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公开(公告)号：US20070265299A1
公开(公告)日：2007-11-15
申请号：US11653798
申请日：2007-01-16
申请人： Brian Lavey , Joseph Kozlowski , Guowei Zhou , Ling Tong , Wensheng Yu , Michael Wong , Bandarpalle Shankar , Neng-Yang Shih , M. Siddiqui , Kristin Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay Girijavallabhan , Dansu Li , Aneta Micula , Seong-Heon Kim , De-Yi Yang , Razia Rizvi
发明人： Brian Lavey , Joseph Kozlowski , Guowei Zhou , Ling Tong , Wensheng Yu , Michael Wong , Bandarpalle Shankar , Neng-Yang Shih , M. Siddiqui , Kristin Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay Girijavallabhan , Dansu Li , Aneta Micula , Seong-Heon Kim , De-Yi Yang , Razia Rizvi
IPC分类号： A61K31/44 , A61K31/4152 , A61K31/4412 , A61K31/4709 , A61K35/00 , A61P11/00 , A61P11/08 , A61P17/06 , A61P3/14 , A61P37/00 , A61P37/08 , A61P9/00 , A61P9/10 , C07D215/06 , C07D233/02 , C07D401/06 , C07D471/02
CPC分类号： C07D403/14 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00
摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPS, ADAMs, TACE, aggrecanase, TNF-α or combinations thereof.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂化物或异构体，其可用于治疗由MMPS，ADAM，TACE，聚集蛋白聚糖蛋白酶，TNF-α或其组合介导的疾病或病症 。
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公开(公告)号：US20070219218A1
公开(公告)日：2007-09-20
申请号：US11653676
申请日：2007-01-16
申请人： Wensheng Yu , Ling Tong , Lei Chen , Joseph Kozlowski , Brian Lavey , Neng-Yang Shih , Vincent Madison , Guowei Zhou , Peter Orth , Zhuyan Guo , Michael Wong , De-Yi Yang , Seong Kim , Bandarpalle Shankar , M. Siddiqui , Kristin Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay Girijavallabhan , Dansu Li , Razia Rizvi , Aneta Micula , Robert Feltz
发明人： Wensheng Yu , Ling Tong , Lei Chen , Joseph Kozlowski , Brian Lavey , Neng-Yang Shih , Vincent Madison , Guowei Zhou , Peter Orth , Zhuyan Guo , Michael Wong , De-Yi Yang , Seong Kim , Bandarpalle Shankar , M. Siddiqui , Kristin Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay Girijavallabhan , Dansu Li , Razia Rizvi , Aneta Micula , Robert Feltz
IPC分类号： A61K31/497 , A61K31/506 , A61K31/4709 , A61K31/4741 , A61K31/4745 , A61K31/4178 , C07D403/14 , C07D491/02 , C07D471/02
CPC分类号： C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00 , C07D473/34 , C07D487/04 , C07D491/04 , C07D495/04
摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂化物，酯或异构体，其可用于治疗由MMP，ADAM，TACE，聚集蛋白聚糖酶，TNF-或组合介导的疾病或病症 其中。
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![Substituted 5-oxo pyrazoles and [1,2,4]triazoles as antiviral agents](/abs-image/US/2006/05/25/US20060111412A1/abs.jpg.150x150.jpg)
3.发明申请公开(公告)号：US20060111412A1
公开(公告)日：2006-05-25
申请号：US11259397
申请日：2005-10-26
申请人： Gerald Shipps , Tong Wang , Kristin Rosner , Patrick Curran , Alan Cooper , Viyyoor Girijavallabhan
发明人： Gerald Shipps , Tong Wang , Kristin Rosner , Patrick Curran , Alan Cooper , Viyyoor Girijavallabhan
IPC分类号： A61K31/4196 , A61K31/4152 , C07D249/12 , C07D231/08
CPC分类号： C07D231/20 , C07D231/22 , C07D401/12 , C07D403/04 , C07D409/12 , C07D417/12
摘要： The present invention provides compounds of formula I wherein X and R1-R7 are as defined herein. Compositions containing these compounds, and methods for inhibiting HCV RNA-dependent RNA polymerase and treating hepatitis C and related disorders using these compounds and compositions are also provided.
摘要翻译： 本发明提供式I化合物，其中X和R 1 -R 7如本文所定义。 还提供了含有这些化合物的组合物，以及用于抑制HCV RNA依赖性RNA聚合酶和使用这些化合物和组合物治疗丙型肝炎和相关病症的方法。
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公开(公告)号：US20070197564A1
公开(公告)日：2007-08-23
申请号：US11653511
申请日：2007-01-16
申请人： Brian Lavey , Joseph Kozlowski , Guowei Zhou , Ling Tong , Wensheng Yu , Michael Wong , Bandarpalle Shankar , Neng-Yang Shih , M. Siddiqui , Kristin Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay Girijavallabhan , Dansu Li , Razia Rizvi , Lei Chen , De-Yi Yang , Robert Feltz , Seong-Heon Kim
发明人： Brian Lavey , Joseph Kozlowski , Guowei Zhou , Ling Tong , Wensheng Yu , Michael Wong , Bandarpalle Shankar , Neng-Yang Shih , M. Siddiqui , Kristin Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay Girijavallabhan , Dansu Li , Razia Rizvi , Lei Chen , De-Yi Yang , Robert Feltz , Seong-Heon Kim
IPC分类号： A61K31/52 , C07D471/02 , A61K31/4745 , A61K31/513 , A61K31/519 , C07D473/02 , C07D487/02
CPC分类号： C07D403/14 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00
摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF-α or combinations thereof.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物或异构体，其可用于治疗由MMP，ADAM，TACE，聚集蛋白聚糖蛋白酶，TNF-α或其组合介导的疾病或病症 。
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公开(公告)号：US20060276506A1
公开(公告)日：2006-12-07
申请号：US11333663
申请日：2006-01-17
申请人： Wensheng Yu , Ling Tong , Lei Chen , Joseph Kozlowski , Brian Lavey , Neng-Yang Shih , Vincent Madison , Guowei Zhou , Peter Orth , Zhuyan Guo , Michael Wong , De-Yi Yang , Seong Kim , Bandarpalle Shankar , M. Siddiqui , Kristin Rosner , Chaoyang Dai , Umar Mansoor , Janeta Popovici-Muller , Vinay Girijavallabhan , Dansu Li
发明人： Wensheng Yu , Ling Tong , Lei Chen , Joseph Kozlowski , Brian Lavey , Neng-Yang Shih , Vincent Madison , Guowei Zhou , Peter Orth , Zhuyan Guo , Michael Wong , De-Yi Yang , Seong Kim , Bandarpalle Shankar , M. Siddiqui , Kristin Rosner , Chaoyang Dai , Umar Mansoor , Janeta Popovici-Muller , Vinay Girijavallabhan , Dansu Li
IPC分类号： A61K31/4709 , A61K31/4245 , A61K31/4178 , C07D413/14 , C07D403/02
CPC分类号： C07D403/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00 , C07D473/34 , C07D487/04 , C07D491/04 , C07D495/04
摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof.
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公开(公告)号：US20060252778A1
公开(公告)日：2006-11-09
申请号：US11142601
申请日：2005-06-01
申请人： Zhuyan Guo , Peter Orth , Zhaoning Zhu , Robert Mazzola , Tin-Yau Chan , Henry Vaccaro , Brian McKittrick , Joseph Kozlowski , Brian Lavey , Guowei Zhou , Sunil Paliwal , Shing-Chun Wong , Neng-Yang Shih , Pauline Ting , Kristin Rosner , Gerald Shipps , M. Siddiqui , David Belanger , Chaoyang Dai , Dansu Li , Vinay Girijavallabhan , Janeta Popovici-Muller , Wensheng Yu , Lianyun Zhao
发明人： Zhuyan Guo , Peter Orth , Zhaoning Zhu , Robert Mazzola , Tin-Yau Chan , Henry Vaccaro , Brian McKittrick , Joseph Kozlowski , Brian Lavey , Guowei Zhou , Sunil Paliwal , Shing-Chun Wong , Neng-Yang Shih , Pauline Ting , Kristin Rosner , Gerald Shipps , M. Siddiqui , David Belanger , Chaoyang Dai , Dansu Li , Vinay Girijavallabhan , Janeta Popovici-Muller , Wensheng Yu , Lianyun Zhao
IPC分类号： C07D471/02 , C07D498/02 , A61K31/519 , A61K31/506 , A61K31/4709 , A61K31/43 , A61K31/4245
CPC分类号： C07D409/14 , C07C235/06 , C07C235/08 , C07C235/10 , C07C2601/08 , C07D207/20 , C07D207/26 , C07D209/44 , C07D215/14 , C07D217/06 , C07D263/32 , C07D295/185 , C07D307/52 , C07D333/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D513/04
摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, TNF-α or combinations thereof.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂化物或异构体，其可用于治疗由MMP，ADAM，TACE，TNF-α或其组合介导的疾病或病症。
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