Invention Grant
US06867334B2 Metabolites of ecteinascidin 743 formed by human cytochrome CYP3A4
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人细胞色素CYP3A4形成的ecteinascidin 743的代谢物
- Patent Title: Metabolites of ecteinascidin 743 formed by human cytochrome CYP3A4
- Patent Title (中): 人细胞色素CYP3A4形成的ecteinascidin 743的代谢物
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Application No.: US09971852Application Date: 2001-10-03
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Publication No.: US06867334B2Publication Date: 2005-03-15
- Inventor: Kenneth L. Rinehart , Jose J. Morales , Joel Reid , Isabel Reymundo , Pablo Floriano , Lola Garcia Gravalos
- Applicant: Kenneth L. Rinehart , Jose J. Morales , Joel Reid , Isabel Reymundo , Pablo Floriano , Lola Garcia Gravalos
- Applicant Address: ES Madrid
- Assignee: Pharma Mar, S.A.
- Current Assignee: Pharma Mar, S.A.
- Current Assignee Address: ES Madrid
- Agency: Fish & Richardson P.C.
- Main IPC: A61K31/357
- IPC: A61K31/357 ; A61K31/36 ; A61K31/39 ; A61K31/47 ; A61K31/472 ; A61K31/4747 ; A61K31/4995 ; A61K35/02 ; A61P35/00 ; C07D217/10 ; C07D217/24 ; C07D317/44 ; C07D317/64 ; C07D317/66 ; C07D327/02 ; C07D411/14 ; C07D491/14 ; C07D497/22 ; C07D515/22 ; C07C205/00
Abstract:
The purification and structure elucidation of several products of the metabolism of Et 743 by human cytochrome CYP3A4 have been accomplished. These compounds are abbreviated herein as “ETM” followed by a numeric value which represents the approximate molecular weight. Three compounds have been identified to date, namely ETM 305, ETM 775 and ETM 204. The structures of these ecteinascidin metabolites are as follows:
Public/Granted literature
- US20020032326A1 Metabolites of ecteinascidin 743 formed by human cytochrome CYP3A4 Public/Granted day:2002-03-14
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