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公开(公告)号：US11925146B2
公开(公告)日：2024-03-12
申请号：US17704843
申请日：2022-03-25
发明人： Xiaofei Shi , Wei Liu , Yingli Cai , Fuqiang Yu
摘要： The present disclosure provides a cultivation method of morels and belongs to the technical field of cultivation of edible fungi. After nutrient contents that can be metabolized and utilized by morel mycelia are scientifically matched, sterilization treatment of exogenous nutrients is eliminated, and the exogenous nutrients are directly compressed for forming. Formed exogenous nutrient blocks and spawn is sowed and covered with soil, so as to realize a potential difference between “rich” and “poor” nutrients in a physical space. When the spawn germinate to form a mycelium network, the mycelia will enter a nutrient-rich exogenous nutrient area, secrete various extracellular enzymes to decompose and utilize these exogenous nutrient blocks, and transport them to a nutrient-poor mycelium network for storage, so as to complete nutrient assimilation and absorption, and reserve energy for later sexual reproduction.
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公开(公告)号：US20230345936A1
公开(公告)日：2023-11-02
申请号：US17900091
申请日：2022-08-31
发明人： Zhiyun YANG , Xiao DING , Junbo YANG , Guoxing WU , Mingxian LAN
摘要： The present disclosure provides a use of a novel environment-friendly agricultural chemical, and belongs to the field of agricultural chemicals. It is found in the present disclosure that methyl 4-hydroxyphenylacetate may be used for controlling plants and preparing herbicides. The methyl 4-hydroxyphenylacetate in the present disclosure has a use concentration greater than 150 mmol/L. The herbicide is prepared by using the methyl 4-hydroxyphenylacetate as an active ingredient in the present disclosure has a good controlling and killing effect on perennial herbs or Half-shrubby plants, especially Eupatorium adenophorum, and has low toxicity, no harm, and no solvent residues after use.
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3.发明申请LOW-MOLECULAR-WEIGHT GLYCOSAMINOGLYCAN DERIVATIVE CONTAINING TERMINAL 2, 5-ANHYDRATED TALOSE OR DERIVATIVE THEREOF 审中-公开低分子量重量糖蛋白糖衍生物含末端2,5-脱水罗非鱼或其衍生物公开(公告)号：US20160060364A1
公开(公告)日：2016-03-03
申请号：US14779934
申请日：2013-12-20
发明人： Jinhua ZHAO , Mingyi WU , Na GAO , Zi LI , Sensen LAI , Longyan ZHAO
IPC分类号： C08B37/00 , A61K9/00 , A61K9/19 , A61K31/726 , A61K9/08
CPC分类号： C08B37/0063 , A61K9/0019 , A61K9/08 , A61K9/19 , A61K31/726 , C07H5/06
摘要： A low-molecular-weight fucosylated glycosaminoglycan (aTFG) containing 2,5-anhydrated talose, alditol, glycosylamine or N-substituted glycosylamine monosaccharide composition thereof, preparation method thereof, pharmaceutical compositions containing the aTFG, and use thereof for preventing and/or treating thrombotic diseases are provided. The aTFG has potent anticoagulant activity targeting at intrinsic coagulation factor Xase, and inhibiting thrombogenesis, and therefore can be used as drugs for preventing and/or treating cardiovascular and cerebrovascular diseases.
摘要翻译： 含有2,5-脱水谷糖，糖醇，糖胺或N-取代的糖胺单糖组合物的低分子量岩藻糖基化糖胺聚糖（aTFG）及其制备方法，含有aTFG的药物组合物及其用于预防和/或治疗 提供血栓性疾病。 aTFG具有针对固有凝血因子Xase的有效的抗凝血活性，并抑制血栓形成，因此可用作预防和/或治疗心血管和脑血管疾病的药物。
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4.发明申请公开(公告)号：US20160039949A1
公开(公告)日：2016-02-11
申请号：US14778966
申请日：2013-12-20
CPC分类号： C08B37/0063 , A61K9/0019 , A61K31/726 , C08B37/00
摘要： Provided are a low-molecular-weight fucosylated glycosaminoglycan derivative (derivative of Low molecular weight Fucosylated Glycosaminoglycan, dLFG) having anticoagulant activity, a preparation method thereof, a pharmaceutical composition comprising dLFG or a pharmaceutically acceptable salt thereof, and the use of dLFG and pharmaceutical composition thereof in preparing medicine for treating thrombotic diseases.
摘要翻译： 提供具有抗凝血活性的低分子量岩藻糖基化糖胺聚糖衍生物（低分子量岩藻糖基化糖胺聚糖衍生物，dLFG）及其制备方法，包含dLFG或其药学上可接受的盐的药物组合物，以及使用dLFG和药物 在制备用于治疗血栓形成疾病的药物中的组合物。
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5.发明授权Use of an urushiol compound in preparation of pharmaceutical compositions for inhibiting Smad3 phosphorylation 有权在制备用于抑制Smad3磷酸化的药物组合物中使用漆酚化合物公开(公告)号：US09139502B2
公开(公告)日：2015-09-22
申请号：US14531309
申请日：2014-11-03
申请人： Southern Hospital, Southern Medical University , Kunming Institute of Botany, Chinese Academy of Sciences
发明人： Fan Fan Hou , Yongxian Cheng , Jing Nie , Jun Al , Jiangbo He
摘要： The invention relates to a use of an urushiol compound (code named GQ-5) in preparation of pharmaceutical compositions for inhibiting Smad3 phosphorylation. We verify that GQ-5 inhibited the interaction of Smad3 with TGF-β type I receptor (TβRI), inhibited subsequent phosphorylation of Smad3, reduced nuclear translocation of Smads complex, and suppressed the transcription of major fibrotic genes such as α-smooth muscle actin (α-SMA), collagen I and fibronectin. Therefore, GQ-5 could be a potent and selective inhibitor of TGF-β1-induced Smad3 phosphorylation, and be used to prepare pharmaceutical compositions for inhibiting Smad3 phosphorylation.
摘要翻译： 本发明涉及一种用于抑制Smad3磷酸化的药物组合物的漆酚化合物（代号GQ-5）的用途。 我们验证GQ-5抑制Smad3与TGF-β的相互作用; I型受体（T＆bgr; RI）抑制Smad3的随后的磷酸化，减少Smads复合物的核易位，并抑制主要纤维化基因如α-平滑肌肌动蛋白（α-SMA），胶原I和纤连蛋白的转录。 因此，GQ-5可能是TGF-β1诱导的Smad3磷酸化的有效和选择性抑制剂，可用于制备抑制Smad3磷酸化的药物组合物。
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6.发明申请USE OF AN URUSHIOL COMPOUND IN PREPARATION OF PHARMACEUTICAL COMPOSITIONS FOR INHIBITING SMAD3 PHOSPHORYLATION 有权在制备用于抑制SMAD3磷酸化的药物组合物中的URUSHIOL化合物的使用公开(公告)号：US20150175511A1
公开(公告)日：2015-06-25
申请号：US14531309
申请日：2014-11-03
申请人： Southern Hospital, Southern Medical University , Kunming Institute of Botany, Chinese Academy of Sciences
发明人： Fan Fan HOU , Yongxian CHENG , Jing NIE , Jun AI , Jiangbo HE
IPC分类号： C07C39/19
摘要： The invention relates to a use of an urushiol compound (code named GQ-5) in preparation of pharmaceutical compositions for inhibiting Smad3 phosphorylation. We verify that GQ-5 inhibited the interaction of Smad3 with TGF-β type I receptor (TβRI), inhibited subsequent phosphorylation of Smad3, reduced nuclear translocation of Smads complex, and suppressed the transcription of major fibrotic genes such as α-smooth muscle actin (α-SMA), collagen I and fibronectin. Therefore, GQ-5 could be a potent and selective inhibitor of TGF-β1-induced Smad3 phosphorylation, and be used to prepare pharmaceutical compositions for inhibiting Smad3 phosphorylation.
摘要翻译： 本发明涉及一种用于抑制Smad3磷酸化的药物组合物的漆酚化合物（代号GQ-5）的用途。 我们验证GQ-5抑制Smad3与TGF-β的相互作用; I型受体（T＆bgr; RI）抑制Smad3的随后的磷酸化，减少Smads复合物的核易位，并抑制主要纤维化基因如α-平滑肌肌动蛋白（α-SMA），胶原I和纤连蛋白的转录。 因此，GQ-5可能是TGF-β1诱导的Smad3磷酸化的有效和选择性抑制剂，可用于制备抑制Smad3磷酸化的药物组合物。
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7.发明公开公开(公告)号：US20230257484A1
公开(公告)日：2023-08-17
申请号：US17788422
申请日：2021-11-09
申请人： KUNMING INSTITUTE OF BOTANY, CHINESE ACADEMY OF SCIENCES , BEIJING DR PLANT BIOTECHNOLOGY CO., LTD.
发明人： Jiangmiao HU , Liu YANG , Yuhua WANG , Rui HE , Yong XIE
IPC分类号： C08B37/00 , C07H3/06 , A61K8/73 , A61K36/8984 , A61K31/716 , A61Q19/08 , A61K9/06 , A61P37/02 , B01D11/02 , B01D21/26
CPC分类号： C08B37/006 , C07H3/06 , A61K8/73 , A61K36/8984 , A61K31/716 , A61Q19/08 , A61K9/06 , A61P37/02 , B01D11/0288 , B01D21/262 , A61K2236/331 , A61K2236/333 , A61K2236/53 , A61K2236/51
摘要： A Dendrobium officinale oligosaccharide, a Dendrobium officinale oligosaccharide derivative and a preparation method and use thereof. The Dendrobium officinale oligosaccharide includes 3-9 glycoside residues and a glucose residue at a non-reducing end; the derivative thereof is obtained by substituting with a hydrophobic residue at the non-reducing end; the preparation method and use of both are also provided.
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公开(公告)号：US20230055502A1
公开(公告)日：2023-02-23
申请号：US17704843
申请日：2022-03-25
发明人： Xiaofei SHI , Wei Liu , Yingli Cai , Fuqiang Yu
摘要： The present disclosure provides a cultivation method of morels and belongs to the technical field of cultivation of edible fungi. After nutrient contents that can be metabolized and utilized by morel mycelia are scientifically matched, sterilization treatment of exogenous nutrients is eliminated, and the exogenous nutrients are directly compressed for forming. Formed exogenous nutrient blocks and spawn is sowed and covered with soil, so as to realize a potential difference between “rich” and “poor” nutrients in a physical space. When the spawn germinate to form a mycelium network, the mycelia will enter a nutrient-rich exogenous nutrient area, secrete various extracellular enzymes to decompose and utilize these exogenous nutrient blocks, and transport them to a nutrient-poor mycelium network for storage, so as to complete nutrient assimilation and absorption, and reserve energy for later sexual reproduction.
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公开(公告)号：US20230404946A1
公开(公告)日：2023-12-21
申请号：US17784637
申请日：2021-06-01
发明人： Yuehu Wang , Jifeng Luo , Qian He , Lu Zhang , Shuya Wei , Mengyuan Xia
摘要： (5R,7R,10R)-12,15-dioxo-α-selinene (PFC-37) is used in the preparation of a drug for preventing and treating a neurodegenerative disease and Parkinson's disease.
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10.发明申请公开(公告)号：US20200283744A1
公开(公告)日：2020-09-10
申请号：US16508712
申请日：2019-07-11
发明人： Li Liu , Xiaojun Pu , Lina Liu , Ping Li , Hong Yang
摘要： Some embodiments of the disclosure provide an application method of a CRISPR/Cas12a gene editing system in the gene editing of Physcomitrella patens (P. patens). According to an embodiment, the application method includes the following steps: 1) constructing a Cas12a protease expression vector by ligating a Cas12a-protease-encoding nucleotide sequence with nuclear localization signals at both ends to a plasmid pAct-Cas9 and initiating expression by a pActin promoter; 2) constructing a gRNA expression vector by ligating a gRNA to a plasmid pU6-sgRNA, and initiating expression by a PpU6 promoter; and 3) transforming P. patens by using the Cas12a protease expression vector, the gRNA expression vector, and the plasmid for resistance expression obtain a mutant plant through screening for resistance.
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