the metered sample to mix with the reagent.