公开(公告)号：US08445490B2

公开(公告)日：2013-05-21

申请号：US13086036

申请日：2011-04-13

Applicant: Tao Wang ,  Annapurna Pendri ,  Zhongxing Zhang ,  Weixu Zhai ,  Guo Li ,  Samuel Gerritz ,  Paul Michael Scola ,  Li-Qiang Sun ,  Qian Zhao ,  Eric Mull

Inventor： Tao Wang ,  Annapurna Pendri ,  Zhongxing Zhang ,  Weixu Zhai ,  Guo Li ,  Samuel Gerritz ,  Paul Michael Scola ,  Li-Qiang Sun ,  Qian Zhao ,  Eric Mull

IPC: A61K31/53 ,  C07D251/18

CPC classification number: C07D487/08 ,  C07D498/08

Abstract: The disclosure provides compounds of formula I, including pharmaceutically acceptable salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.

公开(公告)号：US20120213729A1

公开(公告)日：2012-08-23

申请号：US13210776

申请日：2011-08-16

Applicant: Li-Qiang Sun ,  Eric Mull ,  Qian Zhao ,  Tao Wang ,  Zhongxing Zhang ,  Paul Michael Scola

Inventor： Li-Qiang Sun ,  Eric Mull ,  Qian Zhao ,  Tao Wang ,  Zhongxing Zhang ,  Paul Michael Scola

IPC: A61K31/53 ,  A61K38/21 ,  A61K38/13 ,  A61K31/541 ,  A61K31/5377 ,  C07D403/04 ,  C07D413/12 ,  C07D251/52 ,  C07D403/12 ,  C07D401/14 ,  C07D401/12 ,  A61P31/14 ,  A61K38/20 ,  C07D417/12

CPC classification number: C07D251/52 ,  A61K31/53 ,  A61K45/06 ,  C07D401/04 ,  C07D401/12 ,  C07D403/12 ,  A61K2300/00

Abstract: The disclosure provides compounds of formula I, including pharmaceutically acceptable salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.

Abstract translation: 本公开提供式I化合物，包括药学上可接受的盐，以及使用该化合物的组合物和方法。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。

公开(公告)号：US20090285773A1

公开(公告)日：2009-11-19

申请号：US12464954

申请日：2009-05-13

Applicant: Li-Qiang Sun ,  Paul Michael Scola

Inventor： Li-Qiang Sun ,  Paul Michael Scola

IPC: A61K31/4709 ,  C07D487/00 ,  A61K38/21 ,  A61K38/20 ,  A61K31/7088 ,  A61P31/12

CPC classification number: C07D487/04

Abstract: Hepatitis C virus inhibitors having the general formula are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.

公开(公告)号：US20080152619A1

公开(公告)日：2008-06-26

申请号：US11430611

申请日：2006-05-09

Applicant: Ny Sin ,  Paul Michael Scola ,  Nicholas A. Meanwell ,  Xiangdong Alan Wang ,  Li-Qiang Sun ,  Jie Chen ,  Andrew Charles Good

Inventor： Ny Sin ,  Paul Michael Scola ,  Nicholas A. Meanwell ,  Xiangdong Alan Wang ,  Li-Qiang Sun ,  Jie Chen ,  Andrew Charles Good

IPC: A61K38/20 ,  C07D207/06 ,  A61K31/401 ,  A61P31/14 ,  A61K38/21

CPC classification number: C07K5/0808

Abstract: Hepatitis C virus inhibitors having the general formula are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.

Abstract translation: 公开了具有通式的丙型肝炎病毒抑制剂。 还公开了包含化合物的组合物和使用该化合物抑制HCV的方法。

公开(公告)号：US20070010455A1

公开(公告)日：2007-01-11

申请号：US11481536

申请日：2006-07-06

Applicant: Piyasena Hewawasam ,  Min Ding ,  Li-Qiang Sun ,  Paul Scola

Inventor： Piyasena Hewawasam ,  Min Ding ,  Li-Qiang Sun ,  Paul Scola

IPC: A61K38/05 ,  C07K7/06

CPC classification number: C07K5/0808 ,  A61K38/00

Abstract: The present disclosure relates to tripeptide compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

Abstract translation: 本公开涉及用于治疗丙型肝炎病毒（HCV）感染的三肽化合物，组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。

公开(公告)号：US07144881B2

公开(公告)日：2006-12-05

申请号：US10719184

申请日：2003-11-21

Applicant: Yong-Jin Wu ,  Alexandre L'Heureux ,  Li-Qiang Sun

Inventor： Yong-Jin Wu ,  Alexandre L'Heureux ,  Li-Qiang Sun

IPC: A61K31/535 ,  C07D265/30 ,  C07D211/72 ,  C07D307/78 ,  C07C239/00

CPC classification number: C07C233/60 ,  A61K31/192 ,  A61K31/343 ,  A61K31/40 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/5375 ,  C07C233/58 ,  C07C233/59 ,  C07C2601/02 ,  C07D207/14 ,  C07D213/40 ,  C07D213/61 ,  C07D295/135 ,  C07D307/81

Abstract: The present invention provides novel arylcyclopropylcarboxylic amides and related derivatives having the general Formula I wherein R, R1, R2, R3, R4, R5, R6 and R7 are as defined in the specification, or a nontoxic pharmaceutically acceptable salt, solvate or hydrate thereof which are openers or activators of KCNQ potassium channels. The present invention also provides pharmaceutical compositions comprising said arylcyclopropylcarboxylic amides and to the method of treatment of disorders sensitive to KCNQ potassium channel opening activity such as migraine or a migraine attack, bipolar disorders, epilepsy, acute and chronic pain and anxiety.

Abstract translation: 本发明提供新的芳基环丙基羧酰胺和具有通式I的相关衍生物，其中R 1，R 2，R 2，R 3，R 3， R 4，R 5，R 6和R 7如说明书中所定义，或无毒的药学上可接受的盐 ，其为KCNQ钾通道的开放剂或活化剂的溶剂化物或水合物。 本发明还提供包含所述芳基环丙基羧酰胺的药物组合物和治疗对KCNQ钾通道开放活性敏感的疾病如偏头痛或偏头痛发作，双相情感障碍，癫痫，急性和慢性疼痛和焦虑症的方法。

公开(公告)号：US07135462B2

公开(公告)日：2006-11-14

申请号：US10992548

申请日：2004-11-18

Applicant: Paul Michael Scola ,  Jeffrey Allen Campbell ,  Ny Sin ,  Li-Qiang Sun ,  Xiangdong Alan Wang

Inventor： Paul Michael Scola ,  Jeffrey Allen Campbell ,  Ny Sin ,  Li-Qiang Sun ,  Xiangdong Alan Wang

IPC: A61K38/00

CPC classification number: A61K31/40 ,  A61K31/4709 ,  A61K38/00 ,  C07K5/0808 ,  C07K5/0827

Abstract: Hepatitis C virus inhibitors are disclosed having the general formula: wherein A, R2, R3, R′, B and Y are described in the description. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.

Abstract translation: 公开了具有以下通式的丙型肝炎病毒抑制剂：其中A，R 2，R 3，R'，B和Y在说明书中描述。 还公开了包含化合物的组合物和使用该化合物抑制HCV的方法。

公开(公告)号：US20050267040A1

公开(公告)日：2005-12-01

申请号：US10992548

申请日：2004-11-18

Applicant: Paul Scola ,  Jeffrey Campbell ,  Ny Sin ,  Li-Qiang Sun ,  Xiangdong Wang

Inventor： Paul Scola ,  Jeffrey Campbell ,  Ny Sin ,  Li-Qiang Sun ,  Xiangdong Wang

IPC: A61K31/40 ,  A61K31/4709 ,  A61K31/695 ,  A61K38/00 ,  A61K38/05 ,  A61K38/06 ,  A61K38/21 ,  C07K5/06 ,  C07K5/08 ,  C07K5/083

CPC classification number: A61K31/40 ,  A61K31/4709 ,  A61K38/00 ,  C07K5/0808 ,  C07K5/0827

Abstract: Hepatitis C virus inhibitors are having the general formula: wherein A, R2, R3, R′, B and Y are described in the description. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.

Abstract translation: 丙型肝炎病毒抑制剂具有以下通式：其中A，R 2，R 3，R'，B和Y在说明书中描述。 还公开了包含化合物的组合物和使用该化合物抑制HCV的方法。

公开(公告)号：US06737431B2

公开(公告)日：2004-05-18

申请号：US10383131

申请日：2003-03-06

Applicant: Katherine S. Takaki ,  Li-Qiang Sun ,  Graham Johnson ,  Stephen R. Bertenshaw ,  Derek Denhart ,  Jie Chen

Inventor： Katherine S. Takaki ,  Li-Qiang Sun ,  Graham Johnson ,  Stephen R. Bertenshaw ,  Derek Denhart ,  Jie Chen

IPC: A61K31423

CPC classification number: C07D263/56 ,  A61K31/423 ,  C07D263/57 ,  C07D413/04

Abstract: Novel benzoxazole derivatives which have a binding affinity for the human melatonin receptor and, therefore, are useful as melatonergic agents.

Abstract translation: 对于人褪黑素受体具有结合亲和力的新型苯并恶唑衍生物，因此可用作褪黑激素药。

公开(公告)号：US08933066B2

公开(公告)日：2015-01-13

申请号：US13440003

申请日：2012-04-05

Applicant: Tao Wang ,  Li-Qiang Sun ,  Paul Michael Scola

Inventor： Tao Wang ,  Li-Qiang Sun ,  Paul Michael Scola

IPC: C07D413/14 ,  C07D487/12 ,  A61K31/395 ,  A61K31/53 ,  A61K45/06 ,  C07D487/16 ,  C07D498/16 ,  C07D487/18 ,  C07D498/18

CPC classification number: A61K31/53 ,  A61K45/06 ,  C07D487/16 ,  C07D487/18 ,  C07D498/16 ,  C07D498/18

Abstract: The disclosure provides compounds of formula I, including pharmaceutically acceptable salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.

Abstract translation: 本公开提供式I化合物，包括药学上可接受的盐，以及使用该化合物的组合物和方法。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。