公开(公告)号：US20240199713A1

公开(公告)日：2024-06-20

申请号：US18555844

申请日：2022-04-22

申请人： Macquarie University

发明人： Roger Chung ,  Albert Lee ,  Stephanie Rayner ,  Marco Morsch ,  Luan Luu

IPC分类号： C07K14/47

CPC分类号： C07K14/4738 ,  C07K2319/095

摘要： Provided herein are modified cyclin F polypeptides and nucleic acid molecules encoding the same. In particular, provided herein are modified cyclin F polypeptides that have increased cytoplasmic targeting compared to wild-type cyclin F polypeptides, and functional, truncated modified cyclin F polypeptides, and nucleic acid molecules encoding the same. Also provided herein is the use of the modified cyclin F polypeptides and encoding nucleic acid molecules for enhancing motor neuron survival, inhibiting motor neuron degeneration and treating neurodegenerative conditions, in particular those associated with neuronal TDP-43 proteinopathy.

公开(公告)号：US11924374B2

公开(公告)日：2024-03-05

申请号：US17834883

申请日：2022-06-07

申请人： Cochlear Limited, Macquarie University

发明人： Deborah M. Manchester

IPC分类号： H04M3/42 ,  G16H40/67 ,  H04R25/00

CPC分类号： H04M3/42391 ,  G16H40/67 ,  H04M3/42136 ,  H04R25/554 ,  H04R25/70 ,  H04M2203/053 ,  H04R2225/55

摘要： Real time, remote access to and adjustment of the hearing aid of a patient while the patient is located in a normal life environment that is remote from a hearing professional. A session request initiates a programming session. Adjustable settings from the patient's hearing aid are wirelessly streamed to the patient's mobile device and from the mobile device to a streaming cloud server. The settings are stored on the cloud, streamed from the cloud to a hearing professional's computer or mobile device and displayed. The hearing professional then changes at least one of the adjustable hearing aid settings and the changed settings are streamed to the cloud, stored on the cloud, streamed from the cloud to the patient's mobile device, wirelessly transmitted to the hearing aid and stored there. A telephonic voice connection between the hearing professional and the patient's mobile device is used to transmit the patient's evaluation of changed settings to the hearing professional.

公开(公告)号：US20230337664A1

公开(公告)日：2023-10-26

申请号：US17923294

申请日：2021-05-05

申请人： MACQUARIE UNIVERSITY

发明人： Phillip TAYLOR ,  Vivek KEMPARAJU ,  Soo Jean PARK

IPC分类号： A01N31/02 ,  A01N25/04 ,  A01P17/00

CPC分类号： A01N31/02 ,  A01N25/04 ,  A01P17/00

摘要： The technology relates to the use of 1-octanol, 1-nonanol, a combination thereof or compositions comprising either or both of 1-octanol and 1-nonanol for modifying the behaviour of tephritid fruit flies. In particular the 1-octanol, 1-nonanol or compositions described herein can be used to repel and/or modulate the feeding, mating or oviposition behaviour of tephritid fruit flies such as the Queensland fruit fly and the Mediterranean fruit fly.

公开(公告)号：US20230304048A1

公开(公告)日：2023-09-28

申请号：US17916137

申请日：2021-03-31

申请人： MacQuarie University

发明人： Robert Willows ,  Louise Brown ,  Natalie Curach ,  Ante Jerkovic ,  Kerstin Petroll ,  Jocelyn Johns ,  Samuel King ,  Ari Edmonds

IPC分类号： C12P3/00 ,  C12N15/52 ,  C12N15/70 ,  C12N9/02 ,  C12N9/04

CPC分类号： C12P3/00 ,  C12N15/52 ,  C12N15/70 ,  C12N9/0067 ,  C12Y112/07002 ,  C12N9/0095 ,  C12Y118/01002 ,  C12N9/0006 ,  C12Y101/01 ,  C12N2800/101 ,  H01M8/16

摘要： The present invention relates to recombinant microorganisms for producing biological hydrogen. In addition, the invention relates to nucleic acid constructs and processes for modifying microorganisms for enabling the production of hydrogen therefrom.

公开(公告)号：US20220362404A1

公开(公告)日：2022-11-17

申请号：US17754597

申请日：2020-10-21

申请人： Macquarie University

发明人： Stephanie Rayner ,  Albert Lee ,  Jennilee Davidson ,  Roger Chung

IPC分类号： A61K48/00

摘要： Provided herein are methods for enhancing survival of a neuron, for inhibiting degeneration of a neuron, and for inhibiting abnormal protein accumulation in a neuron, optionally a motor neuron, comprising, consisting or consisting essentially of increasing the level of cyclin F in the neuron regardless of the neuron's level or activity of endogenous cyclin F. Optionally the neuron is in a subject with a neurodegenerative condition or at risk of developing a neurodegenerative condition, typically a neurodegenerative condition associated with a neuronal TDP-43 proteinopathy.

公开(公告)号：US20220288082A1

公开(公告)日：2022-09-15

申请号：US17754135

申请日：2020-09-25

申请人： Macquarie University

发明人： Lars Ittner ,  Yazi Diana Ke

IPC分类号： A61K31/519 ,  A61P25/28

摘要： Provided herein are methods for treating, delaying the onset of, or ameliorating at least one symptom of, dementia associated with #-amyloid (A#) accumulation, and for improving memory in subjects suffering from dementia associated with A# accumulation, comprising administering to subjects in need thereof an effective amount of an inhibitor of LIMK1, wherein the inhibitor comprises a compound of Formula (I) as defined herein, or a pharmaceutically acceptable salt thereof. Also provided are methods for reducing A# toxicity in neurons, comprising exposing neurons to an effective amount of an inhibitor of LIMK1, wherein the inhibitor comprises a compound of Formula (I) as defined herein, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US11428075B2

公开(公告)日：2022-08-30

申请号：US16944796

申请日：2020-07-31

申请人： SAUDI ARABIAN OIL COMPANY ,  Macquarie University

发明人： Chinthaka Pasan Gooneratne ,  Subhas Mukhopadhyay ,  Bodong Li ,  Guodong Zhan ,  Arturo Magana-Mora ,  Timothy Eric Moellendick

IPC分类号： E21B41/00 ,  E21B47/26 ,  E21B47/00 ,  E21B47/12 ,  G01V11/00 ,  H01M10/46 ,  H02N1/04 ,  H02N2/18

摘要： A system includes sensing modules positioned along a length of a drill string. Each sensing module includes a structure arrangement composed of an outer structure body having a cavity and an inner structure body rotatably supported within the cavity. The structure arrangement is coupled to the drill string such that rotation of the drill string produces a relative rotation between the structure bodies. Ball elements are disposed in a gap between the structure bodies and move along a predetermined path defined in the gap in response to relative rotation between the structure bodies. Movable elements are positioned to physically interact with the ball elements as the ball elements move along the predetermined path. Energy harvesters in the sensor modules generate electrical energy from the mechanical energy produced by physical interaction between the ball elements and movable elements. The sensing modules include sensors to measure parameters in the drill string environment.

公开(公告)号：US11322905B2

公开(公告)日：2022-05-03

申请号：US16475747

申请日：2017-12-22

申请人： Macquarie University

发明人： David James Spence ,  Ondrej Kitzler ,  Jipeng Lin ,  Richard Paul Mildren ,  Helen M. Pask ,  Graeme P. A. Malcolm ,  Nils Hempler ,  Stephen Webster

IPC分类号： H01S3/08 ,  H01S3/081 ,  H01S3/083 ,  H01S3/139 ,  H01S3/30

摘要： A single longitudinal mode ring Raman laser including: a pump source outputting a pump light power, resonantly coupled to a first ring resonator; a optical measurement and piezo-actuator for stabilising the resonant coupling of the pump light power to a first ring resonator; a first ring resonator including a Raman gain medium, wherein the Raman gain medium receives the pump light power and undergoes Raman lasing generating resonated Stokes power at the corresponding Stokes output wavelength; the first ring resonator acting as a feedback loop for the pump light power and the resonated Stokes power and outputting a portion of the Stokes power as the laser output.

公开(公告)号：US11194005B2

公开(公告)日：2021-12-07

申请号：US16345225

申请日：2017-10-27

申请人： MACQUARIE UNIVERSITY

发明人： Sam Reisenfeld ,  Audri Biswas

IPC分类号： G01S3/04 ,  G01S3/48 ,  G01S3/72 ,  G01S3/80

摘要： Iterative methods for direction of arrival estimation of a signal at a receiver with a plurality of spatially separated sensor elements are described. A quantized estimate of the angle of arrival is obtained from a compressive sensing solution of a set of equations. The estimate is refined in a subsequent iteration by a computed error based a quantized estimate of the direction of arrival in relation to quantization points offset from the quantization points for the first quantized estimate of the angle of arrival. The iterations converge on an estimated direction of arrival.

公开(公告)号：US20190183527A1

公开(公告)日：2019-06-20

申请号：US16323036

申请日：2017-08-03

申请人： MACQUARIE UNIVERSITY

发明人： John Anthony Cartmill ,  Andrew Gilmore

IPC分类号： A61B17/34 ,  A61B17/3201 ,  A61B17/32 ,  A61B90/30

CPC分类号： A61B17/3468 ,  A61B17/320016 ,  A61B17/3201 ,  A61B17/3417 ,  A61B17/3462 ,  A61B17/3474 ,  A61B90/30 ,  A61B2017/00477 ,  A61B2017/00907

摘要： A laparoscopic guide comprises a hollow body having a longitudinal mid-plane and a cross sectional area that tapers from a proximal end to a distal end thereof. The distal end has a distal end face being oriented substantially perpendicular to the longitudinal mid-plane. The distal end face is adapted for communication with an inlet of a trocar port. The proximal end is adapted for receiving a laparoscopic surgical instrument or the like therein prior to the laparoscopic surgical instrument passing through the trocar port. The proximal end comprises an open end face that is oriented obliquely relative to the distal end face.