公开(公告)号：US20240235359A1

公开(公告)日：2024-07-11

申请号：US18554843

申请日：2021-04-14

申请人： Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e. V.

发明人： Sebastian RABIEN

IPC分类号： H02K49/10 ,  F16H1/16

CPC分类号： H02K49/102 ,  F16H1/16

摘要： The present invention relates to a drive arrangement (1), preferably a worm gear drive arrangement (1), with an output element (3) for performing an output movement and a driving element (2) for driving the output element (3), wherein the driving element (2) and the output element (3) are arranged spaced apart (7) from each other in a contactless manner, wherein at least one magnetic unit (4) for generating a magnetic field (MF) is coupled to the driving element (2) for magnetization at least one driving portion (2P1, 2P2) of the driving element (2), wherein the least one driving portion (2P1, 2P2) is configured to transmit the magnetic field (MF, tMF) at least partially to the output element (3) to drive the output element (3) upon a rotational movement of the driving element (2).

公开(公告)号：US20240039235A1

公开(公告)日：2024-02-01

申请号：US18268710

申请日：2020-12-22

申请人： Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e. V. ,  Ludwig-Maximilians-Universitaet Muenchen

发明人： Alexander WEIGEL ,  Theresa BUBERL ,  Ferenc KRAUSZ ,  Ioachim PUPEZA

IPC分类号： H01S3/13 ,  H01S3/00 ,  G01N21/3586

CPC分类号： H01S3/1307 ,  H01S3/1305 ,  H01S3/0057 ,  H01S3/0078 ,  G01N21/3586

摘要： A laser pulse sequence measuring method for measuring a delay between a pair of pulses from two laser pulse sequences (1, 2), comprises the steps of creating a first laser pulse sequence (1) of first laser pulses (1A) and a second laser pulse sequence (2) of second laser pulses (2A), and generating a delay signal (3) which represents the delay between the pair of pulses from the first and second laser pulse sequences (1, 2), wherein the step of generating the delay signal (3) includes creating intra-pulse difference frequency generation (IPDFG) pulses (4) by applying intra-pulse difference frequency generation to the first laser pulses (1A) in a difference frequency generation (DFG) medium (21), providing phase-stable reference waveforms (5) based on the IPDFG pulses (4), and electro-optic sampling (EOS) of the electric field of the phase-stable reference waveforms (5) with sampling pulses (6) in an EOS medium (22), wherein the sampling pulses (6) are created based on the second laser pulses (2A), for generating an electro-optic sampling (EOS) signal (7), wherein the delay signal (3) is obtained from the EOS signal (7). Furthermore, a spectroscopic measuring method, a laser pulse sequence measuring apparatus (100) and a spectroscopic measuring apparatus are described.

公开(公告)号：US20230230793A1

公开(公告)日：2023-07-20

申请号：US18010669

申请日：2020-06-22

申请人： Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e. V.

发明人： Christian HOPF ,  Bernd HEINEMANN ,  Markus FROESCHLE ,  Moritz ECKERSKORN ,  Niek DEN HARDER

IPC分类号： H01J27/02 ,  H05H3/06 ,  G21B1/11

CPC分类号： H01J27/024 ,  H05H3/06 ,  G21B1/11

摘要： An ion beam extraction apparatus (100), being configured for creating an ion beam (1), in particular adapted for a neutral beam injection apparatus of a fusion plasma plant, comprises an ion source device (10) being arranged for creating ions, and a grid device (20) comprising at least two grids (21, 22) being arranged adjacent to the ion source device (10) and having a mutual grid distance d along a beam axis z, wherein the grids (21, 22) are electrically insulated relative to each other, the grids (21, 22) are arranged for applying different electrical potentials for creating an ion extraction and acceleration field (3) along the beam axis z, and he ion source device (10) and the grid device (20) are arranged in an evacuable ion beam space (30) extending along the beam axis z, wherein at least one of the grids is a movable grid (21), which can be shifted along the beam axis z, and the grid device (20) is coupled with a grid drive device (40) having a drive motor (41), which is arranged for moving the movable grid (21) along the beam axis z and setting the grid distance d between the movable grid (21) and another one of the grids (21, 22). Furthermore, applications of the ion beam extraction apparatus and a method of creating an ion beam along a beam axis z are disclosed.

公开(公告)号：US11274304B2

公开(公告)日：2022-03-15

申请号：US16977679

申请日：2019-03-05

申请人： MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E. V.

发明人： Sascha Kupke ,  Timo Frensing ,  Pawel Zmora ,  Udo Reichl

IPC分类号： C12N15/113 ,  A61K9/00 ,  A61K35/76 ,  A61K39/00

摘要： In a first aspect, the present invention relates to an isolated nucleic acid molecule, in particular, an RNA molecule containing particular substitutions. In a further aspect, the present invention relates to a composition comprising the same as well as virus-like particle, viral vector or virus particle containing the nucleic acid molecule according to the present invention. The virus-like particle, the viral vector or the virus particle is suitable for use as a medicament in particular for treating viral infection. Further, a pharmaceutical composition is provided in particular suitable for use as a pharmaceutical prophylactic vaccine containing the virus-like particle, viral vector or the virus particle or the nucleic acid molecule according to the present invention. Finally, a vaccine for vaccination against viral infection, in particular, influenza viral infection is provided as well as a composition or kit comprising the virus-like particle, viral vector or the virus particle according to the present invention or the nucleic acid molecule according to the present invention in a combination with a wild type viral vector or wild type virus particle said composition or kit is suitable for use in treating or protecting against viral infection.

公开(公告)号：US10969573B2

公开(公告)日：2021-04-06

申请号：US16087863

申请日：2016-03-24

申请人： Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e. V.

发明人： Thomas M. Jovin ,  Anthony De Vries ,  Tobias Freund

IPC分类号： G02B26/00 ,  G02B7/00 ,  G02B21/00 ,  G02B26/08 ,  G02B27/10

摘要： A spatio-temporally light modulated imaging system for confocal imaging an object includes a light modulating micro-mirror device, an imaging optic, and a camera device, wherein a carrier wheel device is provided for carrying multiple pairs of first and second dichroic beam splitters and multiple pairs of first and second emission filters, wherein the carrier wheel device is adjustable in multiple operational positions relative to the first and second optical axes, and wherein a casing is provided. Furthermore, a carrier wheel device for carrying optical members and a method for confocal imaging an object are disclosed.

公开(公告)号：US10898619B2

公开(公告)日：2021-01-26

申请号：US15741717

申请日：2016-07-06

申请人： Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e. V.

发明人： Joachim P. Spatz ,  Fania Geiger ,  Michael Thaller ,  Christian Lingenfelder ,  Heike Boehm

IPC分类号： A61L31/10 ,  A61F9/007 ,  C08B37/08 ,  C08J3/075 ,  C08J3/24 ,  C09D105/08 ,  C08L5/08 ,  A61L27/34 ,  A61L27/20 ,  A61L27/06 ,  A61L31/02 ,  A61L31/04 ,  A61L31/14

摘要： The present invention relates to an ocular device for regulating intraocular fluid pressure comprising or consisting of a tubular body wherein the inner surface of the tubular body or the inner and outer surface is/are coated with covalently immobilized hyaluronic acid (HA). In more specific embodiments, the tubular body comprises or consists of a biocompatible material selected from the group comprising a biocompatible metal such as titanium, ceramics, glass, polymers and composites thereof, and the immobilized hyaluronic acid molecules are linked with further HA molecules to form a HA hydrogel. The ocular device is a stent free from mechanical valves or other mechanical means for actively regulating the flow of intraocular fluid.

公开(公告)号：US10249065B2

公开(公告)日：2019-04-02

申请号：US15572009

申请日：2015-05-08

申请人： Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e. V.

发明人： Henrik Marschner ,  Andre Pampel ,  Harald Moeller

IPC分类号： G06K9/00 ,  G06T11/00 ,  G01R33/56 ,  G06T5/00 ,  G06T5/10 ,  A61B5/055 ,  A61B5/00 ,  G01R33/565 ,  G06T3/00

摘要： A method of image processing of magnetic resonance (MR) images for creating de-noised MR images, comprises the steps of providing image data sets including multiple complex MR images (S7), subjecting the MR images to a wavelet decomposition (S12) for creating coefficient data sets of wavelet coefficients (Sn,m) representing the MR images in a wavelet frequency domain, calculating normalized coefficient data sets of wavelet coefficients Formula (I) (S17), wherein the coefficient data sets are normalized with a quantitative amount of variation, in particular standard deviation Formula (II), of noise contributions included in the coefficient data sets (Sn,m), averaging the wavelet coefficients of each coefficient data set (S18) for providing averaged wavelet coefficients Formula (III) of the coefficient data sets, calculating phase difference maps (Δϕn,m) for all coefficient data sets (S20), wherein the phase difference maps provide phase differences between the phase of each wavelet coefficient and the phase of the averaged wavelet coefficients Formula (III), calculating scaled averaged coefficient data sets of wavelet coefficients by scaling the averaged wavelet coefficients Formula (III) with scaling factors (Cn,m), which are obtained by comparing parts of the normalized wavelet coefficients of the normalized coefficient data sets Formula (I) that are in phase with the averaged wavelet coefficients Formula (III) (S22), calculating rescaled coefficient data sets of wavelet coefficients Formula (IV) (S24) by applying a transfer function Formula (V) on the coefficient data sets (Sn,m) and on the scaled averaged coefficient data sets, wherein the transfer function includes combined amplitude and phase filters, each depending on the normalized coefficient data sets Formula (I) and me phase difference maps (Δϕn,m), resp., and subjecting the rescaled coefficient data sets to a wavelet reconstruction Formula (IV) (S25) for providing the denoised MR images.

公开(公告)号：US20180031818A1

公开(公告)日：2018-02-01

申请号：US15551891

申请日：2015-02-20

申请人： Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e. V.

发明人： Andrea BASSI ,  Jan HUISKEN ,  Benjamin SCHMID

IPC分类号： G02B21/36 ,  G02B21/32 ,  G02B21/12 ,  G02B21/26

CPC分类号： G02B21/367 ,  G02B21/12 ,  G02B21/26 ,  G02B21/32

摘要： The invention is directed to a method for creating an optical tomogram, which comprises the steps providing an optical microscope, arranging a sample (1) in the optical coverage region of a lens (5) of the microscope, setting the focus of the lens to a particular focal plane (2), recording an image of the sample through the microscope, rotating the sample through an angle α, optionally displacing the sample along the longitudinal axis (z) of the lens (5) and/or perpendicular to the plane of the previously recorded image (9) and continuing the method with step d) until a predetermined number of section images (9) of the sample (1) have been recorded, wherein the sample (1) is displaced along the longitudinal axis (z) of the lens (5) and/or perpendicular to the plane of the previously recorded image (9), in accordance with step f), at least once during a rotation of the sample through 360°. Furthermore the invention is directed to an optical microscope for creating tomograms, which comprises at least one lens (5), at least one sample suspension device (10) and at least one illumination device (6), wherein the sample suspension device (10) is rotatable about an axis (3) arranged perpendicular to the longitudinal axis (z) of the lens (5) and is displaceable along the longitudinal axis (z) of the lens (5).

公开(公告)号：US12046866B2

公开(公告)日：2024-07-23

申请号：US17441750

申请日：2019-03-25

申请人： Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e. V. ,  Ludwig-Maximilians-Universitaet Muenchen

发明人： Oleg Pronin ,  Ferenc Krausz ,  Ka Fai Mak ,  Jonathan Brons ,  Maksim Iandulskii

IPC分类号： H01S3/1112 ,  H01S3/00 ,  H01S3/06 ,  H01S3/081 ,  H01S3/094 ,  H01S3/131 ,  H01S3/16

CPC分类号： H01S3/1112 ,  H01S3/0057 ,  H01S3/0604 ,  H01S3/0811 ,  H01S3/0813 ,  H01S3/094061 ,  H01S3/1312 ,  H01S3/1618 ,  H01S3/1623 ,  H01S3/1643

摘要： A multiple frequency comb source apparatus (100) for simultaneously creating a first laser pulse sequence representing a first frequency comb (1) and at least one further laser pulse sequence representing at least one further frequency comb (2), wherein at least two of the first and at least one further pulse sequences have different repetition frequencies, comprises a laser resonator device (10) comprising multiple resonator mirrors including first end mirrors EM1,OC1 providing a first laser resonator (11), a laser gain medium (21, 22) being arranged in the laser resonator device (10), and a pump device (30) being arranged for pumping the laser gain medium (21), wherein the laser resonator device (10) is configured for creating the first and at least one further laser pulse sequences by pumping and passively mode-locking the laser gain medium (21), the resonator mirrors of the laser resonator device (10) include further end mirrors EM2, OC2 providing at least one further laser resonator (12), the first laser resonator (11) and the at least one further laser resonator (12) share the laser gain medium (21), resonator modes of the first laser resonator (11) and the at least one further laser resonator (12) are displaced relative to each other, wherein the resonator modes are located in the laser gain medium (21) at separate beam path spots, and at least one of the first and further end mirrors EM1, EM2, OC1, OC2 is adjustable so that the repetition frequency of at least one of the first and at least one further laser pulse sequences can be set independently from the repetition frequency of the other one of the first and at least one further laser pulse sequences. Furthermore, a spectroscopic measuring method, a spectroscopy apparatus and a multiple frequency comb generation method are described.

公开(公告)号：US20240222542A1

公开(公告)日：2024-07-04

申请号：US18558464

申请日：2022-05-09

申请人： Max-Planck-Gesellschaft Zur Foerderung der Wissenschaften e. V. ,  University of Toronto

发明人： Yiding LIN ,  Zheng YONG ,  Jason MAK ,  Wesley SACHER ,  Joyce POON

IPC分类号： H01L31/107 ,  G02B6/12 ,  G02B6/122

CPC分类号： H01L31/107 ,  G02B6/1228 ,  G02B2006/12123

摘要： A photodetector apparatus (100), being configured for detecting light in the visible or infrared spectrum, comprises a substrate (30), a waveguide (20), a detector section (10), a first contact section (50) and a second contact section (52). The substrate (30) has a substrate surface (32) and a cladding layer (40). The waveguide (20) is arranged above the substrate surface (32) in the cladding layer (40) and is adapted for guiding light. The detector section (10) comprises a p-doped region (12, 14) and an ndoped region (16, 18), and the detector section (10′) is arranged for producing charge carriers by the (10) light guided in the waveguide (20). The first contact section (50) is connected to the p-doped region (12, 14) and the second contact section (52) is connected to the n-doped region (16, 18), the first and second contact sections (50, 52) being connectable to a measuring device for measuring an electrical signal based on the charge carriers produced by the light. The waveguide (20) and the detector section (10) are spaced apart by a portion of the cladding layer (40) with a mutual distance such that optical power of the light guided in the waveguide (20) can be gradually transferred from the waveguide (20) to the detector section (10). Furthermore, a method of detecting light in the visible or infrared spectrum is described.