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公开(公告)号：US07741440B2
公开(公告)日：2010-06-22
申请号：US11879370
申请日：2007-07-16
申请人： Mathieu Hubertus M. Noteborn , Astrid Adriana A. M. Danen-van Oorschot , Jennifer Leigh Rohn , Bertram Weiss , Luisella Toschi
发明人： Mathieu Hubertus M. Noteborn , Astrid Adriana A. M. Danen-van Oorschot , Jennifer Leigh Rohn , Bertram Weiss , Luisella Toschi
CPC分类号： A61K38/162 , A01K2217/05 , A61K38/1709 , A61K48/005 , C07K14/4747 , C07K16/40 , C12N2501/48 , C12N2510/00 , C12N2750/10011 , G01N33/68 , G01N2510/00
摘要： The invention relates to the field of apoptosis. The invention provides novel therapies, for example, novel combinatorial therapies or novel therapeutic compounds that can work alone, sequentially to, or jointly with Apoptin, especially in those cases wherein p53 is completely or partially non-functional.
摘要翻译： 本发明涉及细胞凋亡领域。 本发明提供了新的治疗方法，例如新的组合疗法或可以单独，顺序地或与Apoptin共同工作的新型治疗化合物，特别是在p53完全或部分不起作用的情况下。
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公开(公告)号：US20070197524A1
公开(公告)日：2007-08-23
申请号：US11642975
申请日：2006-12-21
申请人： Nico Brauer , Bernd Buchmann , Christoph Huwe , Bernhard Lindenthal , Gernot Langer , Olaf Peters , Gerd Schubert , Ulrich Bothe , Luisella Toschi , Michaele Peters-Kottig
发明人： Nico Brauer , Bernd Buchmann , Christoph Huwe , Bernhard Lindenthal , Gernot Langer , Olaf Peters , Gerd Schubert , Ulrich Bothe , Luisella Toschi , Michaele Peters-Kottig
IPC分类号： A61K31/5377 , A61K31/4709 , A61K31/428 , A61K31/4178 , A61K31/416 , A61K31/403 , C07D403/02
CPC分类号： C07D209/88
摘要： The present invention relates to carbazoles/fluorenes, to processes for their preparation and to their use for preparing pharmaceutical agents for the treatment of disorders connected to the EP2 receptor.
摘要翻译： 本发明涉及咔唑/芴，其制备方法及其用于制备用于治疗与EP 2受体相关的病症的药物的用途。
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公开(公告)号：US20080058267A1
公开(公告)日：2008-03-06
申请号：US11879370
申请日：2007-07-16
申请人： Mathieu Hubertus Noteborn , Astrid Adriana Danen-van Oorschot , Jennifer Rohn , Bertram Weiss , Luisella Toschi
发明人： Mathieu Hubertus Noteborn , Astrid Adriana Danen-van Oorschot , Jennifer Rohn , Bertram Weiss , Luisella Toschi
IPC分类号： A61K38/16 , A61K31/70 , A61P35/00 , A61P37/00 , C07H21/04 , C07K14/00 , C07K16/00 , C12N15/00 , G01N33/53
CPC分类号： A61K38/162 , A01K2217/05 , A61K38/1709 , A61K48/005 , C07K14/4747 , C07K16/40 , C12N2501/48 , C12N2510/00 , C12N2750/10011 , G01N33/68 , G01N2510/00
摘要： The invention relates to the field of apoptosis. The invention provides novel therapies, for example, novel combinatorial therapies or novel therapeutic compounds that can work alone, sequentially to, or jointly with Apoptin, especially in those cases wherein p53 is completely or partially non-functional.
摘要翻译： 本发明涉及细胞凋亡领域。 本发明提供了新的治疗方法，例如可以独立地，顺序地或与Apoptin共同工作的新型组合疗法或新的治疗化合物，特别是在p53完全或部分不功能的情况下。
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公开(公告)号：US07256274B2
公开(公告)日：2007-08-14
申请号：US09733416
申请日：2000-12-08
申请人： Mathieu Hubertus M. Noteborn , Astrid Adriana A. M. Danen-van Oorschot , Jennifer Leigh Rohn , Bertram Weiss , Luisella Toschi
发明人： Mathieu Hubertus M. Noteborn , Astrid Adriana A. M. Danen-van Oorschot , Jennifer Leigh Rohn , Bertram Weiss , Luisella Toschi
IPC分类号： C07H21/04
CPC分类号： A61K38/162 , A01K2217/05 , A61K38/1709 , A61K48/005 , C07K14/4747 , C07K16/40 , C12N2501/48 , C12N2510/00 , C12N2750/10011 , G01N33/68 , G01N2510/00
摘要： The invention relates to the field of apoptosis. The invention provides novel therapeutic possibilities, for example novel combinatorial therapies or novel therapeutic compounds that can work alone, sequentially to, or jointly with Apoptin, especially in those cases wherein p53 is (partly) nonfunctional.
摘要翻译： 本发明涉及细胞凋亡领域。 本发明提供新颖的治疗可能性，例如可以独立地，顺序地或与Apoptin共同工作的新型组合疗法或新型治疗化合物，特别是在p53是（部分）非功能性的情况下。
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5.发明授权9-chloro-15-deoxyprostaglandin derivatives, process for their preparation and their use as medicaments 失效9-氯-15-脱氧前列腺素衍生物，其制备方法及其作为药物的用途公开(公告)号：US07563924B2
公开(公告)日：2009-07-21
申请号：US11602690
申请日：2006-11-20
申请人： Bernd Buchmann , Daryl Faulds , William Guilford , Gernot Langer , Judy Li , Bernhard Lindenthal , Werner Skuballa , Luisella Toschi
发明人： Bernd Buchmann , Daryl Faulds , William Guilford , Gernot Langer , Judy Li , Bernhard Lindenthal , Werner Skuballa , Luisella Toschi
IPC分类号： C07C69/74 , A61K31/557
CPC分类号： C07C405/00 , C07C2601/04 , C07D309/12
摘要： The present invention relates to 9-chloroprostaglandin derivatives of the general formula I which may be advantageous for the treatment of fertility problems.
摘要翻译： 本发明涉及通式Ⅰ的9-氯前列腺素衍生物，其可有利于治疗生殖问题。
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公开(公告)号：US20080103099A1
公开(公告)日：2008-05-01
申请号：US11906493
申请日：2007-10-01
IPC分类号： A61K38/17 , A61K48/00 , A61P35/00 , A61P37/00 , C07H21/04 , C07K16/18 , C12N15/00 , C12N5/00 , G01N33/53
CPC分类号： A61K38/162 , A01K2217/05 , A61K38/1709 , A61K48/005 , C07K14/4747 , C07K16/40 , C12N2501/48 , C12N2510/00 , C12N2750/10011 , G01N33/68 , G01N2510/00
摘要： The invention relates to the field of apoptosis. The invention provides novel therapies, for example, novel combinatorial therapies or novel therapeutic compounds that can work alone, sequentially to, or jointly with Apoptin, especially in those cases wherein p53 is completely or partially non-functional.
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7.发明申请9-Chloro-15-deoxyprostaglandin derivatives, process for their preparation and their use as medicaments 失效9-氯-15-脱氧前列腺素衍生物，其制备方法及其用作药物公开(公告)号：US20070203096A1
公开(公告)日：2007-08-30
申请号：US11602690
申请日：2006-11-20
申请人： Bernd Buchmann , Daryl Faulds , William Guilford , Gernot Langer , Judy Li , Bernhard Lindenthal , Werner Skuballa , Luisella Toschi
发明人： Bernd Buchmann , Daryl Faulds , William Guilford , Gernot Langer , Judy Li , Bernhard Lindenthal , Werner Skuballa , Luisella Toschi
IPC分类号： A61K31/724 , A61K31/695 , A61K31/557
CPC分类号： C07C405/00 , C07C2601/04 , C07D309/12
摘要： The present invention relates to 9-chloroprostaglandin derivatives of the general formula I which may be advantageous for the treatment of fertility problems.
摘要翻译： 本发明涉及通式Ⅰ的9-氯前列腺素衍生物，其可有利于治疗生殖问题。
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