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1.发明申请公开(公告)号：US20110224217A1
公开(公告)日：2011-09-15
申请号：US13113135
申请日：2011-05-23
申请人： Deborah Sue Mortensen , Maria Mercedes Delgado Mederos , John Joseph Sapienza , Ronald J. Albers , Steven Spencer Clareen , Kimberly Lyn Schwarz , Jason Simon Parnes , Jennifer R. Riggs , Patrick William Papa , Sayee Gajanan Hegde , Jeffrey Mark McKenna
发明人： Deborah Sue Mortensen , Maria Mercedes Delgado Mederos , John Joseph Sapienza , Ronald J. Albers , Steven Spencer Clareen , Kimberly Lyn Schwarz , Jason Simon Parnes , Jennifer R. Riggs , Patrick William Papa , Sayee Gajanan Hegde , Jeffrey Mark McKenna
IPC分类号： A61K31/519 , C12N9/99 , A61K31/522 , A61P35/00 , A61P29/00 , A61P37/02 , A61P3/00 , A61P17/06 , A61P11/06 , A61P11/02 , A61P11/08 , A61P11/00 , A61P3/04 , A61P3/10 , A61P1/00 , A61P25/28 , A61P19/02
CPC分类号： C07D473/00 , C07D473/28 , C07D473/32 , C07D475/00
摘要： Provided herein are Heteroaryl Compounds having the following structure: wherein R1, R3, R4, L, X, Y, A and B are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by inhibition of a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.
摘要翻译： 本文提供了具有以下结构的杂芳基化合物：其中R 1，R 3，R 4，L，X，Y，A和B如本文所定义，包含有效量的杂芳基化合物的组合物和治疗或预防癌症， ，免疫条件，代谢条件和通过抑制激酶途径可治疗或可预防的病症，包括向有需要的患者施用有效量的杂芳基化合物。
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2.发明授权公开(公告)号：US07981893B2
公开(公告)日：2011-07-19
申请号：US11975652
申请日：2007-10-18
申请人： Deborah Sue Mortensen , Maria Mercedes Delgado Mederos , John Joseph Sapienza , Ronald J. Albers , Branden G. Lee , Roy Leonard Harris, III , Graziella Isabel Shevlin , Dehua Huang , Kimberly Lyn Schwarz , Garrick K. Packard , Jason Simon Parnes , Patrick William Papa , Lida Radnia Tehrani , Sophie Perrin-Ninkovic , Jennifer R. Riggs
发明人： Deborah Sue Mortensen , Maria Mercedes Delgado Mederos , John Joseph Sapienza , Ronald J. Albers , Branden G. Lee , Roy Leonard Harris, III , Graziella Isabel Shevlin , Dehua Huang , Kimberly Lyn Schwarz , Garrick K. Packard , Jason Simon Parnes , Patrick William Papa , Lida Radnia Tehrani , Sophie Perrin-Ninkovic , Jennifer R. Riggs
IPC分类号： A61K31/4985
CPC分类号： C07D471/04 , C07D487/04 , C07D498/04
摘要： Provided herein are Heteroaryl Compounds having the following structure: wherein R1, R2, L, X, Y, Z, Q, A and B are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by inhibition of a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.
摘要翻译： 本文提供具有以下结构的杂芳基化合物：其中R1，R2，L，X，Y，Z，Q，A和B如本文所定义，包含有效量的杂芳基化合物的组合物和治疗或预防癌症的方法， 炎性病症，免疫学条件，代谢条件和通过抑制激酶途径可治疗或可预防的病症，包括向有需要的患者施用有效量的杂芳基化合物。
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公开(公告)号：US20110245245A1
公开(公告)日：2011-10-06
申请号：US13156462
申请日：2011-06-09
申请人： Deborah Sue Mortensen , Maria Mercedes Delgado Mederos , John Joseph Sapienza , Ronald J. Albers , Branden G. Lee , Roy Leonard Harris, III , Graziella Isabel Shevlin , Dehua Huang , Kimberly Lyn Schwarz , Garrick K. Packard , Jason Simon Parnes , Patrick William Papa , Lida Radnia Tehrani , Sophie Perrin-Ninkovic , Jennifer R. Riggs
发明人： Deborah Sue Mortensen , Maria Mercedes Delgado Mederos , John Joseph Sapienza , Ronald J. Albers , Branden G. Lee , Roy Leonard Harris, III , Graziella Isabel Shevlin , Dehua Huang , Kimberly Lyn Schwarz , Garrick K. Packard , Jason Simon Parnes , Patrick William Papa , Lida Radnia Tehrani , Sophie Perrin-Ninkovic , Jennifer R. Riggs
IPC分类号： A61K31/5377 , A61K31/4985 , A61P35/02 , A61P29/00 , A61P37/00 , A61P3/00 , A61P17/06 , A61P37/08 , A61P11/08 , A61P11/06 , A61P1/00 , A61P3/04 , A61P3/10 , A61P19/02 , A61P25/00
CPC分类号： C07D471/04 , C07D487/04 , C07D498/04
摘要： Provided herein are Heteroaryl Compounds having the following structure: wherein R1, R2, L, X, Y, Z, Q, A and B are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by inhibition of a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.
摘要翻译： 本文提供具有以下结构的杂芳基化合物：其中R1，R2，L，X，Y，Z，Q，A和B如本文所定义，包含有效量的杂芳基化合物的组合物和治疗或预防癌症的方法， 炎性病症，免疫学条件，代谢条件和通过抑制激酶途径可治疗或可预防的病症，包括向有需要的患者施用有效量的杂芳基化合物。
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4.发明授权公开(公告)号：US07968556B2
公开(公告)日：2011-06-28
申请号：US11975657
申请日：2007-10-18
申请人： Deborah Sue Mortensen , Maria Mercedes Delgado Mederos , John Joseph Sapienza , Ronald J. Albers , Steven Spencer Clareen , Kimberly Lyn Schwarz , Jason Simon Parnes , Jennifer R. Riggs , Patrick William Papa , Sayee Gajanan Hegde , Jeffrey Mark McKenna
发明人： Deborah Sue Mortensen , Maria Mercedes Delgado Mederos , John Joseph Sapienza , Ronald J. Albers , Steven Spencer Clareen , Kimberly Lyn Schwarz , Jason Simon Parnes , Jennifer R. Riggs , Patrick William Papa , Sayee Gajanan Hegde , Jeffrey Mark McKenna
IPC分类号： C07D473/28 , C07D473/18 , C07D519/00 , A61K31/522 , C07D475/00 , C07D487/04 , A61P3/10 , A61P31/04 , A61P11/06
CPC分类号： C07D473/00 , C07D473/28 , C07D473/32 , C07D475/00
摘要： Provided herein are Heteroaryl Compounds having the following structure: wherein R1, R3, R4, L, X, Y, A and B are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by inhibition of a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.
摘要翻译： 本文提供了具有以下结构的杂芳基化合物：其中R 1，R 3，R 4，L，X，Y，A和B如本文所定义，包含有效量的杂芳基化合物的组合物和治疗或预防癌症， ，免疫条件，代谢条件和通过抑制激酶途径可治疗或可预防的病症，包括向有需要的患者施用有效量的杂芳基化合物。
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5.发明授权Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith 有权卤代芳基取代的氨基嘌呤，其组合物及其处理方法公开(公告)号：US07723340B2
公开(公告)日：2010-05-25
申请号：US11332617
申请日：2006-01-12
申请人： Ronald J. Albers , Leticia Ayala , Steven S. Clareen , Maria Mercedes Delgado Mederos , Robert Hilgraf , Sayee G. Hegde , Kevin Hughes , Adam Kois , Veronique Plantevin-Krenitsky , Meg McCarrick , Lisa Nadolny , Moorthy S. S. Palanki , Kiran Sahasrabudhe , John Sapienza , Yoshitaka Satoh , Marianne K. Sloss , Elise Sudbeck , Jonathan Wright , Ian Henderson , Andrew G. Cole
发明人： Ronald J. Albers , Leticia Ayala , Steven S. Clareen , Maria Mercedes Delgado Mederos , Robert Hilgraf , Sayee G. Hegde , Kevin Hughes , Adam Kois , Veronique Plantevin-Krenitsky , Meg McCarrick , Lisa Nadolny , Moorthy S. S. Palanki , Kiran Sahasrabudhe , John Sapienza , Yoshitaka Satoh , Marianne K. Sloss , Elise Sudbeck , Jonathan Wright , Ian Henderson , Andrew G. Cole
IPC分类号： C07D473/32 , A61K31/52 , A61F2/82 , A61P3/10 , A61P11/00 , C07D239/50 , C07D239/48
CPC分类号： C07D473/00 , A61K31/52 , C07D473/32
摘要： Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.
摘要翻译： 本文提供具有以下结构的氨基嘌呤化合物：其中R1，R2和R3如本文所定义，包含有效量的氨基嘌呤化合物的组合物和治疗或预防癌症，心血管疾病，肾脏疾病，自身免疫病症 ，炎性病症，黄斑变性，缺血再灌注损伤，疼痛及相关综合征，疾病相关性消耗，石棉相关病症，肺动脉高压或通过抑制JNK途径可治疗或可预防的病症，包括施用有效量的 氨基嘌呤化合物对需要的患者。
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6.发明申请公开(公告)号：US20090042890A1
公开(公告)日：2009-02-12
申请号：US11975657
申请日：2007-10-18
申请人： Deborah Sue Mortensen , Maria Mercedes Delgado Mederos , John Joseph Sapienza , Ronald J. Albers , Steven Spencer Clareen , Kimberly Lyn Schwarz , Jason Simon Parnes , Jennifer R. Riggs , Patrick William Papa , Sayee Gajanan Hegde , Jeffrey Mark McKenna
发明人： Deborah Sue Mortensen , Maria Mercedes Delgado Mederos , John Joseph Sapienza , Ronald J. Albers , Steven Spencer Clareen , Kimberly Lyn Schwarz , Jason Simon Parnes , Jennifer R. Riggs , Patrick William Papa , Sayee Gajanan Hegde , Jeffrey Mark McKenna
IPC分类号： A61K31/4985 , C07D401/14 , C07D473/00 , A61P35/00 , A61P29/00 , C12N5/00 , A61P37/00 , A61P3/00 , C07D475/00 , A61K31/52
CPC分类号： C07D473/00 , C07D473/28 , C07D473/32 , C07D475/00
摘要： Provided herein are Heteroaryl Compounds having the following structure: wherein R1, R3, R4, L, X, Y, A and B are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by inhibition of a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.
摘要翻译： 本文提供了具有以下结构的杂芳基化合物：其中R 1，R 3，R 4，L，X，Y，A和B如本文所定义，包含有效量的杂芳基化合物的组合物和治疗或预防癌症， ，免疫条件，代谢条件和通过抑制激酶途径可治疗或可预防的病症，包括向有需要的患者施用有效量的杂芳基化合物。
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7.发明申请公开(公告)号：US20090023724A1
公开(公告)日：2009-01-22
申请号：US11975652
申请日：2007-10-18
申请人： Deborah Sue Mortensen , Maria Mercedes Delgado Mederos , John Joseph Sapienza , Ronald J. Albers , Branden G. Lee , Roy Leonard Harris, III , Graziella Isabel Shevlin , Dehua Huang , Kimberly Lyn Schwarz , Garrick K. Packard , Jason Simon Parnes , Patrick William Papa , Lida Radnia Tehrani , Sophie Perrin-Ninkovic , Jennifer R. Riggs
发明人： Deborah Sue Mortensen , Maria Mercedes Delgado Mederos , John Joseph Sapienza , Ronald J. Albers , Branden G. Lee , Roy Leonard Harris, III , Graziella Isabel Shevlin , Dehua Huang , Kimberly Lyn Schwarz , Garrick K. Packard , Jason Simon Parnes , Patrick William Papa , Lida Radnia Tehrani , Sophie Perrin-Ninkovic , Jennifer R. Riggs
IPC分类号： A61K31/4985 , A61P35/00 , A61P37/00 , C07D487/04 , A61K31/5377 , C07D471/04 , A61P3/00 , A61P29/00
CPC分类号： C07D471/04 , C07D487/04 , C07D498/04
摘要： Provided herein are Heteroaryl Compounds having the following structure: wherein R1, R2, L, X, Y, Z, Q, A and B are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by inhibition of a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.
摘要翻译： 本文提供具有以下结构的杂芳基化合物：其中R1，R2，L，X，Y，Z，Q，A和B如本文所定义，包含有效量的杂芳基化合物的组合物和治疗或预防癌症的方法， 炎性病症，免疫学条件，代谢条件和通过抑制激酶途径可治疗或可预防的病症，包括向有需要的患者施用有效量的杂芳基化合物。
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8.发明授权公开(公告)号：US08383634B2
公开(公告)日：2013-02-26
申请号：US13113135
申请日：2011-05-23
申请人： Deborah Sue Mortensen , Maria Mercedes Delgado Mederos , John Joseph Sapienza , Ronald J. Albers , Steven Spencer Clareen , Kimberly Lyn Schwarz , Jason Simon Parnes , Jennifer R. Riggs , Patrick William Papa , Sayee Gajanan Hegde , Jeffrey Mark McKenna
发明人： Deborah Sue Mortensen , Maria Mercedes Delgado Mederos , John Joseph Sapienza , Ronald J. Albers , Steven Spencer Clareen , Kimberly Lyn Schwarz , Jason Simon Parnes , Jennifer R. Riggs , Patrick William Papa , Sayee Gajanan Hegde , Jeffrey Mark McKenna
IPC分类号： A61P11/06 , A61P3/10 , A61P31/04 , C07D473/28 , C07D473/18 , C07D519/00 , C07D487/04 , A61K31/522
CPC分类号： C07D473/00 , C07D473/28 , C07D473/32 , C07D475/00
摘要： Provided herein are Heteroaryl Compounds having the following structure: wherein R1, R3, R4, L, X, Y, A and B are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by inhibition of a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.
摘要翻译： 本文提供了具有以下结构的杂芳基化合物：其中R 1，R 3，R 4，L，X，Y，A和B如本文所定义，包含有效量的杂芳基化合物的组合物和治疗或预防癌症， ，免疫条件，代谢条件和通过抑制激酶途径可治疗或可预防的病症，包括向有需要的患者施用有效量的杂芳基化合物。
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9.发明授权公开(公告)号：US08372976B2
公开(公告)日：2013-02-12
申请号：US13156462
申请日：2011-06-09
申请人： Deborah Sue Mortensen , Maria Mercedes Delgado Mederos , John Joseph Sapienza , Ronald J. Albers , Branden G. Lee , Roy Leonard Harris, III , Graziella Isabel Shevlin , Dehua Huang , Kimberly Lyn Schwarz , Garrick K. Packard , Jason Simon Parnes , Patrick William Papa , Lida Radnia Tehrani , Sophie Perrin-Ninkovic , Jennifer R. Riggs
发明人： Deborah Sue Mortensen , Maria Mercedes Delgado Mederos , John Joseph Sapienza , Ronald J. Albers , Branden G. Lee , Roy Leonard Harris, III , Graziella Isabel Shevlin , Dehua Huang , Kimberly Lyn Schwarz , Garrick K. Packard , Jason Simon Parnes , Patrick William Papa , Lida Radnia Tehrani , Sophie Perrin-Ninkovic , Jennifer R. Riggs
IPC分类号： C07D487/14
CPC分类号： C07D471/04 , C07D487/04 , C07D498/04
摘要： Provided herein are Heteroaryl Compounds having the following structure: wherein R1, R2, L, X, Y, Z, Q, A and B are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by inhibition of a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.
摘要翻译： 本文提供具有以下结构的杂芳基化合物：其中R1，R2，L，X，Y，Z，Q，A和B如本文所定义，包含有效量的杂芳基化合物的组合物和治疗或预防癌症的方法， 炎性病症，免疫学条件，代谢条件和通过抑制激酶途径可治疗或可预防的病症，包括向有需要的患者施用有效量的杂芳基化合物。
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10.发明授权Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith 有权卤代芳基取代的氨基嘌呤，其组合物及其处理方法公开(公告)号：US07521446B2
公开(公告)日：2009-04-21
申请号：US11411413
申请日：2006-04-26
申请人： Ronald J. Albers , Leticia Ayala , Steven S. Clareen , Maria Mercedes Delgado Mederos , Robert Hilgraf , Kevin Hughes , Adam Kois , Veronique Plantevin-Krenitsky , Meg McCarrick , Lisa Nadolny , Moorthy S. S. Palanki , Kiran Sahasrabudhe , Yoshitaka Satoh , Marianne K. Sloss , Elise Sudbeck , Jonathan Wright
发明人： Ronald J. Albers , Leticia Ayala , Steven S. Clareen , Maria Mercedes Delgado Mederos , Robert Hilgraf , Kevin Hughes , Adam Kois , Veronique Plantevin-Krenitsky , Meg McCarrick , Lisa Nadolny , Moorthy S. S. Palanki , Kiran Sahasrabudhe , Yoshitaka Satoh , Marianne K. Sloss , Elise Sudbeck , Jonathan Wright
IPC分类号： C07D473/32 , A61K31/52 , A61P3/10 , A61P11/00 , C07D239/50 , C07D239/48
CPC分类号： A61K31/52 , C07D473/32
摘要： Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.
摘要翻译： 本文提供具有以下结构的氨基嘌呤化合物：其中R1，R2和R3如本文所定义，包含有效量的氨基嘌呤化合物的组合物和治疗或预防癌症，心血管疾病，肾脏疾病，自身免疫病症， 炎性病症，黄斑变性，缺血再灌注损伤，疼痛和相关综合征，疾病相关性消耗，石棉相关病症，肺动脉高压或通过抑制JNK途径可治疗或可预防的病症包括给予有效量的氨基嘌呤 与需要的患者复合。
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