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公开(公告)号：US11417507B2
公开(公告)日：2022-08-16
申请号：US17107481
申请日：2020-11-30
Applicant: Mark A Osgood , Ching Wu
Inventor： Mark A Osgood , Ching Wu
IPC: H01J49/00 , G01N27/622 , H01J49/06 , C07B63/00 , H01J49/04
Abstract: The present invention relates to improving the ability of a hyphenated instrument to analyze a sample benefiting from having the first instrument's analysis of the same sample. A fast switching mechanism can be used as the interface between an ion mobility spectrometer (IMS) and a mass spectrometer (MS) such that the obtained IMS spectrum is converted into a timing diagram that controls the vacuum inlet's size dynamically during analysis of a neutral and/or charged chemical and/or biological species such that a smaller pumping system can be used. In various operational modes of the IMS-MS device, mobility-separated ions are allowed to pass through an ion gate and the vacuum inlet for mass analysis.
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公开(公告)号：US10276358B2
公开(公告)日：2019-04-30
申请号：US15665421
申请日：2017-07-31
Applicant: Ching Wu , Mark A Osgood
Inventor： Ching Wu , Mark A Osgood
Abstract: An ion mobility spectrometry apparatus and method wherein ions are selected using an AC gate, then separated along a drift axis while providing a drift gas flow in a direction that is substantially neither in the direction of the drift axis nor opposite to the drift axis.
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公开(公告)号：US20160005581A1
公开(公告)日：2016-01-07
申请号：US14742653
申请日：2015-06-17
Applicant: Adam Michael Graichen , Robert H. Jackson , Mark A. Osgood , Ching Wu , Jianglin Wu
Inventor： Adam Michael Graichen , Robert H. Jackson , Mark A. Osgood , Ching Wu , Jianglin Wu
CPC classification number: H01J49/0031 , G01N27/622 , G01N30/7233 , H01J49/004
Abstract: A second gate in an Ion Mobility Spectrometer is used to select or block different time windows of the ion mobility spectrum. A second gate in the Ion Mobility Mass Spectrometer is used to modulate peak intensities in the IMS spectrum, allowing each peak in the IMS spectrum to be unambiguously matched with its set of fragment ions in a subsequent MS-MS mass spectrum.
Abstract translation: 离子移动光谱仪中的第二个门用于选择或阻止离子迁移谱的不同时间窗。 离子迁移质谱仪中的第二个栅极用于调制IMS光谱中的峰值强度，允许IMS光谱中的每个峰与其随后的MS-MS质谱中的碎片离子组明确匹配。
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公开(公告)号：US20150303043A1
公开(公告)日：2015-10-22
申请号：US14703868
申请日：2015-05-04
Applicant: Mark A. Osgood , Ching Wu
Inventor： Mark A. Osgood , Ching Wu
CPC classification number: H01J49/004 , C07B63/00 , G01N27/622 , H01J49/0027 , H01J49/0031 , H01J49/0495 , H01J49/067
Abstract: The present invention relates to improving the ability of a hyphenated instrument to analyze a sample benefiting from having the first instrument's analysis of the same sample. A fast switching mechanism can be used as the interface between an ion mobility spectrometer (IMS) and a mass spectrometer (MS) such that the obtained IMS spectrum is converted into a timing diagram that controls the vacuum inlet's size dynamically during analysis of a neutral and/or charged chemical and/or biological species such that a smaller pumping system can be used.
Abstract translation: 本发明涉及提高连字的仪器分析从具有第一仪器对相同样品的分析而受益的样品的能力。 可以将快速切换机制用作离子迁移谱仪（IMS）和质谱仪（MS）之间的界面，使得所获得的IMS光谱被转换成时序图，其在中性分析期间动态地控制真空入口的尺寸， /或带电的化学和/或生物物质，使得可以使用较小的泵送系统。
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公开(公告)号：US20100200745A1
公开(公告)日：2010-08-12
申请号：US12763092
申请日：2010-04-19
Applicant: Mark A. Osgood , Ching Wu
Inventor： Mark A. Osgood , Ching Wu
CPC classification number: H01J49/061 , C07B63/00 , G01N27/622 , Y10T29/49227
Abstract: The present invention generally relates to systems and methods for transmitting beams of charged particles, and in particular to such systems and methods that employ defecting at least one set of grid elements into the same plane to form an ion gate. In addition, an operation method of closing a gate involving alternating voltages on the adjacent gate wires is described.
Abstract translation: 本发明一般涉及用于传送带电粒子束的系统和方法，特别涉及这样的系统和方法，该系统和方法使用将至少一组栅格元件缺陷到同一平面中以形成离子门。 此外，描述了在相邻栅极线上闭合涉及交流电压的栅极的操作方法。
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Patent Agency Ranking
公开(公告)号：US09236234B2
公开(公告)日：2016-01-12
申请号：US14214558
申请日：2014-03-14
Applicant: Ching Wu , Mark A Osgood
Inventor： Ching Wu , Mark A Osgood
CPC classification number: H01J49/061 , C07B63/00 , G01N27/622 , H01J49/0027
Abstract: The present invention uses an AC voltage instead of DC voltage on an ion gate to filter/selectively pass ions. The ions that pass through the AC ion gate can be further separated in a spectrometric instrument. An ion mobility spectrometer using the AC ion gate can achieve better gating performance. For a time of flight ion mobility spectrometer with an AC ion gate, a narrow pulse of selected ions can be passed into a drift tube where they are separated based on their low field ion mobility. Moreover, when the AC voltage at the AC ion gate has a waveform as used for differential ion mobility spectrometry, the time of flight ion mobility spectrometer is converted into a two dimensional separation spectrometer, where ions are first separated based on their high field ion mobility and then further separated based on their low field ion mobility.
Abstract translation: 本发明在离子浇口上使用交流电压而不是直流电压来过滤/选择性地通过离子。 通过AC离子浇口的离子可以在光谱仪器中进一步分离。 使用AC离子浇口的离子迁移谱仪可以获得更好的门控性能。 对于具有AC离子浇口的飞行时间离子迁移谱仪，选择的离子的窄脉冲可以被传送到漂移管中，基于它们的低场离子迁移率，它们被分离。 此外，当AC离子浇口处的AC电压具有用于差示离子迁移率光谱法的波形时，将飞行时间离子迁移谱仪转换成二维分离光谱仪，其中离子首先基于它们的高场离子迁移率而被分离 然后基于它们的低场离子迁移率进一步分离。
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公开(公告)号：US08884221B2
公开(公告)日：2014-11-11
申请号：US13475993
申请日：2012-05-20
Applicant: Ching Wu , Clinton Alawn Krueger , Anthony Joseph Midey , Mark A Osgood
Inventor： Ching Wu , Clinton Alawn Krueger , Anthony Joseph Midey , Mark A Osgood
CPC classification number: G01N27/622
Abstract: An ion mobility spectrometer wherein ions are separated along a drift axis while providing a drift gas flow in a direction that is substantially neither in the direction of the drift axis nor opposite to the drift axis. An ion mobility spectrometer and operation methods use a cross-directional gas flow in a drift tube and/or a segmented drift tube for pre-separation.
Abstract translation: 离子迁移谱仪，其中离子沿着漂移轴线分离，同时在基本上不是在漂移轴线的方向上也不与漂移轴线相反的方向提供漂移气流。 离子迁移谱仪和操作方法在漂移管和/或分段漂移管中使用横向气流用于预分离。
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公开(公告)号：US11024497B2
公开(公告)日：2021-06-01
申请号：US16808353
申请日：2020-03-03
Applicant: Ching Wu , Mark A. Osgood
Inventor： Ching Wu , Mark A. Osgood
IPC: H01J49/06 , H01J49/00 , C07B63/00 , G01N27/622
Abstract: An ion mobility spectrometry apparatus and method used to separate ions and select some of the ions using an AC gate; the selected ions are further separated along a drift axis of a drift tube, where the AC gate is controlled using a series of AC voltages and/or frequencies to select different ions for the drift tube.
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公开(公告)号：US20190285583A1
公开(公告)日：2019-09-19
申请号：US16430309
申请日：2019-06-03
Applicant: Ching Wu , Mark A. Osgood , Eugenie Hainsworth , Clinton Alawn Krueger , Taeman Kim
Inventor： Ching Wu , Mark A. Osgood , Eugenie Hainsworth , Clinton Alawn Krueger , Taeman Kim
Abstract: The IMS apparatus and methods described in this invention involve setting the ion detector at the highest potential of the drift tube and setting the ionization source at ground or near ground potential. The methods allow significantly simple sample introduction without the limitation of the high potential (voltage) concern of the front end sample delivery. The invention also describes bringing samples directly into the ion mobility drift tube. The invention further describes using single syringe for sample introduction via an electrospray ionization method. In addition, automation of the direct spray needle can be achieved by setting up array of the spray needles that are loaded in a manner that rotates and/or moves to the next spray needle in the ESI source region.
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公开(公告)号：US20190259595A1
公开(公告)日：2019-08-22
申请号：US16396715
申请日：2019-04-28
Applicant: Ching Wu , Mark A. Osgood
Inventor： Ching Wu , Mark A. Osgood
Abstract: An ion mobility spectrometry apparatus and method used to separate ions and select some of the ions using an AC gate; the selected ions are further separated along a drift axis of a drift tube, where the AC gate is controlled using a series of AC voltages and/or frequencies to select different ions for the drift tube.
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