公开(公告)号：US07967782B2

公开(公告)日：2011-06-28

申请号：US12648242

申请日：2009-12-28

Applicant: Michael D. Laufer ,  Brian E. Farley ,  Grace Y. Schulz ,  Arthur W. Zikorus ,  Mark P. Parker

Inventor： Michael D. Laufer ,  Brian E. Farley ,  Grace Y. Schulz ,  Arthur W. Zikorus ,  Mark P. Parker

IPC: A61M29/00

CPC classification number: A61B18/08 ,  A61B18/1492 ,  A61B2017/22051 ,  A61B2017/22097 ,  A61B2018/00083 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00285 ,  A61B2018/00404 ,  A61B2018/00488 ,  A61B2018/00755 ,  A61B2018/00797 ,  A61B2018/00875 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1465 ,  A61B2018/1497

Abstract: A catheter delivers an electrode within a vein for a minimally invasive treatment of varicose veins and venous insufficiency using RF energy. The catheter is introduced into a patient and positioned within the section of the vein to be treated. The electrode radiates high frequency energy towards the vein, and the surrounding venous tissue becomes heated and begins to shrink. The catheter includes a controllable member for limiting the amount of shrinkage of the vein to the diameter of the member. The electrode remains active until there has been sufficient shrinkage of the vein. The extent of shrinkage of the vein may be detected by fluoroscopy. After treating one section of the vein, the catheter and the electrode can be repositioned intraluminally within the vein to treat different sections of the vein until all desired venous sections and valves are repaired and rendered functionally competent.

Abstract translation: 导管在静脉内输送电极，以便使用RF能量进行静脉曲张和静脉功能不全的微创治疗。 将导管引入患者并定位在待治疗的静脉的部分内。 电极向静脉辐射高频能量，周围的静脉组织变热并开始收缩。 导管包括可控制的构件，用于限制静脉的收缩量与构件的直径。 电极保持活动，直到静脉充分收缩。 静脉收缩的程度可以通过荧光透视法检测。 在治疗静脉的一部分后，导管和电极可以在静脉内腔内重新定位，以处理静脉的不同部分，直到所有期望的静脉部分和瓣膜被修复并且具有功能上的能力。

公开(公告)号：US07641633B2

公开(公告)日：2010-01-05

申请号：US10396672

申请日：2003-03-25

Applicant: Michael D. Laufer ,  Brian E. Farley ,  Grace Y. Schulz ,  Arthur W. Zikorus ,  Mark P. Parker

Inventor： Michael D. Laufer ,  Brian E. Farley ,  Grace Y. Schulz ,  Arthur W. Zikorus ,  Mark P. Parker

IPC: A61F7/12

CPC classification number: A61B18/08 ,  A61B18/1492 ,  A61B2017/22051 ,  A61B2017/22097 ,  A61B2018/00083 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00285 ,  A61B2018/00404 ,  A61B2018/00488 ,  A61B2018/00755 ,  A61B2018/00797 ,  A61B2018/00875 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1465 ,  A61B2018/1497

Abstract: A catheter delivers an electrode within a vein for a minimally invasive treatment of varicose veins and venous insufficiency using RF energy. The catheter is introduced into a patient and positioned within the section of the vein to be treated. The electrode radiates high frequency energy towards the vein, and the surrounding venous tissue becomes heated and begins to shrink. The catheter includes a controllable member for limiting the amount of shrinkage of the vein to the diameter of the member. The electrode remains active until there has been sufficient shrinkage of the vein. The extent of shrinkage of the vein may be detected by fluoroscopy. After treating one section of the vein, the catheter and the electrode can be repositioned intraluminally within the vein to treat different sections of the vein until all desired venous sections and valves are repaired and rendered functionally competent.

Abstract translation: 导管在静脉内输送电极，以便使用RF能量进行静脉曲张和静脉功能不全的微创治疗。 将导管引入患者并定位在待治疗的静脉的部分内。 电极向静脉辐射高频能量，周围的静脉组织变热并开始收缩。 导管包括可控制的构件，用于限制静脉的收缩量与构件的直径。 电极保持活动，直到静脉充分收缩。 静脉收缩的程度可以通过荧光透视法检测。 在治疗静脉的一部分后，导管和电极可以在静脉内腔内重新定位，以处理静脉的不同部分，直到所有期望的静脉部分和瓣膜被修复并且具有功能上的能力。

公开(公告)号：US20090054884A1

公开(公告)日：2009-02-26

申请号：US12258358

申请日：2008-10-24

Applicant: Brian E. Farley ,  Christopher S. Jones ,  Mark P. Parker ,  Joseph M. Tartaglia ,  Arthur W. Zikorus

Inventor： Brian E. Farley ,  Christopher S. Jones ,  Mark P. Parker ,  Joseph M. Tartaglia ,  Arthur W. Zikorus

IPC: A61B17/12

CPC classification number: A61B18/1492 ,  A61B2017/00084 ,  A61B2017/22038 ,  A61B2017/22051 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00404 ,  A61B2018/124 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1475 ,  A61B2090/3782 ,  A61B2218/002

Abstract: A catheter includes a plurality of expandable primary leads to deliver energy to a fallopian tube, a vein such as a hemorrhoid or an esophageal varix, or another hollow anatomical structure requiring ligation or occlusion. Each of the primary leads includes an electrode located at the working end of the catheter. Separation is maintained between the primary leads such that the leads can receive power of selected polarity. The primary leads are constructed to expand outwardly to place the electrodes into apposition with a hollow anatomical structure. High frequency energy can be applied from the leads to create a heating effect in the surrounding tissue of the anatomical structure. The diameter of the hollow anatomical structure is reduced by the heating effect, and the electrodes of the primary leads are moved closer to one another.

Abstract translation: 导管包括多个可扩张的主要引线，用于向输卵管，诸如痔疮或食管静脉曲张的静脉或需要结扎或闭塞的另一中空解剖结构输送能量。 每个主引线包括位于导管工作端的电极。 在主引线之间保持分离，使得引线可以接收所选极性的功率。 主引线被构造成向外扩展以使电极与中空的解剖结构相配合。 可以从引线施加高频能量以在解剖结构的周围组织中产生加热效果。 中空解剖结构的直径由于加热效应而降低，并且主引线的电极彼此靠近地移动。

公开(公告)号：US07406970B2

公开(公告)日：2008-08-05

申请号：US10900563

申请日：2004-07-28

Applicant: Arthur W. Zikorus ,  Mark P. Parker ,  Christopher S. Jones ,  Douglas M. Petty ,  Brian E. Farley ,  Joseph M. Tartaglia

Inventor： Arthur W. Zikorus ,  Mark P. Parker ,  Christopher S. Jones ,  Douglas M. Petty ,  Brian E. Farley ,  Joseph M. Tartaglia

IPC: A61F5/56 ,  A61B18/18 ,  A61B18/20

CPC classification number: A61B18/1492 ,  A61B2017/00084 ,  A61B2017/22038 ,  A61B2017/22051 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00404 ,  A61B2018/124 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1475 ,  A61B2090/3782 ,  A61B2218/002

Abstract: A catheter includes a plurality of primary leads to deliver energy for ligating a hollow anatomical structure. Each of the primary leads includes an electrode located at the working end of the catheter. Separation is maintained between the primary leads such that each primary lead can individually receive power of selected polarity. The primary leads are constructed to expand outwardly to place the electrodes into apposition with an anatomical structure. High frequency energy can be applied from the leads to create a heating effect in the surrounding tissue of the anatomical structure. The diameter of the hollow anatomical structure is reduced by the heating effect, and the electrodes of the primary leads are moved closer to one another. Where the hollow anatomical structure is a vein, energy is applied until the diameter of the vein is reduced to the point where the vein is occluded. In one embodiment, a secondary lead is surrounded by the primary leads, and extends beyond the primary leads. The secondary lead includes an electrode at the working end of the catheter. The secondary lead can have a polarity opposite to the polarity of the primary leads in a bipolar configuration. The polarity of the leads can be switched and the catheter can be moved during treatment to ligate an extended length of the vein. The catheter can include a lumen to accommodate a guide wire or to allow fluid delivery.

Abstract translation: 导管包括多个主引线以传递用于结扎中空解剖结构的能量。 每个主引线包括位于导管工作端的电极。 在主引线之间保持分离，使得每个主引线可以分别接收所选极性的功率。 主引线被构造成向外扩展以使电极与解剖结构相配合。 可以从引线施加高频能量以在解剖结构的周围组织中产生加热效果。 中空解剖结构的直径由于加热效应而降低，并且主引线的电极彼此靠近地移动。 当中空解剖结构为静脉时，施加能量直到静脉的直径减小到静脉闭塞的位置。 在一个实施例中，次级引线被主引线包围，并且延伸超出主引线。 次级引线包括在导管的工作端的电极。 次级引线可以具有与双极配置中的主引线的极性相反的极性。 可以切换引线的极性，并且可以在治疗期间移动导管以连接延长的静脉长度。 导管可以包括用于容纳导丝或者允许流体输送的内腔。

公开(公告)号：US07041098B2

公开(公告)日：2006-05-09

申请号：US10162057

申请日：2002-06-03

Applicant: Brian E. Farley ,  Dawn A. Henderson ,  Christopher S. Jones ,  Mark P. Parker ,  Joseph M. Tartaglia

Inventor： Brian E. Farley ,  Dawn A. Henderson ,  Christopher S. Jones ,  Mark P. Parker ,  Joseph M. Tartaglia

IPC: A61B18/18

CPC classification number: A61B18/1492 ,  A61B2017/22038 ,  A61B2017/22051 ,  A61B2017/22067 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00404 ,  A61B2018/00488 ,  A61B2018/00589 ,  A61B2018/00898 ,  A61B2018/124 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2090/3782 ,  A61B2218/002

Abstract: A catheter includes a plurality of primary leads to deliver energy for ligating a hollow anatomical structure. Each of the primary leads includes an electrode located at the working end of the catheter. Separation is maintained between the primary leads such that each primary lead can individually receive power of selected polarity. The primary leads are constructed to expand outwardly to place the electrodes into apposition with a hollow anatomical structure. High frequency energy can be applied from the leads to create a heating effect in the surrounding tissue of the anatomical structure. The diameter of the hollow anatomical structure is reduced by the heating effect, and the electrodes of the primary leads are moved closer to one another. Where the hollow anatomical structure is a vein, energy is applied until the diameter of the vein is reduced to the point where the vein is occluded. In one embodiment, a balloon is inflated to occlude the structure before the application of energy. Where the structure is a vein, the inflated balloon obstructs blood flow and facilitates the infusion of saline, medication, or a high-impedance fluid to the vein in order to reduce the occurrence of coagulation and to improve the heating of the vein by the catheter. The catheter can include a lumen to accommodate a guide wire or to allow fluid delivery.

公开(公告)号：US06613045B1

公开(公告)日：2003-09-02

申请号：US09495667

申请日：2000-02-01

Applicant: Michael D. Laufer ,  Brian E. Farley ,  Grace Y. Schulz ,  Arthur W. Zikorus ,  Mark P. Parker

Inventor： Michael D. Laufer ,  Brian E. Farley ,  Grace Y. Schulz ,  Arthur W. Zikorus ,  Mark P. Parker

IPC: A61B1804

CPC classification number: A61B18/08 ,  A61B18/1492 ,  A61B2017/22051 ,  A61B2017/22097 ,  A61B2018/00083 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00285 ,  A61B2018/00404 ,  A61B2018/00488 ,  A61B2018/00755 ,  A61B2018/00797 ,  A61B2018/00875 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1465 ,  A61B2018/1497

Abstract: A catheter delivers an electrode within a vein for a minimally invasive treatment of varicose veins and venous insufficiency using RF energy. The catheter is introduced into a patient and positioned within the section of the vein to be treated. The electrode radiates high frequency energy towards the vein, and the surrounding venous tissue becomes heated and begins to shrink. The catheter includes a controllable member for limiting the amount of shrinkage of the vein to the diameter of the member. The electrode remains active until there has been sufficient shrinkage of the vein. The extent of shrinkage of the vein may be detected by fluoroscopy. After treating one section of the vein, the catheter and the electrode can be repositioned intraluminally within the vein to treat different sections of the vein until all desired venous sections and valves are repaired and rendered functionally competent.

Abstract translation: 导管在静脉内输送电极，以便使用RF能量进行静脉曲张和静脉功能不全的微创治疗。 将导管引入患者并定位在待治疗的静脉的部分内。 电极向静脉辐射高频能量，周围的静脉组织变热并开始收缩。 导管包括可控制的构件，用于限制静脉的收缩量与构件的直径。 电极保持活动，直到静脉充分收缩。 静脉收缩的程度可以通过荧光透视法检测。 在治疗静脉的一部分后，导管和电极可以在静脉内腔内重新定位，以处理静脉的不同部分，直到所有期望的静脉部分和瓣膜被修复并且具有功能上的能力。

公开(公告)号：US06398780B1

公开(公告)日：2002-06-04

申请号：US09497099

申请日：2000-02-03

Applicant: Brian E. Farley ,  Dawn A. Henderson ,  Christopher S. Jones ,  Mark P. Parker ,  Joseph M. Tartaglia

Inventor： Brian E. Farley ,  Dawn A. Henderson ,  Christopher S. Jones ,  Mark P. Parker ,  Joseph M. Tartaglia

IPC: A61B1739

CPC classification number: A61B18/1492 ,  A61B2017/22038 ,  A61B2017/22051 ,  A61B2017/22067 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00404 ,  A61B2018/00488 ,  A61B2018/00589 ,  A61B2018/00898 ,  A61B2018/124 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2090/3782 ,  A61B2218/002

Abstract: A catheter includes a plurality of primary leads to deliver energy for ligating a hollow anatomical structure. Each of the primary leads includes an electrode located at the working end of the catheter. Separation is maintained between the primary leads such that each primary lead can individually receive power of selected polarity. The primary leads are constructed to expand outwardly to place the electrodes into apposition with a hollow anatomical structure. High frequency energy can be applied from the leads to create a heating effect in the surrounding tissue of the anatomical structure. The diameter of the hollow anatomical structure is reduced by the heating effect, and the electrodes of the primary leads are moved closer to one another. Where the hollow anatomical structure is a vein, energy is applied until the diameter of the vein is reduced to the point where the vein is occluded. In one embodiment, a balloon is inflated to occlude the structure before the application of energy. Where the structure is a vein, the inflated balloon obstructs blood flow and facilitates the infusion of saline, medication, or a high-impedance fluid to the vein in order to reduce the occurrence of coagulation and to improve the heating of the vein by the catheter. The catheter can include a lumen to accommodate a guide wire or to allow fluid delivery.

公开(公告)号：US20100106156A1

公开(公告)日：2010-04-29

申请号：US12648242

申请日：2009-12-28

Applicant: Michael D. Laufer ,  Brian E. Farley ,  Grace Y. Schulz ,  Arthur W. Zikorus ,  Mark P. Parker

Inventor： Michael D. Laufer ,  Brian E. Farley ,  Grace Y. Schulz ,  Arthur W. Zikorus ,  Mark P. Parker

IPC: A61B18/14

CPC classification number: A61B18/08 ,  A61B18/1492 ,  A61B2017/22051 ,  A61B2017/22097 ,  A61B2018/00083 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00285 ,  A61B2018/00404 ,  A61B2018/00488 ,  A61B2018/00755 ,  A61B2018/00797 ,  A61B2018/00875 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1465 ,  A61B2018/1497

Abstract: A catheter delivers an electrode within a vein for a minimally invasive treatment of varicose veins and venous insufficiency using RF energy. The catheter is introduced into a patient and positioned within the section of the vein to be treated. The electrode radiates high frequency energy towards the vein, and the surrounding venous tissue becomes heated and begins to shrink. The catheter includes a controllable member for limiting the amount of shrinkage of the vein to the diameter of the member. The electrode remains active until there has been sufficient shrinkage of the vein. The extent of shrinkage of the vein may be detected by fluoroscopy. After treating one section of the vein, the catheter and the electrode can be repositioned intraluminally within the vein to treat different sections of the vein until all desired venous sections and valves are repaired and rendered functionally competent.

Abstract translation: 导管在静脉内输送电极，以便使用RF能量进行静脉曲张和静脉功能不全的微创治疗。 将导管引入患者并定位在待治疗的静脉的部分内。 电极向静脉辐射高频能量，周围的静脉组织变热并开始收缩。 导管包括可控制的构件，用于限制静脉的收缩量与构件的直径。 电极保持活动，直到静脉充分收缩。 静脉收缩的程度可以通过荧光透视法检测。 在治疗静脉的一部分后，导管和电极可以在静脉内腔内重新定位，以处理静脉的不同部分，直到所有期望的静脉部分和瓣膜被修复并且具有功能上的能力。

公开(公告)号：US20090125009A1

公开(公告)日：2009-05-14

申请号：US12264170

申请日：2008-11-03

Applicant: Arthur W. Zikorus ,  Russell B. Thompson ,  Fiona M. Sander ,  Mark P. Parker

Inventor： Arthur W. Zikorus ,  Russell B. Thompson ,  Fiona M. Sander ,  Mark P. Parker

IPC: A61B18/04 ,  A61B19/00 ,  A61M25/00

CPC classification number: A61B18/08 ,  A61B18/1492 ,  A61B2018/0022 ,  A61B2018/00404 ,  A61B2018/046

Abstract: One embodiment comprises an apparatus for applying energy to a hollow anatomical structure having an inner wall. The apparatus comprises an elongate shaft having a distal end and a proximal end opposite the distal end; and a capacitive treatment element located near the distal end. The capacitive treatment element is sized for insertion into the hollow anatomical structure and placement near the inner wall. The capacitive treatment element is configured to create an electric field that extends at least partially into the inner wall. Other devices and methods for treatment of hollow anatomical structures are disclosed as well.

Abstract translation: 一个实施例包括用于向具有内壁的中空解剖结构施加能量的装置。 该装置包括细长轴，其具有远端和与远端相对的近端; 以及位于远端附近的电容性治疗元件。 电容治疗元件的尺寸适于插入中空的解剖结构并且放置在内壁附近。 电容性治疗元件构造成产生至少部分延伸到内壁的电场。 还公开了用于治疗中空解剖结构的其它装置和方法。

公开(公告)号：US07163546B2

公开(公告)日：2007-01-16

申请号：US10309940

申请日：2002-12-03

Applicant: Michael S. Mirizzi ,  Mark P. Parker ,  Radit Tantisira ,  John Rodriguez

Inventor： Michael S. Mirizzi ,  Mark P. Parker ,  Radit Tantisira ,  John Rodriguez

IPC: A61B17/32

CPC classification number: A61B17/00008 ,  A61B17/221 ,  A61B34/20 ,  A61B2017/00778 ,  A61B2017/320044 ,  A61B2034/2055 ,  A61B2090/3945

Abstract: Apparatuses and methods for removing veins, usually varicose veins, rely on endoluminal capture of a distal end of the vein segment to be removed. In the illustrated embodiments, a shaft having reciprocatable penetrating elements is used to engage and capture the distal end of the vein. After rotating the shaft to pull the distal segment of the vein away from the connecting tissue, the shaft is withdrawn proximally, invaginating the segment back to the point of insertion.

Abstract translation: 用于去除静脉（通常为静脉曲张）的装置和方法依赖于去除静脉段的远端的腔内捕获。 在所示实施例中，具有可往复运动的穿透元件的轴用于接合和捕获静脉的远端。 在旋转轴以将静脉的远侧部分远离连接组织之后，轴向近侧撤回，使该部分回到插入点。