公开(公告)号：US06867334B2

公开(公告)日：2005-03-15

申请号：US09971852

申请日：2001-10-03

申请人： Kenneth L. Rinehart ,  Jose J. Morales ,  Joel Reid ,  Isabel Reymundo ,  Pablo Floriano ,  Lola Garcia Gravalos

发明人： Kenneth L. Rinehart ,  Jose J. Morales ,  Joel Reid ,  Isabel Reymundo ,  Pablo Floriano ,  Lola Garcia Gravalos

IPC分类号： A61K31/357 ,  A61K31/36 ,  A61K31/39 ,  A61K31/47 ,  A61K31/472 ,  A61K31/4747 ,  A61K31/4995 ,  A61K35/02 ,  A61P35/00 ,  C07D217/10 ,  C07D217/24 ,  C07D317/44 ,  C07D317/64 ,  C07D317/66 ,  C07D327/02 ,  C07D411/14 ,  C07D491/14 ,  C07D497/22 ,  C07D515/22 ,  C07C205/00

CPC分类号： C07D515/22 ,  C07D217/10 ,  C07D317/64

摘要： The purification and structure elucidation of several products of the metabolism of Et 743 by human cytochrome CYP3A4 have been accomplished. These compounds are abbreviated herein as “ETM” followed by a numeric value which represents the approximate molecular weight. Three compounds have been identified to date, namely ETM 305, ETM 775 and ETM 204. The structures of these ecteinascidin metabolites are as follows:

摘要翻译： 已经完成了人细胞色素CYP3A4对几种Et 743代谢产物的纯化和结构解析。 这些化合物在本文中简称为“ETM”，后面是表示近似分子量的数值。 目前已经鉴定了三种化合物，即ETM 305，ETM 775和ETM 204.这些ecteinidinidin代谢物的结构如下：

公开(公告)号：US06316214B1

公开(公告)日：2001-11-13

申请号：US09309947

申请日：1999-05-11

申请人： Kenneth L. Rinehart ,  Jose J. Morales ,  Joel Reid ,  Isabel Reymundo ,  Pablo Floriano ,  Lola Garcia Gravalos

发明人： Kenneth L. Rinehart ,  Jose J. Morales ,  Joel Reid ,  Isabel Reymundo ,  Pablo Floriano ,  Lola Garcia Gravalos

IPC分类号： C12Q126

CPC分类号： C07D515/22 ,  C07D217/10 ,  C07D317/64

摘要： The purification and structure elucidation of several products of the metabolism of Et 743 by human cytochrome CYP3A4 have been accomplished. These compounds are abbreviated herein as “ETM” followed by a numeric value, which represents the approximate molecular weight. Three compounds have been identified to date, namely ETM 305, ETM 775 and ETM 204. The structures of these ecteinascidin metabolites are as follows:

摘要翻译： 已经完成了人细胞色素CYP3A4对几种Et 743代谢产物的纯化和结构解析。 这些化合物在本文中简称为“ETM”，随后是表示近似分子量的数值。 目前已经鉴定了三种化合物，即ETM 305，ETM 775和ETM 204.这些ecteinidinidin代谢物的结构如下：

公开(公告)号：US07115743B2

公开(公告)日：2006-10-03

申请号：US11009237

申请日：2004-12-10

申请人： Kenneth L. Rinehart ,  Jose J. Morales ,  Joel Reid ,  Isabel Reymundo ,  Pablo Floriano ,  Lola Garcia Gravalos

发明人： Kenneth L. Rinehart ,  Jose J. Morales ,  Joel Reid ,  Isabel Reymundo ,  Pablo Floriano ,  Lola Garcia Gravalos

IPC分类号： C07D221/18

CPC分类号： C07D515/22 ,  C07D217/10 ,  C07D317/64

摘要： The purification and structure elucidation of several products of the metabolism of Et 743 by human cytochrome CYP3A4 have been accomplished. These compounds are abbreviated herein as “ETM” followed by a numeric value which represents the approximate molecular weight. Three compounds have been identified to date, namely ETM 305, ETM 775 and ETM 204. The structures of these ecteinascidin metabolites are as follows:

摘要翻译： 已经完成了人细胞色素CYP3A4对几种Et 743代谢产物的纯化和结构解析。 这些化合物在本文中简称为“ETM”，后面是表示近似分子量的数值。 目前已经鉴定了三种化合物，即ETM 305，ETM 775和ETM 204.这些ecteinidinidin代谢物的结构如下：