公开(公告)号：US07981893B2

公开(公告)日：2011-07-19

申请号：US11975652

申请日：2007-10-18

申请人： Deborah Sue Mortensen ,  Maria Mercedes Delgado Mederos ,  John Joseph Sapienza ,  Ronald J. Albers ,  Branden G. Lee ,  Roy Leonard Harris, III ,  Graziella Isabel Shevlin ,  Dehua Huang ,  Kimberly Lyn Schwarz ,  Garrick K. Packard ,  Jason Simon Parnes ,  Patrick William Papa ,  Lida Radnia Tehrani ,  Sophie Perrin-Ninkovic ,  Jennifer R. Riggs

发明人： Deborah Sue Mortensen ,  Maria Mercedes Delgado Mederos ,  John Joseph Sapienza ,  Ronald J. Albers ,  Branden G. Lee ,  Roy Leonard Harris, III ,  Graziella Isabel Shevlin ,  Dehua Huang ,  Kimberly Lyn Schwarz ,  Garrick K. Packard ,  Jason Simon Parnes ,  Patrick William Papa ,  Lida Radnia Tehrani ,  Sophie Perrin-Ninkovic ,  Jennifer R. Riggs

IPC分类号： A61K31/4985

CPC分类号： C07D471/04 ,  C07D487/04 ,  C07D498/04

摘要： Provided herein are Heteroaryl Compounds having the following structure: wherein R1, R2, L, X, Y, Z, Q, A and B are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by inhibition of a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.

摘要翻译： 本文提供具有以下结构的杂芳基化合物：其中R1，R2，L，X，Y，Z，Q，A和B如本文所定义，包含有效量的杂芳基化合物的组合物和治疗或预防癌症的方法， 炎性病症，免疫学条件，代谢条件和通过抑制激酶途径可治疗或可预防的病症，包括向有需要的患者施用有效量的杂芳基化合物。

公开(公告)号：US08372976B2

公开(公告)日：2013-02-12

申请号：US13156462

申请日：2011-06-09

申请人： Deborah Sue Mortensen ,  Maria Mercedes Delgado Mederos ,  John Joseph Sapienza ,  Ronald J. Albers ,  Branden G. Lee ,  Roy Leonard Harris, III ,  Graziella Isabel Shevlin ,  Dehua Huang ,  Kimberly Lyn Schwarz ,  Garrick K. Packard ,  Jason Simon Parnes ,  Patrick William Papa ,  Lida Radnia Tehrani ,  Sophie Perrin-Ninkovic ,  Jennifer R. Riggs

发明人： Deborah Sue Mortensen ,  Maria Mercedes Delgado Mederos ,  John Joseph Sapienza ,  Ronald J. Albers ,  Branden G. Lee ,  Roy Leonard Harris, III ,  Graziella Isabel Shevlin ,  Dehua Huang ,  Kimberly Lyn Schwarz ,  Garrick K. Packard ,  Jason Simon Parnes ,  Patrick William Papa ,  Lida Radnia Tehrani ,  Sophie Perrin-Ninkovic ,  Jennifer R. Riggs

IPC分类号： C07D487/14

CPC分类号： C07D471/04 ,  C07D487/04 ,  C07D498/04

摘要： Provided herein are Heteroaryl Compounds having the following structure: wherein R1, R2, L, X, Y, Z, Q, A and B are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by inhibition of a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.

摘要翻译： 本文提供具有以下结构的杂芳基化合物：其中R1，R2，L，X，Y，Z，Q，A和B如本文所定义，包含有效量的杂芳基化合物的组合物和治疗或预防癌症的方法， 炎性病症，免疫学条件，代谢条件和通过抑制激酶途径可治疗或可预防的病症，包括向有需要的患者施用有效量的杂芳基化合物。

公开(公告)号：US20110245245A1

公开(公告)日：2011-10-06

申请号：US13156462

申请日：2011-06-09

申请人： Deborah Sue Mortensen ,  Maria Mercedes Delgado Mederos ,  John Joseph Sapienza ,  Ronald J. Albers ,  Branden G. Lee ,  Roy Leonard Harris, III ,  Graziella Isabel Shevlin ,  Dehua Huang ,  Kimberly Lyn Schwarz ,  Garrick K. Packard ,  Jason Simon Parnes ,  Patrick William Papa ,  Lida Radnia Tehrani ,  Sophie Perrin-Ninkovic ,  Jennifer R. Riggs

发明人： Deborah Sue Mortensen ,  Maria Mercedes Delgado Mederos ,  John Joseph Sapienza ,  Ronald J. Albers ,  Branden G. Lee ,  Roy Leonard Harris, III ,  Graziella Isabel Shevlin ,  Dehua Huang ,  Kimberly Lyn Schwarz ,  Garrick K. Packard ,  Jason Simon Parnes ,  Patrick William Papa ,  Lida Radnia Tehrani ,  Sophie Perrin-Ninkovic ,  Jennifer R. Riggs

IPC分类号： A61K31/5377 ,  A61K31/4985 ,  A61P35/02 ,  A61P29/00 ,  A61P37/00 ,  A61P3/00 ,  A61P17/06 ,  A61P37/08 ,  A61P11/08 ,  A61P11/06 ,  A61P1/00 ,  A61P3/04 ,  A61P3/10 ,  A61P19/02 ,  A61P25/00

CPC分类号： C07D471/04 ,  C07D487/04 ,  C07D498/04

摘要： Provided herein are Heteroaryl Compounds having the following structure: wherein R1, R2, L, X, Y, Z, Q, A and B are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by inhibition of a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.

摘要翻译： 本文提供具有以下结构的杂芳基化合物：其中R1，R2，L，X，Y，Z，Q，A和B如本文所定义，包含有效量的杂芳基化合物的组合物和治疗或预防癌症的方法， 炎性病症，免疫学条件，代谢条件和通过抑制激酶途径可治疗或可预防的病症，包括向有需要的患者施用有效量的杂芳基化合物。

公开(公告)号：US20090023724A1

公开(公告)日：2009-01-22

申请号：US11975652

申请日：2007-10-18

申请人： Deborah Sue Mortensen ,  Maria Mercedes Delgado Mederos ,  John Joseph Sapienza ,  Ronald J. Albers ,  Branden G. Lee ,  Roy Leonard Harris, III ,  Graziella Isabel Shevlin ,  Dehua Huang ,  Kimberly Lyn Schwarz ,  Garrick K. Packard ,  Jason Simon Parnes ,  Patrick William Papa ,  Lida Radnia Tehrani ,  Sophie Perrin-Ninkovic ,  Jennifer R. Riggs

发明人： Deborah Sue Mortensen ,  Maria Mercedes Delgado Mederos ,  John Joseph Sapienza ,  Ronald J. Albers ,  Branden G. Lee ,  Roy Leonard Harris, III ,  Graziella Isabel Shevlin ,  Dehua Huang ,  Kimberly Lyn Schwarz ,  Garrick K. Packard ,  Jason Simon Parnes ,  Patrick William Papa ,  Lida Radnia Tehrani ,  Sophie Perrin-Ninkovic ,  Jennifer R. Riggs

IPC分类号： A61K31/4985 ,  A61P35/00 ,  A61P37/00 ,  C07D487/04 ,  A61K31/5377 ,  C07D471/04 ,  A61P3/00 ,  A61P29/00

CPC分类号： C07D471/04 ,  C07D487/04 ,  C07D498/04

摘要： Provided herein are Heteroaryl Compounds having the following structure: wherein R1, R2, L, X, Y, Z, Q, A and B are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by inhibition of a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.

摘要翻译： 本文提供具有以下结构的杂芳基化合物：其中R1，R2，L，X，Y，Z，Q，A和B如本文所定义，包含有效量的杂芳基化合物的组合物和治疗或预防癌症的方法， 炎性病症，免疫学条件，代谢条件和通过抑制激酶途径可治疗或可预防的病症，包括向有需要的患者施用有效量的杂芳基化合物。