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公开(公告)号：US06787300B2
公开(公告)日：2004-09-07
申请号：US09826752
申请日：2001-04-05
IPC分类号： C12Q102
CPC分类号： C12Q1/025 , C07K14/395 , C12R1/865
摘要： Methods of isolating mutant yeast cells with increased life span, as well as mutant yeast cells isolated by the methods, are disclosed. Also described are methods of identifying agents which increase life span of yeast cells, and methods of isolating genes which affect senescence in organisms.
摘要翻译： 公开了分离增加寿命的突变酵母细胞的方法，以及通过该方法分离的突变酵母细胞。 还描述了鉴定增加酵母细胞寿命的试剂的方法，以及分离影响生物衰老的基因的方法。
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公开(公告)号：US06218512B1
公开(公告)日：2001-04-17
申请号：US09323433
申请日：1999-06-01
IPC分类号： C07K1400
CPC分类号： C12Q1/025 , C07K14/395 , C12R1/865
摘要： Methods of isolating mutant yeast cells with increased life span, as well as mutant yeast cells isolated by the methods, are disclosed. Also described are methods of identifying agents which increase life span of yeast cells, and methods of isolating genes which affect senescence in organisms.
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公开(公告)号：US20110098190A1
公开(公告)日：2011-04-28
申请号：US12851225
申请日：2010-08-05
IPC分类号： C40B30/04 , G01N33/573
CPC分类号： C12N15/1137 , C12N9/80 , C12Q1/48 , G01N2333/91142
摘要： Methods of screening for compounds that modulate the expression or activity of Sirt4 are provided. Also provided are methods of modulating insulin secretion, treating metabolic disorders, and treating neurodegenerative disorders by modulating the expression or activity of Sirt4.
摘要翻译： 提供筛选调节Sirt4表达或活性的化合物的方法。 还提供了调节胰岛素分泌，治疗代谢紊乱和通过调节Sirt4的表达或活性来治疗神经变性疾病的方法。
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公开(公告)号：US06228583B1
公开(公告)日：2001-05-08
申请号：US09127670
申请日：1998-07-31
IPC分类号： C12Q168
CPC分类号： C12N15/1082 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , C07K14/47 , C12N9/14 , C12N15/81 , C12N15/8509 , C12Q1/02 , C12Q1/025 , G01N33/5008 , G01N33/5088 , G01N2800/52
摘要： Methods of identifying agents or compounds which are capable of inhibiting the replication and/or accumulation of DNA circles in cells are described. Also described are methods of assessing the ability of a compound to extend life span, as well as methods of extending life span, comprising administering to a cell a compound identified by the assays described herein which extends life span. The invention also pertains to isolated mWRN, or an active derivative or fragment thereof and to an isolated nucleic acid molecule which encodes mWRN, or an active derivative or fragment thereof.
摘要翻译： 描述了鉴定能够抑制细胞中DNA环的复制和/或积累的试剂或化合物的方法。 还描述了评估化合物延长寿命的能力的方法以及延长寿命的方法，包括向细胞施用延长寿命的本文所述测定法鉴定的化合物。 本发明还涉及分离的mWRN或其活性衍生物或片段，以及编码mWRN的分离的核酸分子或其活性衍生物或片段。
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公开(公告)号：US5919618A
公开(公告)日：1999-07-06
申请号：US396001
申请日：1995-02-28
CPC分类号： C12Q1/025 , C07K14/395 , C12R1/865
摘要： Methods of isolating mutant yeast cells with increased life span, as well as mutant yeast cells isolated by the methods, are disclosed. Also described are methods of identifying agents which increase life span of yeast cells, and methods of isolating genes which affect senescence in organisms.
摘要翻译： 公开了分离增加寿命的突变酵母细胞的方法，以及通过该方法分离的突变酵母细胞。 还描述了鉴定增加酵母细胞寿命的试剂的方法以及分离影响生物衰老的基因的方法。
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公开(公告)号：US5874210A
公开(公告)日：1999-02-23
申请号：US861464
申请日：1997-05-22
IPC分类号： C07K14/395 , C12Q1/02
CPC分类号： C12Q1/025 , C07K14/395 , C12R1/865
摘要： Methods of isolating mutant yeast cells with increased life span, as well as mutant yeast cells isolated by the methods, are disclosed. Also described are methods of identifying agents which increase life span of yeast cells, and methods of isolating genes which affect senescence in organisms.
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公开(公告)号：US08546074B2
公开(公告)日：2013-10-01
申请号：US13523412
申请日：2012-06-14
IPC分类号： C12Q1/00 , G01N33/53 , G01N33/567
CPC分类号： C12Q1/68 , C12Q1/44 , G01N2333/4703 , G01N2333/916 , G01N2500/02
摘要： Methods for screening a compound, by providing a test mixture comprising a transcription factor, Sir2, and a Sir2 cofactor with the compound, and evaluating an activity of a component of the test mixture in the presence of the compound are described.
摘要翻译： 描述了通过向化合物提供包含转录因子Sir2和Sir2辅因子的测试混合物并在化合物存在下评价测试混合物的组分的活性来筛选化合物的方法。
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公开(公告)号：US20110218229A1
公开(公告)日：2011-09-08
申请号：US12952805
申请日：2010-11-23
IPC分类号： A61K31/711 , G01N33/53 , C12Q1/68 , A61K31/7105 , A61P3/04
CPC分类号： G01N33/5091 , C07K16/18 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , G01N33/6872 , G01N2333/70567 , G01N2333/98 , G01N2500/10 , G01N2800/044
摘要： SIRT1 regulates the physiology of cells of the adipocyte lineage. Modulators of SIRT1 activity can be used to ameliorate, treat, or prevent diseases and disorders associated with adipose physiology, e.g., obesity, an obesity-related disease, or a fat-related metabolic disorder.
摘要翻译： SIRT1调节脂肪细胞谱系细胞的生理学。 SIRT1活性的调节剂可用于改善，治疗或预防与脂肪生理学相关的疾病和病症，例如肥胖症，肥胖相关疾病或与脂肪有关的代谢紊乱。
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